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| 1 | Perfluorooctane sulfonate(PFOS) and related fluorochemicals in chicken egg in China显示文摘The ubiquitous occurrence of perfluorinated compounds(PFCs) in environmental samples has drawn much attention.Recent human exposure studies found relatively high perfluorooctane sulfonate(PFOS) concentrations in blood samples from several cities in China when compared with other countries.The objectives of the present study were:(1) to measure PFC concentrations and compositions in chicken egg samples from local markets in China;and(2) to conduct a preliminary human health risk assessment of egg consumption.Eight pooled egg samples from eight locations were analyzed for 11 PFCs.The results showed that close to 100% of the PFOS in the egg was distributed in egg yolk and PFOS was not detected in egg white(<0.08 ng/g wet weight,w/w).Of the perfluoroalkylsulfonates,only PFOS was detected in all egg samples,while of the perfluoroalkylcarboxylates,perfluoroundecanoic acid(PFUnDA) was detected in all samples,followed by perfluorooctanoate(PFOA)(75% occurrence) and perfluorodecanoic acid(PFDA)(50% occurrence).PFOS concentrations in egg ranged from 45.0 to 86.9 ng/g w/w.The results suggested that current concentrations of PFOS in domestic chicken eggs are unlikely to cause immediate harm to Chinese populations. | WANG Yuan YEUNG Leo Wai Yin YAMASHITA Nobuyoshi TANIYASU Sachi SO Man Ka Margaret B. MURPHY LAM Paul Kwan Sing | 2008 | Chinese Science Bulletin2008，53，4： | 13 |
| 2 | Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in transient middle cerebral artery occlusion induced ischemic retinopathy显示文摘Ischemia occurs in diabetic retinopathy with neuronal loss, edema, glial cell reactivity and oxidative stress. Epacs, consisting of Epac1 and Epac2, are c AMP mediators playing important roles in maintenance of endothelial barrier and neuronal functions. To investigate the roles of Epacs in the pathogenesis of ischemic retinopathy, transient middle cerebral artery occlusion(t MCAO) was performed on Epac1-deficient(Epac1-/-) mice, Epac2-deficient(Epac2-/-) mice, and their wild type counterparts(Epac1+/+ and Epac2+/+). Two-hour occlusion and 22-hour reperfusion were conducted to induce ischemia/reperfusion injury to the retina. After t MCAO, the contralateral retinae displayed similar morphology between different genotypes. Neuronal loss, retinal edema and increase in immunoreactivity for aquaporin 4(AQP4), glial fibrillary acidic protein(GFAP), peroxiredoxin 6(Prx6) were observed in ipsilateral retinae. Epac2-/- ipsilateral retinae showed more neuronal loss in retinal ganglion cell layer, increased retinal thickness and stronger immunostaining of AQP4, GFAP, and Prx6 than those of Epac2+/+. However, Epac1-/- ipsilateral retinae displayed similar pathology as those in Epac1+/+ mice. Our observations suggest that Epac2-deficiency led to more severe ischemic retinopathy after retinal ischemia/reperfusion injury. | LIU Jin YEUNG Patrick Ka Kit CHENG Lu LO Amy Cheuk Yin CHUNG Stephen Sum Man CHUNG Sookja Kim | 2015 | Science China(Life Sciences)2015，58，6： | 12 |
| 3 | Characterizing the optimal operation of photocatalytic degradation of BDE-209 by nano-sized TiO_2显示文摘Brominated flame retardants have been widely used in industry.There is a rapid growing public concern for their availabilities in the environment.Advanced oxidation process(AOP) is a promising and efficient technology which may be used to remove emerging chemicals such as brominated flame retardants.This study aims at investigating optimal operational conditions for the removal of BDE-209 using nano-scaled titanium(IV) oxide.The residual PBDE congeners after photocatalytical degradation of BDE-209 by TiO 2 were analysed by gas chromatography-mass spectrometry(GC-MS).It was found that the degradability of BDE-209 by TiO 2 was attributed to its photocatalytic activity but not the small size of the particles.The half-life of removing BDE-209 by TiO 2 was 3.05 days under visible light.Tetra-and penta-BDEs were the major degraded products of BDE-209.Optimum conditions for photocatalytical degradation of BDE-209 was found to be at pH 12(93% ± 1%),5,10,20 mg/L(93.0% ± 1.70%,91.6% ± 3.21%,91.9% ± 0.952%,respectively),respectively of humic acid and in the form of anatase/rutile TiO 2(82% ± 3%).Hence,the efficiency of removing BDE-209 can be maximized while being cost effective at the said operating conditions. | Ka Lai Chow Yu Bon Man Jin Shu Zheng Yan Liang Nora Fung Yee Tam Ming Hung Wong | 2012 | Journal of Environmental Sciences2012，24，9： | 8 |
