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| 1 | Bevacizumab for the management of diabetic macular edema显示文摘Diabetic retinopathy (DR) is a leading cause of vision loss in the working-age population and is relatedto 1%-5% of cases of blindness worldwide. Diabetic macular edema (DME) is the most frequent cause of DR vision loss and is an important public health problem. Recent studies have implicated vascular endothelial growth factor (VEGF) in DR and DME pathogenesis, as well as provided evidence of the benefits of anti-VEGF agents for the management of such conditions. Despite the benefits of intravitreal ranibizumab injection for the management of DME, the cost-effectiveness of intravitreal bevacizumab therapy has gained increasing interest in the scientific community. This review summarizes the studies examining bevacizumab for the management of DME, focusing on the efficacy and duration of the clinical benefits of decreasing DME and the improvement of best-corrected visual acuity (BCVA). There is strong evidence that intravitreal bevacizumab injection therapy has a good cost-effective profile in the management of DME and may be associated with laser photocoagulation; however, its clinical superiority in terms of the duration of DME regression and the improvement of BCVA compared with intravitreal ranibizumab and other intravitreal anti-VEGF therapies remains unclear and deserves further investigation. | Francisco Rosa Stefanini J Fernando Arevalo Maurício Maia | 2013 | World Journal of Diabetes2013，4，2： | 18 |
| 2 | Reliability in endoscopic diagnosis of portal hypertensive gastropathy显示文摘AIM: To analyze reliability among endoscopists in diagnosing portal hypertensive gastropathy (PHG) and to determine which criteria from the most utilized classifications are the most suitable. METHODS: From January to July 2009, in an academic quaternary referral center at Santa Casa of S o Paulo Endoscopy Service, Brazil, we performed this singlecenter prospective study. In this period, we included 100 patients, including 50 sequential patients who had portal hypertension of various etiologies; who were previously diagnosed based on clinical, laboratory and imaging exams; and who presented with esophageal varices. In addition, our study included 50 sequentialpatients who had dyspeptic symptoms and were referred for upper digestive endoscopy without portal hypertension. All subjects underwent upper digestive endoscopy, and the images of the exam were digitally recorded. Five endoscopists with more than 15 years of experience answered an electronic questionnaire, which included endoscopic criteria from the 3 most commonly used Portal Hypertensive Gastropathy classifications (McCormack, NIEC and Baveno) and the presence of elevated or flat antral erosive gastritis. All five endosco- pists were blinded to the patients' clinical information, and all images of varices were deliberately excluded for the analysis. RESULTS: The three most common etiologies of portal hypertension were schistosomiasis (36%), alcoholic cirrhosis (20%) and viral cirrhosis (14%). Of the 50 patients with portal hypertension, 84% were Child A, 12% were Child B, 4% were Child C, 64% exhibited previous variceal bleeding and 66% were previously endoscopic treated. The endoscopic parameters, presence or absence of mosaic-like pattern, red point lesions and cherry-red spots were associated with high inter-observer reliability and high specificity for diagnosing Portal Hypertensive Gastropathy. Sensitivity, specificity and reliability for the diagnosis of PHG (%) were as follows: mosaic-like pattern (100; 92.21; High); fine pink speckling (56; 76.62; Unsatisfactory); superficial reddening (69.57; 66.23; Unsatisfactory); red-point lesions (47.83; 90.91; High); cherry-red spots (39.13; 96.10; High); isolated red marks (43.48; 88.31; High); and confluent red marks (21.74; 100; Unsatisfactory). Antral elevated erosive gastritis exhibited high reliability and high specificity with respect to the presence of portal hypertension (92%) and the diagnosis of portal hypertensive gastropathy (88.31%). CONCLUSION: The most suitable endoscopic criteria for the diagnosis of PHG were mosaic-like pattern, redpoint lesions and cherry-red spots with no subdivisions,which were associated with a high rate of inter-observer reliability. | George Fred Soares de Macedo Fabio Gon alves Ferreira Maurício Alves Ribeiro Luiz Arnaldo Szutan Mauricio Saab Assef Lucio Giovanni Battista Rossini | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，7： | 9 |
| 3 | 生态博物馆:是镜子,窗户还是展柜?显示文摘 | 马克·摩尔(Marc Maure) 张晋平(译) | 2005 | 中国博物馆2005，，3： | 9 |
| 4 | Fetal brain tumors:Prenatal diagnosis by ultrasound and magnetic resonance imaging显示文摘Congenital central nervous system tumors diagnosed during pregnancy are rare, and often have a poor prognosis. The most frequent type is the teratoma. Use of ultrasound and magnetic resonance image allows the suspicion of brain tumors during pregnancy. However, the definitive diagnosis is only confirmed after birth by histology. The purpose of this mini-review article is to describe the general clinical aspects of intracranial tumors and describe the main fetal brain tumors. | Herbene Jose Milani Edward Araujo Junior Sergio Cavalheiro Patrícia Soares Oliveira Wagner Jou Hisaba Enoch Quindere Sa Barreto Maurício Mendes Barbosa Luciano Marcondes Nardozza Antonio Fernandes Moron | 2015 | World Journal of Radiology2015，7，1： | 7 |
| 5 | ^(99)Tc^m-tetrofosmin肺癌显像的临床研究(与^(18)F-FDG PET对比)显示文摘目的评价99Tcmtetrofosmin(TF)显像在肺癌诊断中的临床意义。方法用99TcmTF对16例已证实的肺癌患者进行平面和断层显像研究。所有病人均行CT和18F脱氧葡萄糖(FDG)PET检查。用感兴趣区分析法对99TcmTF和18FFDG图像进行定性及定量分析,计算肿瘤及非肿瘤内放射性比。结果CT共检出14个肿瘤病灶,2个因胸膜广泛渗出未能检出。此外8例患者,CT显示了21个受累纵隔淋巴结(>15cm)。99TcmTF平面和断层显像诊断肺癌病灶的灵敏度分别为88%(14/16)和94%(15/16)。所有肺癌病灶均有18FFDG摄取增高。定量分析示18FFDG在肺癌的摄取明显高于99TcmTF(452±150与155±030,t=4029,P<0001)。CT和病理活检示中心坏死的2个肺癌病灶,99TcmTF和18FFDG显像均示肿瘤中心放射性缺损。对于异常淋巴结,平面显像只发现3例病人中的4个淋巴结,而SPECT显像检出17个淋巴结有99TcmTF异常摄取。CT所示的21个异常淋巴结,18FFDG摄取均增高。结论99TcmTF显像用于肺癌患者的诊断有其临床? | 王辉 Maures,S | 1999 | 中华核医学杂志1999，19，1： | 5 |
| 6 | Biliary carcinoembryonic antigen levels in diagnosis of occult hepatic metastases from colorectal carcinoma显示文摘AIM: To prospectively explore the role of carcinoembryonic antigen (CEA) in gallbladder bile in patients with colorectal carcinoma and the morphological and clinical features of neoplasia and the occurrence of hepatic metastases.METHODS: CEA levels in the gallbladder and peripheral blood were studied in 44 patients with colorectal carcinoma and 10 patients with uncomplicated cholelithiasis. CEA samples were collected from the gallbladder bile and peripheral blood during the operation, immediately before extirpating the colorectal neoplasia or cholecystectomy.Values of up to 5 ng/ml were considered normal for bile and serum CEA.RESULTS: In the 44 patients with colorectal carcinoma who underwent operation with curative intent, the average level of serum CEA was 8.5 ng/ml (range: 0.1 to 111.0 ng/ml) and for bile CEA it was 74.5 ng/ml (range: 0.2 to 571.0ng/ml). In the patients with uncomplicated cholelithiasis who underwent cholecystectomy, the average level of serum CEA was 1.9 ng/ml (range: 1.0 to 3.5 ng/ml) and for bile CEA it was 1.2 ng/ml (range: 0.3 to 2.9 ng/ml).The average duration of follow-up time was 16.5 months (range: 6 to 48 months). Four patients who underwent extirpation of the colorectal carcinoma without evidence of hepatic metastasis and with an average bile CEA value of 213.2 ng/ml presented hepatic metastases between three and seventeen months after removal of the primary colorectal neoplasia. Three of them successfully underwent extirpation of the hepatic lesions.CONCLUSION: High CEA levels in gallbladders of patients undergoing curative operation for colorectal carcinoma may indicate the presence of hepatic metastases. Such patients must be followed up with special attention to the diagnosis of such lesions. | Jaques Waisberg Rogério T.Palma Luís Contim Neto Lourdes C.Martins Maurício S.L.Oliveira Carlos A. Nagashima Antonio C.Godoy Fabio S.Goffi | 2003 | World Journal of Gastroenterology2003，9，7： | 5 |
