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| 1 | 青春期多囊卵巢综合征诊治共识显示文摘对于青春期女性的多囊卵巢综合征(PCOS),目前国内外尚无公认的统一诊断标准,且治疗方案的选择也不尽相同。为使国内各级妇产科医师更好地诊治和管理青春期PCOS患者,更新知识,并与国际接轨,国内该领域的专家在参考国外相关共识及指南后,结合我国的具体情况,编写了'青春期多囊卵巢综合征诊治共识',以改变临床医生对PCOS的传统认识,达到规范诊断和治疗青春期PCOS患者的目的。 | Reproductive Endocrinology Group,Chinese Maternal & Child Health Industry Association,National Association of Health Industry & Enterprise Management | 2016 | 生殖医学杂志2016，25，9： | 62 |
| 2 | Enhanced migration of tissue inhibitor of metalloproteinase overexpressing hepatoma cells is attributed to gelatinases: Relevance to intracellular signaling pathways显示文摘AIM: To study the effect of gelatinases (especially MMP-9)on migration of tissue inhibitor of metalloproteinase (TIMP-1) overexpressing hepatoma cells.METHODS: Wild type HepG2 cells, cells stably transfected with TIMP-1 and TIMP-1 antagonist (MMP-9-H401A, a catalytically inactive matrix metalloproteinase (MMP) which still binds and neutralizes TIMP-1) were incubated in Boyden chambers either with or without Galardin (a synthetic inhibitor of MMP-1, -2, -3, -8, -9) or a specific inhibitor of gelatinases.RESULTS: Compared to wild type HepG2 cells, the cells overexpressing TIMP-1 showed 115% migration (P<0.05)and the cells overexpressing MMP-9-H401A showed 62% migration (P<0.01). Galardin reduced cell migration dose dependently in all cases. The gelatinase inhibitor reduced migration in TIMP-1 overexpressing cells predominantly.Furthermore, we examined intracellular signal transduction pathways of TIMP-1-dependent HepG2 cells. TIMP-1deactivates cell signaling pathways of MMP-2 and MMP-9involving p38 mitogen-activated protein kinase. Specific blockade of the ERK pathway suppresses gelatinase expression either in the presence or absence of TIMP-1.CONCLUSION: Overexpressing functional TIMP-1-enhanced migration of HepG2-TIMP-1 cells depends on enhanced MMP-activity, especially MMP-9. | Elke Roeb Anja-Katrin Bosserhoff Sabine Hamacher Bettina Jansen Judith Dahmen Sandra Wagner Siegfried Matern | 2005 | World Journal of Gastroenterology2005，11，8： | 7 |
| 3 | Recurrent thrombotic occlusion of a transjugular intrahepatic portosystemic stent-shunt due to activated protein C resistance显示文摘The transjugular intrahepatic portosystemic stent-shunt (TIPS) has successfully been used in the management of refractory variceal bleeding and ascites in patients with portal hypertension. Major drawbacks are the induction of hepatic encephalopathy and shunt dysfunction. We present a 59-year-old woman with alcoholic liver cirrhosis who received a TIPS because of recurrent bleeding from esophageal varices. Stent occlusion occurred 4 mo after placement of the TIPS. Laboratory testing revealed resistance to activated protein C (APC). Combination therapy with low-dose enoxaparin and clopidogrel could not prevent her recurrent stent occlusion. Finally, therapy with high-dose enoxaparin was sufficient to prevent further shunt complications up to now (follow-up period of 1 year). In conclusion, early occlusion of a TIPS warrants testing for thrombophilia. If risk factors are confirmed,anticoagulation should be intensified. There are currently no evidence-based recommendations regarding the best available anticoagulant therapy and surveillance protocol for patients with TIPS. | Elmar Siewert Jan Salzmann Edmund Purucker Karl Schürmann Siegfried Matern | 2005 | World Journal of Gastroenterology2005，11，32： | 7 |
| 4 | 柑橘天然生物活性物质吖啶酮的研究与利用显示文摘吖啶酮生物碱是一类重要的生物活性物质,芸香科柑橘类植物是天然吖啶酮的主要来源。至今已从柑橘类植物中分离得到20多种吖啶酮生物碱,它们在抗癌、抗肿瘤、抗病毒、抗疟疾和抗白血病等方面有重要作用。我国柑橘资源丰富,利用我国乃至世界丰富的柑橘资源对柑橘吖啶酮的开发利用前景广阔。对柑橘吖啶酮的已有研究多以根茎为实验材料,关于果实中吖啶酮的研究尚无报道。阐述了柑橘吖啶酮的结构特点、生理活性、生物合成和研究进展情况,并提出了植物天然吖啶酮的研究现状和形势,同时指明了在柑橘吖啶酮研究领域存在的问题及今后在此领域的研究重点和方向。 | 孙崇德 李鲜 张上隆 Ulrich Matern 陈昆松 | 2006 | 果树学报2006，23，2： | 6 |
