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| 1 | Requirement for cyclin D3 in germinal center formation and function显示文摘第二等的淋巴的纸巾的幼芽的中心(GC ) 对装高亲密关系的体液的有免疫力的回答批评。当多样化他们的抗体基因时,在 GC 以内的 B 房间经历快速的同种细胞的扩大和选择。尽管 GC B 房间采用一个唯一的 proliferative 程序提供这些进程,这通常被相信,很少联系 GC 的房间周期怎么被安排被知道。D 类型 cyclins 组成使房间能对生理的变化作出回应的房间周期引擎的一个重要部件。房间类型 -- 并且 D 类型 cyclins 的发展阶段特定的角色被描述了,但是 cyclin D 要求没在 GC 反应期间被探讨。在这研究,我们报导 cyclin D3 为切换的增长和 Ig 班大部分是非必需的在 vitro 激活的 B 房间。相反,在 Ccnd3 的 GC 开发 ?/ ?老鼠显著地被损害,作为是 T 房间依赖者抗体反应。在 GC 以内,尽管切换, unswitched B 房间被 cyclin D3 inactivation 影响, IgM?水池更严重地被减少。有趣地尽管有 cyclin D2 表示的补偿增加, Ccnd3 的一个重要数字 ?/ ?GC B 房间处于静止 G0 状态积累。最后,尽管 cyclin D3 inactivation 没在 GC B 房间破坏 BCL6 表示,支持 BCL6 overexpression 的效果完全堵住了 GC,建议 cyclin D3 调整 GC 形成的 BCL6 下游地行动。这是 cyclin D3 玩的第一示范在 B 房间开发的 GC 阶段的一个重要、唯一的角色。 | Jonathan U Peled J Jessica Yu Jeganathan Venkatesh Enguang Bi B Belinda Ding Melissa Krupski-Downs Rita Shaknovich Piotr Sicinski Betty Diamond Matthew D Scharff B Hilda Ye | 2010 | Cell Research2010，20，6： | 3 |
| 2 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 3 | The influence of carbon dioxide on brain activity and metabolism in conscious humans 显示文摘 | Feng X U Jinsoo U H Matthew R B | 2011 | J Cereb Blood Flow Metab2011，31，1： | 1 |
| 4 | Changes in Ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression显示文摘 | Matthews HK Delabre U Rohn JL | 2012 | Dev Cell2012，23，2： | 1 |
| 5 | Acute endophthalmitis following intravitreal triamcinolone acetonide injection显示文摘 | Darius M Moshfeghi Peter K Kaiser Ingrid U Scott Jonathan E Sears Matthew Benz Juan P Sinesterra Richard S Kaiser Sophie J Bakri Raj K Maturi Jonathan Belmont Paul M Beer Timothy G Murray Hugo Quiroz-Mercado William F Mieler | 2003 | American Journal of Ophthalmology2003，，5： | 1 |
| 6 | Effects of mechani-cal loading patterns,bone graft,and proximity to periosteum on bone defect healing显示文摘 | Knothe U R Dolejs S Matthew Miller R | 2010 | Journal of Biomechanics2010，43，14： | 1 |
| 7 | Laparoscopicmyomectomy for symptomatic uterine myomas显示文摘 | H u rst BS Matthews ML Marshburn PB | 2005 | FertilSteril2005，83，8： | 1 |
| 8 | Mass fractionation processes of transition metal isotopes显示文摘 | Zhu X K Guo Y Williams R J P O'Nions R K Matthews A Belshaw N S Canters G W de Waal E C Weser U Burgess B K Salvato B | 2002 | Earth Planet Sci Lett2002，200，12： | 1 |
| 9 | High Quality Video View Interpolation Using a Layered Representation显示文摘 | Zitnick C L Sing B Matthew U | 2004 | ACM Transactions on Graphics2004，23，3： | 1 |
| 10 | Are chan?ges in cardiovascular disease risk factors in midlife women due to chronological aging or to the menopausal transition?显示文摘 | Matthews K A Crawford S L Chae C U | 2009 | J Am Coll Cardiol2009，54，25： | 1 |
| 11 | Neonatal human autologous dendritic cells pulsed with recombinant protein antigen prime the generation of non-polarlzed CD4 T-cell effectors显示文摘 | Matthews N C Power U F Reen D J | 2007 | Int Immunol2007，19，6： | 1 |
| 12 | Fabrication of Iron Disilicide FeSi Thermoelectric Generator by the Tape Casting Method显示文摘 | Matthews Richard D Robertson Hugh | 1999 | Materials and Design1999，20，： | 1 |
| 13 | Cinnamon bark from Seychelles l显示文摘 | ISLIP H T Matthews U W S A | 1950 | Colonial Plant Animal Products1950，，1： | 1 |
| 14 | Chemical basis for the selectivity of ions by the Bacillus subtilis cell wall显示文摘 | DOYLE R J MATTHEWS T H STREIPS U N | 1980 | Bacteriol1980，143，： | 1 |
| 15 | A receptor for the immuno-suppressant FK506 is a cis-trans peptidyl-prolyl isomerase显示文摘 | MATTHEW W H ANDRZEJ G DAVID E U | 1989 | Nature1989，341，： | 1 |
| 16 | Integrating spatial data analysis and GIS: a new implementation using the component object model (COM) 显示文摘 | Matthew J U Michael F G | 2002 | International Journal of Geographical Information Science2002，16，1： | 1 |
| 17 | High-quality video view interpolation using a layered representation 显示文摘 | Zitnick C L Sing Bing K Matthew U | 2004 | ACM Transactions on Graphics2004，23，3： | 1 |
| 18 | Mass fractionation processes of transition metal isotopes显示文摘 | Guo Y Williams R J P O' Nions R K Matthews A Belshaw N Canters G W Waal E C D Weser U Burgess B K Salvato B | 2002 | Earth and Planetary Science Letters2002，200，： | 1 |
| 19 | Integrating spatial data analysis and GIS:a new implementation using the component object model (COM) 显示文摘 | Matthew J U Michael F G | 2002 | International Journal of Geographical Information Science2002，16，1： | 1 |
| 20 | Acute endophthalmitis following intravitreal triamcinolone acetonide injection显示文摘 | Darius M Moshfeghi Peter K Kaiser Ingrid U Scott Jonathan E Sears Matthew Benz Juan P Sinesterra Richard S Kaiser Sophie J Bakri Raj K Maturi Jonathan Belmont Paul M Beer Timothy G Murray Hugo Quiroz-Mercado William F Mieler | 2003 | American Journal of Ophthalmology2003，，5： | 1 |
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