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| 1 | Viral hepatitis update: Progress and perspectives显示文摘Viral hepatitis,secondary to infection with hepatitis A,B,C,D,and E viruses,are a major public health problem and an important cause of morbidity and mortality.Despite the huge medical advances achieved in recent years,there are still points of conflict concerning the pathogenesis,immune response,development of new and more effective vaccines,therapies,and treatment.This review focuses on the most important research topics that deal with issues that are currently being solved,those that remain to be solved,and future research directions.For hepatitis A virus we will address epidemiology,molecular surveillance,new susceptible populations as well as environmental and food detections.In the case of hepatitis B virus,we will discuss host factors related to disease,diagnosis,therapy,and vaccine improvement.On hepatitis C virus,we will focus on pathogenesis,immune response,direct action antivirals treatment in the context of solid organ transplantation,issues related to hepatocellular carcinoma development,direct action antivirals resistance due to selection of resistanceassociated variants,and vaccination.Regarding hepatitis D virus,we describe diagnostic methodology,pathogenesis,and therapy.Finally,for hepatitis E virus,we will address epidemiology(including new emerging species),diagnosis,clinical aspects,treatment,the development of a vaccine,and environmental surveillance. | María B Pisano Cecilia G Giadans Diego M Flichman Viviana E Ré María V Preciado Pamela Valva | 2021 | World Journal of Gastroenterology2021，27，26： | 8 |
| 2 | Effects of cellulase and xylanase enzymes mixed with increasing doses of Salix babylonica extract on in vitro rumen gas production kinetics of a mixture of corn silage with concentrate显示文摘An in vitro gas production(GP) technique was used to investigate the effects of combining different doses of Salix babylonica extract(SB) with exogenous fibrolytic enzymes(EZ) based on xylanase(X) and cellulase(C), or their mixture(XC; 1:1 v/v) on in vitro fermentation characteristics of a total mixed ration of corn silage and concentrate mixture(50:50, w/w) as substrate. Four levels of SB(0, 0.6, 1.2 and 1.8 m L g–1 dry matter(DM)) and four supplemental styles of EZ(1 μL g–1 DM; control(no enzymes), X, C and XC(1:1, v/v) were used in a 4×4 factorial arrangement. In vitro GP(m L g–1 DM) were recorded at 2, 4, 6, 8, 10, 12, 24, 36, 48 and 72 h of incubation. After 72 h, the incubation process was stopped and supernatant p H was determined, and then filtered to determine dry matter degradability(DMD). Fermentation parameters, such as the 24 h gas yield(GY24), in vitro organic matter digestibility(OMD), metabolizable energy(ME), short chain fatty acid concentrations(SCFA), and microbial crude protein production(MCP) were also estimated. Results indicated that there was a SB?EZ interaction(P<0.0001) for the asymptotic gas production(b), the rate of gas production(c), GP from 6 to 72 h, GP2(P=0.0095), and GP4(P=0.02). The SB and different combination of enzymes supplementation influenced(P<0.001) in vitro GP parameters after 12 h of incubation; the highest doses of SB(i.e., 1.8 m L g–1 DM), in the absence of any EZ, quadratically increased(P<0.05) the initial delay before GP begins(L) and GP at different incubation times, with lowering b(quadratic effect, P<0.0001) and c(quadratic effect, P<0.0001; linear effect, P=0.0018). The GP was the lowest(P<0.05) when the highest SB level was combined with cellulose. There were SB?EZ interactions(P<0.001) for OMD, ME, the partitioning factor at 72 h of incubation(PF72), GY24, SCFA, MCP(P=0.0143), and p H(P=0.0008). The OMD, ME, GY24 and SCFA with supp lementation of SB extract at 1.8 m L g–1 DM were higher(P<0.001) than the other treatments, however,PF72 was lower(quadratic effect, P=0.0194) than the other levels. Both C and X had no effect(P>0.05) on