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| 1 | 中医诊治慢性疲劳免疫功能紊乱综合征的探讨显示文摘采用中西医两种观点,根据慢性疲劳免疫功能紊乱综合征(CFIDS)可能的病因,症状、诊断和治疗进行了回顾。对中医药诊断,针灸和草药治疗该病进行了探讨。 | Lee,MH 黄亦琦 | 1993 | 国外医学(中医中药分册)1993，15，6： | 148 |
| 2 | Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonism显示文摘 | Fu YS Cheng YC Lin MY Cheng H Chu PM Chou SC Shih YH Ko MH Sung MS | 2006 | 中国生物学文摘2006，20，10： | 138 |
| 3 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 4 | Androgen receptor: structure, role in prostate cancer and drug discovery显示文摘Androgens and androgen receptors (AR) play a pivotal role in expression of the male phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate cancer, are associated with alterations in AR functions. Indeed, androgen blockade by drugs that prevent the production of androgens and/or block the action of the AR inhibits prostate cancer growth. However, resistance to these drugs often occurs after 2-3 years as the patients develop castration-resistant prostate cancer (CRPC). In CRPC, a functional AR remains a key regulator. Early studies focused on the functional domains of the AR and its crucial role in the pathology. The elucidation of the structures of the AR DNA binding domain (DBD) and ligand binding domain (LBD) provides a new framework for understanding the functions of this receptor and leads to the development of rational drug design for the treatment of prostate cancer. An overview of androgen receptor structure and activity, its actions in prostate cancer, and how structural information and high-throughput screening have been or can be used for drug discovery are provided herein. | MH Eileen TAN Jun LI H Eric XU Karsten MELCHER Eu-leong YONG | 2015 | Acta Pharmacologica Sinica2015，36，1： | 39 |
| 5 | 迷走神经磁调制治疗脑卒中后吞咽困难显示文摘中风涉及脑干引起广泛的神经系统缺陷,包括口腔咽部吞咽困难(OD)。随着迷走神经刺激在脑卒中动物中的研究显示运动功能的改善,本研究探讨重复经颅磁刺激(rTMS)在人类卒中后吞咽功能恢复中的作用。这项假对照,双盲,平行研究包括30例缺血性或出血性中风,所有患者均表现为慢性延髓表现。在干预组中,TMS线圈放置在左侧乳突刺激迷走神经,2个星期内每天10次。 | 柏和风 顾旭东 Lin WS Chou CL Chang MH | 2018 | 中国康复2018，33，3： | 30 |
| 6 | 影响颅内动脉瘤破裂风险的患者个体特征(英文)显示文摘BACKGROUND AND PURPOSE Knowledge about risk factors contributes to understanding the pathophysiological mechanisms that cause intracranial aneurysm rupture and helps to develop possible treatment strategies.We aimed to study lifestyle and personal characteristics as risk factors for the rupture of intracranial aneurysms.METHODS We performed a case-control study with 250 patients with an aneurysmal subarachnoid hemorrhage and 206 patients with an unruptured intracranial aneurysm.All patients with an aneurysmal subarachnoid hemorrhage and patients with a unruptured intracranial aneurysm were asked to fill in a structured questionnaire about their lifestyle and medical history.For patients with an unruptured intracranial aneurysm,we also collected data on the indication for imaging.With logistic regression analysis,we identified independent risk factors for aneurysmal rupture.RESULTS Reasons for imaging in patients with an unruptured intracranial aneurysm were atherosclerotic disease(23%),positive family history(18%),headache(8%),preventive screening(3%),and other(46%).Factors that increased risk for aneurysmal rupture were smoking(odds ratio,1.9;95% confidence interval,1.2-3.0) and migraine(2.4;1.1-5.1);hypercholesterolemia decreased this risk(0.4;0.2-1.0),whereas a history of hypertension did not independently