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| 1 | Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia显示文摘BACKGROUND In recent years,increasing evidence of second neoplasms associated with gastrointestinal stromal tumors(GIST)has been found.Numerous case reports,mostly retrospective studies and a few reviews,have been published.To our knowledge,however,no systematic review or meta-analysis of the existing data has been performed so far.AIM To prepare a compilation,as complete as possible,of all reported second tumor entities that have been described in association with GIST and to systematically analyze the published studies with regard to frequency,localization,and types of GIST-associated neoplasms.METHODS The MEDLINE and EBSCO databases were searched for a combination of the keywords GIST/secondary,synchronous,coincident/tumor,neoplasm,and relevant publications were selected by two independent authors.RESULTS Initially,3042 publications were found.After deletion of duplicates,1631 remained,and 130 papers were selected;22 of these were original studies with a minimum of 20 patients,and 108 were case reports.In the 22 selected studies,comprising a total number of 12050 patients,an overall rate of GIST-associated neoplasias of 20%could be calculated.Most second neoplasias were found in the gastrointestinal tract(32%)and in the male and female urogenital tract(30%).The specific risk scores of GISTs associated with other tumors were significantly lower than those without associated neoplasias.CONCLUSION In this first systematic review,we could confirm previously reported findings of a more than coincidental association between GIST and other neoplasias.The question whether there is an underlying causal association will need further investigation.Our data suggest that even GIST with a very low risk of disease progression should prompt screening for second neoplasia and subsequent frequent controls or extended staging. | Johanna Waidhauser Anne Bornemann Martin Trepel Bruno Markl | 2019 | World Journal of Gastroenterology2019，25，30： | 10 |
| 2 | Stage migration vs immunology: The lymph node count story in colon cancer显示文摘Lymph node staging is of crucial importance for the therapy stratification and prognosis estimation in colon cancer. Beside the detection of metastases,the number of harvested lymph nodes itself has prognostic relevance in stage Ⅱ/Ⅲ cancers. A stage migration effect caused by missed lymph node metastases has been postulated as most likely explanation for that. In order to avoid false negative node staging reporting of at least 12 lymph nodes is recommended. However,this threshold is met only in a minority of cases in daily practice. Due to quality initiatives the situation has improved in the past. This,however,had no influence on staging in several studies. While the numbers of evaluated lymph nodes increased continuously during the last decades the rate of node positive cases remained relatively constant. This fact together with other indications raised doubts that understaging is indeed the correct explanation for the prognostic impact of lymph node harvest. Several authors assume that immune response could play a major role in this context influencing both the lymph node detectability and the tumor's behavior. Further studies addressing this issue are need. Based on the findings the recommendations concerning minimal lymph node numbers and adjuvant chemotherapy should be reconsidered. | Bruno Markl | 2015 | World Journal of Gastroenterology2015，21，43： | 6 |
| 3 | Sex differences in the gut microbiome drive hormone-dependent regulation of autoimm- unity 显示文摘 | Markle JGM Frank DN Steven MT | 2013 | Science2013，339，6123： | 1 |
| 4 | Acute pyelonephritis:comparison of diagnosis with 99m Tc-DMSA,SPECT,spiral CT,MRI imaging,and power Doppler US in an experimental pig mode显示文摘 | Blask ARN Markle BM | 2001 | Radiology2001，21，8： | 1 |
| 5 | In vitro effect of different medium molecular hydroxyethyl starch solution and lactated Ringer's solution on coagulation using Sonoclot显示文摘 | Konrad CJ Markl TJ Schuepter GK | 2000 | Anesth Analg2000，90，： | 1 |
| 6 | Killing microorganisms by pulsed electric fields显示文摘 | Grahl T Markl H | 1996 | Applied Microbiology Bioteehnology1996，45，12： | 1 |
| 7 | Estimation of global aortic pulse wave velocity by flow-sensitive 4D MRI显示文摘 | Markl M Wallis W Brendecke S | 2010 | Magn Reson Med2010，63，： | 1 |
| 8 | Multiple sporadic gas-troin- testinal stromal tumours arising at different gastrointestinal sites: pattern of involvement of the muscularis propria as a clue to inde- pendent primary GISTs 显示文摘 | Agaimy A Markl B Arnholdt H | 2009 | Virchows Arch2009，455，2： | 1 |
| 9 | Comparison of testing acute toxicity on embryo of zebrafish, Brachydanio rerio and RTG-2 cytotoxicity as possible alternatives to the acute fish test 显示文摘 | Lange M Gebauer W Markl J | 1995 | Chemosphere1995，30，11： | 1 |
| 10 | Gasket loading constants显示文摘 | Rossheim D B Markl A R C | 1943 | Mechanical Engineering1943，65，9： | 1 |
| 11 | Analysis and generalized correction of the effect of spatial gradient field distortions in diffusion-weighted imaging显示文摘 | Bammer R Markl M Barnett A | 2005 | Magn Reson Med2005，50，： | 1 |
| 12 | Bisphenol A exposure, effects, and policy: a wildlife perspective 显示文摘 | Flint S Markle T Thompson S Wallace E | 2012 | Journal of Environmental Management2012，104，： | 1 |
| 13 | In Vitro Effects of Different Medium Molecular Hydroxyethyl Starch Solutions and Lactated Ringer’s Solution on Coagulation Using SONOCLOT显示文摘 | Christoph J. Konrad Timo J. Markl Guido K. Schuepfer Joachim Schmeck Helmut R. Gerber | 2000 | Anesthesia & Analgesia2000，，2： | 1 |
| 14 | LEO:an autonomic query optimizer for DB2显示文摘 | Markl V Lohman G M Raman V | 2003 | IBM System Journal2003，42，1： | 1 |
| 15 | Aneurysmal subarachnoid hemorrhage in elderly patients: long-term outcome and prognostic factors in an interdisciplinary treatment approach显示文摘 | Karsten Sch?ller Maike Massmann Gertraud Markl Mathias Kunz Gunther Fesl Hartmut Brückmann Thomas Pfefferkorn J?rg-Christian Tonn Christian Schichor | 2013 | Journal of Neurology2013，，4： | 1 |
| 16 | A Comparison of DirectRadio Frequency Sampling and Conventional GNSSReceiver Architectures显示文摘 | MARKL P DENNIS M A | 2005 | Navigation[0028 - 1522 ]2005，52，2： | 1 |
| 17 | The efforts and costs of a muhifactorial and interdisciplinary team approach to falls prevention for older home care clients at risk for fall- ing : a randomized controlled trial 显示文摘 | Markle - Reid M Browne G Gafni A | 2010 | Can J Aging2010，29，1： | 1 |
| 18 | Marine tumor vaccine carriers:structure of the molluscan hemocyanins KLH and htH显示文摘 | Markl J Lieb B Gebauer W | 2001 | J Cancer Res Clin Oncol2001，127，2： | 1 |
| 19 | Dialysis cultures 显示文摘 | Portner R Markl H | 1998 | Appl Microbial Biotechnol1998，，50： | 1 |
| 20 | Killing of micro-organisms by pulsed elvctric fields显示文摘 | AHL T MARKL H | 1996 | Applied Microbiology and Biochnology1996，45，： | 1 |
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