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| 1 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 2 | Reciprocal mouse and human limb phenotypes caused by gainand loss-of-function mutations affecting lmbr1显示文摘 | Clark R M Marker P C Roessler E | 2001 | Genetics2001，159，2： | 1 |
| 3 | BMP5 and the molecular, skeletal, and soft-tissue alterations in short ear mice显示文摘 | King J A Marker P C Seung K J | 1994 | Dev Biol1994，166，1： | 1 |
| 4 | BMP5 and the molecular,skeletal,and soft-tissue alterations in short ear mice显示文摘 | KINGSLEY D M KING J A MARKER P C | 1994 | Dev Biol1994，166，： | 1 |
| 5 | Resuscitation from Severe hemorrhage显示文摘 | Willian C Shoe Marker Anderew.B | | 0，，2： | 1 |
| 6 | BMP5and the molecular,skeletal,and soft-tissue alterations in short ear mice显示文摘 | KING J A MARKER P C SEUNG K J | 1994 | Dev Biol1994，166，： | 1 |
| 7 | Spectrum of bmp5 mutations from germline mutagenesis experiments in mice显示文摘 | MARKER P C SEUNG K BLAND A E | 1996 | Genetics1996，145，： | 1 |
| 8 | Organic carbon in the Hmn- ber River显示文摘 | Tipping E Marker A F Butterwick C | 1997 | The Science of total environment1997，195，： | 1 |
| 9 | Inhibition of the epidelraal growth factor receptor increases expression of genes that stimulate in- flammation, apoptosis, and cell attachment 显示文摘 | Woodworth C D Michael E Marker D | 2005 | Mol Cancer Ther2005，4，4： | 1 |
| 10 | Multiple immunoregulatory defect s in type2diabetes 显示文摘 | Kukreja C G Marker J | 2002 | J Clin Invest2002，109，： | 1 |
| 11 | Resuscitation from severe hemorrhage显示文摘 | Willian C Shoe Marker Anderew B | 1996 | Crit Care Med1996，24，2： | 1 |
| 12 | Surface precision of optical membranes with curvature 显示文摘 | Marker D K Jenkins C H | 1997 | Optics Express1997，1，11： | 1 |
| 13 | Reciprocal mouse and human limb phenotypes caused by gain- and loss-of-function mutations affecting lmbr1显示文摘 | Clark R M Marker P C Roessler E | 2001 | Genetics2001，159，2： | 1 |
| 14 | A novel candidate gene for mouse and human preaxial polydactyly with altered expression in limbs of Hemimelic extra-toes mutant mice显示文摘 | Clark R M Marker P C Kingsley D M | 2000 | Genomics2000，67，1： | 1 |
| 15 | Hormonal, cellular, and molecular control of prostatic development显示文摘 | Marker P C Donjacour A A Dahiya R | 2003 | Dev Biol2003，253，2： | 1 |
| 16 | Surface precision of optical membranes with curvature显示文摘 | MARKER D K JENKINS C H | 1997 | Optics Express1997，1，11： | 1 |
| 17 | Fertility preservation in gynecologic cancer显示文摘 | Marker A Trope C | 2001 | Acta Obstet Gynecol Scand2001，80，： | 1 |
| 18 | Inte- gration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer显示文摘 | Lange C A Gioeli D Hammes S R Marker P C | 2007 | Ann Rev Physiol2007，69，： | 1 |
| 19 | Automation extraction and de- scription of human gait models for recognition purpose 显示文摘 | David C Marker N John C | 2003 | Computer Vision and Image Understanding2003，90，1： | 1 |
| 20 | Identification of effective strategies to promote language in deaf children with cochlear implants显示文摘 | Cruz I Quittner AL Marker C | 2013 | Child development2013，84，2： | 1 |
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