influence the risk.CONCLUSIONS Smoking,migraine and,inversely,hypercholesterolemia are independent risk factors for aneurysmal rupture.Data from the questionnaire are insufficient to conclude whether hypercholesterolemia or its treatment with statins exerts a risk-reducing effect.The pathophysiological mechanisms through which smoking and migraine increase the risk of aneurysmal rupture should be investigated in further studies.Although a history of hypertension does not increase risk of rupture,a sudden rise in blood pressure might still trigger aneurysmal rupture. | Vlak MH Rinkel GJ Greebe P Algra A | 2013 | 中华神经外科疾病研究杂志2013，12，3： | 17 |
| 7 | Qingyi decoction protects against myocardial injuries induced by severe acute pancreatitis显示文摘BACKGROUND We studied the protective effects of Qingyi decoction(QYD)(a Traditional Chinese Medicine)against severe acute pancreatitis(SAP)-induced myocardial infarction(MI).AIM To study the function and mechanism of QYD in the treatment of myocardial injuries induced by SAP.METHODS Ultrasonic cardiography,hematoxylin and eosin staining,immunohistochemistry,qRT-PCR,western blot,enzyme-linked immunosorbent assays,and apoptosis staining techniques were used to determine the effects of QYD following SAP-induced MI in Sprague-Dawley rats.RESULTS Our SAP model showed severe myocardial histological abnormalities and marked differences in the symptoms,mortality rate,and ultrasonic cardiography outputs among the different groups compared to the control.The expression of serum cytokines[interleukin(IL)-1?,IL-6,IL-8,IL-12,amyloidβ,and tumor necrosis factor-α]were significantly higher in the SAP versus QYD treated group(P<0.05 for all).STIM1 and Orai1 expression in myocardial tissue extracts were significantly decreased post QYD gavage(P<0.001).There was no significant histological difference between the 2-aminoethyl diphenylborinate inhibitor and QYD groups.The SAP group had a significantly higher apoptosis index score compared to the QYD group(P<0.001).CONCLUSION QYD conferred cardio-protection against SAP-induced MI by regulating myocardial-associated protein expression(STIM1 and Orai1). | Lei Li Yong-Qi Li Zhong-Wei Sun Cai-Ming Xu Jun Wu Ge-Liang Liu Ahmed MH Bakheet Hai-Long Chen | 2020 | World Journal of Gastroenterology2020，26，12： | 17 |
| 8 | 运用生色基因标记黄瓜根围促生菌(PGPR)筛选菌株显示文摘采用三亲交配方法 ,通过Tn7转座系统将lacZY标记基因导入黄瓜根围促生菌 (PG PR)筛选菌株PseudomonasfluorescensCN1 1 6和PseudomonascorrugataCN31的利福平抗性突变株中 ;标记假单胞菌菌株则被赋予了利用乳糖作为唯一碳源的能力 ,在只有乳糖的M9培养基上生长能分解X Gal,菌落显出特有的蓝色 ;经Southern杂交分析 ,证明标记基因lacZY存在于转化菌株的染色体上 ;经验证标记菌株标记性状稳定 ,与对应的野生菌株比较其它性状如培养性状、形态特征、生防效果等基本不变 ;PGPR菌株利福平抗性和生色基因标记的结合 (双标记 )能最大限度地将土壤中引入的PGPR菌株与土著细菌分开 ,检测下限可达 1 0CFU mL ,为PGPR在根围的分子生态学研究提供了一个较好的工具。 | 陈晓斌 张炳欣 楼兵干 Ryder MH | 2001 | 微生物学报2001，41，3： | 11 |
| 9 | 时代的演变与会计的未来显示文摘 | 沃.,史MH 孙菊生 | 1996 | 经济译文1996，，6： | 10 |
| 10 | 槲皮素结合Irinotecan或SN-38治疗或许对胃癌细胞的生长有抑制作用显示文摘目前尚无槲皮素结合irinotecan/SN-38治疗胃癌(GC)的研究报道。本文研究的目的是探讨槲皮素结合iri—notecan/SN-38能否更有效地降低癌细胞转移相关基因和蛋白质的表达,并减缓GC的发展。对象与方法:①体外研究。将经培养后的人类胃癌细胞(AGS)分别放入槲皮素(6.25,12.5,25,50,100μM)、SN-38(2.5,5,25,50,100nM)和槲皮素+SN-38中进行48h等处理后. | 张晗思 Lei CS Hou YC Pai MH | 2018 | 国际老年医学杂志2018，39，2： | 10 |
