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| 1 | Influence of hepatitis viruses on clinico-pathological profiles and long-term outcome in patients undergoing surgery for hepatocellular carcinoma显示文摘BACKGROUND: The global risk of hepatocellular carcinoma(HCC) is largely due to hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. In recent years, however, an increased prevalence of non-viral HCC has been noted. The clinical impact of the presence/absence of viral infections in HCC remains controversial. The present study aimed to assess the effect of hepatitis viruses on demographics, clinical and pathological features and long-term outcome in a large cohort of Romanian patients who underwent surgery for HCC. METHODS: The study included 404 patients with HCC who had undergone resection, transplantation or radiofrequency ablation at a single institution between 2001 and 2010. The patients were divided into four groups: 85 patients with hepatitis B virus infection (HBV group), 164 patients with hepatitis C virus infection (HCV group), 39 patients with hepatitis B and C virus co-infection (HBCV group), and 116 patients without viral infection (non-BC group). RESULTS: The patients of both HBV (56.0±11.3 years) and HBCV groups (56.0±9.9 years) were significantly younger than those of the HCV (61.0±8.5 years, P=0.001) and non-BC groups(61.0±13.0 years, P=0.002). Interestingly, the prevalence of liver cirrhosis was significantly lower in the non-BC group (47%)than in any other subsets (72%-90%, P<0.002). Furthermore, the non-BC patients were more advanced according to the Barcelona Clinic Liver Cancer stages than the patients of the HCV or HBCV groups (P<0.020); accordingly, they were more frequently assessed beyond the Milan criteria than any other groups (P=0.001). No significant differences in the disease-free or overall survival rates were observed among these groups. CONCLUSIONS: Patients with non-viral HCC are diagnosed at advanced ages and stages, a situation plausibly due to the poor effectiveness of cancer surveillance in community practice. The presence of viral infections does not appear to impair the longterm prognosis after surgical treatment in patients with HCC; however, there is a trend for worse disease-free survival rates in HBCV patients, though statistical significance was not reached. | Anna-Maria Tanase Traian Dumitrascu Simona Dima Razvan Grigorie Agnes Marchio Pascal Pineau Irinel Popescu | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，2： | 7 |
| 2 | Bakuchiol in the Management of Acne-affected Skin显示文摘 | Chaudhuri RK Marchio F | | 0，，07： | 1 |
| 3 | c-fos-induced growth factor/VEGF-D induces angiogenesis in vivo and in vitro显示文摘 | Marconcini L Marchio S Morbilelli L | 1999 | Proc Natl Acad Sci USA1999，96，17： | 1 |
| 4 | Retro and on-going commissioning tool applied to an existing building: operability and results of IPMVP显示文摘 | Ginestet S Marchio D | 2010 | Energy2010，35，4： | 1 |
| 5 | Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients 显示文摘 | Marchio A Pineau P Meddeb M | 2000 | Oncogene2000，19，33： | 1 |
| 6 | Overexpression of the RON gene in human breast carcinoma显示文摘 | Maggiora P Marchio S Stella MC | 1998 | Oncogene1998，16，22： | 1 |
| 7 | Forkhead box Ai expression in breast cancer is associated with luminal subtype and good prognosis显示文摘 | Thorat MA Marchio C Morimiya A | 2008 | J Clin Pathol2008，61，3： | 1 |
| 8 | Clarification of blood orange juice by uhrafiltration: analyses of operating parameters, membrane fouling and juice quality显示文摘 | CASSANO A MARCHIO M DRIOLI E | 2007 | Desalination2007，，212： | 1 |
| 9 | Control tuning of a simplified VAV system: methodology and impact on'energy consumption and IAQ显示文摘 | Ginestet S Marchio D | 2010 | Energy and Buildings2010，42，8： | 1 |
| 10 | Are there optimum temperature and humidity set points for supermarkets 显示文摘 | Matthieu Orphelin Dominique Marchio Shanta L D'Alanzo | 1999 | ASHRAE Trans1999，105，1： | 1 |
| 11 | Extensive analysis of duplicated-inverted hepatitis B virus integrations in human hepatocellular carcinoma显示文摘 | Pineau P Marchio A Mattei M G | 1998 | J Gen Virol1998，79，3： | 1 |
| 12 | Does chromosome 17 centromere copy number predict polysomy in breast cancer? A fluorescence in situ hybridization and microarray-based CGH analysis显示文摘 | Marchio C Lambros M B Gugliotta P | 2009 | J Pathol2009，219，1： | 1 |
| 13 | Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization显示文摘 | Marchio A Meddeb M Pineau P | 1997 | Genes Chromosomes Cancer1997，18，1： | 1 |
| 14 | Overexpression of the RON gene in human breast carcinoma 显示文摘 | Maggiora P Marchio S Stella MC | 1998 | Oncogene1998，16，22： | 1 |
| 15 | Structure and emission properties of Er3Q9(Q=8-Quinolinolate)显示文摘 | ARTIZZU F DEPLANO P MARCHIO L | 2005 | Inorg Chem2005，44，4： | 1 |
| 16 | Triple negative breast cancer: molecular profiling and prognostic impact in adjuvant anthracycline - treated patients显示文摘 | Tan DS Marchio C Jones RL | 2007 | Breast Cancer Res Treat2007，6，： | 1 |
| 17 | Triple negative breast cancer: molecular profiling and prognostic impact in adjuvant anthracycline treated patient 显示文摘 | Tan DS Marchio C Jones RL | 2008 | Breast Cancer Res Treat2008，111，1： | 1 |
| 18 | c-fos-induced growth factor/vascular endothelial growth factor D induces angiogenesis in vivo and in vitro显示文摘 | Marconcini L Marchios MorbidelliL | 1999 | Proc Natl Acad Sci USA1999，96，17： | 1 |
| 19 | The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered BAR显示文摘 | de Th?H Lavau C Marchio A | 1991 | Cell1991，66，4： | 1 |
| 20 | High chromosome instability and occasional R249S TP53 Mutation characterize hepatocellular carcinoma in Romania显示文摘 | Agnès Marchio Anna-Maria Tanase Traian Dumitrascu Mariana Mihaila Simona Dima Anne Dejean Irine Popescu Gabriela Oprisan Pascal Pineau | 2010 | Cancer Genetics and Cytogenetics2010，，1： | 1 |
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