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| 1 | Helicobacter pylori in dental plaque and stomach of patients from Northern Brazil显示文摘AIM: To establish whether virulence factor genes vacA and cagA are present in Helicobacter pylori (H. pylori) retrieved from gastric mucosa and dental plaque in pa-tients with dyspepsia. METHODS: Cumulative dental plaque specimens and gastric biopsies were submitted to histological exami-nation, rapid urease test and polymerase chain reac-tion (PCR) assays to detect the presence of cagA and vacA polymorphisms.RESULTS: Detection of H. pylori from dental plaque and gastric biopsy samples was greater by PCR com-pared to histological examination and the rapid ure-ase test. DNA from H. pylori was detected in 96% of gastric mucosa samples and in 72% of dental plaque samples. Sixty-three (89%) of 71 dental plaque sam-ples that were H. pylori-positive also exhibited identical vacA and cagA genotypes in gastric mucosa. The most common genotype was vacAs1bm1 and cagA positive, either in dental plaque or gastric mucosa. These viru-lent H. pylori isolates were involved in the severity of clinical outcome.CONCLUSION: These pathogenic strains were found simultaneously in dental plaque and gastric mucosa, which suggests that gastric infection is correlated with the presence of H. pylori in the mouth. | Mnica Baraúna Assumpo Luisa Caricio Martins Hivana Patricia Melo Barbosa Katarine Antonia dos Santos Barile Sintia Silva de Almeida Paulo Pimentel Assumpo Tereza Cristina de Oliveira Corvelo | 2010 | World Journal of Gastroenterology2010，16，24： | 29 |
| 2 | Interleukin-1 and TNF-α polymorphisms and Helicobacter pylori in a Brazilian Amazon population显示文摘AIM:To study the association between Interleukin-1(IL-1)and tumor necrosis factor(TNF)-αpolymorphisms,infection by Helicobacter pylori(H pylori)and the development of gastrointestinal diseases.METHODS:Genomic DNA was extracted from the peripheral blood of 177 patients with various gastrointestinal diseases and from 100 healthy volunteers.The polymorphisms in IL-1βand TNF-αgenes were analyzed using the polymerase chain reactionrestriction fragment length polymorphism method(PCRRFLP)and those from IL-1RN with PCR.The presence of infection due to H pylori and the presence of the CagA toxin were detected by serology.The histopathological parameters in the gastric biopsies of the patients were according to the Sydney classification.RESULTS:A comparison of the frequencies of the different polymorphisms studied among the patients and the control group demonstrated that the allele IL1RN*2 was more frequent among patients with gastric ulcers and adenocarcinoma.Carriers of the allele ILRN*2 and those with reactive serology for anti-CagA IgG had a greater risk of developing peptic ulcer and gastric adenocarcinoma,as well as a higher degree of inflammation and neutrophilic activity in the gastric mucosa.CONCLUSION:Our results indicate a positive association between IL-1RN gene polymorphism and infection by positive H pylori CagA strains and the development of gastric ulcers and adenocarcinoma. | Hivana Patricia Melo Barbosa Luisa Caricio Martins Sidney Emanuel Batista dos Santos Samia Demachki Mnica Baraúna Assumpo Charliana Damasceno Arago Tereza Cristina de Oliveira Corvelo | 2009 | World Journal of Gastroenterology2009，15，12： | 17 |
