|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Omentum facilitates liver regeneration显示文摘AIM:To investigate the mechanism of liver regeneration induced by fusing the omentum to a small traumatic injury created in the liver. We studied three groups of rats. In one group the rats were omentectomized; in another group the omentum was left in situ and was not activated,and in the third group the omentum was activated by polydextran particles. METHODS:We pre-activated the omentum by injecting polydextran particles and then made a small wedge wound in the rat liver to allow the omentum to fuse to the wound. We monitored the regeneration of the liver by determining the ratio of liver weight/body weight,by histological evaluation (including immune staining for cytokeratin-19,an oval cell marker),and by testing for developmental gene activation using reverse transcription polymerase chain reaction (RT-PCR). RESULTS:There was no liver regeneration in the omentectomized rats,nor was there significant regeneration when the omentum was not activated,even though in this instance the omentum had fusedwith the liver. In contrast,the liver in the rats with the activated omentum expanded to a size 50% greater than the original,and there was histologically an interlying tissue between the wounded liver and the activated omentum in which bile ducts,containing cytokeratin-19 positive oval cells,extended from the wound edge. In this interlying tissue,oval cells were abundant and appeared to proliferate to form new liver tissue. In rats pre-treated with drugs that inhibited hepatocyte growth,liver proliferation was ongoing,indicating that regeneration of the liver was the result of oval cell expansion. CONCLUSION:Activated omentum facilitates liver regeneration following injury by a mechanism that depends largely on oval cell proliferation. | Ashok K Singh Nishit Pancholi Jilpa Patel Natalia O Litbarg Krishnamurthy P Gudehithlu Perianna Sethupathi Mark Kraus George Dunea Jose AL Arruda | 2009 | World Journal of Gastroenterology2009，15，9： | 2 |
| 2 | Family history and disease outcomes in patients with Crohn's disease:A comparison between China and the United States显示文摘AIM To investigate the differences in family history of inflammatory bowel disease(IBD) and clinical outcomes among individuals with Crohn's disease(CD) residing in China and the United States.METHODS We performed a survey-based cross-sectional study of participants with CD recruited from China and the United States.We compared the prevalence of IBD family history and history of ileal involvement,CD-related surgeries and IBD medications in China and the United States,adjusting for potential confounders.RESULTS We recruited 49 participants from China and 145 from the United States.The prevalence of family history of IBD was significantly lower in China compared with the United States(China:4.1%,United States:39.3%).The three most commonly affected types of relatives were cousin,sibling,and parent in the United States compared with child and sibling in China.Ileal involvement(China:63.3%,United States:63.5%) and surgery for CD(China:51.0%,United States:49.7%) were nearly equivalent in the two countries.CONCLUSION The lower prevalence of familial clustering of IBD in China may suggest that the etiology of CD is less attributed to genetic background or a family-shared environment compared with the United States.Despite the potential difference in etiology,surgery and ileal involvement were similar in the two countries.Examining the changes in family history during the continuing rise in IBD may provide further insight into the etiology of CD. | Pei-Qi Wang Jun Hu Elie S Al Kazzi Eboselume Akhuemonkhan Min Zhi Xiang Gao Raquel Holand de Paula Pessoa Sami Ghazaleh Tuhina Cornelius Suhel Abbas Sabunwala Shadi Ghadermarzi Kartikeya Tripathi Mark Lazarev Pin-Jin Hu Susan Hutfless | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 2 |
| 3 | “Vertically trans-ferred' overpressures in Brunei:Evidence for a new mecha-nism for the formation of high-magnitude overpressure显示文摘 | Mark R P Richard R H Richard E S C al | 2007 | Geology2007，35，11： | 1 |
| 4 | Sympathetic- nerve activity during sleep in normal subjects显示文摘 | Somers VK Dyken ME Mark AL | 1993 | N Engl J Med1993，328，4： | 1 |
| 5 | Selective leptin resistance : a new concept in leptin physiology with cardiovascular implications 显示文摘 | Mark AL Correia ML Rahmouni K | 2002 | J Hypertens2002，20，7： | 1 |
| 6 | Clinical implications of variations in anti‐infliximab antibody levels in patients with inflammatory bowel disease显示文摘 | Casper Steenholdt Magid Al‐khalaf J?rn Brynskov Klaus Bendtzen Ole ?. Thomsen Mark A. Ainsworth | 2012 | Inflamm Bowel Dis2012，，12： | 1 |
| 7 | Tissue expression and immunolocalization of tumor necrosis factor - alpha in postinfarction dysfunction myocardium 显示文摘 | Irwin MW Mark S Mann DL et al | 1999 | Circulation1999，99，11： | 1 |
| 8 | Pegylated Interferon and ribavirin-induced interstitial pneumonitis With ARDS 显示文摘 | Abi-Nassif S Mark EJ Fogel RB el al | 2003 | Chest2003，124，1： | 1 |
| 9 | Flow-mediated and reflex changes in large peripheral artery tone in humans 显示文摘 | Anderson EA Mark AL | 1989 | Circulation1989，79，1： | 1 |
| 10 | Selective leptin resistance: a new concept in leptin physiology with eardiovascu lar implications 显示文摘 | Mark AL Correia ML Rahmouni K | 2002 | J Hypertens2002，20，7： | 1 |
| 11 | Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity显示文摘 | Rahmouni K Mark AL Haynes WG | 2004 | Am J Physiol Endocrinol Metab2004，286，6： | 1 |
| 12 | Signaling events induced by lipopolysaccharide-activated Toll-like receptor 2显示文摘 | Yang RB Mark MR Gumey AL | 1999 | J Immunol1999，163，2： | 1 |
| 13 | Safety and efficacy of inhaled nitric oxide treatment for pre- mature infants with respiratory distress syndrome:follow-up e- valuation at early school age显示文摘 | PATRIANAKOS-HOOBLER Al MARKS JD MSALL ME | 2015 | Acta Paediatr2015，100，4： | 1 |
| 14 | Basiliximab versus antihymocyte globulin for prevention of acute renal allograft rejection 显示文摘 | Hans S Bruce K Mark D e! al | 2001 | Transplantation2001，72，： | 1 |
| 15 | Supply-chain networks:a complex adaptive systems perspective显示文摘 | Suranaa A Kumara S Greaves Mark et al | 2005 | International Journal of Production Research2005，43，20： | 1 |
| 16 | Obesity-induced hypertension : new concepts from the emerging biology of obesity显示文摘 | Mark AL Marcelo Correia Donald A | 1999 | Hypertension1999，33，： | 1 |
| 17 | Selective leptin resistance revisited 显示文摘 | Mark AL | 2013 | Am JPhysiol Regul Integr Comp Physiol2013，305，6： | 1 |
| 18 | Dental adhesives in contemporary restorative dentistry显示文摘 | Mark AL Wayne WB | 1998 | Dental Clin North Am1998，42，4： | 1 |
| 19 | Interpretation and quantification of penile blood flow studies using duplex ultrasonography显示文摘 | Juan AL Mark AE Jonathan PJ | 1991 | Urol1991，146，： | 1 |
| 20 | Prevalence of infeetion with herpes simplex virus types 1 and 2 in Australia:a nationwide population based survey显示文摘 | Cunningham AL Taylor R Taylor J Marks C Shaw J Mindel A | 2006 | Sex Transm Infect2006，82，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员