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| 1 | Clostridium difficile causing acute renal failure: Case presentation and review显示文摘AIM: Clostridium difficile infection is primarily a nosocomial infection but asymptomatic carriers of Clostridium difficile can be found in up to 5% of the general population.Ampicillin, cephalosporins and clindamycin are the antibiotics that are most frequently associated with Clostridium difficile-associated diarrhea or colitis. Little is known about acute renal failure as a consequence of Clostridium difficile-associated diarrhea.METHODS: In this case report, we describe the course of Clostridium difficile-associated diarrhea in an 82-yearold patient developing acute renal failure. Stopping the offending agent and symptomatic therapy brought a rapid improvement of diarrhea and acute renal failure, full recovery was gained 18 d after admission. In a systematic review we looked for links between the two conditions.RESULTS: The link between Clostridium difficilr-associated diarrhea and acute renal failure in our patient was most likely volume depletion. However, in experimental studies a direct influence of Clostridium difficile toxins on renal duct cells could be shown.CONCLUSION: Rapid diagnosis, nonspecific supportive treatment and specific antibiotic treatment, especially in the elderly, may lower excess mortality Clostridium difficile-associated diarrhea and renal failure being possible complications. | Jasmin Arrich Gottfried H.Sodeck Gürkan Seng(o|¨)lge Christoforos Konnaris Marcus Müllner Anton N.Laggner Hans Domanovits | 2005 | World Journal of Gastroenterology2005，11，8： | 15 |
| 2 | Percutaneous left atrial appendage closure:Technical aspects and prevention of periprocedural complications with the watchman device显示文摘Transcatheter closure of the left atrial appendage has been developed as an alternative to chronic oral anticoagulation for stroke prevention in patients with atrial fibrillation, and as a primary therapy for patients with contraindications to chronic oral anticoagulation. The promise of this new intervention compared with warfarin has been supported by several, small studies and two pivotal randomized trial with the Watchman Device. The results regarding risk reduction for stroke have been favourable although acute complications were not infrequent. Procedural complications, which are mainly related to transseptal puncture and device implantation, include air embolism, pericardial effusions/tamponade and device embolization. Knowledge of nature, management and prevention of complications should minimize the risk of complications and allow transcatheter left atrial appendage closure to emerge as a therapeutic option for patients with atrial fibrillation at risk for cardioembolic stroke. | Sven M bius-Winkler Nicolas Majunke Marcus Sandri Norman Mangner Axel Linke Gregg W Stone Ingo D hnert Gerhard Schuler Peter B Sick | 2015 | World Journal of Cardiology2015，7，2： | 14 |
| 3 | Expression of c-kit receptor in human cholangiocarcinoma and in vivo treatment with imatinib mesilate in chimeric mice显示文摘瞄准:与额外的肝的 cholangiocarcinoma (CC ) 从病人在胆道癌症房间线和组织学的节调查 c 工具包表示并且与 imatinib mesilate 评估在试管内和在试管内治疗的功效。方法:在从有额外的肝的 CC 的 19 个病人的人的胆道癌症房间线 Mz-ChA-2 和 EGI-1 和组织学的节的 c 工具包的蛋白质表示被免疫弄污,免疫细胞化学,和免疫组织化学估计。胆道癌症房间线 Mz-ChA-2 和 EGI-1 上的 imatinib mesilate 的 anti-proliferative 效果是由自动化房间数的学习在试管内。另外,免疫缺乏的 NMRI 老鼠(Taconic ) 皮下地与 5x10 (6 ) 被注射房间线 MzChA-2 和 EGI-1 的房间。在到达了 200 mm3 的瘤体积以后,每日的治疗在 50 mg/kg 或生理盐水(NS ) 的剂量以 imatinib mesilate intraperitoneally 被开始。