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| 1 | Characterization of six tumorsuppressor genes and microsatellite instability in hepatocellular carcinomain southern African blacks显示文摘AIM To analyse cumulative loss of heterozygosity (LOH) of chromosomal regions and tumor suppressor genes in hepatocellular carcinomas (HCCs) from 20 southern African blacks. METHODS p53, RB1, BRCA1, BRCA2, WT1 and E cadherin genes were analysed for LOH, and p53 gene was also analysed for the codon 249 mutation, in tumor and adjacent non tumorous liver tissues using molecular techniques and 10 polymorphic microsatellite markers. RESULTS p53 codon 249 mutation was found in 25% of the subjects, as was expected, because many patients were from Mozambique, a country with high aflatoxin B 1 exposure. LOH was found at the RB1, BRCA2 and WT1 loci in 20%(4/*!20) of the HCCs, supporting a possible role of these genes in HCC. No LOH was evident in any of the remaining genes. Reports of mutations of p53 and RB1 genes in combination, described in other populations, were not confirmed in this study. Change in microsatellite repeat number was noted at 9/*!10 microsatellite loci in different HCCs, and changes at two or more loci were detected in 15%(3/*!20) of subjects. CONCLUSION We propose that microsatellite/genomic instability may play a role in the pathogenesis of a subset of HCCs in black Africans. | Martins C Kedda MA Kew MC | 1999 | World Journal of Gastroenterology1999，5，6： | 21 |
| 2 | 感染性休克病人的血流动力学特点及意义显示文摘目的 了解感染性休克病人早期血流动力学改变的特点及与预后关系。方法 临床前瞻性研究 ,监测感染性休克早期血流动力学改变并分析与预后的关系。结果 共连续观察 4 8例病人 ,其中 2 5例(5 2 % )死亡。一些指标的水平在死亡者与生存者间差别较大 ,其中包括平均肺动脉压 (MPAP)、肺动脉楔压 (PAWP)、体 /肺循环阻力指数 (SVRI/PVRI)、左 /右心做功 (LCW/RCW )和左 /右心每搏动 (LCSW/RCSW)等血流动力学指标和氧合指数、动脉混合静脉血含氧量差 (a vDO2 )、全身性炎症反应综合征(SIRS)指标积分等。结论 感染性休克病情凶险 。 | 赵擎宇 贾清颜 Weigand MA Martin E Bardenheuer HJ | 2002 | 中华急诊医学杂志2002，11，3： | 16 |
| 3 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 4 | Efficacy and safety of FIREHAWK abluminal groove filled biodegradable polymer sirolimus-eluting stents for the treatment of long coronary lesions: nine-month angiographic and one-year clinical results from TARGET I trial lona cohort显示文摘 | XU Bo GAO Run-lin ZHANG Rui-yan WANG Hai-chang LI Zhan-quan YANG Yue-jin MA Chang-sheng HAN Ya-ling Alexandra J. Lansky HUO Yong LI Wei Martin B. Leon | 2013 | Chinese Medical Journal2013，，6： | 8 |
| 5 | Innate and adaptive immune responses toward nanomedicines显示文摘Since the commercialization of the frst liposomes used for drug delivery,Doxil/Caelyx® and Myocet®,tremendous progress has been made in understanding interactions between nanomedicines and biological systems.Fundamental work at the interface of engineering and medicine has allowed nanomedicines to deliver therapeutic small molecules and nucleic acids more effciently.While nanomedicines are used in oncology for immunotherapy or to deliver combinations of cytotoxics,the clinical successes of gene silencing approaches like patisiran lipid complexes(Onpattro®)have paved the way for a variety of therapies beyond cancer.In parallel,the global severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic has highlighted the potential of mR NA vaccines to develop immunization strategies at unprecedented speed.To rationally design therapeutic and vaccines,chemists,materials scientists,and drug delivery experts need to better understand how nanotechnologies interact with the immune system.This review presents a comprehensive overview of the innate and adaptative immune systems and emphasizes the intricate mechanisms through which nanomedicines interact with these biological functions. | Iara Maíra de Oliveira Viana Sabrina Roussel Joan Defrêne Eliana Martins Lima Frédéric Barabé Nicolas Bertrand | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 5 |
