|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Inactive matrix Gla protein is elevated in patients with inflammatory bowel disease显示文摘BACKGROUND Matrix Gla protein(MGP)is a vitamin K dependent peptide which has an established role in suppression of vascular calcification.Recent studies have pointed to a possible link between immunomodulatory effect of MGP and inflammatory bowel disease(IBD).AIM To compare plasma levels of dephosphorylated and uncarboxylated MGP(dpucMGP)between IBD patients and controls.METHODS This cross-sectional study was conducted on 70 patients with IBD(30 patients with ulcerative colitis and 40 patients with Crohn’s disease)and 60 age and gender matching healthy controls.Plasma dp-ucMGP levels were analyzed from blood samples by CLIA method using IDS-iSYS InaKtif MGP(Immunodiagnostic Systems,Frankfurt,Germany)according to the manufacturer's instructions.fecal calprotectin(FC)levels were determined from stool samples by turbidimetric immunoassay method using Bühlmann fecal calprotectin turbo assay(Bühlmann Laboratories Aktiengesellschaft,Schonenbuch,Switzerland).Other parameters were analyzed according to the standard laboratory procedures.RESULTS Plasma levels of dp-ucMGP were significantly higher in patients with IBD compared to the healthy control group(629.83±124.20 pmol/mL vs 546.7±122.09 pmol/mL,P<0.001),and there was no significant difference between patients with Crohn’s disease and patients with ulcerative colitis(640.02±131.88 pmol/mL vs 616.23±113.92 pmol/mL,P=0.432).Furthermore,a significant positive correlation of plasma dp-ucMGP levels was found with both FC levels(r=0.396,P<0.001)and high sensitivity C-reactive protein(hsCRP)levels(r=0.477,P<0.001).Moreover,in the total study population a significant positive correlation was found between dp-ucMGP with age(r=0.210,P=0.016)and waist circumference(r=0.264,P=0.002).Multiple linear regression analysis showed that dp-ucMGP levels retained significant association with FC(β±SE,0.06±0.02,P=0.003).CONCLUSION Study results support experimental data of MGP immunomodulatory IBD effect and indicate potential involvement in the pathophysiology of the disease,and possibly extraintestinal manifestations. | Darko Brnic Dinko Martinovic Piero Marin Zivkovic Daria Tokic Marino Vilovic Doris Rusic Ivana Tadin Hadjina Christian Libers Sandro Glumac Daniela Supe-Domic Ante Tonkic Josko Bozic | 2020 | World Journal of Gastroenterology2020，26，32： | 5 |
| 2 | Role of endoscopic ultrasound in anticancer therapy:Current evidence and future perspectives显示文摘The digestive system is one of the most common sites of malignancies in humans.Since gastrointestinal tumors represent a massive global health burden both in terms of morbidity and health care expenditures,scientists continuously develop novel diagnostic and therapeutic methods to ameliorate the detrimental effects of this group of diseases.Apart from the well-established role of the endoscopic ultrasound(EUS)in the diagnostic course of gastrointestinal and hepatobiliary malignancies,we have recently become acquainted with a vast array of its therapeutic possibilities.A multitude of previously established,evidence-based methods that might now be guided by the EUS emerged:Radiofrequency ablation,brachytherapy,fine needle injection,celiac plexus neurolysis,and endoscopic submucosal dissection.In this review we endeavored to provide a comprehensive overview of the role of these methods in different malignancies of the digestive system,primarily in the treatment and symptom control in pancreatic cancer,and additionally in the management of hepatic,gastrointestinal tumors,and pancreatic cysts. | Andre Bratanic Dorotea Bozic Antonio Mestrovic Dinko Martinovic Marko Kumric Tina Ticinovic Kurir Josko Bozic | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 2 |