肿瘤体积与游标 caliper 被计算。在 14 d 以后,老鼠被牺牲,肿瘤和决定的肿瘤质量切除了。结果:Immunoblotting 在 EGI-1 房间在 Mz-ChA-2 和缺席揭示了 c 工具包的存在。有 c 工具包抗体的 Immunocytochemistry 在 EGI-1 房间在 Mz-ChA-2 房间和 c 工具包的缺席显示了 cytoplasmatic 和受体蛋白质的膜的本地化。c 工具包在 19 中的 7 个被表示(37%) 额外的肝的人的 CC 织物取样, 2 出现了一中等并且染色的 5 一相当弱的免疫。在 5 micromol/L 的低集中的 Imatinib mesilate 在 c 工具包引起了重要生长抑制积极房间线 Mz-ChA-2 (31%) ,然而并非在 c 工具包 negative,房间衬里 EGI-1 (0%)(P<0.05 ) 。在 10 micromol/L 的中间的集中的 Imatinib mesilate 禁止了两根细胞线(51% 对 57%) 的细胞的生长。在 20 micromol/L 的更高的集中的 Imatinib mesilate 似乎在两根房间线上有一般有毒的效果。IC50 价值分别地是 9.7 micromol/L 和 11 micromol/L。在有 imatinib mesilate 的在试管内处理的 14 d 以后,使用妄想的老鼠模型,积极 Mz-ChA-2 肿瘤有的 c 工具包显著地减少的体积和团作为与 NS 处理(P<0.05 ) 相比。与那相对照,忍受 c 工具包 negative EGI-1 肿瘤的鼠标的处理没作为与 NS 处理相比导致肿瘤体积和质量的任何变化。结论:c 工具包表示是可检测的在一对在胆道癌症的低蛋白质水平中等。Imatinib mesilate 在肿瘤生长在试管内和 c 工具包表示诚实的在试管内依赖者上施加显著效果。 | Thomas Kamenz Karel Caca Thilo Blüthner Andrea Tannapfel Joachim Mssner Marcus Wiedmann | 2006 | World Journal of Gastroenterology2006，12，10： | 7 |
| 4 | Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis显示文摘AIM:To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1 ) gene in patients with spontaneous bacterial peritonitis (SBP).METHODS:MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites.RESULTS:The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However,in the subgroup of patients with alcoholic cirrhosis (n=80),carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%,P=0.021). CONCLUSION:In patients with alcoholic liver cirrhosis,the-2518 MCP-1 genotype AA is a risk factor for the development of SBP. | Erwin Gbele Marcus Mhlbauer Hartwig Paulo Monika Johann Christin Meltzer Franz Leidl Norbert Wodarz Reiner Wiest Jrgen Schlmerich Claus Hellerbrand | 2009 | World Journal of Gastroenterology2009，15，44： | 7 |
| 5 | Association between facet joint osteoarthritis and the Oswestry Disability Index显示文摘AIM:To investigate the correlation of facet joint osteoarthritis(FJOA) at lumbar levels L4/L5 and L5/S1 and the Oswestry Disability Index(ODI).METHODS:The study involved lumbar MRIs of 591 patients with a mean age of 47.3 years.The MRIs of the lumbar spine were performed on a 1.5 Tesla scanner(Magnetom Avanto,Siemens AG,Erlangen,Germany) using a dedicated receive only spine coil.After initial blinding,each dataset was evaluated by 2 board certified radiologist with more than 5 years experience in musculoskeletal imaging.In total 2364 facet joints were graded.Degenerative changes of the facet joints were evaluated according to the 4-point scale as proposed by Weishaupt et al Functional status was assessed using the ODI.The index is scored from 0 to 100 and interpreted as follows:0%-20%,minimaldisability; 20%-40%,moderate disability; 40%-60%,severe disability; 60%-80%,crippled; 80%-100%,patients are bedbound.Spearman's coefficient of rank correlation was used for statistical analysis,with significance set at P < 0.05.RESULTS:In total 2364 facet joints at lumbar levels L4/5 and L5/S1 were analysed in 591 individuals.FJOA was present in 97%(L4/L5) and 98%(L5/S1).At level L4/5(left/right) 17/15(2.9%/2.5%) were described as grade 0,146/147(24.7%/24.9%) as grade 1,290/302(49.1%/51.1%) as grade 2 and 138/127(23.4%/21.5%) as grade 3.At level L5/S1(left/right) 10/11(1.7%/1.9%) were described as grade 0,136/136(23.0%/23.0%) as grade 1,318/325(53.8%/55.0%) as grade 2 and 127/119(21.5%/20.1%) as grade 3.Regarding the ODI scores,patients' disability had a minimum of 0% and a maximum of 91.11% with an arithmetic mean