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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Nutraceutical composition, antioxidant activity and hypocholesterolemic effect of a water- soluble enzymatic extract from rice bran 显示文摘 | Revilla E Maria CS Miramontes E | 2009 | Food Research International2009，42，3： | 1 |
| 3 | The effect of different animal types on the prediction(calibration) equations used for pig carcass classication显示文摘 | Zelenák L K? rmendy L Maria Vada-Kovács | 2004 | Journal of Food Engineering2004，61，： | 1 |
| 4 | Use of Real-time quantitative polymerase chain reaction to monitor the evolution of Brucella rnelitertsis DNA load during therapy and post-therapy follow-up in patiens with brucellosis 显示文摘 | Elena N Juan CS Maria JC | 2006 | Clin Infectious Dis2006，42，5： | 1 |
| 5 | Alcohol,vitamin A and β-carotene:adverse interactions,including hepatotoxicity and carcinogenicity显示文摘 | Maria LA Lieber CS | 1999 | Am J Clin Nutr1999，69，6： | 1 |
| 6 | A review of current and emergent biofilm control strategies显示文摘 | Manuel S Lucia CS Maria JV | 2010 | Food Science and Technology2010，43，6： | 1 |
| 7 | Oxidative stress in earthworms short- and long-termexposed to highly Hg-contaminated soils显示文摘 | Andrea C Maria JS Francesca B Rocio M Juan CS | 2011 | Journal ofHazardous Materials2011，194，10： | 1 |
| 8 | Na^+,K^+ ATPase activity is markedly reduced by cis-4-decenoic acid in synaptic plasma membranes from cerebral cortex of rats显示文摘 | de Assis DR Maria RC Ferreira GC Schuck PF Latini A Dutra-Filho CS | 2006 | Exp Neurol2006，197，1： | 1 |
| 9 | GSTM1,GSTT1 and GSTP1 genotypes and gcnotoxicity of hydroquinone in human lymphocytes显示文摘 | Maria do CS Jorge G Isabel DS | | 0，，04： | 1 |
| 10 | Nutraceutical composition,antioxidant activity and hypocholesterolemic effect of a water- soluble enzymatic extract from rice bran 显示文摘 | Revilla E Maria CS Miramontes E | 2009 | Food Research International2009，42，3： | 1 |
| 11 | Pulmonary Embolism Prophylaxis in More Than 30,000 Total Knee Arthroplasty Patients:Is There a Best Choice显示文摘 | Monti Khatod MD Maria CS Inacio MS Stefano A Bini MD | | 0，，02： | 1 |
| 12 | Erlotinib therapy in a patient with non-small cell lung cancer and brain metastases显示文摘 | Giuseppe A Carmela A Maria CS | | 0，，01： | 1 |
| 13 | Qualitative and quantitative evaluation of the genomic DNA extracted from GMOand non-GMO foodstuffs with four different extraction methods显示文摘 | Clelia P Maria CS Luisa P | 2004 | J Agric Food Chem2004，52，： | 1 |
| 14 | The test1 automated system, a new method for measuring the erythrocyte sedimatation rate显示文摘 | Mario P Stefania DT Maria CS | 1998 | Am J Clin Pathol1998，110，： | 1 |
| 15 | Immunosuppressive treatment and radiotherapy in kidney transplant patients:A systematic review显示文摘BACKGROUND Immunosuppression(IS)therapy may contribute to cancer development.Some authors have proposed to reduce immunosuppression drugs dose in case of viral infections,in immunosuppression-related diseases,and in patients undergoing radiotherapy.The present analysis reports the results of a systematic review on kidney transplant recipients undergoing immunosuppression and radiotherapy.AIM To define if it is necessary reduce immunosuppression drugs during radiotherapy.METHODS The literature search was based on three electronic databases(Pubmed,Scopus,and Web of Science)using selected keywords linked through the'AND'and'OR'Boolean operators to build specific strings for each electronic search engine.Two researchers independently screened the citations,and disagreement was resolved by discussion or through the intervention of a third author.The review was conducted and reported according to the PRISMA statement.Extracted data were narratively synthesized,and,where possible,frequencies,percentages,and ranges were calculated.RESULTS The literature search resulted in 147 citations.After abstracts screening,21 records were selected for full-text evaluation.Fifteen of these were excluded,leaving six papers considered suitable for analysis.There is still no clear evidence that withdrawing antimetabolites and/or calcineurin inhibitors and/or mammalian target of rapamycin-inhibitors,as opposed to continuing maintenance IS,improves patient survival in kidney transplant recipients with cancer undergoing radiotherapy.Only few retrospective studies on small cancer patient cohorts are available in this setting,but without comparison of different immunosuppression treatments.Even where immunosuppression therapy was described,patient survival seemed to be correlated only with cancer stage and type.CONCLUSION The results of this systematic review do not support the reduction of immunosuppression dose in patients undergoing radiotherapy. | Valentina Lancellotta Andrea D'Aviero Bruno Fionda Calogero Casà Ilaria Esposito Francesco Preziosi Anna Acampora Fabio Marazzi György Kovács Barbara Alicja Jereczek-Fossa Alessio Giuseppe Morganti Vincenzo Valentini Maria Antonietta Gambacorta Jacopo Romagnoli Luca Tagliaferri | 2022 | World Journal of Radiology2022，14，3： | 0 |
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