| 3 | Uncontractable 4-connected graphs显示文摘 | Martinov N | | 6:0，，： | 1 |
| 4 | Mast cell degranulation mediates compound 48/80-induced hyperalgesia in mice显示文摘 | Devavani Chatterjea Abigail Wetzel Madison Mack Camilla Engblom Juliann Allen Carolina Mora-Solano Luisa Paredes Evelyn Balsells Tijana Martinov | 2012 | Biochemical and Biophysical Research Communications2012，，2： | 1 |
| 5 | Antenatalpresentation of Bardet-Biedl syndrome may mimic Meckelsyndrome显示文摘 | Karmous-Benailly H Martinovic J Gubler MC | 2005 | Am J Hum Genet2005，76，3： | 1 |
| 6 | Direct effects, compensation, and recovery in female fathead minnows exposed to a model aromatase inhibitor显示文摘 | Villeneuve D L Mueller N D Martinovic D | 2009 | Environ Health Perspect2009，117，62： | 1 |
| 7 | The new ILAE report on classification and evidencebased commentary on Panayiotopoulos syndrome and autonomic status epilepticus显示文摘 | Martinovic Z | 2007 | Epilepsia2007，48，6： | 1 |
| 8 | Liquid flow resi- dence time in a fibrous fixed bed reactor with recycle 显示文摘 | Martinov M Hadjiev D Vlaev S | 2010 | Bioresource Technology2010，101，4： | 1 |
| 9 | Paradoxic activation of the renin - angiotensin system in twin -twin transfusion syndrome: an explanation for cardiovascular disturbances in the recipient 显示文摘 | Mahieu - Caputo D Meulemans A Martinovic J | 2005 | Pediatr Res2005，58，4： | 1 |
| 10 | Elevated monocyte chemoattractant protein- 1 serum levels in patients at risk for coronary artery disease显示文摘 | MARTINOVIC I ABEGUNEWARDENE N SEUL M | 2005 | Circ J2005，69，： | 1 |
| 11 | Fetal toxic effects and angiotensin- 1I -receptor antagonists显示文摘 | Martinovic J Benachi A Laurent N | 2001 | Lancet2001，35，2： | 1 |
| 12 | Laser desorption Fourier transform mass spectrometry of lignins显示文摘 | Srzic D Martinovic S Klasine L | 1995 | Rapid Commun Mass Spectrom1995，9，3： | 1 |
| 13 | Single-Commodity Vehicle Rou-ting Problem with Pickup and Delivery Service显示文摘 | Martinovic G Aleksi I Baumgartner A | | 0，，2008： | 1 |
| 14 | Effect of Tenon Length on Flexibility of Mortise and Tenon Joint显示文摘 | HAJDAREVIC S MARTINOVIC S | 2014 | Procedia Engineer- ing2014，26，9： | 1 |
| 15 | Preventing depres-sion in adolescents with epilepsy显示文摘 | Martinovic Z Simonovic P Djokic R | 2006 | Epilepsy Behav2006，9，4： | 1 |
| 16 | Does the metabolic syndrome impact left-ventricular mechanics? A two-dimensional speckle tracking study显示文摘 | Marijana Tadic Cesare Cuspidi Anka Majstorovic Biljana Pencic Sladjana Backovic Branislava Ivanovic Radisav Scepanovic Jelena Martinov Vesna Kocijancic Vera Celic | 2014 | Journal of Hypertension2014，，： | 1 |
| 17 | Repair of recurrent coarctation using an ascending aortic autograft显示文摘 | Moosdorf R Lindemann S | 2005 | Thorac Cardiov Surg2005，53，4： | 1 |
| 18 | Increased expression of monocarboxylate transporter 1 after acute ischemia of isolated,perfused mouse hearts显示文摘 | Martinov V Rizvi SM Weiseth SA | 2009 | Life Sci2009，85，910： | 1 |
| 19 | Accuracy of fetal lung volume assessed by three-dimensional sonography显示文摘 | Ruano R Martinovic J Dommergues M | 2005 | Ultrasound obstet Gynecol2005，26，： | 1 |
| 20 | Reproduc- tive toxicity of vinclozolin in the fathead minnow: Con- fuming an anti-androgenic mode of action 显示文摘 | Martinovic D Blake L S Durhan E J | 2008 | Environ- mental Toxicology and Chemistry2008，27，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员