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| 1 | 应用药物代谢动力学模型评价前列腺不同组织的MRI增强作用显示文摘目的 :应用两室药物代谢动力学模型评价前列腺癌、前列腺增生和正常前列腺周围带的MRI增强特点。方法 :对 78例经病理组织学证实的前列腺癌 ,使用GESignaAdvantage 1.5T超导磁共振成像仪 ,采用FMPSPGR序列针对前列腺 (4层或 5层 )进行动态增强扫描 ,层厚 7mm ,层间间隔 2mm ,连续扫描采样 35次 ,Gd -DTPA经肘静脉置留导管按0 1mmol/kg体重在扫描开始的同时快速注射。将扫描数据传送的计算机工作站 ,应用两室药物代谢动力学模型进行分析 ,分别计算出不同ROI,前列腺癌、前列腺良性增生和正常前列腺周围带的最大增强指数 (maximenhancementindex)、对造影剂的吸收幅度 (amplitudeofuptake)、造影剂的交换率 (exchangerate)和造影剂分布指数 (distributionindex)。结果 :最大增强指数、对造影剂的吸收幅度、造影剂的交换率和造影剂分布指数以前列腺癌最高 ,前列腺增生次之 ,正常前列腺周围带最低。前列腺癌和正常前列腺周围带之间所有参数均存在极显著统计学差异 (P ≤ 0 .0 0 6 ) ,而前列腺增生和正常前列腺周围带之间所有参数也存在显著统计学差异 (P≤ 0 .0 3)。结论 :MRI药物代谢动力学模型能够更加准确的反映前列腺肿瘤组织和非肿瘤组织的血液供应特点 。 | 王滨 Martin Lowry Lindsay Wturnbull | 2001 | 医学影像学杂志2001，11，6： | 15 |
| 2 | 前列腺癌治疗前后动态增强MRI评价显示文摘目的 :应用MRI和动态增强MRI药物代谢动力学模型评价前列腺癌治疗前后的疗效 ,确定MRI的价值。方法 :对 16例经组织学证实的前列腺癌分别在治疗前后进行常规和动态增强MRI检查。治疗分别为单纯激素替代治疗 (7例 )和激素替代治疗加外放射治疗 (9例 )。MRI检查常规应用GESignaAdvantage 1.5T超导磁共振成像仪 ,静脉注射Gd DTPA(0 .1mmol/kg体重 )。应用两室药物代谢动力学模型分别计算肿瘤病灶、前列腺良性增生和正常前列腺周围带的最大增强指数、对比剂吸收幅度、对比剂的交换率和对比剂分布指数。结果 :治疗前后PSA由 39.5 4ng/ml降为 10 .39ng/ml(P =0 .0 4 6 ) ,由MRI测量获得的肿瘤体积明显缩小 (2 .85cm3 至 0 .84cm3 ,P =0 .0 1) ,前列腺良性增生和正常前列腺周围带也明显缩小 (P <0 .0 1)。治疗前后肿瘤病灶最大增强指数和对比剂分布指数降低 ,但未见统计学差异 ;对比剂吸收幅度和交换率明显降低 (P =0 .0 0 4 ,0 .0 0 2 )。前列腺良性增生的最大增强指数和对比剂分布指数降低 (P =0 .2 84 ,0 .2 2 1) ;对比剂吸收幅度和交换率明显降低 (P =0 .0 1,0 .0 0 7)。正常周围带的对比剂吸收幅度、交换率和分布指数明显降低 (P=0 .0 0 3,0 .0 1,0 .0 4 )。结论 :动态增强MRI能够全面反映前列腺癌治疗前? | 王滨 Martin LOWRY Lindsay W TURNBULL | 2003 | 医学影像学杂志2003，13，4： | 5 |
| 3 | National prevalence and correlates of walking and bicycling to school显示文摘 | MARTIN S L LEE S M LOWRY R | 2007 | Am J Prevent Med2007，33，： | 1 |
| 4 | Hydrodehal-genation of 1-to 3-carbon halogenat-ed organic compounds in water using a palladium catalyst and hydrogen gas 显示文摘 | Lowry G V Martin R | 1999 | Env Sci & Tech1999，33，： | 1 |
| 5 | Pregnancy complicated by preeclampsia-eclampsia with the syndrome of hemolysis, elevated live ren-zymes,and low platelet count:howrapid is post partum recovery 显示文摘 | Martin JNJr Blake PG Lowry SL | 1990 | Obstet Gynecol1990，76，： | 1 |
| 6 | Evaluation of vaccines in the EUTB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis显示文摘 | Williams A Hatch GJ Clark SO Gooch KE Hatch KA Hall GA Huygen K Ottenhoff TH Franken KL Andersen P Doherty TM Kaufmann SH Grode L Seiler P Martin C Gicquel B Cole ST Brodin P Pym AS Dalemans W Cohen J Lobet Y Goonetilleke N McShane H Hill A Parish T Smith D Stoker NG Lowrie DB Kallenius G Svenson S Pawlowski A Blake K Marsh PD | 2005 | Tuberculosis (Edinb)2005，85，12： | 1 |
| 7 | Pregnancy complicated by preeclampsia-eclampsia with the syndrome of hemolysis,elevated liver enzymes,and low platelet count:how rapid is post partum recovery显示文摘 | Martin JN Jr Blake PG Lowry SL etal | 1990 | Obstet Gynecol1990，76，： | 1 |
| 8 | Role of dynamic contrast enhanced MRI in monitoring early response of locally advanced breast cancer to neoadjuvant chemotherapy显示文摘 | Martin D. Pickles Martin Lowry David J. Manton Peter Gibbs Lindsay W. Turnbull | 2005 | Breast Cancer Research and Treatment2005，，1： | 1 |
