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| 1 | Value of screening endoscopy in evaluation of esophageal,gastric and colon cancers显示文摘Esophageal,gastric,and colorectal cancers are deadly diseases that continue to plague our world today.The value of screening endoscopy in evaluating these types of cancers is a critical area of discussion due to a potential reduction in morbidity and mortality.This article describes how to identify a good screening test and explains what are important criteria in the field of screening endoscopy.Furthermore,the current status and progress of screening endoscopy for esophageal,gastric,and colorectal cancer will be evaluated and discussed.Mass screening programs have not been implemented for esophageal and gastric carcinomas in those with average or low risk populations.However,studies of high-risk populations have found value and a cost-benefit in conducting screening endoscopy.Colorectal cancer,on the other hand,has had mass screening programs in place for many years due to the clear evidence of improved outcomes.As the role of endoscopy as a screening tool has continued to develop,newer technology and techniques have emerged to improve its utility.Many new image enhancement techniques and computer processing programs have shown promise and may have a significant role in the future of endoscopic screening.These developments are paving the way for improving the diagnostic and therapeutic capability of endoscopy in the field of gastroenterology. | Tae H Ro Michelle A Mathew Subhasis Misra | 2015 | World Journal of Gastroenterology2015，21，33： | 9 |
| 2 | Hematological disorders and pulmonary hypertension显示文摘Pulmonary hypertension(PH),a serious disorder with a high morbidity and mortality rate,is known to occur in a number of unrelated systemic diseases.Several hematological disorders such as sickle cell disease,thalassemia and myeloproliferative diseases develop PH which worsens the prognosis.Associated oxidant injury and vascular inflammation cause endothelial damage and dysfunction.Pulmonary vascular endothelial damage/dysfunction is an early event in PH resulting in the loss of vascular reactivity,activation of proliferative and antiapoptotic pathways leading to vascular remodeling,elevated pulmonary artery pressure,right ventricular hypertrophy and premature death.Hemolysis observed in hematological disorders leads to free hemoglobin which rapidly scavenges nitric oxide(NO),limiting its bioavailability,and leading to endothelial dysfunction.In addition,hemolysis releases arginase into the circulation which converts L-arginine to ornithine,thus bypassing NO production.Furthermore,treatments for hematological disorders such as immunosuppressive therapy,splenectomy,bone marrow transplantation,and radiation have been shown to contribute to the development of PH.Recent studies have shown deregulated iron homeostasis in patients with cardiopulmonary diseases including pulmonary arterial hypertension(PAH).Several studies have reported low iron levels in patients with idiopathic PAH,and iron deficiency is an important risk factor.This article reviews PH associated with hematological disorders and its mechanism:and iron homeostasis and its relevance to PH. | Rajamma Mathew Jing Huang Joseph M Wu John T Fallon Michael H Gewitz | 2016 | World Journal of Cardiology2016，8，12： | 6 |
| 3 | Observation of Bose - Einstein condensation in a dilute atomic vapor显示文摘 | ANDERSON M H ENSHER J R MATHEWS M R | 1995 | Science1995，269，5221： | 2 |
| 4 | Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation显示文摘AIM: To study the genesis of neointima formation in pulmonary hypertension(PH), we investigated the role of caveolin-1 and related proteins. METHODS: Male Sprague Dawley rats were given monocrotaline(M, 40 mg/kg) or subjected to hypobaric hypoxia(H) to induce PH. Another group was given M and subjected to H to accelerate the disease process(M + H). Right ventricular systolic pressure, right ventricular hypertrophy, lung histology for medial hypertrophy and the presence of neointimal lesions were examined at 2 and 4 wk. The expression of caveolin-1 and its regulatory protein peroxisome proliferator-activated receptor(PPAR) γ, caveolin-2, proliferative and antiapoptotic factors(PY-STAT3, p-Erk, Bcl-x L), endothelial nitric oxide synthase(e NOS) and heat shock protein(HSP) 90 in the lungs were analyzed, and the results from M + H group were compared with the controls, M and H groups. Double immunofluorescence technique was used to identify the localization of caveolin-1 in pulmonary arteries in rat lungs and in human PH lung