|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Anticancer and cytotoxic properties of the latex of Calotropis procera in a transgenic mouse model of hepatocellular carcinoma显示文摘瞄准:评估牛角属 procera 的弄干的乳胶(DL ) 的反癌症性质,热带药用的植物,在肝细胞癌并且到的 X15-myc 转基因的老鼠模型阐明它在房间文化的行动的机制。方法:小转基因的老鼠口头上地为 15 wk 用 DL (为 5 d/wk 的 400 mg/kg ) 的水的暂停被喂,他们的肝在 20 wk 为组织病理学说的变化被检验。脉管的内皮生长因素(VEGF ) 的浆液层次也在这些动物被测量。描绘活跃部分, DL 被提取,石油醚由甲醇列在后面。methanolic 摘录是用非极、极的溶剂的联合的硅胶 G 列上的亚 fractionated,十一部分被获得。每部分用 tetrazolium (MTT ) 在肝细胞瘤(Huh7 )(AML12 ) 和 non-hepatoma (COS-1 ) 房间行和非转变的 hepatocytes 上为细胞毒素的效果被分析试金。最后,细胞死亡的机制被测量 Bcl2 的层次调查, caspase 3 并且 DNA 破碎。结果:老鼠的 DL 处理对 hepatocarcinogenesis 显示出完全的保护。没有不利效果在这些动物被观察。浆液 VEGF 水平显著地作为与对照动物相比在对待的老鼠被降低。当 AML12 房间被节省时,房间文化研究表明 methanolic 在 Huh-7 和 COS-1 房间 DL 以及它的部分提取 8 导致的广泛的细胞死亡。这被 DNA 的广泛的破碎在 Huh-7 和 COS-1 房间伴随。在象 Bcl2 和 caspase 那样的 apoptosis 的正规标记的层次的没有变化 3 被观察。结论:C 的 DL。procera 与 apoptosis 的常规小径由于它的可辨的目标和不干涉为反癌症治疗有潜力。 | Tenzin Choedon Ganeshan Mathan Soneera Arya Vijay L Kumar Vijay Kumar | 2006 | World Journal of Gastroenterology2006，12，16： | 3 |
| 2 | p-Coumaric acid ameliorates ethanol-induced kidney injury by inhibiting inflammatory cytokine production and NF-κB signaling in rats显示文摘Objective: To examine the effects of p-coumaric acid on ethanol-induced kidney injury in Swiss Wistar rats.Methods: Ethanol(25% v/v) was used to induce nephrotoxicity in rats. p-Coumaric acid was orally administered at 50, 100, or 200 mg/kg body weight. The levels of oxidative parameters were determined; pro-inflammatory biomarkers were analyzed by Western blotting and apoptotic protein was analyzed by immunohistochemistry. Results: Ethanol treated rats showed decreased levels of antioxidants and aberrant production of pro-inflammatory cytokines(IL-6, IL1β, TNF-α), NF-κB activation and imbalance of proand anti-apoptotic proteins(Bcl-2, Bax, caspase 3). Meanwhile, p-coumaric acid restored antioxidant levels and decreased the levels of inflammatory cytokines, NF-κB, and proapoptotic proteins and increased Bcl-2 expression. Conclusions: p-Coumaric acid ameliorates ethanol-induced kidney injury by restoring antioxidant production and suppressing cellular apoptosis and inhibiting NF-κB expression.p-Coumaric acid should be further investigated as a promising candidate for ethanol-induced kidney toxicity. | Ramakrishnan Sabitha Kumari Nishi Vinoth Prasanna Gunasekaran Govindhan Annamalai Balupillai Agilan Mathan Ganeshan | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，5： | 2 |
| 3 | Carbon nanomaterials for cardiovascular theranostics:Promises and challenges显示文摘Cardiovascular diseases(CVDs)are the leading cause of death worldwide.Heart attack and stroke cause irreversible tissue damage.The currently available treatment options are limited to“damage-control”rather than tissue repair.The recent advances in nanomaterials have offered novel approaches to restore tissue function after injury.In particular,carbon nanomaterials(CNMs)have shown significant promise to bridge the gap in clinical translation of biomaterial based therapies.This family of carbon allotropes(including graphenes,carbon nanotubes and fullerenes)have unique physiochemical properties,including exceptional mechanical strength,electrical conductivity,chemical behaviour,thermal stability and optical properties.These intrinsic properties make CNMs ideal materials for use in cardiovascular theranostics.This review is focused on recent efforts in the diagnosis and treatment