OMD, p H, ME, GY24, SCFA and MP. The combination of SB with EZ increased(P<0.001) OMD, ME, SCFA, PF72 and GP24, whereas there was no impact on p H. It could be concluded that addition of SB extract, C, and X effectively improved the in vitro rumen fermentation, and the combination of enzyme with SB extract at the level of 1.2 m L g–1 was more effective than the other treatments. | Abdelfattah Z M Salem German Buendía-Rodríguez Mona M M Elghandour María A Mariezcurrena Berasain Francisco J Pea Jiménez Alberto B Pliego Juan C V Chagoyán María A Cerrillo Miguel A Rodríguez | 2015 | Journal of Integrative Agriculture2015，14，1： | 4 |
| 3 | A multi-ob-jective model for locating fire stations 显示文摘 | MASOOD A B MAR K M COLONEL A A | 1998 | European Jour-nal of Operational Research1998，110，： | 1 |
| 4 | The flooding time synchro- nization protocol 显示文摘 | MAR(')TI M KUSY B | 2004 | 2nd International Confer- ence on Embedded Networked Sensor Systems Baltimore MD USA2004，2004，： | 1 |
| 5 | Systematic re- view of perioperative and quality of-life outcomes fol lowing surgical management of localised renal cancer 显示文摘 | MaeLennan S Imamura M Lapitan M C ()mar M I Lain T B Hilvano-Cabungcal A M | 2012 | Eur Urol2012，62，： | 1 |
| 6 | A survey of bondgraphs : theory, applications and programs 显示文摘 | JENNY M D MAR/SOL D CLAUDE B | 1991 | Journal of the Franklin Institute1991，328，： | 1 |
| 7 | Review on thermal energy storage with phase change:Materials,heat transfer analysis and applications显示文摘 | Zalba B Mar?n J M Cabeza L F | 2003 | Applied Thermal Engineering2003，23，： | 1 |
| 8 | Progress in the development of animal models of acute kidney injury and its impact on drug discovery显示文摘 | Ana B Sanz Marí a Dolores Sanchez-Ni? o Catalina Martí n-Cleary Alberto Ortiz Adriá n M Ramos | 2013 | Expert Opinion on Drug Discovery2013，，7： | 1 |
| 9 | 查看详情显示文摘 | María L G P Patricia P B Roberto R G José L M V Antonia G F | | 0，，27： | 1 |
| 10 | Characterisation andphotocatalytic properties of titania-silica mixed oxides doped withAg and Pt显示文摘 | Llano B Restrepo G Marín J M | 2010 | Applied Catalysis A:General2010，387，12： | 1 |
| 11 | Ultrasound-guided supraclavicular vs infraclavicular brachial plexus blocks in children显示文摘 | De JoséMaría B Banús E Navarro Egea M | 2008 | Paediatr Anaesth2008，18，9： | 1 |
| 12 | Application of mass spectrometry to the characterization and quantification of food-derived bioactive peptides显示文摘 | DEL MAR CONTRERAS M LPEZ-EXPSITO I HERNNDEZ-LEDESMA B | 2008 | Journal of AOAC International2008，91，4： | 1 |
| 13 | Computed tomography in the diagnosis of blunt thoracic injury显示文摘 | Mars B Durham R Shapiro M | 1994 | Am J Trauma1994，168，6： | 1 |
| 14 | Removal of cad- mium from aqueous solutions by adsorption onto orange waste 显示文摘 | PI~REZ MAR~N A B ZAPATA V M ORTUNO J F | 2007 | Journal of hazardous materials2007，139，1： | 1 |
| 15 | New plant introductions with resistance to the soybean aphid显示文摘 | Mar M Hammond R B Martin S K | 2008 | Crop Sci2008，，48： | 1 |
| 16 | Review on thermal energy storage with phase change:materials,heat transfer analysis and applications显示文摘 | Zalba B Marín J M Cabeza L F | 2003 | Applied Thermal Engineering2003，23，3： | 1 |
| 17 | Composite sam- pling of highway runoff显示文摘 | CLARK D L ASCE A M MAR B W | 1981 | Journal of Environmental Engi- neering ?1981，107，5： | 1 |
| 18 | CuInS 2 thin films obtained by spray pyrolysis for photovoltaic applications显示文摘 | Sahal M Mar B Mollar M | 2009 | Thin Solid Films2009，517，7： | 1 |
| 19 | Effects of thermal and mechanical pre-treatments of secondary sludge on biogas production under thermophilic conditions 显示文摘 | Climent M Ferrer I Mar M B | 2007 | Chemical Engineering Journal2007，133，13： | 1 |
| 20 | Study on nonenzymatic browning in cookies, crackers and breakfast cereals by maltulose and furosine determination显示文摘 | MAITE R M JUANLUIS G B MAR V AGUSTIN O | 2004 | J Cereal Sci2004，39，2： | 1 |
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