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| 1 | Accuracy and responses of genomic selection on key traits in apple breeding显示文摘The application of genomic selection in fruit tree crops is expected to enhance breeding eficiency by increasing prediction accuracy,increasing selection intensity and decreasing generation interval.The objectives of this study were to assess the accuracy of prediction and selection response in commercial apple breeding programmes for key traits.The training population comprised 977 individuals derived from 20 pedigreed fllsib families.Historic phenotypic data were available on 10 traits related to productivity and fruit external appearance and genotypic data for 7829 SNPs obtained with an llumina 20K SNP array.From these data,a genome-wide prediction model was built and subsequently used to calculate genomic breeding values of five application fllsib families.The application families had genotypes at 364 SNPs from a dedicated 512 SNP array,and these genotypic data were extended to the high-density level by imputation.These five families were phenotyped for 1 year and their phenotypes were compared to the predicted breeding values.Accuracy of genomic prediction across the 10 traits reached a maximum value of 0.5 and had a median value of 0.19.The accuracies were strongly affected by the phenotypic distribution and heritability of traits.In the largest family,significant selection response was observed for traits with high heritability and symmetric phenotypic distribution.Traits that showed non-significant response often had reduced and skewed phenotypic variation or low heritability.Among the five application families the accuracies were uncorrelated to the degree of relatedness to the training population.The results underline the potential of genomic prediction to accelerate breeding progress in outbred fruit tree crops that still need to overcome long generation intervals and extensive phenotyping costs. | Hélène Muranty Michela Troggio Inès Ben Sadok Mehdi Al Rifaï Annemarie Auwerkerken Elisa Banchi Riccardo Velasco Piergiorgio Stevanato W.Eric van de Weg Mario Di Guardo Satish Kumar François Laurens Marco C.A.M.Bink | 2015 | Horticulture Research2015，2，1： | 14 |
| 2 | Reelin induces EphB activation显示文摘进功能的 neuronal 网络的新生的神经原的集成在 neuronal 进程和与另外的神经原的 synaptic 接触的形成的发展中的大脑,生长和树枝状要求房间的移植到他们的最后的位置。在协调区别事件的这个复杂序列的信号之中的一个中央播放器是分泌 glycoprotein Reelin,它也调制 synaptic 粘性,学习并且在成年大脑的记忆形成。到 ApoER2 和 VLDL 受体的 Reelin 有约束力, LDL 受体家庭的二个成员,开始包含细胞内部的细胞质的适配器蛋白质 Disabled-1 的酷氨酸 phosphorylation 的发信号的串联,它指向 neuronal 细胞骨架并且最终控制在整个发展中的大脑放神经原。然而, Reelin 信号与另外的调停受体的发信号串联交往调整大脑开发和粘性的不同方面,是可能的。EphB 酷氨酸 kinases 经由通过 ephrin B transmembrane 蛋白质的双向发信号调整房间粘附和排斥依赖者过程。这里,我们证明 Reelin 绑在 EphB transmembrane 蛋白质的细胞外的领域,导致受体聚类和向前在神经原发信号的 EphB 的激活,独立于“古典”的 Reelin 受体, ApoER2 和 VLDLR。因此,鼠标缺乏 EphB1 和 EphB2 显示 CA3 海马趾的金字塔形的神经原的一个放的缺点,类似于那在 Reelin 缺乏的鼠标,和这房间迁居,缺点取决于 EphB 蛋白质的 kinase 活动。一起,我们的数据为在向前发信号的 Reelin 和 EphB 之间的信号集成提供生物化学、功能的证据。 | Elisabeth Bouche Mario I Romero-Ortega Mark Henkemeyer Timothy Catchpole Jost Leemhuis Michael Frotscher Petra May Joachim Herz Hans H Bock | 2013 | Cell Research2013，23，4： | 5 |
| 3 | Genomic prediction of fruit texture and training population optimization towards the application of genomic selection in apple显示文摘Texture is a complex trait and a major component of fruit quality in apple.While the major effect of MdPG1,a gene controlling firmness,has already been exploited in elite cultivars,the genetic basis of crispness remains poorly understood.To further improve fruit texture,harnessing loci with minor effects via genomic selection is therefore necessary.In this study,we measured acoustic and mechanical features in 537 genotypes to dissect the firmness and crispness components of fruit texture.Predictions of across-year phenotypic values for these components were calculated using a model calibrated with 8,294 SNP markers.The best prediction accuracies following cross-validations within the training set of 259 genotypes were obtained for the acoustic linear distance(0.64).Predictions for biparental families using the entire training set varied from low to high accuracy,depending on the family considered.While adding siblings or half-siblings into the training set did not clearly improve predictions,we performed an optimization of the training set size and composition for each validation set.This allowed us to increase prediction accuracies by 0.17 on average,with a maximal accuracy of 0.81 when predicting firmness in the‘Gala’בPink Lady’family.Our results therefore identified key genetic parameters to consider when deploying genomic selection for texture in apple.In particular,we advise to rely on a large training population,with high phenotypic variability from which a‘tailored training population’can be extracted using a priori information on genetic relatedness,in order to predict a specific target population. | Morgane Roth Hélène Muranty Mario Di Guardo Walter Guerra Andrea Patocchi Fabrizio Costa | 2020 | Horticulture Research2020，7，1： | 4 |
