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| 1 | From bariatric to metabolic surgery:Looking for a'diseasemodifier'surgery for type 2 diabetes显示文摘In this review the recent evolution of the comprehension of clinical and metabolic consequences of bariatric surgery is depicted. At the beginning bariatric surgery aim was a significant and durable weight loss. Later on, it became evident that bariatric surgery was associated with metabolic changes, activated by unknown pathways, partially or totally independent of weight loss. Paradigm of this 'metabolic' surgery is its effects on type 2 diabetes mellitus(T2DM). In morbid obese subjects it was observed a dramatic metabolic response leading to decrease blood glucose, till diabetes remission, before the achievement of clinically significant weight loss, opening the avenue to search for putative antidiabetic 'intestinal' factors. Both proximal duodenal(still unknown) and distal(GLP1) signals have been suggested as hormonal effectors of surgery on blood glucose decrease. Despite these findings T2 DM remission was never considered a primary indication for bariatric surgery but only a secondary one. Recently T2 DM remission in obese subjects with body mass index(BMI) greater than 35 has become a primary aim for surgery. This change supports the idea that 'metabolic surgery' definition could more appropriate than bariatric, allowing to explore the possibility that metabolic surgery could represent a 'disease modifier' for T2 DM. Therefore, several patients have undergone surgery with a primary aim of a definitive cure of T2 DM and today this surgery can be proposed as an alternative therapy. How much surgery can be considered truly metabolic is still unknown. To be truly 'metabolic' it should be demonstrated that surgery could cause T2 DM remission not only in subjects with BMI > 35 but also with BMI < 35 or even < 30. Available evidence on this topic is discussed in this mini-review. | Renzo Cordera Gian Franco Adami | 2016 | World Journal of Diabetes2016，7，2： | 3 |
| 2 | Serumn leptin concentrations during the menstrual cycle in normal-weight women: Effect of an oral triphasic estrogen-progestin medication 显示文摘 | Giordano G Cordera R | 2000 | Eur J Endocrinol2000，142，： | 1 |
| 3 | Caveolin-I is essential for glimepiride-indueed insulin secretion in the pancreatic βTC-6 cell line显示文摘 | Puddu A Salani B Cordera R | 2008 | Biochem Biophys Res Commun2008，375，2： | 1 |
| 4 | Open versus laparoscopic splenectomy for idiopathic thrombocytopenic purpura:clinical and economic analysis显示文摘 | Cordera F Long KH Nagorney DM | 2003 | Surgery2003，134，1： | 1 |
| 5 | Open versus laparoscopic splenectomy for idiopathic thrombocytopenic purpura: clinical and e- conomic analysis 显示文摘 | Cordera F Long KH Nagomey DM | 2003 | Surgery2003，134，1： | 1 |
| 6 | Effect of in vivo vanadate treatment on insulin receptor tyrosine kinase activity in partially pancreatectomized diabetic rats显示文摘 | CORDERA R ANDRAGHETTI G DEFRONZO R A | 1990 | Endocrinol1990，126，4： | 1 |
| 7 | Open versus laparoscopic splenectomy for idiopathic thrombocytopenic purpura:clinical and economic analysis显示文摘 | Cordera F Long KH Nagorney DM | 2003 | Surgery2003，134，1： | 1 |
| 8 | Open Venus laparoscopic splenectomy for idiopathic thrombocytopenic purpura: clinical and economic analysis 显示文摘 | Cordera F Long K H Nagomey D M | 2003 | Surgery2003，134，1： | 1 |
| 9 | Open versus laparoseopic splenectomy for idiopathic thrombocytopenic purpura: clinical and economic analysis 显示文摘 | Cordera F Long K H Nagomey D M | 2003 | Surgery2003，134，1： | 1 |
| 10 | Epidemiology of primary intracranial tumours in NW Italy, a population based study: stable incidence in the last two decades显示文摘 | S Cordera E Bottacchi GD'Alessandro | 2002 | J Neurol2002，249，： | 1 |
| 11 | Modelling the spatial interactionsbetween workplace and residential location显示文摘 | IbeasA Cordera R Coppola P | 2013 | Transportation Re-search Part A: Policy and Practice2013，49，3： | 1 |
| 12 | Epidemiology of primary intracranial tumors in NW Italy,a population based study:stable incidence in the last two decades显示文摘 | Cordera S Bottacchi E D'Alessandro G | | 0，，03： | 1 |
| 13 | Open versus laparoscopic splenectomy for idiopathic thrombocytopenic purpura:Clinical and economic analysis显示文摘 | Fernando Cordera Kirsten Hall Long | 2003 | Surgery2003，134，1： | 1 |
| 14 | Estrogen receptors as therapeutic targets in breast cancer显示文摘 | Ariazi E A Ariazi J L Cordera F | 2006 | Curr Top Med Chem2006，6，3： | 1 |
| 15 | Open versus laparoscopic splenectomy for idiopathic thrombocytopenic purpura: chnical and economic analysis显示文摘 | CORDERA F LONG KH NAGORNEY DM | 2003 | Surgery2003，134，1： | 1 |
| 16 | Young women and breast cancer:challenges and answers-report from the Sixth Annual International Symposi- um,Mexico, 20 - 21 October 2014 显示文摘 | Cordera DB Marx A | 2014 | Ecancermedicalscience2014，22，8： | 1 |
| 17 | Estrogen receptorsas therapeutic targets in breast cancer 显示文摘 | Ariazi E A Ariazi J L Cordera F | 2006 | Curt Top Med Chem2006，6，3： | 1 |
| 18 | Open versus laparoscopic splenectomy for idiopathic thrombocytopenic purpura: clinical and economic analysis显示文摘 | CORDERA F LONG KH NAGORNEY DM | 2003 | Surgery2003，134，1： | 1 |
| 19 | Steroid receptors and their role in the biology and control of breast cancer growth 显示文摘 | Cordera F Jordan VC | 2006 | Semin Oncol2006，33，： | 1 |
| 20 | Open versus lapa-roscopic splenectomy for idiopathic thrombocytopenic purpu-ra :clinical and economic analysis显示文摘 | Cordera F Long KH Nagomey DM | 2003 | Surgery2003，134，： | 1 |
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