of 32.77% ± 17.02%.The majority of patients(48.39%) had moderate functional disability(21%-40%).There was no significant correlation between FJOA and ODI on both sides of lumbar level L4/5 and on the left side of lumbar level L5/S1.A weak positive correlation was evaluated between ODI and FJOA on the right side of lumbar level L5/S1.CONCLUSION:The missing correlation of FJOA and ODI confirms our clinical experience that imaging alone is an insufficient approach explaining low back pain.Clinical correlation is imperative for an adequate diagnostic advance in patients with low back pain. | Adel Maataoui Thomas J Vogl Marcus Middendorp Konstantinos Kafchitsas M Fawad Khan | 2014 | World Journal of Radiology2014，6，11： | 6 |
| 6 | Treatment of biliary tract cancer with NVP-AEW541:Mechanisms of action and resistance显示文摘AIM:To investigate in vitro treatment with NVPAEW541,a small molecule inhibitor of insulin-like growth factor-1 receptor(IGF-1R),in biliary tract cancer (BTC),since this disease is associated with a poor prognosis due to wide resistance to chemotherapeutic agents and radiotherapy.METHODS:Cell growth inhibition by NVP-AEW541 was studied in vitro in 7 human BTC cell lines by automated cell counting.In addition,the anti-tumoral mechanism of NVP-AEW541 was studied by Western blotting,cell cycle analysis and reverse transcription-polymerase chain reaction(RT-PCR).Anti-tumoral drug effect in combination with gemcitabine,5-fluorouracil(5-FU)and Polo-like kinase 1 inhibitor BI2536 was also studied. RESULTS:In vitro treatment with NVP-AEW541 suppressed growth in all human BTC cell lines,however response was lower in gallbladder cancer.Treatment withNVP-AEW541 was associated with dephosphorylation of IGF-1R and AKT.In contrast,phosphorylation of p42/p44 and Stat3 and expression of Bcl-xL were inconsistently downregulated.In addition,treated cells showed cell cycle arrest at the G1/S-checkpoint and an increase in sub-G1 peak.Moreover,IGF-1R and its ligands IGF-1 and IGF-2 were co-expressed in RT-PCR,suggesting an autocrine loop of tumor cell activation.Combined with gemcitabine,NVP-AEW541 exerted synergistic effects, particularly at low concentrations,while effects of combination with 5-FU or BI 2536 were only additive. CONCLUSION:Our findings suggest that NVP-AEW541 is active against BTC in vitro and potentiates the efficacy of gemcitabine. | Samuel Wolf Jana Lorenz Joachim Mssner Marcus Wiedmann | 2010 | World Journal of Gastroenterology2010，16，2： | 5 |
| 7 | Determination of surface color of‘all yellow’mango cultivars using computer vision显示文摘Image processing techniques are increasingly applied in sorting applications of agricultural products.This work has assessed the use of image processing for inspecting surface color of two Thai mango cultivars.A computer vision system(CVS)was developed and experiments were conducted to monitor peel color change during the ripening process.Conversion of RGB to CIE-LAB values was done via image processing and prediction models were developed to estimate color parameters from CVS data.Performance evaluations showed insufficient prediction for L values(R2=0.42-0.58),but better results for A and B values(R2=0.90-0.95 and 0.80-0.82,respectively).Compared to the calculated color values hue angle and chroma,a yellowness index computed from intermediate XYZ values was found to be much more adept at accurately predicting peel color from CVS data.Correlations were strong for both cultivars(R2=0.93 for‘Nam Dokmai’and R2=0.95 