2篇
您的检索式：作者名="Mariafrancesca"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Glutamine transporters as pharmacological targets: From function to drug design显示文摘Among the different targets of administered drugs,there are membrane transporters that play also a role in drug delivery and disposition.Moreover,drug-transporter interactions are responsible for off-target effects of drugs underlying their toxicity.The improvement of the drug design process is subjected to the identification of those membrane transporters mostly relevant for drug absorption,delivery and side effect production.A peculiar group of proteins with great relevance to pharmacology is constituted by the membrane transporters responsible for managing glutamine traffic in different body districts.The interest around glutamine metabolism lies in its physio-pathological role;glutamine is considered a conditionally essential amino acid because highly proliferative cells have an increased request of glutamine that cannot be satisfied only by endogenous synthesis.Then,glutamine transporters provide cells with this special nutrient.Among the glutamine transporters,SLC1A5,SLC6A14,SLC6A19,SLC7A5,SLC7A8 and some members of SLC38 family are the best characterized,so far,in both physiological and pathological conditions.Few 3D structures have been solved by CryoEM;other structural data on these transporters have been obtained by computational analysis.Interactions with drugs have been described for several transporters of this group.For some of them,the studies are at an advanced stage,for others,the studies are still in nuce and novel biochemical findings open intriguing perspectives. | Mariafrancesca Scalise Lorena Pochini Michele Galluccio Lara Console Cesare Indiveri | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 5 |
| 2 | Effects of Gastric Bypass on Type 2 Diabetes in Patients with BMI 30 to 35显示文摘 | Nicola Scopinaro Giovanni F. Adami Francesco S. Papadia Giovanni Camerini Flavia Carlini Lucia Briatore Gabriella Andraghetti Mariafrancesca Catalano Renzo Cordera | 2014 | Obesity Surgery2014，，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员