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| 1 | Impact of a clinical pathway on treatment outcome in patients with acute pancreatitis显示文摘AIM:To determine the impact of a clinical pathway(CP) on acute pancreatitis(AP) treatment outcome.METHODS:A retrospective analysis of medical records was performed. We compared the results of AP treatment outcome over two time periods in our centre,before(2006-2007) and after(2010-2012) the implementation of a CP. The CP comprised the following indicators of quality:performance of all laboratory tests on admission(including lipids and carbohydrate deficient transferrin),determination of AP aetiology,abdomen ultrasound(US) within the first 24 h after admission,contrast-enhanced computed tomography of the abdomen in all cases of suspected pancreatic necrosis,appropriately selected and sufficiently used antibiotic therapy(if necessary),pain control,adequate hydration,control of haemodynamic parameters and transfer to the Intensive Care Unit(ICU)(if necessary),endoscopic retrograde cholangiopancreatography(ERCP) in biliary AP,surgical treatment(if necessary),and advice on outpatient follow-up after discharge. A comparison of the length of stay with that in other Slovenian hospitals was also performed.RESULTS:There were 139 patients treated in the three-year period after the introduction of a CP,of which 81(58.3%) were male and 58(41.7%) female. The patients' mean age was 59.6 ± 17.3 years. The most common aetiologies were alcoholism and gallstones(38.8% each),followed by unexplained(11.5%),drug-induced,hypertriglyceridemia,post ERCP(2.9% each) and tumours(2.2%). Antibiotic therapy was prescribed in 72(51.8%) patients. Abdominal US was performed in all patients within the first 24 h after admission. Thirty-two(23.0%) patients were treated in the ICU. Four patients died(2.9%). In comparison to 2006-2007,we found an increased number of alcoholic and biliary AP and an associateddecrease in the number of unexplained aetiology cases. The use of antibiotics also significantly decreased after the implementation of a CP(from 70.3% to 51.8%; P = 0.003). There was no statistically significant difference in mortality(1.8% vs 2.9%). The length of stay was significantly shorter when compared to the Slovenian average(P = 0.018).CONCLUSION:The introduction of a CP has improved the treatment of patients with AP,as assessed by all of the observed parameters. | Miroslav Vujasinovic Jana Makuc Bojan Tepes Apolon Marolt Zdenko Kikec Nace Robac | 2015 | World Journal of Gastroenterology2015，21，30： | 13 |
| 2 | Expression of cyclooxygenase-2 is associated with p53 accumulation in premalignant and malignant gallbladder lesions显示文摘瞄准:在胆囊癌和它的先锋损害在表示和 p53 累积上检验在 cyclooxygenase-2 (COX-2 ) 之间的关系。方法:包括正常胆量 blader 上皮,发育异常(11 低档 dyplasia 和 16 高级发育异常) 的 27 个盒子和 27 腺癌的 14 个盒子的 68 件胆囊织物样品被免疫组织化学为 COX-2 表示和 p53 累积评估。在 COX-2 表示, p53 累积和 clinicopathological 特征之中的关系被分析。结果:COX-2 被表示在 14.3% 正常胆囊上皮, 70.3% 发育异常的 epite hlium,和 59.2% 腺癌。当划分了成低档和高级发育异常时, COX-2 在 5 是积极的(45.4%) 低档的盒子并且 14 (87.5%) 高级发育异常(P = 0.019 ) 。p53 的累积在 5 被检测(31.2%) 癌的高级发育异常并且在 13 的盒子(48.1%) 。没有 p53 累积在正常上皮或低档发育异常被发现。在表示上的 COX-2 在 18 中的 17 个被观察(94.4%) 有从没有 p53 累积的 50 个盒子的与 20 比较的 p53 累积(40.0%) 的盒子(P <
0.001 ) 。结论:在在正常上皮,低档发育异常和高级发育异常之中的 COX-2 表示的有效差量建议在 COX-2 的表示上,酶是在胆囊 carcinogenensis 的一个早事件。自从有 COX-2 表示的 p53 相互关联的累积,而且,在表示上的 COX-2 在高级发育异常和癌可能是的胆囊观察了部分由于 p53 的机能障碍。 | Mateja Legan Bo(s|ˇ)tjan Luzar Vera Ferlan Marolt Andrej C(o|¨)r | 2006 | World Journal of Gastroenterology2006，12，21： | 7 |
| 3 | Investigation of creep behaviours of gypsum specimens with flaws under different uniaxial loads显示文摘The aim of this study is to identify the influence of the dip angle of a pre-existing macrocrack on the lifetime and ultimate deformation of rock-like material. Prediction of lifetime has been studied for three groups of specimens under axial static compressive load levels. The specimens were investigated from 65% to 85% of UCS(uniaxial compressive strength) at an interval of 10% of UCS for the groups of specimens with a single modelled open flaw with a dip angle to the loading direction of 30°(first group), at