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| 1 | 围术期心律失常的诊断与治疗显示文摘麻醉和手术的病人常发生心律失常,而目前常用麻醉药和操作引起的心律失常的发生率尚不十分清楚,因此麻醉中ECG监测是必不可少的,用Holter(连续)监测可发现60%以上的病人在麻醉手术时显示心律失常。围术期发生的心律失常多数并不严重,但当损害心肌功能,进一步影响心肌供氧平衡或转变为潜在威胁生命的室性心律失常则相当严重。检查和诊断导联选择麻醉时可选用标准双极导联、加压单极导联或单极胸前导联。现常用两个改进双极标准肢体导联来监测心律失常,即:(1) | Mathews E L 郑鹏 牛新华 | 1992 | 国外医学(麻醉学与复苏分册)1992，13，4： | 11 |
| 2 | Parenting preschoolers with autism: Socioeconomic influences on wellbeing and sense of competence显示文摘BACKGROUND Previous research suggests that parents raising a child with autism experience higher levels of psychological distress than parents of typically developing children and parents of children with other developmental disorders. Little is known, however, about the intersection between the effects of socioeconomic status(SES) on the wellbeing and sense of parental competency of parents of preschoolers with autism and how it relates to child symptom severity.AIM To examine the relationship between their child's symptom severity, SES, as measured by neighbourhood advantage and occupational status, on the psychological wellbeing and perceived parenting competence among parents of preschoolers with autism.METHODS Parents of 117 preschool-aged children with a diagnosis of autism spectrum disorder(ASD), 107 mothers and 54 fathers, completed questionnaires about their child's symptoms of ASD and functioning, their own perceptions of their wellbeing and parental competence on entry to an early intervention program in Sydney, Australia. Parents also provided demographic information pertaining to their occupation, level of education attained and address(postcode). All children were also assessed for their severity of symptoms using the Autism Diagnostic Observation Schedule. The Australian Socioeconomic Index of occupationalstatus as a measure of familial SES and the Index of Relative Socio-economic Advantage and Disadvantage as a measure of neighbourhood advantage were used to examine the impact of SES on parental sense of competence and wellbeing.RESULTS Compared to normative populations, both mothers and fathers in our sample reported significantly higher levels of parenting sense of efficacy but lower levels of interest in the parenting role. Mothers also displayed higher levels of satisfaction. Both mothers and fathers displayed higher levels of depression than normative populations with mothers also reporting greater levels of stress and anxiety. Child symptom severity was associated with maternal parenting competency with these relationships amplified among mothers with higher familial SES and who lived in areas of greater neighbourhood advantage.Increased adaptive functioning was associated with better maternal wellbeing,particularly among mothers who lived in areas of greater neighbourhood advantage. Contrastingly, paternal parenting competence was generally not influenced by child adaptive functioning or symptom severity, although for those in higher familial SES brackets, children's symptom severity and maladaptive symptoms were negatively related to paternal sense of parenting efficacy. There was a trend towards moderate relationships between lower familial SES and greater depression, stress and anxiety among fathers, but no relationship with their child's ASD symptom severity or functioning.CONCLUSION SES differentially impacts wellbeing and sense of parenting competence and its relationship to the impact of child symptoms for mothers and fathers of preschoolers with autism. | Nisha E Mathew Karen L O Burton Anne Schierbeek Rudi ?rn?ec Amelia Walter Valsamma Eapen | 2019 | World Journal of Psychiatry2019，9，2： | 6 |
| 3 | Efficacy and safety of liquid nitrogen cryotherapy for treatment of Barrett's esophagus显示文摘AIM To evaluate the efficacy and safety of liquid nitrogen cryotherapy as a primary or rescue treatment for BE,with and without dysplasia,or intramucosal adenocarcinoma (IMC).METHODS This was a retrospective,single-center study carried out in a tertiary care center including 45 patients with BE who was treatment-na?ve or who had persistent intestinal metaplasia(IM),dysplasia,or IMC despite prior therapy.Barrett's mucosa was resected via EMR when clinically appropriate,then patients underwent cryotherapy until eradication or until deemed to have failed treatment.Surveillance biopsies were taken at standard intervals.RESULTS From 2010 through 2014,33 patients were studied regarding the efficacy of cryotherapy.Overall,29 patients (88%) responded to cryotherapy,with 84% having complete regression of all dysplasia and cancer.Complete eradication of cancer and dysplasia was seen in 75% of subjects with IMC; the remaining two subjects did not respond to cryotherapy.Following cryotherapy,15 patients with high-grade dysplasia (HGD) had 30% complete regression,50% IM,and 7% low-grade dysplasia (LGD); one subject had persistent HGD.Complete eradication of dysplasia occurred in all 5 patients with LGD.In 5 patients with IM,complete regression occurred in 4,and IM persisted in one.In 136 cryotherapy sessions amongst 45 patients,adverse events included chest pain (1%),stricture (4%),and one gastrointestinal bleed in a patient on dual antiplatelet therapy who had previously undergone EMR.CONCLUSION Cryotherapy is an efficacious and safe treatment modality for Barrett's esophagus with and without dysplasia or intramucosal adenocarcinoma. | Kristen Suchniak-Mussari Charles E Dye Matthew T Moyer Abraham Mathew Thomas J McGarrity Eileen M Gagliardi Jennifer L Maranki John M Levenick | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 4 |
