| 2 | Silencing RhoA inhibits migration and invasion through Wnt/β-catenin pathway and growth through cell cycle regulation in human tongue cancer显示文摘地岬相当或相同的事物基因家庭成员 A (RhoA ) 作为肿瘤的一个批评管理者被识别了好攻击的行为。在 thisstudy,我们在位于有鳞的细胞 carcinomaof 舌头(TSCC ) 的生长,移植,和侵略下面的机制估计了 RhoA 的角色。TSCC 房间线 SCC-4 和 CAL27 击倒的稳定的 RhoA 用 Lentiviral transfection 被完成。房间移植,侵略,和房间增长上的 RhoA 弄空的 Theeffects 是坚定的。TSCC 房间线上的可能的位于决定 Galectin-3 (Gal-3 ) 的表示下面 mechanismof RhoA 弄空被也评估,在 vivo 的 -catenin, andmatrix metalloproteinase-9 (MMP-9 ) 。同时, TSCC 生长的内在的机制被 cyclin D1/2 的分析学习, p21 CIP1/WAF1 , 和 p27 Kip1 蛋白质层次。Immunohistochemical 评价被执行进一步证明 Gal-3 和 -catenin expression.We 的改变发现了那,在与在舌头的人的 TSCC 房间注射的老鼠, RhoA 层次与在正常纸巾的那些相比在主要肿瘤和 metastasizedlymph 节点是更高的。RhoA 的 Silencing 显著地减少了肿瘤生长, Gal-3 的 decreasedthe 层次, -catenin, MMP-9,和 cyclin D1/2,并且增加了 p21 CIP1/WAF1 和 p27 Kip1 。在 vitro, RhoA 击倒也导致了房间移植,侵略,和增长的抑制。我们的数据建议 RhoA 由通过分别地通过房间周期规定表明小径 andcell 增长的 Wnt/-catenin 调整房间移植和侵略在 TSCC 前进起 asignificant 作用。RhoA 可能是 TSCC 的一个新奇治疗学的目标。 | Guoxin Yan Ronghai Zou Zhenggang Chen Bing Fan Zhaoyan Wang Ying Wang Xiaonan Yin Dong Zhang Lei Tong Fang Yang Weina Jiang Wensheng Fu Jiwei Zheng Martin O. Bergo Martin Dalin Jiawei Zheng Shulan Chen Jianhua Zhou | 2014 | Acta Biochimica et Biophysica Sinica2014，46，8： | 7 |
| 4 | Author Correction:Galectin-3 gene silencing inhibits migration and invasion of human tongue cancer cells in vitro via downregulating β-Catenin显示文摘During recent check of our article entitled“Galectin-3 gene silencing inhibits migration and invasion of human tongue cancer cells in vitro via downregulatingβ-Catenin”published in Acta Pharmacologica Sinica,we found that there were several mistakes in the final assemble of figures:(1)in Fig.2B,figures of Untreated and Gal-3-siRNA of SCC-4 at 0 h were selected from the same group of CAL27 respectively,and the figure of Control-siRNA of SCC-4 at 48 h was from the Untreated group of SCC-4 at 48 h;(2)in Fig.2B,the figure of Control-siRNA of CAL27 at 48 h was wrongly selected;(3)in Fig.2C,the figure of Control-siRNA of CAL27 was selected from the same group of SCC-4.Although the mistakes resulted from our carelessness in the process of assembling figures due to the similarity of the involved figures,the conclusions of the original article or the text of the article and the figure legends were not affected.We apologize sincerely for any inconvenience caused. | Dong Zhang Zheng-gang Chen Shao-hua Liu Zuo-qing Dong Martin Dalin Shi-san Bao Ying-wei Hu Feng-cai Wei | 2023 | Acta Pharmacologica Sinica2023，44，3： | 0 |
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