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| 1 | Culture-guided treatment approach for Helicobacter pylori infection:Review of the literature显示文摘The progressive loss of efficacy of standard eradication therapies has made the treatment of Helicobacter pylori(H.pylori)more challenging than ever.Endoscopicguided antibiotic susceptibility testing had previously been suggested to guide treatment after failure of second-line therapies.However,its role has expanded over the years,in accordance with the current Maastricht Guidelines.Several authors have dealt with this topic,developing both efficacy trials and cost-effectiveness trials against resistant H.pylori infections as well as infections in nave patients.However,results are not homogeneous enough to provide definite advice,because antibiotic resistance is not the only reason for treatment failure.Moreover,the culture-guided approach is surrounded by many practical issues,such as the availability of both endoscopy units and microbiology laboratories,and the need for a standard of quality that cannot be satisfied everywhere.Finally,pre-treatment susceptibility testing should be partand not the only weapon-of a targeted,personalized strategy to overcome H.pylori infection. | Giovanni Cammarota Gianluca Ianiro Stefano Bibbò Teresa Antonella Di Rienzo Luca Masucci Maurizio Sanguinetti Antonio Gasbarrini | 2014 | World Journal of Gastroenterology2014，20，18： | 3 |
| 2 | Anti-tumor necrosis factor α therapy associates to type 17 helper T lymphocytes immunological shift and significant microbial changes in dextran sodium sulphate colitis显示文摘BACKGROUND Anti-tumor necrosis factor α(TNFα) represents the best therapeutic option to induce mucosal healing and clinical remission in patients with moderate-severe ulcerative colitis. On the other side gut microbiota plays a crucial role in pathogenesis of ulcerative colitis but few information exists on how microbiota changes following anti-TNFα therapy and on microbiota role in mucosal healing.AIM To elucidate whether gut microbiota and immune system changes appear following anti TNFα therapy during dextran sulfate sodium(DSS) colitis.METHODS Eighty C57 BL/6 mice were divided into four groups: 'No DSS', 'No DSS + antiTNFα', 'DSS' and 'DSS + anti-TNFα'. 'DSS' and 'DSS + anti-TNFα' were treated for 5 d with 3% DSS. At day 3, mice whithin 'No DSS+anti-TNFα' and'DSS+anti-TNFα' group received 5 mg/kg of an anti-TNFα agent. Forty mice were sacrificed at day 5, forty at day 12, after one week of recovery post DSS. The severity of colitis was assessed by a clinical score(Disease Activity Index), colon length and histology. Bacteria such as Bacteroides, Clostridiaceae, Enterococcaceae and Fecalibacterium prausnitzii(F. prausnitzii) were evaluated by quantitative PCR.Type 1 helper T lymphocytes(Th1), type 17 helper T lymphocytes(Th17) and CD4+ regulatory T lymphocytes(Treg) distributions in the mesenteric lymph node(MLN) were studied by flow cytometry.RESULTS Bacteria associated with a healthy state(i.e., such as Bacteroides, Clostridiaceae and F. prausnitzii) decreased during colitis and increased in course of anti-TNFαtreatment. Conversely, microorganisms belonging to Enterococcaceae genera,which are linked to inflammatory processes, showed an opposite trend.Furthermore, in colitic mice treated with anti-TNFα microbial changes were associated with an initial increase(day 5 of the colitis) in Treg cells and a consequent decrease(day 12 post DSS) in Th1 and Th17 frequency cells. Healthy mice treated with anti-TNFα showed the same histological, microbial and immune features of untreated colitic mice. 'No DSS + anti-TNFα' group showed a lymphomononuclear infiltrate both at 5 th and 12 th d at hematoxylin and eosin staining, an increase of in Th1 and Th17 frequency at day 12, an increase of Enterococcaceae at day 5, a decrease of Bacteroides and Clostridiaceae at day 12.CONCLUSION Anti-TNFα treatment in experimental model of colitis improves disease activity but it is associated to an increase in Th17 pathway together with gut microbiota alteration. | Valentina Petito Cristina Graziani Loris R Lopetuso Marco Fossati Alessandra Battaglia Vincenzo Arena Domenico Scannone Gianluca Quaranta Andrea Quagliariello Federica Del Chierico Lorenza Putignani Luca Masucci Maurizio Sanguinetti Alessandro Sgambato Antonio Gasbarrini Franco Scaldaferri | 2019 | World Journal of Gastroenterology2019，25，12： | 2 |