| 11 | Repeated operations for infiltrative low - grade gliomas without intervening therapy.显示文摘OBJECT:Progression of infiltrative low-grade gliomas(LGGs)has been reported previously.The limitations ofsuch studies include diverse histological grading systems,intervening therapy,and the lack of histological confir-mation of malignant tumor progression.The aim of this study was to determine tumor progression in adult patientswith an initial diagnosis of infiltrative LGG who subsequently underwent a repeated operation,but no other inter-vening therapy.The authors examined factors that may be associated with tumor progression. | Schmidt MH Berger MS Lamborn KR Aldape K McDermott MW Prados MD Chang SM | 2003 | 中国神经肿瘤杂志2003，1，2： | 8 |
| 12 | 骨折相关性感染定义的共识显示文摘骨折相关性感染(fracture related infection,FRI)是创伤骨科一种常见的严重并发症.迄今为止,尚无明确定义,因此很难对该并发症带来的影响进行准确评估和对现有的研究展开比较.为解决这一难题,在AO基金会的支持下,我们成立了一个由科学家和医学专家组成的专家组,旨在对FRI定义达成的共识. | Metsemakers WJ Morgenstern M McNally MA Moriarty TF McFadyen I Scarborough M Athanasou NA Ochsner PE Kuehl R Raschke M Borens O 谢肇 Velkes S Hungerer S Kates SL Zalavras C Giannoudis PV Richard RG Verhofstad MH 喻胜鹏 孙东 汪小华 | 2018 | 中华骨科杂志2018，38，9： | 8 |
| 13 | Antioxidative and anti-endotoxin effects of propofol on endothelial cells显示文摘Objective To investigate the antioxidant and anti-endotoxin effects of propofol on endothelial cells and the possible mechanisms.Methods Cultured endothelial cells were treated with hydrogen peroxide (H 2O 2), propofol + H 2O 2, lipopolysaccharide (LPS) and propofol + LPS, respectively. Endothelial cell damage was monitored for possible lactic dehydrogenase (LDH) release. The transcription and the protein expression levels of endothelial nitric oxide synthase (eNOS) were measured.Results LDH release was higher in groups treated with H 2O 2 or LPS than in the control group. After pretreatment with propofol, the effects induced by H 2O 2 were attenuated, but propofol did not decrease the LDH release induced by LPS. Both H 2O 2 and LPS significantly increased the eNOS transcript levels and the increases were significantly attenuated after pretreatment with propofol. Both H 2O 2 and LPS significantly increased the eNOS protein expression and the increase was attenuated after pretreatment with propofol. Conclusion Propofol could protect endothelial cells against oxidative stress by inhibiting eNOS transcription and protein expression, but could not antagonise endotoxin induced cell injuries. | 彭志勇 罗敏 叶仕桥 Critchley Lester AH Joynt Gavin M Ho Anthony MH 姚尚龙 | 2003 | Chinese Medical Journal2003，，5： | 7 |
| 14 | Phylogenetic diversity of bacteria in an earth-cave in Guizhou Province, Southwest of China显示文摘 | Zhou JR Gu YQ Zou CS Mo MH | 2007 | 中国生物学文摘2007，21，9： | 6 |
| 15 | Advances in dye-sensitized solar cell显示文摘THE conversion of visible light to electricity using semiconductors as light absorbers has beenan important area of research for many years. In the 1970s, highly efficient photovoltaiccells based on silicon were developed (the light-to-electrical conversion efficiency≥25%),which provides energy to aircrafts. Then semiconductor liquid-junction photoelectrochemicalcell started to be investigated. Generally speaking, highly efficient liquid-junction photoelec-trochemical solar cells can be obtained by using semiconductors such as Si, GaAs and WSe.(band gap≈(1.3±0.3) eV). Conversion efficiencies over 15% have been acquired on solarcells consisting of single crystals of Si or GaAs. But the serious photocorrosion and high | Jing, BW Zhang, MH Shen, T | 1997 | Chinese Science Bulletin1997，42，23： | 6 |