tissue. RESULTS: In the M + H group, PH was more severe compared with M or H group. In the 4 wk M+H group, several arteries with reduced caveolin-1 expression in endothelial layer coupled with an increased expression in smooth muscle cells(SMC), exhibited neointimal lesions. Neointima was present only in the arteries exhibiting enhanced caveolin-1 expression in SMC. Lung tissue obtained from patients with PH also revealed neointimal lesions only in the arteries exhibiting endothelial caveolin-1 loss accompanied by an increased caveolin-1 expression in SMC. Reduction in e NOS and HSP90 expression was present in the M groups(2 and 4 wk), but not in the M + H groups. In both M groups and in the M + H group at 2 wk, endothelial caveolin-1 loss was accompanied by an increase in PPARγ expression. In the M + H group at 4 wk, increase in caveolin-1 expression was accompanied by a reduction in the PPARγ expression. In the H group, there was neither a loss of endothelial caveolin-1, eNOS or HSP 90, nor an increase in SMC caveolin-1 expression; or any alteration in PPARγ expression. Proliferative pathways were activated in all experimental groups. CONCLUSION: Enhanced caveolin-1 expression in SMC follows extensive endothelial caveolin-1 loss with subsequent neointima formation. Increased caveolin-1 expression in SMC, thus, may be a prelude to neointima formation. | Jing Huang John H Wolk Michael H Gewitz James E Loyd James West Eric D Austin Rajamma Mathew | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 5 | Inhibitory kappa B kinase 2 activates airway epithelial cells to stimulate bone marrow macrophages 显示文摘 | MATHEW B PARK GY CAO H | 2007 | Am J Respir Cell Mol Biol2007，36，5： | 1 |
| 6 | Continuous-mixtures vapor-liquid equilibria computations based on true boiling point distillations 显示文摘 | HAYNES H W MATHEWS M A | 1991 | Ind Eng Chem Res1991，30，： | 1 |
| 7 | Detection of cerebral hypoperfusion during trial carotid occlusion with reversal following extracranialintracranial bypass prior to permanent occlusion显示文摘 | Walker BS Mathews D Batjer H | 1994 | Clin Nucl Med1994，19，： | 1 |
| 8 | Aldosterone induces mesangial cell apoptosis both in vivo and in vitro显示文摘 | MATHEW JT PATNI H CHAUDHARY AN | 2008 | Am J Physiol Renal Physiol2008，295，1： | 1 |
| 9 | Dynalign: an algorithmfor finding the secondary structure common to two RNA se-quences 显示文摘 | MATHEWS D H TURNER D H | 2002 | J Mol Biol2002，317，2： | 1 |
| 10 | Parametric study on the combined thermal and hydraulic performance of single phase micro pin-fin heat sinks part I: Square and circle geometries 显示文摘 | JOHN T J MATHEW B HEGAB H | 2010 | International Journal of Thermal Sciences2010，49，11： | 1 |
| 11 | Excretion of Phosphate and Soluble Organic Phosphorous Compounds by Zooplankton 显示文摘 | POMEROY L R MATHEWS H M MIN H S | 1963 | Limnol Oceanogr1963，，8： | 1 |
| 12 | Endoscopy assisted percutaneous anterior interbody fusion with subcutaneous suprafascial internal fixation: evolution of technique and surgical considerations 显示文摘 | Mathews H H Long B H | 1995 | Orthop Int ED1995，3，： | 1 |
| 13 | Type B responseregulators of Arabidopsis play key roles in cytokinin signaling and plant de-velopment显示文摘 | ARGYROS R D MATHEWS D E CHIANG Y H | 2008 | Plant Cell2008，20，： | 1 |
| 14 | Activation tagging in tomato identifies a transcriptional regulator of anthocyanin biosynthesis,modification,and transport显示文摘 | Mathews H Clendennen S K Caldwell C G | | 0，，： | 1 |
| 15 | The mitochondrial car- diolipin remodeling enzyme lysocardiolipin acyltransferase (LYCAT) is a novel target in pulmonary fibrosis显示文摘 | Huang L Mathew B Li H | 2014 | Am J Respir Crit Care Med2014，189，11： | 1 |
| 16 | Deter- mining embedding dimension for phase-space recon- struction using a geometrical construction显示文摘 | Kennel Mathew B Brown R Abarbanel H D I | 1992 | Phy Rev A1992，45，： | 1 |
| 17 | Control of hyperhydricity of mango somatic embryos显示文摘 | MONSALUD M J MATHEWS H LITZ R E | 1995 | Plant Cell Tissue and Organ Culture1995，42，2： | 1 |
| 18 | Clinical results of Maverick lumbar total disc replacement:two-year prospective follow-up显示文摘 | LeHuec JC Mathews H Basso Y | 2005 | Orthop Clin North Am2005，36，3： | 1 |
| 19 | Activation tagging in tomato identifies a transcriptional regulator of anthocyanin biosynthesis, modification, and transport 显示文摘 | MATHEWS H CLENDENNEN S K CALDWELL C G | 2003 | Plant Cell2003，15，8： | 1 |
| 20 | Fault diagnosis of rolling element bearings using basis pursuit 显示文摘 | Yang H Y Mathew J Ma L | 2005 | Mechanical Systems and Signal Processing2005，19，2： | 1 |
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