| 7 | Origin of pit chains in the floor of lunar Copernican craters显示文摘There are small pit chains in the floor of lunar Copernican craters. They are usually so small in scale that there are few lunar spacecrafts to detect their detailed morphology. Combining camera data from Lunar Orbiter, Lunar Reconnaissance Orbiter (LRO), Kaguya and Chang’e-1 missions, 5 representative large Copernican craters on various terrains of the lunar surface are chosen to study the origin of the pit chains in the crater floor. The morphology and distribution characteristic of the pit chains are referred by the high resolution images in this research. It is suggested that it is the magma activities from the subsurface magma layer combining with the existence of fractures and faults under the crater floor that leaded the formation of the pit chains. The model is further verified and discussed using the regolith thickness data in the crater floor. Our model suggests that the pit chains are still developing in the floor of the Copernican craters and the Moon may not be totally cold. Finally, the model limitation and potential future work are discussed based on available data. | XIAO ZhiYong 1* , ZENG ZuoXun 1,2 , XIAO Long 1,2 , FA WenZhe 3 & HUANG Qian 3,4 1 Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074, China 2 Research Center for Space Science and Technology, China University of Geosciences, Wuhan 430074, China 3 Institut de Physique du Globe de Paris, 4 Avenue de Neptune, Saint Maur des Fosse’s, 94100, France 4 Shanghai Astronomical Observatory, Chinese Academy of Sciences, Shanghai 200030, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，12： | 4 |
| 8 | Resection of a rapid-growing 40-cm giant liver hemangioma显示文摘Hemangiomas are the most frequent benign tumors of the liver. Most hemangiomas are asymptomatic and therefore largely diagnosed only in routine screening tests. Usually they are small and require no specific treatment. In some situations they can reach great dimensions, causing some discomfort to the patient. Resection of liver hemangioma is indicated in cases of great dimension tumors causing symptoms such as pain, nausea or bloating caused by compression of adjacent organs. We report a case of a rare giant hemangioma with rapid growth in short time:a 50 year old female reported to our institution with a 40 cm giant liver hemangioma and then underwent a left hepatectomy. | Andreas JM Koszka Fabio G Ferreira Caio GG de Aquino Maurício A Ribeiro André S Gallo Elisa MC Aranzana Luiz A Szutan | 2010 | World Journal of Hepatology2010，2，7： | 3 |
| 9 | Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells显示文摘AIM: To study the therapeutic effect of three tubeguides with electrical conductivity associated to mesenchymal stem cells(MSCs) on neuro-muscular regeneration after neurotmesis.METHODS: Rats with 10-mm gap nerve injury were tested using polyvinyl alcohol(PVA), PVA-carbon nanotubes(CNTs) and MSCs, and PVA-polypyrrole(PPy). The regenerated nerves and tibialis anterior muscles were processed for stereological studies after 20 wk. The functional recovery was assessed serially for gait biomechanical analysis, by extensor postural thrust, sciatic functional index and static sciatic functionalindex(SSI), and by withdrawal reflex latency(WRL). In vitro studies included cytocompatibility, flow cytometry, reverse transcriptase polymerase chain reaction and karyotype analysis of the MSCs. Histopathology of lung, liver, kidneys, and regional lymph nodes ensured the