| 16 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | The Lancet . 2005 (9472)2005，，9472： | 6 |
| 17 | 急性缺血性脑卒中后低脉压与不良预后相关显示文摘众所周知,脉压与心脏功能、动脉僵硬度、体液状态和血管事件有关。该研究旨在探讨基于中国台湾地区脑卒中登记资料的急性缺血性脑卒中(acute ischemic stroke,AIS)患者入院时脉压的预后作用。 | 刘莉 叶鹏 Tang SC Yin JH Liu CH Sun MH Lee JT Sun Y Hsu CS Sun MC Lin CH Chen CH Lien LM Muo CH Jeng JS Hsu CY | 2017 | 中华高血压杂志2017，25，7： | 5 |
| 18 | A Novel Electrocatalysis Method for Organic Pollutants Degradation显示文摘A novel electrocatalysis, ferrous ion catalyzed anodic-cathodic electrocatalysis (FACEC), was developed for organic pollutants degradation, which could promote the degradation by achieving synergetic effects of both anodic oxidation and cathodic indirect oxidation. The degradation rate of model pollutants phenol by FACEC could increase by nearly 30% comparing with that of anodic electrocatalysis, and the current efficiency could reach 67%. | Zhou, MH Wu, ZC Wang, DH | 2001 | Chinese Chemical Letters2001，12，10： | 5 |
| 19 | 低密底脂蛋白和城油三酯在动脉粥样硬化发生中的作用显示文摘 | Jeff.,MH | 1994 | 美国医学会杂志(中文版)1994，13，5： | 5 |
| 20 | Impaired norepinephrine regulation of monocyte inflammatory cytokine balance in heart failure显示文摘AIM To evaluate the effect of norepinephrine on inflammatory cytokine expression in ex vivo human monocytes and monocytic THP-1 cells. METHODS For human monocyte studies, cells were isolated from 12 chronic heart failure(HF)(66 ± 12 years, New York Heart Association functional class Ⅲ-Ⅳ, left ventricular ejection fraction 22% ± 9%) and 14 healthy subjects(66 ± 12 years). Monocytes(1 × 106/mL) were incubated with lipopolysaccharide(LPS) 100 ng/m L, LPS + norepinephrine(NE) 10-6 mol/L or neither(control) for 4 h. Tumor necrosis factor-alpha(TNFα) and interleukin-10(IL-10) production were determined by ELISA. Relative contribution of α- and β-adrenergic receptor subtypes on immunomodulatory activity of NE was assessed in LPSstimulated THP-1 cells incubated with NE, the α-selective agonist phenylephrine(PE), and the β-selective agonist isoproterenol(IPN). NE-pretreated THP-1 cells were also co-incubated with the β-selective antagonist propranolol(PROP), α2-selective antagonist yohimbine(YOH) or the α1-selective antagonist prazosin(PRAZ). RESULTS Basal TNFα concentrations were higher in HF vs healthy subjects(6.3 ± 3.3 pg/mL vs 2.5 ± 2.6 pg/mL, P = 0.004). Norepinephrine's effect on TNFα production was reduced in HF(-41% ± 17% HF vs -57% ± 9% healthy, P = 0.01), and proportionately with NYHA FC. Increases in IL-10 production by NE was also attenuated in HF(16% ± 18% HF vs 38% ± 23% healthy, P = 0.012). In THP-1 cells, NE and IPN, but not PE, induced a dosedependent suppression of TNFα. Co-incubation with NE and antagonists revealed a dose-dependent inhibition of the NE suppression of TNFα by PROP, but not by YOH or PRAZ. Dose-dependent increases in IL-10 production were seen with NE and IPN, but not with PE. This effect was also antagonized by PROP but not by YOH or PRAZ. Pretreatment of cells with IPN attenuated the effects of NE and IPN, but did not induce a response to PE.CONCLUSION NE regulation of monocyte inflammatory cytokine production may be reduced in moderate-severe HF, and may be mediated through β-adrenergic receptors. | Tien MH Ng Myron L Toews | 2016 | World Journal of Cardiology2016，8，10： | 4 |
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