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| 1 | Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair显示文摘AIM To determine endothelin-1(ET-1)concentration before and after surgical coarctectomy and evaluate its association with left ventricular geometric change.METHODSA prospective,cohort study of 24 patients aged 2 d to 10years with coarctation of the aorta undergoing surgical repair.A sub-cohort of patients with age<1 mo was classified as'neonates'.Echocardiograms were performed just prior to surgery and in the immediate post-op period to assess left ventricle mass index and relative wall thickness(RWT).Plasma ET-1 levels were assessed at both time points.Association between ET-1 levels and ventricular remodeling was assessed.RESULTSPatients<1 year demonstrated higher pre-op ET-1 than post-op(2.8 pg/m L vs 1.9 pg/m L,P=0.02).Conversely,patients>1 year had no change in ET-1 concentration before and after surgery(1.1 vs 1.4,NS).Pre-op,patients<1 year demonstrated significantly higher ET-1 than older children(2.8 vs 1.1,P=0.001).Post-op there was no difference between the age groups(1.9 vs 1.4,NS).Neither RWT nor left ventricle mass index(LVMI)varied from pre-op to post-op.The subset of neonates showed a strong positive correlation between pre-op ET-1 and RWT(r=0.92,P=0.001).Patients with ET-1>2 pg/m L preop demonstrated higher LVMI(65.7 g/m^(2.7) vs 38.5 g/m^(2.7),P=0.004)and a trend towards higher RWT(45%vs39%,P=0.07)prior to repair than those with lower ET-1concentration.CONCLUSIONET-1 concentration is significantly variable in the perioperative period surrounding coarctectomy.Older children and infants have different responses to surgical repair suggesting different mechanisms of activation. | Benjamin Steven Frank Tracy T Urban Suhong Tong Courtney Cassidy Max B Mitchell Christopher S Nichols Jesse A Davidson | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 2 | Cardiovascular surgery in children with Marfan syndrome or Loeys-Dietz syndrome显示文摘 | Melanie D. Everitt Nelangi Pinto John A. Hawkins Max B. Mitchell Peter C. Kouretas Anji T. Yetman | 2009 | The Journal of Thoracic and Cardiovascular Surgery2009，，6： | 1 |
| 3 | Beyond Budgeting: Case Studies in North American Financial Services 显示文摘 | Mitchell Max | 2005 | Joumal of Performance Management2005，18，1： | 1 |
| 4 | Cardiac preconditioning induction of endogenous tolerance to ischemia - reperfusion injury显示文摘 | Daniel R Meldrum Max B Mitchell Anirban Banerjee | 1993 | Arch Surg1993，128，： | 1 |
| 5 | Unilateral decrease in thalamic activity observed with positron emission tomography in patients with chronic neuropathic pain显示文摘 | Michael J. Iadarola Mitchell B. Max Karen Faith Berman Michael G. Byas-Smith Robert C. Coghill Richard H. Gracely Gary J. Bennett | 1994 | Pain1994，，1： | 1 |
| 6 | ABC Trends in the Banking Sector: a Practitioner's Perspective显示文摘 | Max Mitchell 2004 | 2004 | Journal of Performance Management2004，17，3： | 1 |
| 7 | Advances and perspectives in discovery and functional analysis of small secreted proteins in plants显示文摘Small secreted proteins(SSPs)are less than 250 amino acids in length and are actively transported out of cells through conventional protein secretion pathways or unconventional protein secretion pathways.In plants,SSPs have been found to play important roles in various processes,including plant growth and development,plant response to abiotic and biotic stresses,and beneficial plant–microbe interactions.Over the past 10 years,substantial progress has been made in the identification and functional characterization of SSPs in several plant species relevant to agriculture,bioenergy,and horticulture.Yet,there are potentially a lot of SSPs that have not been discovered in plant genomes,which is largely due to limitations of existing computational algorithms.Recent advances in genomics,transcriptomics,and proteomics research,as well as the development of new computational algorithms based on machine learning,provide unprecedented capabilities for genome-wide discovery of novel SSPs in plants.In this review,we summarize known SSPs and their functions in various plant species.Then we provide an update on the computational and experimental approaches that can be used to discover new SSPs.Finally,we discuss strategies for elucidating the biological functions of SSPs in plants. | Xiao-Li Hu Haiwei Lu Md Mahmudul Hassan Jin Zhang Guoliang Yuan Paul E.Abraham Him K.Shrestha Manuel I.Villalobos Solis Jin-Gui Chen Timothy J.Tschaplinski Mitchel J.Doktycz Gerald A.Tuskan Zong-Ming(Max)Cheng Xiaohan Yang | 2021 | Horticulture Research2021，8，1： | 1 |
| 8 | Morbidity of the Arterial Switch Operation 显示文摘 | Serban Stoica Esther Carpenter David Campbell Max Mitchell Eduardo da Cruz Dunbar Ivy Francois Lacour-Gayet | 2012 | Annals of Thoracic Surgery2012，93，6： | 1 |
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