for‘Maha Chanok’).Results from classification analysis indicated satisfactory results for classifying fruits according to ripeness based on yellowness.Success rates of true positives in the categories unripe,ripe and overripe ranged 72%-92%for‘Nam Dokmai’and 98%-100%for‘Maha Chanok’.Therefore,it was shown that the CVS was capable of producing accurate color values for the two mango cultivars investigated.The findings of this study can be incorporated for development of a robust system for quality prediction and establishment of a CVS for automatic grading and sorting of mangos. | Marcus Nagle Kiatkamjon Intani Giuseppe Romano Busarakorn Mahayothee Vicha Sardsud Joachim Müller | 2016 | International Journal of Agricultural and Biological Engineering2016，9，1： | 5 |
| 8 | Correlation of lumbar lateral recess stenosis in magnetic resonance imaging and clinical symptoms显示文摘AIM To assess the correlation of lateral recess stenosis(LRS) of lumbar segments L4/5 and L5/S1 and the Oswestry Disability Index(ODI).METHODS Nine hundred and twenty-seven patients with history of low back pain were included in this uncontrolled study.On magnetic resonance images(MRI) the lateral recesses(LR) at lumbar levels L4/5 and L5/S1 were evaluated and each nerve root was classified into a 4-point grading scale(Grade 0-3) as normal,not deviated,deviated or compressed.Patient symptoms and disability were assessed using ODI.The Spearman's rank correlation coefficient was used for statistical analysis(P < 0.05).RESULTS Approximately half of the LR revealed stenosis(grade 1-3;52% at level L4/5 and 42% at level L5/S1) with 2.2% and 1.9% respectively reveal a nerve root compression.The ODI score ranged from 0%-91.11% with an arithmetic mean of 34.06% ± 16.89%.We observed a very weak statistically significant positive correlation between ODI and LRS at lumbar levels L4/5 and L5/S1,each bilaterally(L4/5 left:rho < 0.105,P < 0.01;L4/5 right:rho < 0.111,P < 0.01;L5/S1 left:rho 0.128,P < 0.01;L5/S1 right:rho < 0.157,P < 0.001).CONCLUSION Although MRI is the standard imaging tool for diagnosing lumbar spinal stenosis,this study showed only a weak correlation of LRS on MRI and clinical findings.This can be attributed to a number of reasons outlined in this study,underlining that imaging findings alone are not sufficient to establish a reliable diagnosis for patients with LRS. | Annina SplettstoBer M Fawad Khan Bernd Zimmermann Thomas J Vogl Hanns Ackermann Marcus Middendorp Adel Maataoui | 2017 | World Journal of Radiology2017，9，5： | 4 |
| 9 | 西印度洋地区海草生态系统显示文摘海草是海洋被子植物,广泛分布在温带和热带的海岸带水域,是地球上水生生态系统中最具生产力的生物之一。在西印度洋地区大概有13种海草,这些海草覆盖了12000kg海岸线的近岸柔软海底广大区域。海草床一般分布在潮间带和潮下带,有时向下延伸至40m,并经常出现在珊瑚礁和红树林附近。由于具有很高的初级生产力和复杂的栖息环境,海草供养了许多底栖生物和浮游生物。许多鱼类和贝类,包括那些具有商业价值的种类都被吸引到海草栖息地,将海草作为其食物来源和避难场所,特别是在它们的幼年期。分布在西印度洋海草床附近广泛而丰富的鱼类资源就足以说明这一点。这些鱼分别属于天竺鲷科、亚科、玻甲鱼科、银鲈科、虾虎鱼科、隆头鱼科、裸颊鲷科、笛鲷科、单角亚科、鹦嘴鱼科、科、篮子鱼科、海龙科和Teraponidae科。因此,西印度洋地区的海草生态系统无论对当地还是整个地区的渔业发展都是非常有价值的资源。尽管如此,与其他地区相比,该地区有关海草资源的研究还十分缺乏,而且大多数研究也都集中在植物多样性和生态学上。本文主要阐述西印度洋地区海草床研究现状,特别强调鱼类和渔业。目前,该课题的大多数研究主要是在东非海岸开展的,如肯尼亚,坦桑尼亚,莫桑比克以及南非东部地区,而在索马里和西印度洋地区的岛屿国家(塞舌尔、科摩罗、法属留尼旺岛、毛里求斯、马达加斯加等)此类研究却很少,有关海草鱼类生态系统的论文也少有发表,而且大部分都是描述性的。因此,需要通过研究和实验获得有关描述模式和处理方法的科学知识。关于海草鱼类群落的定量研究,类似本文所介绍的案例研究在西印度洋地区是很少的,而这些研究对于渔业的管理前景而言是必不可少的。值得强调的是由于海岸人口的不断增长以及人类活动的侵扰给该地区海草床带来的压力与日俱增,如污染,海水富营养化,沉积作用,捕鱼以及无脊椎动物的采集等活动,而这些活动对于海草床的影响却鲜为人知。因此,需要开展广泛的研究,为西印度洋地区海草生态系统可持续管理提供有用的信息服务。 | Martin Gullstrm Maricela de la Torre Castro Salomo O.Bandeira Mats Bjrk Mattis Dahlberg Nils Kautsky Patrik Rnnbck Marcus C.hman 章任群 | 2002 | AMBIO-人类环境杂志2002，31，7： | 2 |
