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| 1 | Repair of thalassemic human β-globin mRNA in mammalian cells by antisense oligonucleotides 显示文摘 | Halina S Maria JS Sudhir A | 1996 | Proc Natl Acad Sci USA1996，93，12： | 1 |
| 2 | A radiographic comparison of apical root resorption after orthodontic treatment with a standard edgewise and a straight-wire edgewise technique显示文摘 | Maria M Andrea V Nils JS | | 0，，06： | 1 |
| 3 | Apoptosis induced by a low-carbohydrate and high-protein diet in rat livers显示文摘AIM: To determine whether high-protein, high-fat, and low-carbohydrate diets can cause lesions in rat livers.METHODS: We randomly divided 20 female Wistar rats into a control diet group and an experimental diet group. Animals in the control group received an AIN-93 M diet, and animals in the experimental group received an Atkins-based diet(59.46% protein, 31.77% fat, and 8.77% carbohydrate). After 8 wk, the rats were anesthetized and exsanguinated for transaminases analysis, and their livers were removed for flow cytometry, immunohistochemistry, and light microscopy studies. We expressed the data as mean ± standard deviation(sd) assuming unpaired and parametric data; we analyzed differences using the student's t-test. statistical significance was set at P < 0.05.RESULTS: We found that plasma alanine aminotransferase and aspartate aminotransferase levels were significantly higher in the experimental group than in the control group. According to flow cytometry, the percentages of nonviable cells were 11.67% ± 1.12% for early apoptosis, 12.07% ± 1.11% for late apoptosis, and 7.11% ± 0.44% for non-apoptotic death in the experimental diet group and 3.73% ± 0.50% for early apoptosis, 5.67% ± 0.72% for late apoptosis, and 3.82% ± 0.28% for non-apoptotic death in the control diet group. The mean percentage of early apoptosis was higher in the experimental diet group than in the control diet group. Immunohistochemistry for autophagy was negative in both groups. sinusoidal dilation around the central vein and small hepatocytes was only observed in the experimental diet group, and fibrosis was not identified by hematoxylin-eosin or Trichrome Masson staining in either group.CONCLUSION: Eight weeks of an experimental diet resulted in cellular and histopathological lesions in rat livers. Apoptosis was our principal finding; elevated plasma transaminases demonstrate hepatic lesions. | Maria Emília L Monteiro Analucia R Xavier Felipe L Oliveira Porphirio JS Filho Vilma B Azeredo | 2016 | World Journal of Gastroenterology2016，22，22： | 1 |
| 4 | Thoracic epidurals in heart valve surgery: neurologist risk evaluation 显示文摘 | Miguel C Angeles C Maria JS | 2002 | J Cardiothac Vasc Anesth2002，16，10： | 1 |
| 5 | New protocol for the isolation of nitrocellulosefrom gunpowders: Utility in their identification显示文摘 | Maria Lopez Lopez Maria Angeles Ferndndez de la Ossa Gali- ndo JS | 2010 | Talanta2010，81，45： | 1 |
| 6 | Adherence to vita-min D recommendations among US infants显示文摘 | Cria GP Andrea JS Maria ED | 2010 | Pediatrics2010，125，4： | 1 |
| 7 | Structures of wild-type and mutant human spermidine/spermine Nl-acetyltransferase, a potential therapeutic drug target显示文摘 | Maria CB Vito G Jiang JS | 2006 | Biochemistry2006，1，7： | 1 |
| 8 | Carotid plaque area: a tool for targeting and evaluating vascular preventive therapy显示文摘 | David JS Michael E Maria D | 2002 | Stroke2002，33，： | 1 |
| 9 | Oxidative stress in earthworms short- and long-termexposed to highly Hg-contaminated soils显示文摘 | Andrea C Maria JS Francesca B Rocio M Juan CS | 2011 | Journal ofHazardous Materials2011，194，10： | 1 |
| 10 | Structures of wild-type and mutant human spermidine/ spermine N'-ac, etyhransferase,apotential therapeutic drug target显示文摘 | Maria CB Vito G Jiang JS | 2006 | Biochemistry2006，103，7： | 1 |
| 11 | Helping relationship kkills in nurses: the validation of a measurement instrument 显示文摘 | Rosa PM Maria JS Miguel DP | 2011 | Rev Esc Enferm USP2011，45，6： | 1 |
| 12 | Fractionation of the major whey proteins and isolation of β-Lactoglobulin variants by anion exchange chromatography显示文摘 | Maria JS José AT Lígia RR | | 0，，： | 1 |
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