biomaterials biocompatibility. RESULTS: SSI remained negative throughout and independently from treatment. Differences between treted groups in the severity of changes in WRL existed, showing a faster regeneration for PVA-CNTs-MSCs(P < 0.05). At toe-off, less acute ankle joint angles were seen for PVA-CNTs-MSCs group(P = 0.051) suggesting improved ankle muscles function during the push off phase of the gait cycle. In PVA-PPy and PVA-CNTs groups, there was a 25% and 42% increase of average fiber area and a 13% and 21% increase of the 'minimal Feret's diameter' respectively. Stereological analysis disclosed a significantly(P < 0.05) increased myelin thickness(M), ratio myelin thickness/axon diameter(M/d) and ratio axon diameter/fiber diameter(d/D; g-ratio) in PVA-CNT-MSCs group(P < 0.05). CONCLUSION: Results revealed that treatment with MSCs and PVA-CNTs tube-guides induced better nerve fiber regeneration. Functional and kinematics analysis revealed positive synergistic effects brought by MSCs and PVA-CNTs. The PVA-CNTs and PVA-PPy are promising scaffolds with electric conductive properties, bio- and cytocompatible that might prevent the secondary neurogenic muscular atrophy by improving the reestablishment of the neuro-muscular junction. | Jorge Ribeiro Tiago Pereira Ana Rita Caseiro Paulo Armada-da-Silva Isabel Pires Justina Prada Irina Amorim Sandra Amado Miguel Franca Carolina Goncalves Maria Ascensao Lopes Jose Domingos Santos Dina Morais Silva Stefano Geuna Ana Lúcia Luís Ana Colette Maurício | 2015 | World Journal of Stem Cells2015，7，6： | 2 |
| 10 | Assessing the estrogenic potency in a Portuguese wastewater treatment plant using an integrated approach显示文摘The estrogenic potency of a wastewater treatment plant(WWTP) was evaluated using chemical and biological analyses,which showed that after the station treatment processes some of the selected endocrine disruptor compounds(EDCs) were still present in the treated effuent(e.g.,bisphenol A,alkylphenols,estrone) .Thus,the most common endocrine EDCs were identified and quantified and the overall estrogenicity of the treated effuent assessed by integrating the results.Male goldfish(Carassius auratus) were used as biological indicators in a 28-day experiment.Vitellogenin(Vtg) ,gonadosomatic and hepatosomatic indices,steroids(17β-estradiol and 11-ketotestosterone) and histopathology were biomarkers used in fish to evaluate WWTP treated effuent estrogenicity,in combination with instrumental analyses.The results showed a significant increase(P<0.01) in plasma and liver Vtg,which were significantly correlated(r=0.66;P<0.01) .The gonadosmatic index was significantly(P<0.01) reduced in exposed fish.The steroid analyses revealed significant elevations in 17β-estradiol and depressed 11-ketotestosterone concentrations.The histological examinations show changes in exposed fish gonads,such as regressed testes and in some cases(43%to 75%) the development of ovo-testis in fish exposed to 50% and 100% treated effuent. | Mário S.Diniz Rita Maurício Mira Petrovic Maria J.López De Alda Leonor Amaral Isabel Peres Damiá Barceló Fernando Santana | 2010 | Journal of Environmental Sciences2010，22，10： | 2 |
| 11 | Propolis: Is there a potential for the development of new drugs?显示文摘 | José Maurício Sforcin Vassya Bankova | 2010 | Journal of Ethnopharmacology2010，，2： | 2 |