| 9 | Effect of dopamine agonists on prolactinomas and normal pituitary assessed by dynamic contrast enhanced magnetic resonance imaging (DCE-MRI)显示文摘 | Alireza M. Manuchehri Thozhukat Sathyapalan Martin Lowry Lindsay W. Turnbull Christopher Rowland-Hill Stephen L. Atkin | 2007 | Pituitary2007，，3： | 1 |
| 10 | Pregnancy complicated by preeclampsia-eclampsia with the syndrome of hemolysis, elevated liverenzymes,and low platelet count: how rapid is postpartum recovery显示文摘 | Martin JN Jr Blake PG Lowry SL | 1990 | Obstet Gynecol1990，76，51： | 1 |
| 11 | Pregnancy complicated by preeclampsia-eclampsia with the syndrome of hemolysis,elevated liver enzymes,and low platelet count:how rapid is postpartum recovery ?显示文摘 | Martin JN Jr Blake PG Lowry SL | 1990 | Obstet Gynecol1990，76，7： | 1 |
| 12 | Region- and Type-Specific Induction of Matrix Metalloproteinases in Post–Myocardial Infarction Remodeling显示文摘 | Eric M. Wilson Sina L. Moainie Julia M. Baskin Abigail S. Lowry Anne M. Deschamps Rupak Mukherjee T Sloane Guy Martin G. St John-Sutton Joseph H. Gorman L Henry Edmunds Robert C. Gorman Francis G. Spinale | 2003 | Circulation: Journal of the American Heart Association2003，，22： | 1 |
| 13 | The natural history of HELLP syndrome:Patterns of disease progression and regression显示文摘 | MARTIN JN JR BLAKE PG LOWRY SL | 1991 | Am J Obstet Gynecol1991，164，61： | 1 |
| 14 | Diffusion changes precede size reduction in neoadjuvant treatment of breast cancer 显示文摘 | Martin D Gibbs P Lowry M | 2006 | Magn Reson Imaging2006，24，5： | 1 |
| 15 | Prognostic value of pre-treatment DCE-MRI parameters in predicting disease free and overall survival for breast cancer patients undergoing neoadjuvant chemotherapy显示文摘 | Martin D. Pickles David J. Manton Martin Lowry Lindsay W. Turnbull | 2008 | European Journal of Radiology2008，，3： | 1 |
| 16 | Role of dynamic contrast enhanced MRI in monitoring early response of locally advanced breast cancer to neoadjuvant chemotherapy显示文摘 | Martin D. Pickles Martin Lowry David J. Manton Peter Gibbs Lindsay W. Turnbull | 2005 | Breast Cancer Research and Treatment2005，，1： | 1 |
| 17 | The natural history of HELLP syndrome: patterns of disease progression and regression显示文摘 | Martin JN Jr Blake PG Lowry SL | 1991 | Am J Obstet Gynecol1991，164，： | 1 |
| 18 | Pregnancy complicated by preeclampsia-eclampsia with the syndrome of hemolysis, elevated liver enzymes, and low platelet count: How rapid is postpartum recovery? 显示文摘 | Martin JN Jr Blake PG Lowry SL | 1990 | Obstet Gynecol1990，76，： | 1 |
| 19 | Pregnancy Complicated by pre-eclampsia-eclampsia with the syndrome of hemolysis,elevated liver enzymes and low platelet Count;how rapid is postpartum recovery显示文摘 | Martin JN Jr Blake PG Lowry SL | 1990 | Obstet Gynecol1990，76，4： | 1 |
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