| 6 | Plant Programmed Cell Death Caused by an Autoactive Form of Prf Is Suppressed by Co-Expression of the Prf LRR Domain显示文摘在西红柿, NBARC-LRR 抵抗(R) 蛋白质 Prf 与 Pto 或分 kinase 在音乐会行动对 Pseudomonas syringae pv 决定免疫。西红柿(Pst ) 。发信号的调停 Prf 的防卫被二顺序无关的藏匿 Pst 的受动器蛋白质, AvrPto 和 AvrPtoB 的识别开始,由西红柿 Pto 或分。Prf 检测这些相互作用并且激活发信号包括与 Pst 生长的拘捕被联系的局部性的规划细胞死亡(PCD ) 导致宿主防卫回答。当短暂地在 Nicotiana benthamiana 的叶子表示了时,我们发现有在在在 NBARC 领域的 IHD 主题(isoleucine-histidine-aspartic 酸) 的 D1416 的单个氨基酸替换的 Prf 变体引起受动器无关的 PCD,建议 D1416 起在 Prf 的激活的一个重要作用。Prf (NPrf ) 和 LRR 领域的 N 终端区域为发信号的这 autoactive Prf 房间死亡被要求但是为 PrfD1416V 蛋白质的累积非必需。显著地, Prf LRR 然而并非 NPrf 的合作表示与 PrfD1416V, AvrPto/Pto, AvrPtoB/Pto, Pto (PtoY207D ) 的一种 autoactive 形式,或分完全压制 PCD。然而, Prf LRR 不防碍 PCD 由 Rpi-blb1D475V 引起了,表明事件的不同 R 调停蛋白质的 PCD,或由 MAPKKK 的 overexpression 引起了, Prf 下游地行动的蛋白质。而且,我们发现当与 Prf LRR 领域共同表示时, PrfD1416V 蛋白质是不能的在植物房间积累,多半向房间死亡解释抑制。为 PrfD1416V 的导致 LRR 的降级的机制是未知的,但是可以在 Prf 或到独立 LRR 的绑定的 intramolecular 相互作用包含干扰到为 Prf 稳定性被需要的另外的主机蛋白质。 | Xinran Du Min Miao Xinrong Ma Yongsheng Liu Joseph C. Kuhl Gregory B. Martin Fangming Xiao | 2012 | Molecular Plant2012，5，5： | 4 |
| 7 | Polarisation optics for biomedical and clinical applications:a review显示文摘Many polarisation techniques have been harnessed for decades in biological and clinical research,each based upon measurement of the vectorial properties of light or the vectorial transformations imposed on light by objects.Various advanced vector measurement/sensing techniques,physical interpretation methods,and approaches to analyse biomedically relevant information have been developed and harnessed.In this review,we focus mainly on summarising methodologies and applications related to tissue polarimetry,with an emphasis on the adoption of the Stokes-Mueller formalism.Several recent breakthroughs,development trends,and potential multimodal uses in conjunction with other techniques are also presented.The primary goal of the review is to give the reader a general overview in the use of vectorial information that can be obtained by polarisation optics for applications in biomedical and clinical research. | Chao He Honghui He Jintao Chang Binguo Chen Hui Ma Martin J.Booth | 2021 | Light(Science & Applications)2021，10，11： | 4 |
| 8 | Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers显示文摘Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ morphogenesis.Its impact on beef cattle muscle growth remains undefined.Method: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of age.At 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells.The resulting steers were harvested at 14 months of age.Results: Vitamin A administration increased cattle growth at 2 months.At 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and MYOG.Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro.More myotubes and a higher degree of myogenesis was observed in vitamin A groups.Consistently,vitamin A increased Latissimus dorsi(LD) muscle fiber size at harvest.In addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers.Furthermore,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal muscle.Conclusion: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers. | Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu Martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 9 | Loss of heterozygosity for loci on chromosome arms 1p and 10q in oligoden-droglial tumors: relationship to outcome and chemosensitivity显示文摘Oligodendroglial tumors frequently have deletions ofchromosomal loci on lp and l9q.Loas of heterozygosity(LOH)of chromosome 10 may be a negative prognostic factor.We reviewed 23 patients with oligodendroglial tumors,toevaluate the frequency of lp and 10q LOH and correlate with clinical outcome.Three loci(DlS402,DlSl 172,MCT118)on lp and 2 loci(Dl0S520 and D10S521)on 10q were analyzed for LOH using PCR techniques. | Thiessen B Maguire JA McNeil K Huntsman D Martin MA Horsman D | 2003 | 中国神经肿瘤杂志2003，1，4： | 3 |