| 4 | Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation显示文摘AIM: To study the genesis of neointima formation in pulmonary hypertension(PH), we investigated the role of caveolin-1 and related proteins. METHODS: Male Sprague Dawley rats were given monocrotaline(M, 40 mg/kg) or subjected to hypobaric hypoxia(H) to induce PH. Another group was given M and subjected to H to accelerate the disease process(M + H). Right ventricular systolic pressure, right ventricular hypertrophy, lung histology for medial hypertrophy and the presence of neointimal lesions were examined at 2 and 4 wk. The expression of caveolin-1 and its regulatory protein peroxisome proliferator-activated receptor(PPAR) γ, caveolin-2, proliferative and antiapoptotic factors(PY-STAT3, p-Erk, Bcl-x L), endothelial nitric oxide synthase(e NOS) and heat shock protein(HSP) 90 in the lungs were analyzed, and the results from M + H group were compared with the controls, M and H groups. Double immunofluorescence technique was used to identify the localization of caveolin-1 in pulmonary arteries in rat lungs and in human PH lung tissue. RESULTS: In the M + H group, PH was more severe compared with M or H group. In the 4 wk M+H group, several arteries with reduced caveolin-1 expression in endothelial layer coupled with an increased expression in smooth muscle cells(SMC), exhibited neointimal lesions. Neointima was present only in the arteries exhibiting enhanced caveolin-1 expression in SMC. Lung tissue obtained from patients with PH also revealed neointimal lesions only in the arteries exhibiting endothelial caveolin-1 loss accompanied by an increased caveolin-1 expression in SMC. Reduction in e NOS and HSP90 expression was present in the M groups(2 and 4 wk), but not in the M + H groups. In both M groups and in the M + H group at 2 wk, endothelial caveolin-1 loss was accompanied by an increase in PPARγ expression. In the M + H group at 4 wk, increase in caveolin-1 expression was accompanied by a reduction in the PPARγ expression. In the H group, there was neither a loss of endothelial caveolin-1, eNOS or HSP 90, nor an increase in SMC caveolin-1 expression; or any alteration in PPARγ expression. Proliferative pathways were activated in all experimental groups. CONCLUSION: Enhanced caveolin-1 expression in SMC follows extensive endothelial caveolin-1 loss with subsequent neointima formation. Increased caveolin-1 expression in SMC, thus, may be a prelude to neointima formation. | Jing Huang John H Wolk Michael H Gewitz James E Loyd James West Eric D Austin Rajamma Mathew | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 5 | Molecular cloning, expression, and partial characterization of a second human tissue factor-pathway inhibitor 显示文摘 | Sprecher CA Kisiel W Mathew e S | 1994 | Proc Natl Acad Sci USA1994，91，8： | 1 |
| 6 | Performance of the horizon advanced lead-acid battery显示文摘 | JAY BENNY E DATTA Ajoy MATHEWS Charles | 1994 | Proceedings of the Annual Battery Conference Jan 11-131994，，： | 1 |
| 7 | Phosphorus in Hawaiian Kikuyugrass Pastures and Potential Phosphorus Release to Water显示文摘 | Mathews B W Carpenter J R Sollenberger L E | 2005 | Journal of Environmental Quality2005，，4： | 1 |
| 8 | Multiple type-B re-sponse regulators mediate cytokinin signal transduction in Arabidopsis显示文摘 | MASON M G MATHEWS D E ARGYROS D A | 2005 | Plant Cell2005，17，： | 1 |
| 9 | Relationship of electro- cardiographic left ventricular hypertrophy to mortality and cardiovascular morbidity in high-risk patients 显示文摘 | Lonn E Mathew J Pogue J | 2003 | Eur J Cardiovasc Prev Rehabil2003，10，6： | 1 |
| 10 | Effects of atrial natriuretic peptide in clinical acute renal failure显示文摘 | Rahman S N Kim G E Mathew A S | 1994 | Kidney Int1994，45，： | 1 |
| 11 | Global eddy permitting simulations of surface ocean nitrogen, iron, sulfur cycling显示文摘 | CHU Shao ping ELLIOTT Scott MALTRUD Mathew E | 2003 | Chemosphere2003，20，2： | 1 |
| 12 | Type B responseregulators of Arabidopsis play key roles in cytokinin signaling and plant de-velopment显示文摘 | ARGYROS R D MATHEWS D E CHIANG Y H | 2008 | Plant Cell2008，20，： | 1 |
| 13 | Characterisation of ferulic acid incorporated starch-chitosan blend films显示文摘 | Mathew S Abraham T E | 2008 | Food Hydrocolloids2008，，22： | 1 |
| 14 | Bridged y-carbolines and derivatives possessing selective and combined affinity for 5-HT2 and D2 receptors 显示文摘 | MEWSHAW R E SILVERMAN L S MATHEW R M et aJ | 1993 | J Med Chern1993，36，10： | 1 |
| 15 | Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proli- feration and differentiation显示文摘 | Yang Y J Baltus A E Mathew R S | 2012 | Cell2012，151，5： | 1 |
| 16 | Phylogenyof Andropogoneae inferred from phytochrome B, GBSSI, andndhF 显示文摘 | Mathews S Spangler R E Mason-Gamer R J | 2002 | Int J Plant Sci2002，163，44： | 1 |
| 17 | Single-agent Arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia:long-term follow-up data显示文摘 | Mathews V George B Chendamarai E | | 0，，24： | 1 |
| 18 | Domains of elF1A that mediate binding to elF2, elF3 and elF5B and promote ternary complex recruitment in vivo 显示文摘 | Olsen D A S Savner E M Mathew A | 2003 | The EM- BO journal2003，22，2： | 1 |
| 19 | Control of hyperhydricity of mango somatic embryos显示文摘 | MONSALUD M J MATHEWS H LITZ R E | 1995 | Plant Cell Tissue and Organ Culture1995，42，2： | 1 |
| 20 | CD44 is expressed in hepatocellular carcinoma showing vascular invasion显示文摘 | Mathew J Hines J E Obafunwa J O | 1996 | Pathol1996，179，1： | 1 |
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