| 10 | The Continuous Challenge of Citrus Tristeza Virus Control显示文摘 | M Bar-Joseph R Marcus R F Lee | 1989 | Annual Review of Phytopathology1989，，： | 2 |
| 11 | Development of an inflatable solar dryer for improved postharvest handling of paddy rice in humid climates显示文摘Rice is the staple food for more than three billion people worldwide.Although considerable progress has been made with respect to improved breeds and production practices,losses during postharvest handling remain considerable.Drying and storage of paddy are two key stages where management can be improved.For rice,grain moisture content of 14%prevents microbiological activity,while a level of about 12%minimizes quality losses over prolonged storage periods.Due to the need for simple and economical technologies,an inflatable solar dryer(ISD)was developed based on adaptations of the Hohenheim-type solar tunnel dryer.To form a drying tunnel,transparent polyethylene(PE)film attaches by zipper to a reinforced black polyvinyl chloride(PVC)film.To reduce heat loss,a flexible multilayer floor was used along the drying area.The tunnel does not need a substructure as it is stabilized adequately from pressure created by two axial flow ventilators.During experiments,paddy was spread on the floor and mixed with a special roller bar.The ISD has been evaluated for paddy in the Philippines during both rainy and dry seasons and was subsequently optimized.Sun drying and shade drying were carried out in parallel for comparison and product was evaluated for moisture content and quality in terms of milling recovery and head rice yield.Moisture content was reduced from 23%to 14%within 26-52 h of continuous operation during the rainy season and 16%to 14%within 4-26 h of drying during the dry season.In both seasons,the final moisture content of 12%was reached after prolonged drying periods.Quality was not found to be affected with respect to drying treatment.The ISD showed advantages over sun drying,despite longer drying periods. | Ana Salvatierra-Rojas Marcus Nagle Martin Gummert Tom de Bruin Joachim Müller | 2017 | International Journal of Agricultural and Biological Engineering2017，10，3： | 2 |
| 12 | Video display terminals and miscarriage 显示文摘 | McChesney R Golden A | 2000 | J Am Med Womens Assoc2000，55，2： | 1 |
| 13 | 显示文摘 | Marcus J A M | 1994 | J Organomet Chem1994，482，： | 1 |
| 14 | Assessing landslide potential using GIS, soil wet -ness modeling and topographic attributes, Payene River, Idaho 显示文摘 | Lineback G M Marcus W A Aspinall R Custer S G | 2001 | Geomorphology2001，37，： | 1 |
| 15 | The anodic dissolution and passivation of Ni-Cr-Fe alloys studied by esca显示文摘 | Marcus P Grimal J M | 1992 | Corrosion Science1992，33，5： | 1 |
| 16 | Piscicidal properties of piperovatine from Piper piscatorum 显示文摘 | Marcus A M Rodriguez E | 1998 | J Ethnophar macol1998，60，2： | 1 |
| 17 | Surface effects in metal microclusters显示文摘 | Jiang P Jona F Marcus P M | 1987 | Phys Rev1987，36，： | 1 |
| 18 | Refusal to eat in the elderly显示文摘 | Marcus E L Berry E M | 1998 | Nutr Rev1998，56，6： | 1 |
| 19 | A longitudinal analysis of unmet need for oral treatment in a national sample of medical HIV patients显示文摘 | Marcus M Maida CA Coulter ID | 2005 | Am J Public Health2005，95，： | 1 |
| 20 | Refined food addiction:a classic substance use disorder 显示文摘 | IFLAND J R PREUSS H G MARCUS M T | 2009 | Med Hypothe- ses2009，72，5： | 1 |
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