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| 1 | Nasogastric or nasointestinal feeding in severe acute pancreatitis显示文摘AIM:To assess the rate of spontaneous tube migration and to compare the effects of naso-gastric and nasointestinal(NI)(beyond the ligament of Treitz) feeding in severe acute pancreatitis(SAP).METHODS:After bedside intragastric insertion,tube position was assessed,and enteral nutrition(EN) started at day 4,irrespective of tube localization.Patients were monitored daily and clinical and laboratory parameters evaluated to compare the outcome of patients with nasogastric(NG) or NI tube.RESULTS:Spontaneous tube migration to a NI site occurred in 10/25(40%) prospectively enrolled SAP patients,while in 15(60%) nutrition was started with a NG tube.Groups were similar for demographics and pancreatitis aetiology but computed tomography(CT) severity index was higher in NG tube patients than in NI(mean 6.2 vs 4.7,P=0.04).The CT index seemed a risk factor for failed obtainment of spontaneous distal migration.EN trough NG or NI tube were similar in terms of tolerability,safety,clinical goals,complications and hospital stay.CONCLUSION:Spontaneous distal tube migration is successful in 40% of SAP patients,with higher CT severity index predicting intragastric retention;in such cases EN by NG tubes seems to provide a pragmatic alternative opportunity with similar outcomes. | Matteo Piciucchi Elettra Merola Massimo Marignani Mari-anna Signoretti Roberto Valente Lucia Cocomello Flavia Baccini Francesco Panzuto Gabriele Capurso Gianfranco Delle Fave | 2010 | World Journal of Gastroenterology2010，16，29： | 13 |
| 2 | Hepatitis B in patients with hematological diseases: An update显示文摘Hepatitis B virus(HBV) reactivation(HBVr) in patients undergoing immunosuppressive therapy is still a hot topic worldwide. Its prevention and management still represents a challenge for specialists dealing with immunosuppressed patients. Aim of this paper is to provide a critical review of the relevant information emerged in the recent literature regarding HBV reactivation following immunosuppressive treatments for oncohematological tumors. A computerized literature search in MEDLINE was performed using appropriate terms arrangement, including English-written literature only or additional relevant articles. Articles published only in abstract form and case reports not giving considerable news were excluded. Clinical manifestation of HBVr can be manifold, ranging from asymptomatic self-limiting anicteric hepatitis to life-threatening fulminant liver failure. In clusters of patients adverse outcomes are potentially predictable. Clinicians should be aware of the inherent risk of HBVr among the different virological categories(active carriers, occult HBV carriers and inactive carriers, the most intriguing category), and classes of immunosuppressive drugs. We recommend that patients undergoing immunosuppressive treatments for hematological malignancies should undergo HBV screening. In case of serological sign(s) of current or past infection with the virus, appropriate therapeutic or preventive strategies are suggested, according to both virological categories, risk of HBVr by immunosuppressive drugsand liver status. Either antiviral drug management and surveillance and pre-emptive approach are examined, commenting the current international recommendations about this debated issue. | Chiara Coluccio Paola Begini Alfredo Marzano Adriano Pellicelli Barbara Imperatrice Giulia Anania Gianfranco Delle Fave Massimo Marignani | 2017 | World Journal of Hepatology2017，9，25： | 5 |
| 3 | Hepatitis C virus-related B cell subtypes in non Hodgkin's lymphoma显示文摘AIM:To evaluate if indolent B cell-non Hodgkin's lymphoma(B-NHL) and diffuse large B-cell lymphoma(DLBCL) in hepatitis C virus(HCV) positive patients could have different biological and clinical characteristics requiring different management strategies.METHODS:A group of 24 HCV related B-NHL patients(11 indolent,13 DLBCL) in whom the biological and clinical characteristics were described and confronted.Patients with DLBCL were managed with the standard of care of treatment.Patients with indolent HCV-related B-NHL were managed with antiviral treatment pegylated interferon plus ribavirin and their course observed.The outcomes of the different approaches were compared.RESULTS:Patients with DLBCL had a shorter duration of HCV infection and a higher prevalence of HCV genotype 1 compared to patients with indolent B-NHL in which HCV genotype 2 was the more frequent genotype.Five of the 9 patients with indolent HCV-relatedB-NHL treated with only antiviral therapy,achieved a complete response of their onco-haematological disease(55%).Seven of the 13 DLBCL patients treated with immunochemotheraphy obtained a complete response(54%).CONCLUSION:HCV genotypes and duration of HCV infection differed between B-NHL subtypes.Indolent lymphomas can be managed with antiviral treatment,while DLBCL is not affected by the HCV infection. | Adriano M Pellicelli Massimo Marignani Valerio Zoli Mario Romano Aldo Morrone Lorenzo Nosotti Giuseppe Barbaro Antonio Picardi Umberto Vespasiani Gentilucci Daniele Remotti Cecilia D'Ambrosio Caterina Furlan Fabrizio Mecenate Ettore Mazzoni Ignazio Majolino Roberto Villani Arnaldo Andreoli Giorgio Barbarini | 2011 | World Journal of Hepatology2011，3，11： | 4 |
