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| 1 | Review of incidence and outcomes of treatment of cholangiocarcinoma in patients with primary sclerosing cholangitis显示文摘Primary sclerosing cholangitis(PSC)is a premalignant condition and a welldocumented risk factor for cholangiocarcinoma(CCA)which is the most common malignancy in this setting and the leading cause of deaths in the recent years,with an increasing incidence.PSC-associated CCA has a geographical distribution that follows the incidence of PSC,with an observed ascending gradient from the Eastern to the Western and from the Southern to the Northern countries.It may arise at any location along the biliary tree but is most common in the perihilar area.Patients with PSC and intrahepatic or perihilar CCA are typically not suitable for liver resection,which is otherwise the treatment of choice with curative intent in patients with resectable tumours,providing a radical resection with clear margins can be achieved.This largely relates to the commonly advanced stage of liver disease at presentation,which allows consideration for liver resection only for a very limited number of suitable patients with PSC.On the other hand,remarkable progress has been reached in the last decades with the implementation of a protocol combining neoadjuvant chemoradiation and orthotopic liver transplantation(OLT)for the treatment of perihilar CCA,within specific criteria.Excellent results have been achieved particularly for PSC patients with this cancer,who seem to benefit the most from this treatment,having converted this into an accepted indication for transplantation and the standard of care in several experienced centres.Intrahepatic CCA as an indication for OLT remains controversial and has not been accepted given disappointing previous results.However,as recent studies have shown favourable outcomes in early intrahepatic CCA,it may be that under defined criteria,OLT may play a more prominent role in the future.Distal CCA in the context of PSC requires aggressive surgical treatment with curative intent,when feasible.This review provides insight about particular features of CCA in the setting of PSC,with a main focus on its incidence,considerations relating to its anatomical location and implications to treatment and outcomes,through the viewpoint of historical evolution of management,and future perspectives. | Francesca Saffioti Vasileios K Mavroeidis | 2021 | World Journal of Gastrointestinal Oncology2021，13，10： | 2 |
| 2 | Surgical ampullectomy:A comprehensive review显示文摘Tumours of the ampulla of Vater are relatively uncommon lesions of the digestive system.They are typically diagnosed at an earlier stage than other types of tumours in this region,due to their tendency to invoke symptoms by obstructing the bile duct or pancreatic duct.Consequently,many are potentially curable by excision.Surgical ampullectomy(SA)(or transduodenal ampullectomy)for an ampullary tumour was first described in 1899,but was soon surpassed by pancreatoduodenectomy(PD),which offered a more extensive resection resulting in a lower risk of recurrence.Ongoing innovation in endoscopic techniques over recent decades has led to the popularization of endoscopic papillectomy(EP),particularly for adenomas and even early cancers.The vast majority of resectable ampullary tumours are now treated using either PD or EP.However,SA continues to play a role in specific circumstances.Many authors have suggested specific indications for SA based on their own data,practices,or interpretations of the literature.However,certain issues have attracted controversy,such as its use for early ampullary cancers.Consequently,there has been a lack of clarity regarding indications for SA,and no evidence-based consensus guidelines have been produced.All studies reporting SA have employed observational designs,and have been heterogeneous in their methodologies.Accordingly,characteristics of patients and their tumours have differed substantially across treatment groups.Therefore,meaningful comparisons of clinical outcomes between SA,PD and EP have been elusive.Nevertheless,it appears that suitably selected cases of ampullary tumours subjected to SA may benefit from favourable peri-operative and long-term outcomes with very low mortality and significantly long survival,hence its role in this setting warrants further clarification,while it can also be useful in the management of specific benign entities.Whilst the commissioning of a randomised controlled trial seems unlikely,well-designed observational studies incorporating adjustments for confounding variables may become the best available comparative evidence for SA,potentially informing the eventual development of consensus guidelines.In this comprehensive review,we explore the role of SA in the modern management of ampullary lesions. | Darren L Scroggie Vasileios K Mavroeidis | 2021 | World Journal of Gastrointestinal Surgery2021，13，11： | 2 |
