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| 1 | Alcoholic pancreatitis:New insights into the pathogenesisand treatment显示文摘Acute pancreatitis is a necro-inflammatory disease of the exocrine pancreas that is characterized by inappropriate activation of zymogens, infiltration of the pancreas by inflammatory cells, and destruction of the pancreatic exocrine cells. Acute pancreatitis can progress to a severe life-threatening disease. Currently there is no pharmacotherapy to prevent or treat acute pancreatitis. One of the more common factors associated with acute pancreatitis is alcohol abuse. Although commonly associated with pancreatitis alcohol alone is unable to cause pancreatitis. Instead, it appears that alcohol and its metabolic by-products predispose the pancreas to damage from agents that normally do not cause pancreatitis, or to more severe disease from agents that normally cause mild pancreatic damage. Over the last 10 to 20 years, a tremendous amount of work has defined a number of alcohol-mediated biochemical changes in pancreatic cells. Among these changes are: Sustained levels of intracellular calcium, activation of the mitochondrial permeability transition pore, endoplasmic reticulum stress, impairment in autophagy, alteration in the activity of transcriptional activators, and colocalization of lysosomal and pancreatic digestive enzymes. Elucidation of these changes has led to a deeper understanding of the mechanisms by which ethanol predisposes acinar cells to damage. This greater understanding has revealed a number of promising targets for therapeutic intervention. It is hoped that further investigation of these targets will lead to the development of pharmacotherapy that is effective in treating and preventing the progression of acute pancreatitis. | Dahn L Clemens Katrina J Schneider Christopher K Arkfeld Jaclyn R Grode Mark A Wells Shailender Singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 10 |
| 2 | Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guérin mutants that secrete listeriolysin显示文摘 | Grode L Seiler P Baumann S | | 0，，09： | 1 |
| 3 | Application of Mycobacterial Proteomics to Vaccine Design:Improved Protectionby Mycobacterium bovis BCG Prime-Rv3407 DNA Boost Vaccination against Tuberculosis显示文摘 | Mollenkopf HJ Grode L Mattow J | 2004 | Infect immun2004，72，11： | 1 |
| 4 | Safety and immunogenicity of the recombinant BCG vaccine VPM1002in a phase 1 open-label randomized clinical trial显示文摘 | Grode L Ganoza CA Brohm C | 2013 | Vaccine2013，31，9： | 1 |
| 5 | Coagulopathy and eathecholamine in severe head injury 显示文摘 | KEARNEY T J BENTT L GRODE M | 1992 | J Trauma1992，32，5： | 1 |
| 6 | Cell-mediated immunity induced by recombinant Mycobactefium bovis Calmette-Guerin strains against an intracellular bacterial pathogen:importance of antigen secretion or membrane-targeted antigen diplay as lipoprotein for vaccine efficacy显示文摘 | Grode L Kuesar M Fenstede J | 2002 | J Immu2002，168，3： | 1 |
| 7 | Increased vaccine efficacy against tuberculosis of reeombinant Mycobacterium boris bacille Calmette-Guerin mutants that secrete listeriolysin显示文摘 | Grode L Seiler P Baumann S | 2005 | J Clin Invest2005，115，9： | 1 |
| 8 | Application of Mycobacterial proteomics to vaccine desine:improved protection by Mycobacterium bovis BCG pfime-Rv3407 DNA boost vaccination against tuberculosis 显示文摘 | Mollenkopf HJ Grode L Mattow J | 2004 | Infect lmmun2004，72，： | 1 |
| 9 | Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guerin mutants that secrete listeriolysin显示文摘 | GRODE L SEILER P BAUMANN S | 2005 | J Clin Invest2005，115，： | 1 |
| 10 | Coagulopathy and catecholamines in severe head injury 显示文摘 | Bentt L Grode M | 1992 | J Trauma1992，32，2： | 1 |
| 11 | Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guérin mutants that secrete liste riolysin显示文摘 | Grode L Seiler P Baumann S | 2005 | J Clin Invest2005，115，9： | 1 |
| 12 | Protection against murine tu- berculosis by an attenuated recombinant Salmonella typhirnuri um vaccine strain that secretes the 30-kDa antigen of Mycobacte- riumbovis BCG显示文摘 | Hess J Grode L Hellwig J | 2000 | FEMS Immnnol Med Microbiol2000，27，4： | 1 |
| 13 | Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium boris bacille Calmette-Guerin mutant that secrete listeriolysin显示文摘 | Grode L Seller P Baumann S | 2005 | Clin Invest2005，115，： | 1 |
| 14 | Evaluation of vaccines in the EUTB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis显示文摘 | Williams A Hatch GJ Clark SO Gooch KE Hatch KA Hall GA Huygen K Ottenhoff TH Franken KL Andersen P Doherty TM Kaufmann SH Grode L Seiler P Martin C Gicquel B Cole ST Brodin P Pym AS Dalemans W Cohen J Lobet Y Goonetilleke N McShane H Hill A Parish T Smith D Stoker NG Lowrie DB Kallenius G Svenson S Pawlowski A Blake K Marsh PD | 2005 | Tuberculosis (Edinb)2005，85，12： | 1 |
| 15 | Protection against murine tuberculosis by an attenuated recombinant Salmonella typhimurium vaccine strain that secretes the 30 kDa-antigen of Mycobacterium bovis BCG显示文摘 | Grode L Hellwig J | 2000 | FEMS Immunol Med Microbiol2000，27，： | 1 |
| 16 | Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guerin mutants that secrete listeriolysin显示文摘 | Grode L Seiler P Baumann S Hess J Brinkmann V Nasser Eddine A Man P Goosmann C Bandermann S Smith D Bancroft GJ Reyrat JM van Solingen D Raupach B Ksufmann SH | 2005 | J Clin Invest2005，115，9： | 1 |
| 17 | Application of mycobacterial proteomics to vaccine design:improved protection by Mycobacterium bovis BCG prime-Rv3407 DNA boost vaccination against tuberculosis显示文摘 | Mollenkopf HJ Grode L Mattow J | 2004 | Infect Immun2004，72，11： | 1 |
| 18 | Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guérin mutants that secrete listeriolysin显示文摘 | Grode L Seiler P Baumann S | | 0，，09： | 1 |
| 19 | Application of mycobacterial proteomics to vaccine design:improved protection by Mycobacterium bovis BCG prime-Rv3407 DNA boost vaccination against tuberculosis显示文摘 | Mollenkopf H J Grode L Mattow J | 2004 | Infect Immun2004，72，11： | 1 |
| 20 | Application of myco- bacterial proteomics to vaccine design : improved protection by My- cobacterium bovis BCG prime-Rv3407 DNA boost vaccination a- gainst tuberculosis 显示文摘 | Mollenkopf HJ Grode L Mattow J | 2004 | Infect Immun2004，72，11： | 1 |
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