| 10 | DYNAMIC VARIATIONS OF WATER QUALITY IN TAIHU LAKE AND MULTIVARIATE ANALYSIS OF ITS INFLUENTIAL FACTORS显示文摘DYNAMIC VARIATIONS OF WATER QUALITY IN TAIHU LAKE AND MULTIVARIATE ANALYSIS OF ITS INFLUENTIAL FACTORSDYNAMICVARIATIONSOFWATE... | Qiming Cai Xiyun Gao Yuwei Chen Shengwei Ma Dokulil Martin | 1996 | Chinese Geographical Science1996，6，4： | 2 |
| 11 | Postoperative Complications and Mortality Following Colectomy for Ulcerative Colitis显示文摘 | Shanika de Silva Christopher Ma Marie–Claude Proulx Marcelo Crespin Belle S. Kaplan James Hubbard Martin Prusinkiewicz Andrew Fong Remo Panaccione Subrata Ghosh Paul L. Beck Anthony MacLean Donald Buie Gilaad G. Kaplan | 2011 | Clinical Gastroenterology and Hepatology2011，，11： | 2 |
| 12 | Revealing complex optical phenomena through vectorial metrics显示文摘Advances in vectorial polarization-resolved imaging are bringing new capabilities to applications ranging from fundamental physics through to clinical diagnosis.Imaging polarimetry requires determination of the Mueller matrix(MM)at every point,providing a complete description of an object’s vectorial properties.Despite forming a comprehensive representation,the MM does not usually provide easily interpretable information about the object’s internal structure.Certain simpler vectorial metrics are derived from subsets of the MM elements.These metrics permit extraction of signatures that provide direct indicators of hidden optical properties of complex systems,while featuring an intriguing asymmetry about what information can or cannot be inferred via these metrics.We harness such characteristics to reveal the spin Hall effect of light,infer microscopic structure within laser-written photonic waveguides,and conduct rapid pathological diagnosis through analysis of healthy and cancerous tissue.This provides new insight for the broader usage of such asymmetric inferred vectorial information. | Chao He Jintao Chang Patrick S.Salter Yuanxing Shen Ben Dai Pengcheng Li Yihan Jin Samlan Chandran Thodik Mengmeng Li Aziz Tariq Jingyu Wang Jacopo Antonello Yang Dong Ji Qi Jianyu Lin Daniel S.Elson Min Zhang Honghui He Hui Ma Martin J.Booth | 2022 | Advanced Photonics2022，4，2： | 2 |
| 13 | Squamous cell carcinoma of the tongue after bone marrow transplantation in a patient with Fanconi anemia显示文摘 | Salum FG Martins GB de Figueiredo MA | 2006 | Braz Dent J2006，17，2： | 1 |
| 14 | Identifying critical limits for soil quality indicators in agro-ecosystems Agriculture显示文摘 | Arshad MA Martin S | 2002 | Ecosystems & Environment2002，88，2： | 1 |
| 15 | Immunomodulation of vascular endothelium显示文摘 | Martin ML Contort RE Hordy MA | 1990 | Jsurg Res1990，48，： | 1 |
| 16 | Methodological considerations in the determination of working length显示文摘 | Martine Z Lozano MA Fomer Navarro L | 2001 | Int Endod J2001，34，5： | 1 |
| 17 | Ulnar neuropathy:Incidence,outcome and risk factors in sedated or anesthetized patients显示文摘 | Warner MA Warner ME Martin JT | 1994 | Anesthesiology1994，81，： | 1 |
| 18 | Transcranial magnetic stimulation as a complementary treatment for aphasia 显示文摘 | Martin PI Naeser MA Theoret H | 2004 | Semin Speech Lang2004，25，2： | 1 |
| 19 | Genetic diversity in European Chestnut populations by means of genomic and genic microsatellite markers显示文摘 | Martin MA Mattioni C Cherubini M | 2010 | Tree Genetics & Genomes2010，6，5： | 1 |
| 20 | Association between alcohol consumption and insulin sensitivity and cardiovascular disease risk ractors:the Insulin Resistance and Atherosclerosis Study显示文摘 | Bell RA Mayer-Davis EJ Martin MA | 2000 | Diabetes Care2000，23，11： | 1 |
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