an interval of 5% of UCS increment for the groups of specimens with single(second group), and double sequential open flaws with a dip angle to the loading direction of 60°(third group). This study shows that crack propagation in specimens with a single flaw follows the same sequences. At first, wing cracks appear, and then shear crack develops from the existing wing cracks. Shear cracking is responsible for specimen failure in all three groups. A slip is expected in specimens from the third group which connects two individual modelled open flaws. The moment of the slip is noticed as a characteristic rise in the axial deformation at a constant load level. It is also observed that axial deformation versus time follows the same pattern, irrespective of local geometry. Specimens from the first group exhibit higher axial deformation under different load levels in comparison with the specimens from the second and third groups. | Tina Marolt Cebasek Thomas Frühwirt | 2018 | Journal of Rock Mechanics and Geotechnical Engineering2018，10，1： | 2 |
| 4 | Optimizing the medium perfusion rate in bone tissue engineering bioreae- tors 显示文摘 | Grayson W L Marolt D Bhumiratana S | 2011 | Bioteehnology and Bioengineering2011，108，5： | 1 |
| 5 | Engineering bone tissue from human embryonic stem cells显示文摘 | Darja Marolt | 2012 | Proc Natl Acad Sci U S A2012，109，22： | 1 |
| 6 | Specific activation of the Bacillus quorum-sensing systems by isoprenylated phero-mone variants显示文摘 | Ansaldi M Marolt D Stebe T | | 0，，06： | 1 |
| 7 | Effects of Pamidronate on Human Alveolar Osteoblasts In Vitro显示文摘 | Darja Marolt Matthew Cozin Gordana Vunjak-Novakovic Serge Cremers Regina Landesberg | 2012 | Journal of Oral and Maxillofacial Surgery2012，，5： | 1 |
| 8 | Bone and cartilage tissue constructs grown using human bone marrow stromal cells, silk scaffolds and rotating bioreactors显示文摘 | Marolt D Augst A Freed LE | 2006 | Biomaterials2006，27，36： | 1 |
| 9 | Bone and cartilage tissue con-structs grown using human bone marrow stromal cells,silk scaffoldsand rotating bioreactors显示文摘 | Marolt D Augst A Freed LE | 2006 | Biomaterials2006，36，： | 1 |
| 10 | Proliferative and apoptotic activity in hepatocellular carcinoma and surrouding non - nepolastic liver tissue显示文摘 | Pizem J Marolt VF Luzar B | 2001 | Pflugers Arch2001，442，： | 1 |
| 11 | Bone scaffold architecture modulates the development of mineralized bone matrix by human embryonic stem cel s显示文摘 | Marcos-Campos I Marolt D Petridis P | | 0，，： | 1 |
| 12 | Bone and cartilage tissue con-structs grown using human bone marrow stromal cells,silk scaffoldsand rotating bioreactors显示文摘 | Marolt D Augst A Freed L E | 2006 | Biomaterials2006，27，36： | 1 |
| 13 | Proliferative and apoptoctic activity in hepatocellular carcinoma and surrouding non - neoplastic liver tissue显示文摘 | Pizem J Marolt VF Luzar B | 2001 | Pflugers Arch2001，442，61： | 1 |
| 14 | Bonescaffold architecture modulates the development of min-eralized bone matrix by human embryonic stem cells显示文摘 | Marcos-Campos I Marolt D Petridis P | 2012 | Biomaterials2012，33，： | 1 |
| 15 | Bioreactor engi- neering of stem cell environments 显示文摘 | Tandon N Marolt D Cimetta E | 2013 | Biotechnol Adv2013，31，7： | 1 |
| 16 | A connectionist approach to automatic transcription of polyphonic piano music 显示文摘 | MAROLT M A | 2004 | IEEE Trans on Multimedia2004，6，3： | 1 |
| 17 | A mid-level representation for melody-based retrieval in audio collections显示文摘 | Marolt M | 2008 | IEEE Transactions on Multimedia2008，10，8： | 1 |
| 18 | Proliferative and apoptotic activity in hepatocellular carcinoma and surround- ing nor-neopastic liver tissue显示文摘 | Pizem J Marolt V F Luzar B | 2001 | Pflugers Arch2001，442，611： | 1 |
| 19 | Bone and cartilage tissue constructs grownusing human bone marrow stromal cells,silk scaffolds and rotating bioreactors显示文摘 | Marolt D Augst A Freed LE et a1 | 2006 | Biomaterials2006，27，36： | 1 |
| 20 | Optimizing the medium perfusion rate in bone tissue engineering bioreactors显示文摘 | Grayson WL Marolt D Bhumiratana S | 2010 | Biotechnol Bioeng2010，108，5： | 1 |
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