| 5 | Cholesterol crystal binding of biliary immunoglobulin A: visualization by fluorescence light microscopy显示文摘AIM To assess potential contributions of biliary IgA for crystal agglomeration into gallstones, we visualized cholesterol crystal binding of biliary IgA.METHODS Crystal-binding biliary proteins were extracted from human gallbladder bile using lectin affinity chromatography. Biliary IgA was isolated from the bound protein fraction by immunoaffinity chromatography. Pure cholesterol monohydrate crystals were incubated with biliary IgA and fluoresceine isothiocyanate (FITC)-conjugated anti-lgA at 37C. Samples were examined under polarizing and fluorescence light microscopy with digital image processing.RESULTS Binding of biliary IgA to cholesterol monohydrate crystals could be visualized with FITC-conjugated anti-lgA antibodies. Peak fluorescence occurred at crystal edges and dislocations. Controls without biliary IgA or with biliary IgG showed no significant fluorescence.CONCLUSION Fluorescence light microscopy provided evidence for cholesterol crystal binding of biliary IgA. Cholesterol crystalbinding proteins like IgA might be important mediators of crystal agglomeration and growth of cholesterol gallstones by modifying the evolving crystal structures in vivo. | Frank Lammert Stefan Südfeld Norbert Busch Siegfried Matern | 2001 | World Journal of Gastroenterology2001，7，2： | 6 |
| 6 | Side effects of budesonide in liver cirrhosis due to chronic autoimmune hepatitis: Influence of hepatic metabolism versus portosystemic shunts on a patient complicated with HCC显示文摘AIM: To investigate the systemic availability of budesonide in a patient with Child A drrhosis due to autoimmune hepatitis (AIH) and primary hepatocellular carcinoma, who developed serious side effects.METHODS: Serum levels of budesonide, 6β-OH-budesonide and 16α-OH-prednisolon were measured by HPLC/MS/MS;portosysternic shunt-index (SI) was determined by 99mTc nuclear imaging. All values were compared with a matched control patient without side effects.RESULTS: Serum levels of budesonide were 13-fold increased in the index patient. The ratio between serum levels of the metabolites 6β-OH-budesonide and 16α-OH-prednisolone, respectively, and serum levels of budesonide was diminished (1.0 vs. 4.0 for 6β-OH-budesonide, 4.2 vs.10.7 for 16α-OH-prednisolone). Both patients had portosystemic SI (5.7% and 3.1%) within the range of healthy subjects.CONCLUSION: Serum levels of budesonide vary up to 13-fold in AIH patients with Child A cirrhosis in the absence of relevant portosysternic shunting. Reduced hepatic metabolism, as indicated by reduced metabolite-to-drug ratio, rather than portosystemic shunting may explain systemic side effects of this drug in cirrhosis. | Andreas Geier Carsten Gartung Christoph G.Dietrich Hermann E.Wasmuth Patrick Reinartz Siegfried Matern | 2003 | World Journal of Gastroenterology2003，9，12： | 3 |
| 7 | Risk Factors of Learning Disabilities in Chinese Children in Wuhan显示文摘Objective To investigate prevalence rate of learning disabilities (LD) in Chinese children, and to explore related risk factors, and to provide theoretical basis for preventing such disabilities.Methods One thousand and one hundred fifty one children were randomly selected in primary schools. According to criteria set by ICD-10, 118 children diagnosed as LD were classified into the study group. Four hundred and ninety one children were classified into the normal control group. Five hundred and forty two children were classified into the excellent control group. The study instruments included PRS (The pupil rating scale revised screening for learning disabilities), Conners' children behavior check-list taken by parents and YG-WR character