| 12 | The functional complex network approach to foster forest resilience to global changes显示文摘Human impacts on Earth's ecosystems have greatly intensified in the last decades. This is reflected in unexpected disturbance events, as well as new and increasing socio-economic demands, all of which are affecting the resilience of forest ecosystems worldwide and the provision of important ecosystem services. This Anthropocene era is forcing us to reconsider past and current forest management and silvicultural practices, and search for new ones that are more flexible and better at dealing with the increasing uncertainty brought about by these accelerating and cumulative global changes. Here, we briefly review the focus and limitations of past and current forest management and silvicultural practices mainly as developed in Europe and North America. We then discuss some recent promising concepts, such as managing forests as complex adaptive systems, and approaches based on resilience, functional diversity, assisted migration and multi-species plantations, to propose a novel approach to integrate the functionality of species-traits into a functional complex network approach as a flexible and multi-scale way to manage forests for the Anthropocene. This approach takes into consideration the high level of uncertainty associated with future environmental and societal changes. It relies on the quantification and dynamic monitoring of functional diversity and complex network indices to manage forests as a functional complex network. Using this novel approach, the most efficient forest management and silvicultural practices can be determined, as well as where, at what scale, and at what intensity landscape-scale resistance, resilience and adaptive capacity of forests to global changes can be improved. | Christian Messier Jürgen Bauhus Frederik Doyon Fanny Maure Rita Sousa-Silva Philippe Nolet Marco Mina Núria Aquilué Marie-Josée Fortin Klaus Puettmann | 2019 | Forest Ecosystems2019，6，3： | 2 |
| 13 | Development of Junction Elements from Study of the Bionics显示文摘The applications of bionic methodology developed by the Laboratory of Design and Material Selection as basis in the creation of junction elements were demonstrated. These elements favor the application of Ecodesign in reference to the effec-tiveness of product dismount aiming the reduction of ambient impact in all its phases of use. The creation,the development and the confection of new junction elements were described,and case studies of new products developed specifically with this purpose were presented. | Wilson Kindlein Junior Luis Henrique Alves Cndido André Canal Marques Sandra Souza dos Santos Maurício da Silva Viegas | 2007 | Journal of Bionic Engineering2007，4，1： | 2 |
| 14 | Structure,developmental expression,and physiological regulation of zebra fish IGF-binding protein-1显示文摘 | Maures T J Duan C | 2002 | Endocrinology2002，143，： | 1 |
| 15 | Influence of mercury chloride on adenosine deaminase activity and gene expression in zebrafish ( Danio rerio ) brain显示文摘 | Mario Roberto Senger Denis Broock Rosemberg Kelly Juliana Seibt Renato Dutra Dias Maurício Reis Bogo Carla Denise Bonan | 2010 | Neurotoxicology2010，，3： | 1 |
| 16 | Retiform haeman- gioendothelioma 显示文摘 | Dufau J P Pierre C De Saint Maur P P | 1997 | Ann Pathol1997，17，1： | 1 |
| 17 | Propolis effects on pro-inflammatory cytokine production and Toll-like receptor 2 and 4 expression in stressed mice显示文摘 | Ana Carolina Pagliarone Cláudio Lera Orsatti Michelle Cristiane Búfalo Fabiane Missima Tatiana Fernanda Bachiega Jo?o Pessoa Araújo Júnior José Maurício Sforcin | 2009 | International Immunopharmacology2009，，11： | 1 |
| 18 | Leveling aerogeophysical data using amoving differential median filter显示文摘 | Eirik Mauring Ola kihle | | 0，，01： | 1 |
| 19 | Ischaemic stroke in young adults: predictors of outcome and recurrence 显示文摘 | Nedeltchev K der Maur TA Georgiadis D et al | 2005 | J Neurol Neurosurg Psychiatry2005，76，2： | 1 |
| 20 | Acute and Chronic Administration of the Branched-Chain Amino Acids Decreases Nerve Growth Factor in Rat Hippocampus显示文摘 | Giselli Scaini Lis Mairá Mello-Santos Camila B. Furlanetto Isabela C. Jeremias Francielle Mina Patrícia F. Schuck Gustavo C. Ferreira Luiza W. Kist Talita C. B. Pereira Maurício R. Bogo Emilio L. Streck | 2013 | Molecular Neurobiology2013，，3： | 1 |
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