| 3 | Therapeutic Efficacy by Recombinant Human Granulocyte/Monocyte-Colony Stimulating Factor on Mucositis Occurring in Patients with Oral and Oropharynx Tumors Treated with Curative Radiotherapy显示文摘 | Masucci G Broman P Kelly C | | 0，，03： | 1 |
| 4 | Regulation of expression of bcl-2 protein family member Bim by T cell receptor triggering显示文摘 | Sandalova E Wei CH Masucci MG | 2004 | Proc Natl Acad Sci USA2004，101，9： | 1 |
| 5 | Role of four-dimensional ultrasound Cspatiotemporal image correlation and sonographybased automated volume count) in prenatal assessment of atrial morphology in cardiosplenic syndromes显示文摘 | Paladini Dv Sglavo G Masucci Av | 2011 | Ultrasound Obstet Gyneco\''2011，380，： | 1 |
| 6 | The Us3 protein kinase of herpes simplex virus 1 blocks apoptosis and induces phosporylation of the Bc1-2 family member Bad显示文摘 | Cartier A Komai T Masucci M G | | 0，，01： | 1 |
| 7 | The Us3 protein kinase of herpes simplex virus 1 blocks apoptosis and induces phosporylation of the Bcl-2 family member Bad 显示文摘 | Cartier A Komai T Masucci MG | 2003 | Exp Cell Res2003，291，1： | 1 |
| 8 | Cost - effectiveness of the carbon - 13 urea breath test for the detection of Helicobacter pylori: an economic analysis 显示文摘 | Masucci L Blackhouse G Goeree R | 2013 | Ont Health Technol Assess Set2013，13，20： | 1 |
| 9 | The TTG gene is required to specify epidermal cell fate and cell patterning in the Arabidopsis root显示文摘 | Galway ME Masucci JD Lloyd AM Walbot V Davis RW Schiefelbein JW | 1994 | Dev Biol1994，166，2： | 1 |
| 10 | Long-term outcomes for adult craniopharyngioma following radiation therapy显示文摘 | Laurence Masson-Cote Giuseppina Laura Masucci Eshetu G. Atenafu Barbara-Ann Millar Michael Cusimano Sidney Croul Warren Mason Normand J. Laperriere Arjun Sahgal | 2013 | Acta Oncologica2013，，1： | 1 |
| 11 | Liquid chrom- atographic and tandem mass spectrometric assay for evalu- ation of in vivo inhibition of rat brain monoamine oxidases (MAO) A and B following a single dose of MAO inhibi- tots : application of biomarkers in drug discovery 显示文摘 | Lang W Masucci J A CaldweU G W | 2004 | Ana- bctlcal Biochemistry2004，333，1： | 1 |
| 12 | Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis显示文摘 | Roldan AL Cubellis MV Masucci MT | 1990 | EMBOJ1990，9，2： | 1 |
| 13 | New results on non-perfect sharing of multiple secrets显示文摘 | Santis A D Masucci B | 2007 | The Journal of Systems and Software2007，80，： | 1 |
| 14 | The homeobox gene GLABRA2 is required for position-dependent cell differentiation in the root epidermis of Arabidopsis thaliana显示文摘 | Masucci JD Rerie WG Foreman DR Zhang M Galway ME Marks MD Schiefelbein JW | 1996 | Development1996，122，4： | 1 |
| 15 | GM-CSF augments the IL-2 induced cytotoxic activity of human lymphocytes in the absence and presence of mouse or chimeric monoclonal antibodies显示文摘 | Masucci G Raghammer P | 1990 | Cancer Immunol Immunother1990，31，： | 1 |
| 16 | Prognostic significance of tumor iNOS and COX-2 in stage III malignant cutaneous melanoma显示文摘 | Johansson CC Egyházi S Masucci G | 2009 | Cancer Immunol Immunother2009，58，7： | 1 |
| 17 | EB~ and genomic instability-a new look at the role of the virus in the pathogenesis of Burkitt's lymphoma显示文摘 | Gruhne B Kamranvar SA Masucci MG | 2009 | Semin Cancer Biol2009，19，6： | 1 |
| 18 | The Canadian Association of Radiation Oncology Scope of Practice Guidelines for Lung, Liver and Spine Stereotactic Body Radiotherapy显示文摘 | A. Sahgal D. Roberge D. Schellenberg T.G. Purdie A. Swaminath J. Pantarotto E. Filion Z. Gabos J. Butler D. Letourneau G.L. Masucci L. Mulroy A. Bezjak L.A. Dawson M. Parliament | 2012 | Clinical Oncology2012，，9： | 1 |
| 19 | Differential regulation of MHC class- Ⅰ - restricted and unrestricted cytotoxicity by the Us3 protein kinase of herpes simplex virus-1 显示文摘 | Cartier A Masucci MG | 2004 | Scand J Immunol2004，60，6： | 1 |
| 20 | Tumor viruses and replica- tire immortality - avoiding the telomere hurdle 显示文摘 | Chen X Kamranvar SA Masucci MG | 2014 | Semin Cancer Biol2014，26，： | 1 |
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