of heart diseases using graphenes and carbon nanotubes.The first section introduces currently available derivatives of graphenes and carbon nanotubes and discusses some of the key characteristics of these materials.The second section covers their application in drug delivery,biosensors,tissue engineering and immunomodulation with a focus on cardiovascular applications.The final section discusses current shortcomings and limitations of CNMs in cardiovascular applications and reviews ongoing efforts to address these concerns and to bring CNMs from bench to bedside. | Keshav Narayan Alagarsamy Sajitha Mathan Weiang Yan Alireza Rafieerad Saravanan Sekaran Hanna Manego Sanjiv Dhingra | 2021 | Bioactive Materials2021，6，8： | 2 |
| 4 | Xylose transport in the human jejunum显示文摘 | Rolston DD Mathan VI | 1989 | Dig Dis Sci1989，34，4： | 1 |
| 5 | Quantitative and ultra- structural analysis of rectal mueosal mast cells in acute infectious di- arrhea 显示文摘 | Pulimood A B Mathan M M Mathan V I | 1998 | Digest Dis Sci1998，43，9： | 1 |
| 6 | A regioselective multicomponent protocol for the synthesis of novel bioactive 4-hydroxyquinolin-2(1H)-one grafted monospiropyrrolidine and thiapyrro-lizidine hybrids显示文摘 | Mathan S Chokkalingam U Kumarasamy C | 2014 | Molecular diversity2014，18，： | 1 |
| 7 | Endophytic colonization of rice by a diazotrophic strain of Serratia marcescens显示文摘 | Gyaneshwar P James KK Mathan N | 2001 | Journal of Bacteriology2001，183，8： | 1 |
| 8 | Vitamin B12 synthesis by human small intestinal bacteria 显示文摘 | Albert MJ Mathan VI Baker SJ | 1980 | Nature1980，283，： | 1 |
| 9 | Endophyticcolonization of rice by a diazotrophic strain of Serratia marcescens 显示文摘 | Gyaneshwar P James E K Mathan N | 2001 | Journal of Bacteriology2001，183，8： | 1 |
| 10 | Adherent Escherichia coli in colorectal mucosal biopsies: A histological and ultrastructural evaluation显示文摘 | Susama Patra Subash Samal Gagandeep Kang Anna Pulimood Minnie Mathan Balakrishnan Ramakrishna | 2012 | Indian Journal of Pathology and Microbiology2012，，4： | 1 |
| 11 | Colonoscopic study of 50 显示文摘 | Shah S Thomas V Mathan M patients with colonic tuberculosis | 1992 | Gut1992，33，： | 1 |
| 12 | Human plasmacytoid dendritic cells from molecules to intercellular communication network显示文摘 | Mathan TS Figdor CG Buschow SI | 2013 | Front Immunol2013，，4： | 1 |
| 13 | Morphogenesis of fetal rat duodenal villi 显示文摘 | Mathan M Moxey P C Trier J S | 1976 | Am J Anat1976，146，： | 1 |
| 14 | Colonoscopic,study of 50 patients with colonic tuberculosis显示文摘 | Shah S Thomas V Mathan M | 1992 | Gut1992，33，： | 1 |
| 15 | Xylose transport in the human jejunum显示文摘 | Rolston DDK Mathan Ⅵ | 1989 | Dig Dis Sci1989，34，4： | 1 |
| 16 | Quantiative and ultrastructuralanalysis of rectal mast cellsin acute infectious diarrhea显示文摘 | Pul Imood A B Mathan M M Mathan VI | 1998 | Dig Dis Sci1998，43，9： | 1 |
| 17 | Overview of high- risk HPV's 16 and 18 infected cervical cancerzpathogenesis to prevention显示文摘 | Ramakrishnan S Partricia S Mathan G | 2015 | Biomed Pharmacother2015，70，： | 1 |
| 18 | Morphology of rectal mucosa of pa tients with shigellosis显示文摘 | Mathan M M Mathan V I | 1991 | Rev Infect Dis1991，13，14： | 1 |
| 19 | Xylose transport in the human jejunum显示文摘 | Rolston D D Mathan V I | 1989 | Dig Dis Sci1989，34，4： | 1 |
| 20 | Morphology of rectal mucosa of patients with shigellosis显示文摘 | Mathan MM Mathan VI | 1991 | Rev Infect Dis1991，13，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员