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| 1 | Gastric precancerous lesions are associated with gene variants in Helicobacter pylori -susceptible ethnic Malays显示文摘AIM: To identify genes associated with gastric pre-cancerous lesions in Helicobacter pylori (H. pylori )susceptible ethnic Malays. METHODS: Twenty-three Malay subjects with H. pylori infection and gastric precancerous lesions identified during endoscopy were included as 'cases'. Thirtyseven Malay subjects who were H. pylori negative and had no precancerous lesions were included as 'controls'. Venous blood was collected for genotyping with Affymetrix 50K Xba1 kit. Genotypes with call rates < 90% for autosomal single nucleotide polymorphisms (SNPs) were excluded. For each precancerous lesion, associated SNPs were identified from Manhattan plots, and only SNPs with a χ2 P value < 0.05 and Hardy Weinberg Equilibrium P value > 0.5 was considered as significant markers. RESULTS: Of the 23 H. pylori -positive subjects recruited, one sample was excluded from further analysis due to a low genotyping call rate. Of the 22 H. pylori positive samples, atrophic gastritis only was present in 50.0%, complete intestinal metaplasia was present in 18.25%, both incomplete intestinal metaplasia and dysplasia was present in 22.7%, and dysplasia only was present in 9.1%. SNPs rs9315542 (UFM1 gene), rs6878265 (THBS4 gene), rs1042194 (CYP2C19 gene) and rs10505799 (MGST1 gene) were significantly associated with atrophic gastritis, complete intestinal metaplasia, incomplete metaplasia with foci of dysplasia and dysplasia, respectively. Allele frequencies in 'cases' vs 'controls' for rs9315542, rs6878265, rs1042194 and rs10505799 were 0.4 vs 0.06, 0.6 vs 0.01, 0.6 vs 0.01 and 0.5 vs 0.02, respectively. CONCLUSION: Genetic variants possibly related to gastric precancerous lesions in ethnic Malays susceptible to H. pylori infection were identified for testing in subsequent trials. | Sathiya Maran Yeong Yeh Lee Shuhua Xu Nur-Shafawati Rajab Norhazrini Hasan Syed Hassan Syed Abdul Aziz Noorizan Abdul Majid Bin Alwi Zilfalil | 2013 | World Journal of Gastroenterology2013，19，23： | 5 |
| 2 | ASQ Certification Program Gains Wider Recognition显示文摘 | La Londe P C | 2000 | Quality Progress2000，33，4： | 1 |
| 3 | Response surface modeling and optimization of process parameters for aqueous extrac- tion of pigments from prickly pear ( Opuntia ficus-indica ) fruit 显示文摘 | Maran J P Manikandan S | 2012 | Dyes and Pigments2012，95，3： | 1 |
| 4 | Box-behnken design based statistical modeling for ultrasound-assisted extraction of corn silk polysaccharide 显示文摘 | Maran J P Manikandan S Thirugrtanasambandham K | 2013 | Carbohydrate Polymers2013，92，1： | 1 |
| 5 | Continuous glucose monitoring reveals delayed nocturnal hypoglycemia after intermittent high-intensity exercise in nontrained patients with type 1 diabetes显示文摘 | Maran A Pavan P Bonsembiante B | 2010 | Diabetes Technol Ther2010，12，10： | 1 |
| 6 | Radical neck dissection:a 19-year experience显示文摘 | Maran AG Amin M Wilson JA | 1989 | J Laryngol Otol1989，103，08： | 1 |
| 7 | High ratio of interfo- llicular CD8/FOXP3-positive regulatory T cells is associated with a high FLIPI index and poor overall survival in follicular lymphoma 显示文摘 | Saifi M Maran A Raynand P | 2010 | Exp Ther Med2010，1，6： | 1 |
| 8 | Cellular uptake of gold nanoparticles directly cross-linked with carrier peptides by osteosarcoma cells 显示文摘 | Mandal D Maran A Yaszemski M J | 2009 | J Mater Sci : Mater Med2009，20，： | 1 |
| 9 | Purification and partial characterization of a thrombin-like enzyme,balterobin,from the venom of Bothrop salternatus显示文摘 | Smolka M B Maran G Oliver B | 1998 | Toxicon1998，36，： | 1 |
| 10 | Continuous subcutaneous glucose monitoring in diabetic patients显示文摘 | Maran A Crepaldi C Tiengo A | 2002 | Diabetes Care2002，25，2： | 1 |
| 11 | Occupational stress,anxiety and coping strategies in police officers显示文摘 | ACQUADRO MARAN D VARETTO A ZEDDA M | 2015 | Occup Med(Lond)2015，65，6： | 1 |
| 12 | The persistence of symptoms in patients with globus pharyngeus显示文摘 | Deary IJ Maran AG | 1991 | Clin Otolaryngol1991，16，3： | 1 |
| 13 | Removal of residual phenols from coke wastewater by adsorption显示文摘 | Vázquez I Rodríguez-Iglesias J Maran?ń E | 2007 | Journal of Hazardous Materials2007，147，： | 1 |
| 14 | Laryngocele显示文摘 | Stell P Maran A | 1975 | J Laryngol Otol1975，89，： | 1 |
| 15 | Acute urinary retention in children 显示文摘 | Marans Rachel Mandel Asaf Gielchinsky Ilan | 2012 | Harefuah2012，151，6： | 1 |
| 16 | Distal regulatory elements are required for Fshr expression,in vivo显示文摘 | Hermann BP Hombaker KI Maran RR | 2010 | Molecular and Cellular En- d:rinology2010，26，4： | 1 |
| 17 | Development of model for barrier and optical properties of tapioca starch based edible films显示文摘 | J. Prakash Maran V. Sivakumar R. Sridhar K. Thirugnanasambandham | 2013 | Carbohydrate Polymers2013，，2： | 1 |
| 18 | Modeling and optimization of ultrasound-assisted extraction of polysaccharide from Cucurbita moschata显示文摘 | Maran J P Mekala V Manikandan S | 2013 | Carbohydrate Polymers2013，92，2： | 1 |
| 19 | Low to high 2 fedelity simulation: A continusum of medical education显示文摘 | Maran N Glavin R | 2003 | Medical Education2003，37，： | 1 |
| 20 | Microwave assisted extraction of pectin from waste Citrullus lanatus fruit rinds显示文摘 | Prakash Maran J Sivakumar V Thirugnanasambandham K | 2014 | Carbohydrate Polymers2014，101，： | 1 |
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