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| 1 | Childhood obesity: a life-long health risk显示文摘童年肥胖在全世界为医生,父母,和健康机构成为了主要健康担心。童年肥胖在生活不仅在青春期间而且以后为另外的疾病与增加的风险被联系,包括糖尿病,动脉的高血压,冠的动脉疾病,和脂肪肝疾病。重要地,肥胖在孩子和年轻成年人已经加速动脉粥样硬化前进。关于在 vasculature 的 pathophysiological 变化,与老化和肥胖相关的畸形有关的生理的变化的惹人注目的类似与肥胖引起 “ 的概念兼容; premature”脉管的老化。这篇文章考察由于肥胖位于加速的脉管的疾病发展下面的因素。它也强调在加重另外的疾病的发展作为一个疾病条件和它的容许的角色认出童年肥胖的重要性。为在生活以后的疾病危险性的童年肥胖的重要性,和对预防和治疗的需要也被讨论。 | Matthias BARTON | 2012 | Acta Pharmacologica Sinica2012，33，2： | 5 |
| 2 | The therapeutic potential of endothelin receptor antagonists in cardiovascular disease显示文摘 | Matthias Barton MD Wolfgang Kiowski MD | 2001 | Current Hypertension Reports2001，，4： | 1 |
| 3 | Meyer postmenopausal hypertension mechanisms and therapy显示文摘 | Matthias Barton Matthias R | 2009 | Hypertension2009，54，： | 1 |
| 4 | Guidelines to the Practice of Anesthesia Revised Edition 2013显示文摘 | Richard Merchant Daniel Chartrand Steven Dain Gregory Dobson Matthias Kurrek Annie Lagacé Shean Stacey Barton Thiessen | 2013 | Canadian Journal of Anesthesia/Journal canadien d’anesthésie2013，，1： | 1 |
| 5 | Endothelial dysfunction and atherosclerosis: Endothelin receptor antagonists as novel therapeutics显示文摘 | Matthias Barton MD | 2000 | Current Hypertension Reports2000，，1： | 1 |
| 6 | Need for research on estrogen receptor function:importance for postmenopausal hormone therapy and atherosclerosis显示文摘 | Matthias R Meyer Elvira Haas Matthias Barton | 2008 | Gender Medicine2008，，： | 1 |
| 7 | The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular function显示文摘 | Matthias R. Meyer Eric R. Prossnitz Matthias Barton | 2011 | Vascular Pharmacology2011，，1： | 1 |
| 8 | Signaling, physiological functions and clinical relevance of the G protein-coupled estrogen receptor GPER显示文摘 | Eric R. Prossnitz Matthias Barton | 2009 | Prostaglandins and Other Lipid Mediators2009，，3： | 1 |
| 9 | Angiotensin Ⅱ increases vascular and renal endothelin-1 and functional endothelin converting enzyme activity in vivo: role of ETA receptors for endothelin regulation 显示文摘 | Matthias Barton Sidney Shaw Livius V | 1997 | Biochemical and Biophysical Reserch Communications1997，238，： | 1 |
| 10 | Microvascular response to transfusion in elective spine surgery显示文摘AIM To investigate the microvascular(skeletal muscle tissue oxygenation; SmO_2) response to transfusion in patients undergoing elective complex spine surgery.METHODS After IRB approval and written informed consent, 20 patients aged 18 to 85 years of age undergoing > 3level anterior and posterior spine fusion surgery were enrolled in the study. Patients were followed throughout the operative procedure, and for 12 h postoperatively. In addition to standard American Society of Anesthesiologists monitors, invasive measurements including central venous pressure, continual analysis of stroke volume(SV), cardiac output(CO), cardiac index(CI), and stroke volume variability(SVV) was performed. To measure skeletal muscle oxygen saturation(SmO_2) during the study period, a non-invasive adhesive skin sensor based on Near Infrared Spectroscopy was placed over the deltoid muscle for continuous recording of optical spectra. All administration of fluids and blood products followed standard procedures at the Hospital for Special Surgery, without deviation from usual standards of care at the discretion of the Attending Anesthesiologist based on individual patient comorbidities, hemodynamic status, and laboratory data. Time stamps were collected for administration of colloids and blood products, to allow for analysis of SmO_2 immediately before, during, and after administration of these fluids, and to allow for analysis of hemodynamic data around the same time points. Hemodynamic and oxygenation variables were collected continuously throughout the surgery, including heart rate, blood pressure, mean arterial pressure, SV, CO, CI, SVV, and SmO_2. Bivariate analyses were conducted to examine the potential associations between the outcome of interest, SmO_2, and each hemodynamic parameter measured using Pearson's correlation coeffi-cient, both for the overall cohort and within-patients individually. The association between receipt of packed red blood cells and SmO_2 was performed by running an interrupted time series model, with SmO_2 as our outcome, controlling for the amount of time spent in surgery before and after receipt of PRBC and for the inherent correlation between observations. Our model was fit using PROC AUTOREG in SAS version 9.2. All other analyses were also conducted in SAS version 9.2(SAS Institute Inc., Cary, NC, United States).RESULTS Pearson correlation coefficients varied widely between SmO_2 and each hemodynamic parameter examined. The strongest positive correlations existed between ScvO_2(P = 0.41) and SV(P = 0.31) and SmO_2; the strongest negative correlations were seen between albumin(P =-0.43) and cell saver(P =-0.37) and SmO_2. Correlations for other laboratory parameters studied were weak and only based on a few observations. In the final model we found a small, but significant increase in SmO_2 at the time of PRBC administration by 1.29 units(P = 0.0002). SmO_2 values did not change over time prior to PRBC administration(P = 0.6658) but following PRBC administration, SmO_2 values declined significantly by 0.015 units(P < 0.0001).CONCLUSION Intra-operative measurement of SmO_2 during large volume, yet controlled hemorrhage, does not show a statistically significant correlation with either invasivehemodynamic, or laboratory parameters in patients undergoing elective complex spine surgery. | J Matthias Walz Ottokar Stundner Federico P Girardi Bruce A Barton Aimee R Koll-Desrosiers Stephen O Heard Stavros G Memtsoudis | 2017 | World Journal of Orthopedics2017，8，1： | 0 |
| 11 | 雌激素的血管作用:快速作用,新的机制和治疗潜力<英文>显示文摘Although estrogen-dependent effects on thevasculature were first observed more than a centuryago, many of the mechanisms by which estrogensinteract with the vascular wall have been identified onlyin the past 15 years. Estrogens bind to vascularestrogen receptors (ER), including the ERα, the novelERβ as well as to membrane-bound receptors. | Matthias BARTON | 1999 | 中国药理学报1999，20，8： | 0 |
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