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| 1 | Genetic susceptibility to autoimmune liver disease显示文摘Autoimmune hepatitis(AIH),primary sclerosing cholangitis(PSC) and primary biliary cirrhosis(PBC) are considered as putative autoimmune diseases of the liver.Whereas strong evidence that bacterial infection may trigger PBC exists,the etiologies for PSC and AIH remain unknown.Although there have been significant discoveries of genetic polymorphisms that may underlie the susceptibility to these liver diseases,their associations with environmental triggers and the subsequent implications have been difficult to elucidate.While single nucleotide polymorphisms within the negative costimulatory molecule cytotoxic T lymphocyte antigen 4(CTLA-4) have been suggested as genetic susceptibility factors for all three disorders,we discuss the implications of CTLA-4 susceptibility alleles mainly in the context of PBC,where Novosphingobium aromaticivorans,an ubiquitous alphaproteobacterium,has recently been specifically associated with the pathogenesis of this devastating liver disease.Ultimately,the discovery of infectious triggers of PBC may expand the concept of genetic susceptibility in immune-mediated liver diseases from the concept of aberrant immune responses against self-antigens to insufficient and/or inappropriate immunological defense mechanisms allowing microbes to cross natural barriers,establish infection and damage respective target organs. | Jochen Mattner | 2011 | World Journal of Hepatology2011，3，1： | 3 |
| 2 | Lysosomal glycosphingolipid recognition by NKT cells显示文摘 | Zhou D Mattner J Cantu C | 2004 | Science2004，306，11： | 1 |
| 3 | Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercacemie analogue of 1,25-dihy-droxyvitamin D3显示文摘 | Mattner F Smiroldo S Galbiati F | | 0，，2： | 1 |
| 4 | Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections 显示文摘 | Mattner J Debord KL Ismail N | 2005 | Nature2005，434，7032： | 1 |
| 5 | Inhibition of Thdevelopment and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1,25-dihydroxyvitamin D(3)显示文摘 | Mattner F Smiroldo S Galbiati F | 2000 | Eur J Immunol2000，30，2： | 1 |
| 6 | Lothar elastisches verformungs ver-halten des eisenbahnoberbaus 显示文摘 | Leykauf Gunther Mattner | 1990 | Eisenbahnigenieur1990，41，3： | 1 |
| 7 | Conservation genetics and implications for restoration of Hemigenia exilis (Lamiacee),a serpentine endemic from Western Australia显示文摘 | MATTNER J ZAWKO G ROSSETTO M | 2002 | Biological Conservation2002，107，： | 1 |
| 8 | An expeditious synthesis of a biscyclam with an aromatic linker显示文摘 | Xu DQ Mattner PG Prasad K | 1996 | Tetrahedron Lett1996，37，30： | 1 |
| 9 | Elastisches Verformungs Ver - Halten des Eisenhahnolaetbaus显示文摘 | Leykauf Gunther&Mattner Lothar | 1990 | Eisenbahnigenieur1990，41，3： | 1 |
| 10 | Impact of bacterial and fungal donor organ contamination in lung, heart-lung, heart and liver transplantation 显示文摘 | Mattner F Kola A Fischer S | 2008 | Infection2008，36，3： | 1 |
| 11 | Forming cohesive calcium oxalate layers on marble surfaces for stone conservation 显示文摘 | King H E Mattner D C Pltimper O | 2014 | Crystal Growth and Desing2014，14，： | 1 |
| 12 | Lysosomal glycosphingolipid recognition by NKT cells显示文摘 | Zhou D Mattner J Cantu C 3rd | 2004 | Science2004，306，5702： | 1 |
| 13 | Evaluation of CLINDE as potent translocator protein ( 18 kDa) SPECT radiotracer reflecting the degree of neuroinflam- mation in a rat model of microglial activation 显示文摘 | Arlicot N Katsifis A Garreau L Mattner F Vergote J Dural S | 2008 | Eur J Nucl Med Mol Imaging2008，35，12： | 1 |
| 14 | Lysosomal glycosphingolipid recognition by NKT cells显示文摘 | Zhou D Mattner J Cantu C | 2004 | Science2004，306，11： | 1 |
| 15 | Factors that impact on the ability of biofumigants to suppress fungal pathogens and weeds of strawberry显示文摘 | Mattner S W Porter I J Gounder R K | 2007 | Crop Protection2007，27，8： | 1 |
| 16 | Surveillance ofinvasive mold infections in lung t ransplant recipient s:effectof antimycotic prophylaxis with itraconazole and voriconazole显示文摘 | Mattner F Chaberny IF Weissbrodt H | 2005 | Mycoses2005，48，1： | 1 |
| 17 | Mechanisms of autoimmune liver disease显示文摘 | Baier JL Mattner J | 2014 | Discovery Medicine2014，，18： | 1 |
| 18 | Structure and function of a potent agonist for the semi invariant natural killer T cell receptor显示文摘 | Cantu C 3rd Mattner J | 2005 | Nat Immunol2005，6，81： | 1 |
| 19 | Lysosomal glyeosphingolipid rec- ognition by NKT cells显示文摘 | Zhou D Mattner J Cantu C | 2004 | Science2004，306，： | 1 |
| 20 | Vaccination for Parkinson's disease显示文摘 | Schneeberger A Mandler M Mattner F | 2012 | Parkinsonism Relat Disord2012，18，1： | 1 |
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