| 4 | Ponseti method compared with soft-tissue release for the management of clubfoot:A meta-analysis study显示文摘AIM: To compare the functional outcomes of patients who underwent open surgery vs Ponseti method for the management of idiopathic clubfoot and to determine whether correlations exist between functional outcome and radiographic measurements.METHODS: A meta-analysis of the literature was conducted for studies concerning primary treatment of patients with idiopathic clubfoot. We searched PubM ed Medline, EMBASE, and the Cochrane Library databases from January 1950 to October 2011. Meta-analyses were performed on outcomes from 12 studies. Pooled means, SDs, and sample sizes were either identified in the results or calculated based on the results of each study.RESULTS: Overall, 835 treated idiopathic clubfeet in 516 patients were reviewed. The average follow-up was 15.7 years. Patients managed with Ponseti method did have a higher rate of excellent or good outcome than patients treated with open surgery(0.76 and 0.62, respectively), but not quite to the point of statistical significance(Q = 3.73, P = 0.053). Age at surgery wasnot correlated with the functional outcome for the surgically treated patients(r =-0.32, P = 0.68). A larger anteroposterior talocalcaneal angle was correlated with a higher rate of excellent or good outcomes(r = 0.80, P = 0.006). There were no other significant correlations between the functional and radiographic outcomes.CONCLUSION: The Ponseti method should be considered the initial treatment of idiopathic clubfeet, and open surgery should be reserved for clubfeet that cannot be completely corrected. | Marios G Lykissas Alvin H Crawford Emily A Eismann Junichi Tamai | 2013 | World Journal of Orthopedics2013，4，3： | 3 |
| 5 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 6 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 7 | Label-free electroehemical detection of protein based on a ferrocene-bearing cationic polythiophene and aptamer显示文摘 | Fabien L F Hoang A H Mario L | 2006 | Anal Chem2006，，78： | 1 |
| 8 | Strategic environmental assessment of plans and programs: A methodology for estimating effects on biodiversity显示文摘 | MARIo D JUAN C I DOLORES H | 2001 | Environmental Management2001，28，2： | 1 |
| 9 | Drug-eluting bioabsorbable magnesium stent显示文摘 | Di Mario C Griffiths H Goktekin O | 2004 | J Int Cardiology2004，17，6： | 1 |
| 10 | A method for calibration and validation subset partitioning显示文摘 | ROBERTO K H G MARIO C U A GLEDSON E J | 2005 | Talanta2005，67，4： | 1 |
| 11 | Comparison of the rates of Vitam in Degradation when mixed with Metal sulphate or metal amino acid chelates 显示文摘 | Marchetti Mario Dew ayne Ashmea H Tossania | 2000 | Joural of food composition and analysis2000，13，6： | 1 |
| 12 | Long-term endothelin receptor antagonism attenuates coronary plaque progression in patients with early atherosclerosis显示文摘 | Yoon M H Reriani M Mario G | 2013 | International journal of cardiology2013，168，2： | 1 |
| 13 | A attachment style and the per- ception of others : the role of projective mechanisms 显示文摘 | MARIO M NETFA H | 1999 | Journal of personality and social psychology1999，，6： | 1 |
| 14 | Drug elu- ring bioabsorbable magnesium stent显示文摘 | Di Mario C Griffiths H Goktekin O | 2004 | J Interv Cardi- ol2004，17，6： | 1 |
| 15 | Efficient MAC in cognitive radio systems:a game-theoretic approach显示文摘 | Mark F Mario C Jean-Pierre H | | 0，，04： | 1 |
| 16 | Randomized comparison of coronary stent implantation under ultrasound or angiographic guidan- ce to reduce stent restenosis (OPTICUS Study) 显示文摘 | Mudra H di Mario C de Jaegere P | 2001 | Circulation2001，104，12： | 1 |
| 17 | Mas deficiency in FVB/N mice produces marked changes in lipid and glycemic metabolism显示文摘 | Santos S H Fernandes L R Mario E G | 2008 | Diabetes2008，57，： | 1 |
| 18 | RanGen: A Random Network Generator for Activity-on-the-Node Networks 显示文摘 | Erik D Mario V Willy H | 2003 | Journal of Scheduling (S1094-6136)2003，6，1： | 1 |
| 19 | Effects of pH, water stress and tem- perature on in vitro cultures of ectomycorrhizal fungi from Mediter- ranean forests显示文摘 | Fernando S Mario H Pilar T | 2001 | Cryp togamie Mycol2001，22，4： | 1 |
| 20 | Engineering N-linked protein glycosylation with diverse O antigen lipopolysaccharide structures in Escherichia coli显示文摘 | Mario FF Michael W Marcela H | 2005 | Proc Natl Acad Sci USA2005，102，8： | 1 |
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