| 3 | A Mathematical Representation of Near-fault Ground Motions显示文摘 | MAVROEIDIS G P PAPAGEORGIOU A S | 2003 | Bulletin of Seismological Society of American2003，93，3： | 1 |
| 4 | A mathematical representation of near-fault ground motions显示文摘 | Mavroeidis G P Papageorgiou A S | 2003 | Bulletin of the Seismological Society of America2003，93，3： | 1 |
| 5 | Near-fauh ground motions, and the response of elastic and inelastic single-degree-of-freedom (SDOF) systems 显示文摘 | MAVROEIDIS G P DONG G PAPAGEORGIOU A S | 2004 | Earthquake Engineering & Structural Dynamics2004，33，9： | 1 |
| 6 | A Mathematical Representation ofNear-fault Ground Motions显示文摘 | MAVROEIDIS G P | 2003 | Bulletin of the Seismologi-cal Society of America2003，93，3： | 1 |
| 7 | Biopsy-proven resolution of renal light-chain deposition disease after autologous stem cell transplantation 显示文摘 | Petrakis I Stylianou K Mavroeidi V | 2010 | Nephrel Dial Transplant2010，25，6： | 1 |
| 8 | A mathematical representation of near- fault ground motions 显示文摘 | Mavroeidis G P | 2003 | Bulletin of the Seismological Society of America2003，93，3： | 1 |
| 9 | Near-fault ground motions,and the response of elastic and inelastic single-degree-of-freedom system显示文摘 | Mavroeidis G P Dong G Papageorgiou A S | 2004 | Earthquake Engineering and Structural Dynamics2004，33，9： | 1 |
| 10 | Near-fault ground motions, and the response of elastic and inelastic single-degree-of-freedom Earthquake Engineering and Structural system显示文摘 | Mavroeidis G P Dong G Papageorgiou A S | 2004 | Dynamics2004，33，9： | 1 |
| 11 | Rapamycin Ameliorates Proteinuria and Restores Nephrin and Podocin Expression in Experimental Membranous Nephropathy显示文摘 | Stavros Stratakis Kostas Stylianou Ioannis Petrakis Vasiliki Mavroeidi Rafaela Poulidaki Christina Petra Demitrios Moisiadis Spyros Stratigis Eleftheria Vardaki Lydia Nakopoulou Eugene Daphnis Xuan Zhang | 2013 | Clinical and Developmental Immunology2013，，： | 1 |
| 12 | Near-fault ground motions,and the response of elastic and inelastic single-degree-of-freedom system显示文摘 | Mavroeidis G P Dong G Papageorgiou A S | 2004 | Earthquake Engineering and Structural Dynamics2004，33，9： | 1 |
| 13 | Near-fault Ground Motions,and the Response of Elastic and Inelastic Single-degree-of-freedom System显示文摘 | Mavroeidis G P Dong G Papageorgiou A S | 2004 | Earthquake Engineering and Structural Dynamics2004，33，： | 1 |
| 14 | Near-fault ground motions, and the response of elastic and inelastic single-degree-of- freedom system显示文摘 | Mavroeidis G P Dong G Papageorgiou A S | 2004 | Earthquake Engineering and Structural Dynamics2004，33，： | 1 |
| 15 | Near - fauh ground motions and the response of elastic and inelastic single - degree - of - freedom sys- tem 显示文摘 | Mavroeidis G P Dong G Papageorgiou A S | 2004 | Earthquake Engineering and Structural Dynamics2004，33，9： | 1 |
| 16 | A Mathematical Representation of Near-fault Ground Motions显示文摘 | Mavroeidis G P Papageorgiou A S | 2003 | Bulletin of the Seismological Society of America2003，93，3： | 1 |
| 17 | Rapamycin induced ultrastructural and molecular alterations in glomerular podocytes in healthy mice显示文摘 | Stylianou K Petrakis I Mavroeidi V | | 0，，08： | 1 |
| 18 | A mathematical representation of near-fault ground motions显示文摘 | MAVROEIDIS G P PAPAGEORDIOU A S | 2003 | Bulletin of Seismological Society of America2003，93，3： | 1 |
| 19 | Near - Fault Ground Motions, and the Response of Elastic and Inelastic Single - degree - of - freedom (SDOF) Systems 显示文摘 | Mavroeidis G P Dong G and Papageorgiou A S | 2004 | Earthquake Engineering & Structural Dynamics2004，，9： | 1 |
| 20 | Weak Instrument Robust Tests in GMM and the New Keynesian Phillips curve显示文摘 | Kleibergen F Mavroeidis S | 2009 | Journal of Business and Economic Statistics2009，27，3： | 1 |
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