check-list. Results The prevalence rate of LD in Chinese children was 10.3%. Significant differences were observed between LD and normally learning children, and between the LD group and the excellent group, in terms of scores of Conners' behavior check-list (P<0.05). The study further showed that individual differences in character between the LD group and the control groups still existed even after controlling individual differences in age, IQ, and gender. Some possible causal explanations contributing to LD were improper teaching by parents, low educational level of the parents, and children's characteristics and social relationships. Conclusion These data underscore the fact that LD is a serious national public health problem in China. LD is resulted from a number of factors. Good studying and living environments should be created for LD children. | BIN YAO AND HAN-RONG WUDepartment of Children and Adolescent Health, Maternity and Child Health Care, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China | 2003 | Biomedical and Environmental Sciences2003，16，4： | 2 |
| 8 | Diagnostic Efficiency of Troponin T Measurements in Acute Myocardial Infarction显示文摘 | Hugo A. Katus Andrew Remppis Franz J. Neumann Thomas Scheffold Klaus W. Diederich Gabi Vinar Andreas Noe Gabi Matern Wolfgang Kuebler | 1991 | Circulation1991，，3： | 2 |
| 9 | Genetic risk factors for hepatic fibrosis in chronic liver diseases 显示文摘 | WASMUTH HE LAMMERT F MATERN S | 2003 | Med Klin2003，98，12： | 1 |
| 10 | Non-invasive quantification of liver perfusion with dynamic computed tomography and a dual-input one compartment model显示文摘 | Van Beers BE Smith AM | 2000 | Clin Sci2000，99，6： | 1 |
| 11 | Biliary secretory immunoglobulin A is a major of the new group of cholesterol crystal-binding proteins显示文摘 | Busch N Lammert F Matern S | 1998 | Gastroenterology1998，115，1： | 1 |
| 12 | Non-invasive prenatal testing (NIPT) by maternal plasma DNA sequencing显示文摘 | Position Statement from the Italian College of Fetal Maternal Medicine | 2013 | J Prenat Med2013，7，2： | 1 |
| 13 | ECPPA (Estudo Colaborativo pare Preveneao da Preeclampsia corn Aspirina) Collaborative Group 显示文摘 | ECPPA : randomised trial of low dose aspirin for the prevention of maternal and fetal complications in high risk pregnant women | 1996 | Br J Obstet Gynaecol1996，103，1： | 1 |
| 14 | Radioassay of UDP-glucuronosyl- transferase activities towards endogenous substrates using labeled UDP- glucnronic acid and an organic solvent extraction procedure显示文摘 | Matern H Heinemann H Matern S | 1994 | Analytical Biochemistry1994，219，： | 1 |
| 15 | Formation of trans-caffeoyl-CoA from trans-4-coumaroyl-CoA by Zn2+-dependent enzymes in cultured plant cells and its activation by an elicitor-induced pH shift显示文摘 | KNEUSEL R E MATERN U NLCOLAY K | 1989 | Arch Biochem Biophys1989，269，： | 1 |
| 16 | Non-invasive quantification of liver perfusion with dynamic computed tomography and a dual-input one-compartmental model显示文摘 | Materne R Van Beers BE Smith AM | 2000 | Clin Sci2000，99，6： | 1 |
| 17 | Multidrug resis-tance and response to antiretroviral treatment显示文摘 | DIETRICH C G GEIER A MATERN S | 2002 | Lancet2002，359，9323： | 1 |
| 18 | Hepatic perfusion parameters in chronic liver disease:dynamic CT measure- ments correlated with disease severity 显示文摘 | van Beers BE Leconte I Materne R | 2001 | A JR Am J Roent- geno12001，176，3： | 1 |
| 19 | He- patic perfusion parameters in chronic liver disease: dynamic CT measurements correlated with disease severity 显示文摘 | VAN BEERS B E LECONTE I MATERNE R | 2001 | AJR Am J Roentgenol2001，176，3： | 1 |
| 20 | Matrixmetalloproteinases and colorectal cancer显示文摘 | Roeb E Matern S | 2003 | Med Klin2003，98，12： | 1 |
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