| 4 | Patients with hematological malignancies and serological signs of prior resolved hepatitis B显示文摘Hepatitis B virus (HBV) infection affects a large part of the world population. Within the different virological HBV categories that have been identified, patients with occult HBV infection represent a peculiar group. These individuals harbor a replication competent virus, inhibited in its replicative function. Accordingly, cases of reactivations have been observed in immunosuppressed individuals who lose immunological control over the infection. Patients with hematological malignancies (HM) are treated with intense myeloand immunosuppres-sive chemotherapy regimens which favor HBV reactivation. This event can have severe consequences, such as hepatitis flare, hepatic failure and even death. In addition, it can lead to delays or interruptions of curative treatments, resulting in a decreased disease free and overall survival. In this review, we will examine the event of HBV reactivation in patients with signs of resolved HBV infection undergoing treatment for HM and propose possible management strategies. | Massimo Marignani Elia Gigante Paola Begini Alfredo Marzano Michela di Fonzo Ilaria Deli Sara Gallina Maria Christina Cox Gianfranco Delle Fave | 2012 | World Journal of Gastrointestinal Oncology2012，4，3： | 3 |
| 5 | Reversal of iron deficiency anemia after eradication of Helicobacter pylori infection in patients with asymptomatic gastritis显示文摘 | Annibale B Marignani M Monarca B | 1999 | Ann Intern Med1999，131，： | 1 |
| 6 | Reversal of long- standing iron deficiency anaemia after eradication of Helicobacter pylori infection显示文摘 | Marignani M Angeletti S Bordi C Malagnino F Mancino C Delle Fave G | 1997 | Scand J Gastroenterol1997，32，6： | 1 |
| 7 | Planning restoration in a cultural landscape in Italy using an object-based approach and historical analysis显示文摘 | MARIGNANI M ROCCHINI D TORRI D | 2008 | Landscape and Urban Planning2008，84，1： | 1 |
| 8 | The multitasking tumor suppressor kinase显示文摘 | MARIGNANI PA | 2005 | JClinPathol2005，58，： | 1 |
| 9 | L actobacillus rhamnosus protects human colonic muscle from pathogen lipopolysaccharide‐induced damage显示文摘 | F. Ammoscato A. Scirocco A. Altomare P. Matarrese C. Petitta B. Ascione R. Caronna M. Guarino M. Marignani M. Cicala P. Chirletti W. Malorni C. Severi | 2013 | Motil2013，，12： | 1 |
| 10 | LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest显示文摘 | Marignani PA Kanai F Carpenter CL | 2001 | J Biolchern2001，276，32： | 1 |
| 11 | HCV-positive status and hepatitis flares in patients with B-cell non-Hodgkin’s lymphoma treated with rituximab-containing regimens显示文摘 | Massimo Marignani Manuela Mangone M. Christina Cox Stefano Angeletti Barbara Veggia Antonella Ferrari Michela di Fonzo Paola Begini Elia Gigante Giacinto Laverde Antonietta Aloe-Spiriti Bruno Monarca Gianfranco Delle Fave | 2010 | Digestive and Liver Disease2010，，2： | 1 |
| 12 | Reversal of long standing iron deficiency anemia after eradication of Helicobacter pylori 显示文摘 | MARIGNANI M ANGELETHI S BORDI C | 1997 | Scand J Gastroenterol1997，32，6： | 1 |
| 13 | Reversal of iron deficiency anemiaafter Helicobacter pylori eradication inpatients with asy mptomatic gastritis显示文摘 | Annibbale B Marignani M Monarca B | 1999 | Ann Intern med1999，131，： | 1 |
| 14 | LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest显示文摘 | MARIGNANI P A KANAI F CARPENTER C L | 2001 | J Biol Chem2001，276，32： | 1 |
| 15 | Probiotics and Severe Acute Pancreatitis 显示文摘 | Capurso Marignani piciucchi et ai | 2008 | Clin Gastroenterol2008，42，1： | 1 |
| 16 | Reversal of long-standing iron deficiency anemia after eradication of Helicobacter pylori infection显示文摘 | Marignani M Angeletti S Brodi C | 1997 | Scand J Gastroenterol1997，32，65： | 1 |
| 17 | Lack of hepatitis B virus reactivation after anti-tumor necrosis factor α agents therapy in antibody to hepatitis B core antigen positive/hepatitis B surface antigen negative subjects with chronic inflammatory arthropathies显示文摘 | M.I. Biondo V. Germano M. Pietrosanti M. Canzoni M. Marignani T. Stroffolini S. Salemi R. D’Amelio | 2013 | European Journal of Internal Medicine2013，，： | 1 |
| 18 | Reversal of iron deficiency anemia after Helicobacter pylori eradication in patients with asymptomatic gastritis 显示文摘 | Annibale B Marignani M Monarca B | 1999 | Ann Intern Med1999，131，9： | 1 |
| 19 | Reversal of iron deftciencv anemia after eradication of Helicobaeter pylori infection in patients with asymptomatic gastritis显示文摘 | ANNIBALE B MARIGNANI M MONARCA B | 1999 | Ann InternMed1999，131，： | 1 |
| 20 | LKB1 associates with BRG1 and is nec essary for BRG1-induced growth arrest显示文摘 | Kanai F Carpenter CL | 2001 | J Biol Chem2001，7，3： | 1 |
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