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| 1 | 影响颅内动脉瘤破裂风险的患者个体特征(英文)显示文摘BACKGROUND AND PURPOSE Knowledge about risk factors contributes to understanding the pathophysiological mechanisms that cause intracranial aneurysm rupture and helps to develop possible treatment strategies.We aimed to study lifestyle and personal characteristics as risk factors for the rupture of intracranial aneurysms.METHODS We performed a case-control study with 250 patients with an aneurysmal subarachnoid hemorrhage and 206 patients with an unruptured intracranial aneurysm.All patients with an aneurysmal subarachnoid hemorrhage and patients with a unruptured intracranial aneurysm were asked to fill in a structured questionnaire about their lifestyle and medical history.For patients with an unruptured intracranial aneurysm,we also collected data on the indication for imaging.With logistic regression analysis,we identified independent risk factors for aneurysmal rupture.RESULTS Reasons for imaging in patients with an unruptured intracranial aneurysm were atherosclerotic disease(23%),positive family history(18%),headache(8%),preventive screening(3%),and other(46%).Factors that increased risk for aneurysmal rupture were smoking(odds ratio,1.9;95% confidence interval,1.2-3.0) and migraine(2.4;1.1-5.1);hypercholesterolemia decreased this risk(0.4;0.2-1.0),whereas a history of hypertension did not independently influence the risk.CONCLUSIONS Smoking,migraine and,inversely,hypercholesterolemia are independent risk factors for aneurysmal rupture.Data from the questionnaire are insufficient to conclude whether hypercholesterolemia or its treatment with statins exerts a risk-reducing effect.The pathophysiological mechanisms through which smoking and migraine increase the risk of aneurysmal rupture should be investigated in further studies.Although a history of hypertension does not increase risk of rupture,a sudden rise in blood pressure might still trigger aneurysmal rupture. | Vlak MH Rinkel GJ Greebe P Algra A | 2013 | 中华神经外科疾病研究杂志2013，12，3： | 17 |
| 2 | Life expectancy after perimesencephalic subarachnoid hemorrhage 显示文摘 | GREEBE P RINKEL G J | 2007 | Stroke2007，38，4： | 1 |
| 3 | Life expectancy after perimesencephalic subarachnoid hemorrhage 显示文摘 | Greebe P Rinkel GJ | 2007 | Stroke2007，38，4： | 1 |
| 4 | Trigger factors for rupture of intracranial aneurysms in relation to patient and aneurysm characteristics显示文摘 | Vlak MH Rinkel GJ Greebe P | 2012 | J Neurol2012，259，7： | 1 |
| 5 | Independent riskfactors for intracranial aneurysms and their joint effect: acase-control study显示文摘 | Vlak MH Rinkel GJ Greebe P | 2013 | Stroke2013，44，4： | 1 |
| 6 | Late recurrence of subarachnoid hemorrhage after treatment for ruptured aneurysms: patient characteristics and outcomes 显示文摘 | Wermer MJ Rinkel GJ Greebe P | 2005 | Neurosurgery2005，56，2： | 1 |
| 7 | Independent risk factors for intracranial aneurysms and their joint effect: a case-control study 显示文摘 | Vlak MH Rinkel GJ Greebe P | 2013 | Stroke2013，44，4： | 1 |
| 8 | Life expectancy after perimesencephalic subarachnoid hemorrhage显示文摘 | Greebe P Rinkel GJ | | 0，，04： | 1 |
| 9 | Trigger factors for rupture of intracranial aneurysms in relation to patient and aneurysm characteristics 显示文摘 | Vlak MH Rinkel GJ Greebe P | 2012 | J Neurol2012，259，7： | 1 |
| 10 | Late recurrence of subarachnoid hemorrhage after treatment for ruptured aneurysms: patient characteristics and outcomes 显示文摘 | Wermer M J Rinkel GJ Greebe P | 2005 | Neurosurgery2005，56，2： | 1 |
| 11 | Trigger factors and their attributable risk for rupture of intracranial aneurysms: a case-crossover study显示文摘 | Vlak MH Rinkel GJ Greebe P | 2011 | Stroke2011，42，7： | 1 |
| 12 | Incidence of recur- rent subaraehnoid hemorrhage after clipping for ruptured in tracranial aneurysms显示文摘 | Wermer MJ Greebe P Algra A Rinkel GJ | 2005 | Stroke2005，36，11： | 1 |
| 13 | Life expectancy after perimesencephalic subarachnoid hemorrhage显示文摘 | Greebe P Rinkel GJ | | 0，，： | 1 |
| 14 | Life expectancy after perimesencephalic subarachnoid hemorrhage显示文摘 | Greebe P Rinkel G J | 2007 | Stroke2007，38，4： | 1 |
| 15 | Invasional 'mehdown' on an oceanic island 显示文摘 | O'DOWD D J GREEB P T LAKE P S | 2001 | Ecology Letters2001，6，9： | 1 |
| 16 | Patients with unrupturedintracranial aneurysms at the waiting list for intervention : Risk ofrupture显示文摘 | Geurts M Timmers C Greebe P | 2014 | Joumal of Neurology2014，261，： | 1 |
| 17 | Trigger factors and their attributable risk for rupture of intracranial aneurysms: a case-crossover study 显示文摘 | MHM Vlak GJE Rinkel P Greebe | 2011 | Stroke2011，42，： | 1 |
| 18 | Family history of subarachnoid haemorrhage:supplemental value of scrutinizing all relatives显示文摘 | Greebe P Bromberg JE Rinkel G J | | 0，，： | 1 |
| 19 | Life expectancy after perimesencephalic subarachnoid hemorrhage显示文摘 | Greebe P Rinkel G J | 2007 | Stroke2007，38，4： | 1 |
| 20 | Life expectancy after perimesencephalic subarachnoid hemorrhage显示文摘 | Greebe P Rinkel GJE | 2007 | Stroke2007，38，4： | 1 |
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