| 3 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 4 | Multiple haploids, triploids, and tetraploids found in modern-day “living fossil” Ginkgo biloba显示文摘Ginkgo biloba,the last extant representative of a lineage of Mesozoic gymnosperms,is one of the few seed plants with an exceptionally long(~300 Myr)evolutionary history free of genome-wide duplications(polyploidy).Despite this genome conservatism,we have recently found a viable spontaneous tetraploid Ginkgo sapling during routine screening of several plants,demonstrating that natural polyploidy is possible in Ginkgo.Here we provide a much wider flow cytometry survey of ploidy in some European Ginkgo collections,and own seedlings(>2200 individuals and~200 cultivars).We found a surprisingly high level of ploidy variation in modern-day Ginkgo and documented altogether 13 haploid,3 triploid,and 10 tetraploid Ginkgo plants or cultivars,most of them being morphologically distinct from common diploids.Haploids frequently produced polyploid(dihaploid)buds or branches.Tetraploids showed some genome size variation.The surveyed plants provide a unique resource for future Ginkgo research and breeding,and they might be used to accelerate the modern diversification of this nearly extinct plant lineage. | PetrŠmarda Lucie Horová Ondřej Knápek Heidi Dieck Martin Dieck Katarína Ražná Pavel Hrubík Laszlo Orlóci Laszlo Papp Kristýna Veselá Pavel Veselý Petr Bureš | 2018 | Horticulture Research2018，5，1： | 4 |
| 5 | Complications and Outcome After Acute Stroke: Does Dysphagia Matter?显示文摘 | D.G. Smithard NA O’Neill C. Park J. Morris R. Wyatt R. England D.F. Martin | 1996 | Stroke A Journal of Cerebral Circulation1996，，7： | 2 |
| 6 | Posttraumatic cerebral arterial spasm:transcranial Doppler ultrasound,cerebral blood flow,angiographic findings显示文摘 | Martin NA Doberstein C Zane C | 1992 | J Neurosurgery1992，77，4： | 1 |
| 7 | Hyperemia fol- lowing traumatic brain injury: relationship to intracranial hy- pertension and outcome 显示文摘 | Kelly DF Kordestani RK Martin NA | 1996 | J Neurosurg1996，85，5： | 1 |
| 8 | Nonunion of distal femoral fractures : a systematic review 显示文摘 | Ebraheim NA Martin A Sochacki KR | 2013 | Orthop Surg2013，5，1： | 1 |
| 9 | Lymphocyte Subsets in Peripheral Blood of Dogs a Flow Cviometric Study显示文摘 | Martin Faldyna Lenka Levá Pavlína Kn(o)tigová | 2001 | Vet Immunol Immunopathol2001，83，： | 1 |
| 10 | Indapamide(Natrilix):The agent of choice in the trentment of recurrent renal calculi associated with idiopathic hypercalciuria显示文摘 | MC Martins AM Meyers NA Whalley | 1996 | Br J Urol1996，78，2： | 1 |
| 11 | Intraoperative digital subtraction angiography and the surgical treatment of intracranial aneurysms and vascular malformations显示文摘 | Martin NA Bentson J Vinuela F | 1990 | J Neurosurgery1990，73，4： | 1 |
| 12 | Posttraumatic cerebral arterial spasm:Transcranial Doppler ultrasound,cerebral blood flow,and angiographic findings显示文摘 | Martin NA Doberstein C Zane C | 1992 | J Nearosurgery1992，77，： | 1 |
| 13 | What is the true nature of the osteoblastic hematopoietic stem cell niche显示文摘 | Askmyr M Sims NA Martin TJ Purton LE | | 0，，： | 1 |
| 14 | Determination of bacterial load by real-time PCR using a broad-range(universal)probe and primers set显示文摘 | Nadkarni MA Martin FE Jacques NA | 2002 | Microbiology2002，148，： | 1 |
| 15 | Biometrical genetics 显示文摘 | Evans DM Gillespie NA Martin NG | 2002 | Biol Psychol2002，61，： | 1 |
| 16 | The combination of endovascular and surgical techniques for the treatment of intracranial aneurysms显示文摘 | Martin NA | 1998 | Neurosurg Clin North Am1998，9，： | 1 |
| 17 | tert -Butylation of glycerol catalysed by ion-exchange resins显示文摘 | Katarína Klepá?ová Du?an Mravec Martin Bajus | 2005 | Applied Catalysis A General2005，，2： | 1 |
| 18 | Cerebral metabolism following traumatic brain injury:new discoveries with implications for treatment 显示文摘 | Brooks GA Martin NA | 2014 | Front Neurosci2014，8，： | 1 |
| 19 | Hyperemia following tranmatic brain injury:relationship to intracranial hypertension and outcome显示文摘 | Kelly DE Kordestani RK Martin NA | 1996 | J Neurosurg1996，85，5： | 1 |
| 20 | Posttraumatic cerebral arterial spasm: transcranial Doppler ultrasound, cerebral blood flow, and angiographic findings 显示文摘 | Martin NA Doberstein C Zanec | 1992 | J Neurosurg1992，77，： | 1 |
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