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| 1 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 2 | A Fluorescent Alternative to the Synthetic Strigolactone GR24显示文摘Strigolactones 最近被含有在未葬、地下在更高的植物的发展小径。在 vitro 并且在 vivo 便于 strigolactones 的分子、化学的性质,我们发展了一荧光灯 strigolactone 分子, CISA-1,经由一篇小说综合了柔韧的方法, high-yielding,和使用的简单开始的材料。我们证明 CISA-1 穿上大量已知的 strigolactone 活动和进一步的报告一偶然在是为 strigolactone 类似物的严峻的生物活动的一个高度敏感、快速的方法的 Arabidopsis 的 rooting 试金。在这 rooting 试金和广泛地使用的 Orobanche 萌芽试金, CISA-1 比通常测试的 GR24 显示出更强壮的生物活动。CISA-1 和 GR24 在禁止是同等地有效的在 Arabidopsis 开花期茎分叉。在两分叉并且偶然 rooting 试金,我们也证明那项 CISA-1 活动依赖于最大 strigolactone 发信号小径。在水甲醇答案, CISA-1 在附近三方面比 GR24 更稳定,它可以贡献在各种各样的生物测试观察的增加的活动。 | Amanda Rasmussen Thomas Heugebaert Cedrick Matthys Rik Van Deun Francois-Didier Boyer1 Sofie Goormachtig Christian Stevens Danny Geelen | 2013 | Molecular Plant2013，6，1： | 3 |
| 3 | 光敏剂间-四羟基苯二氢卟酚及其复合物对人T淋巴细胞白血病细胞的作用显示文摘目的 观察光敏剂间-四羟基苯二氢卟酚(mTHPC)及其复合物HSA-mTHPC对人T淋巴细胞白血病细胞(Jurkat)的作用,探讨人血白蛋白(HSA)纳米颗粒作为mTHPC载体的可行性.方法 利用流式细胞仪测定Jurkat细胞对mTHPC及HSA-mTHPC的摄取率,通过测定不同浓度mTHPC及HSA-mTHPC孵育Jurkat细胞后的存活率、细胞膜完整性和增殖率,评价两种药物的摄取率和细胞毒性.结果 浓度1.0 mg/L,孵育4、24 h Jurkat细胞的摄取率为:mTHPC单体:98.07%、99.07% HSA-mTHPG中mTHPC:98.13%、99.19% HSA单体:2.77%、4.84%.光照后Jurkat细胞活性和增殖率呈显著剂量、时间依赖的下降,mTHPC浓度为1.0 mg/L时,4、24、48 h存活率和增殖率分别为13.27%、5.46%、4.99%和2.68%、0.91%、0.62%,HSA-mTHPC对细胞生长和增殖的抑制与mTHPC单体比较未见下降(P>0.05).光照后LDH活性呈现显著剂量、时间依赖的上升,mTHPC浓度为1.0mg/L时,4、24、48 h LDH活性分别为:80.99%、99.38%、100.67%.结论 mTHPC是一种杀伤力强的光敏剂型,能有效进入肿瘤细胞,并导致细胞损害.HSA纳米颗粒不影响细胞对mTHPC的摄取,可以作为其载体. | 郑顺贞 Karin Low Matthis Wacker Arno Wiehe Sylvia Wagner Klaus Langer Hagen von Briesen 邹声泉 | 2010 | 中华实验外科杂志2010，27，10： | 2 |
| 4 | Prevalence and impact on quality of life of peripheral neuropathy with or without neuropathic pain in type 1 and type 2 diabetic patients attending hospital outpatients clinics显示文摘 | K. Van Acker D. Bouhassira D. De Bacquer S. Weiss K. Matthys H. Raemen C. Mathieu I.M. Colin | 2009 | Diabetes and Metabolism2009，，3： | 2 |
| 5 | Management of 1000 vestibular schwannomas (acoustic neuromas):surgical management and results with an emphasis on complications and how to avoid them显示文摘 | Samii M Matthies C | 1997 | Neurosurgery1997，40，： | 1 |
| 6 | A finite element model for predicting the biomechanical behaviour of the human lumbar spine显示文摘 | Pitzen T Geisler F Matthis D | 2002 | Control Eng Pract2002，10，1： | 1 |
| 7 | Management of 1000 vestibular schwannomas (acoustic neuromas):the facial nerve-preservation and restitution of function显示文摘 | Samii M Matthies C | 1997 | Neurosurgery1997，40，： | 1 |
| 8 | Isolation of a human intestinal bacterium capable of daidzein and genistein conversion显示文摘 | MATTHIES A BLAUT M BRAUNE A | 2009 | Appl Environ Microbiol2009，，75： | 1 |
| 9 | Ecological consequences of the phylogenetic and physiological diversities of acetogens显示文摘 | Harold L. Drake Kirsten Küsel Carola Matthies | 2002 | Antonie van Leeuwenhoek (-)2002，，1： | 1 |
| 10 | Manangement of 1000 vestibular schwannomas (acoustic neuromas) :surgical management and results with an em- phasis on complications and how to avoid them 显示文摘 | Samii M Matthies C | 1997 | Neurosurgery1997，40，1： | 1 |
| 11 | A portable,autonomous,urban reconnaissance robot 显示文摘 | Matthies L Xiong Y Hogg R | 2002 | Robotics and Autonomous Systems2002，，40： | 1 |
| 12 | RAPD variation in relation to population size and plant fitness in the rare Gentianella germanica (Gentianaceae) 显示文摘 | FISCHER M MATTHIES D | 1998 | American Journal of Botany1998，85，： | 1 |
| 13 | Management of 1000 vestibular sehwannomas(acoustic neuromas):hearing ftmetion in 1000 tumor resections显示文摘 | Samii M Matthies C | 1997 | Neurosurgery1997，40，2： | 1 |
| 14 | Application of multimedia models for screening assessment of long-range transport potential and overall persistence显示文摘 | Klasmeier J Matthies M Macleod M | 2006 | Environ Sci Technol2006，40，1： | 1 |
| 15 | Motion of threaded cages in posterior lumbar interbody fusion 显示文摘 | Pitzen T Geisler FH Matthis D | 2000 | Eur Spine J2000，9，6： | 1 |
| 16 | FRP for concrete construction: activities in Europe 显示文摘 | Taerwe L R Matthys S | 1999 | Concrete International ACI1999，21，10： | 1 |
| 17 | Leaching and transformation of glufosinate-ammonium and its main metabolite in a layered soil显示文摘 | Behrendt H Matthies M Gildemeister H | 1990 | Environ Toxicol Chem1990，9，： | 1 |
| 18 | Diagnosis of root avulsion in traumatic brachial plexus injuries: value of computer- ized tomography myelography and magnetic resonance imaging显示文摘 | Carvalho GA Nikkhah G Matthies CM | 1997 | J Neurosurg1997，86，1： | 1 |
| 19 | Stress-strain behavior of large-scale circular columns confined with FRP composites显示文摘 | MATTHYS S TOUTANJI H TAERWE L | 2006 | Journal of Structural Engineering2006，132，1： | 1 |
| 20 | A high-protein diet induces sustained reductions in appetite,adlibitum caloric intake,and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations显示文摘 | Weigle DS Breen PA Matthys CC | 2005 | Am J Clin Nutr2005，82，1： | 1 |
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