| 4 | Profiles and removal efficiency of polycyclic aromatic hydrocarbons by two different types of sewage treatment plants in Hong Kong显示文摘Sewage discharge could be a major source of polycyclic aromatic hydrocarbons(PAHs) in the coastal waters. Stonecutters Island and Shatin Sewage Treatment Works(SCISTW and STSTW)in Hong Kong, adopted chemically enhanced primary treatment and biological treatment,respectively. This study aimed at(1) determining the removal efficiencies of PAHs,(2) comparing the capabilities in removing PAHs, and(3) characterizing the profile of each individual PAHs, in the two sewage treatment plants(STPs). Quantification of 16 PAHs was conducted by a Gas Chromatography. The concentrations of total PAHs decreased gradually along the treatment processes(from 301 ± 255 and 307 ± 217 ng/L to 14.9 ± 12.1 and 63.3 ± 54.1 ng/L in STSTW and SCISTW, respectively). It was noted that STSTW was more capable in removing total PAHs than SCISTW with average total removal efficiency 94.4% ± 4.12% vs. 79.2% ± 7.48%(p < 0.05). The removal of PAHs was probably due to sorption in particular matter, confirmed by the higher distribution coefficient of individual and total PAHs in solid samples(dewatered sludge contained92.5% and 74.7% of total PAHs in SCISTW and STSTW, respectively) than liquid samples(final effluent-total contained 7.53% and 25.3% of total PAHs in STSTW and SCISTW, respectively).Despite the impressive capability of STSTW and SCISTW in removing PAHs, there was still a considerable amount of total PAHs(1.85 and 39.3 kg/year, respectively for the two STPs) being discharged into Hong Kong coastal waters, which would be an environmental concern. | Yu Bon Man Ka Lai Chow Zhang Cheng Wing Yin Mo Yung Hau Chan James Chung Wah Lam Frankie Tat Kwong Lau Wing Cheong Fung Ming Hung Wong | 2017 | Journal of Environmental Sciences2017，29，3： | 5 |
| 5 | Transfusion-transmitted hepatitis E:What we know so far?显示文摘Hepatitis E virus(HEV)is a major cause of viral hepatitis globally.There is growing concern about transfusion-transmitted HEV(TT-HEV)as an emerging global health problem.HEV can potentially result in chronic infection in immunocompromised patients,leading to a higher risk of liver cirrhosis and even death.Between 0.0013%and 0.281%of asymptomatic blood donors around the world have HEV viremia,and 0.27%to 60.5%have anti-HEV immunoglobulin G.HEV is infectious even at very low blood concentrations of the virus.Immunosuppressed patients who develop persistent hepatitis E infection should have their immunosuppressant regimen reduced;ribavirin may be considered as treatment.Pegylated interferon can be considered in those who are refractory or intolerant to ribavirin.Sofosbuvir,a nucleotide analog,showed modest antiviral activity in some clinical studies but sustained viral response was not achieved.Therefore,rescue treatment remains an unmet need.The need for HEV screening of all blood donations remains controversial.Universal screening has been adopted in some countries after consideration of risk and resource availability.Various pathogen reduction methods have also been proposed to reduce the risk of TT-HEV.Future studies are needed to define the incidence of transmission through transfusion,their clinical features,outcomes and prognosis. | Carmen Ka Man Cheung Sunny Hei Wong Alvin Wing Hin Law Man Fai Law | 2022 | World Journal of Gastroenterology2022，28，1： | 5 |
| 6 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 7 | Projection of the Zhujiang(Pearl) River Delta's potential submerged area due to sea level rise during the 21st century based on CMIP5 simulations显示文摘Projections of potential submerged area due to sea level rise are helpful for improving understanding of the influence of ongoing global warming on coastal areas. The Ensemble Empirical Mode Decomposition method is used to adaptively decompose the sea level time series in order to extract the secular trend component. Then the linear relationship between the global mean sea level(GMSL) change and the Zhujiang(Pearl) River Delta(PRD)sea level change is calculated: an increase of 1.0 m in the GMSL corresponds to a 1.3 m(uncertainty interval from1.25 to 1.46 m) increase in the PRD. Based on this relationship and the GMSL rise projected by the Coupled Model Intercomparison Project Phase 5 under three greenhouse gas emission scenarios(representative concentration pathways, or RCPs, from low to high emission scenarios RCP2.6, RCP4.5, and RCP8.5), the PRD sea level is calculated and projected for the period 2006–2100. By around the year 2050, the PRD sea level will rise 0.29(0.21 to 0.40) m under RCP2.6, 0.31(0.22 to 0.42) m under RCP4.5, and 0.34(0.25 to 0.46) m under RCP8.5, respectively.By 2100, it will rise 0.59(0.36 to 0.88) m, 0.71(0.47 to 1.02) m, and 1.0(0.68 to 1.41) m, respectively. In addition,considering the extreme value of relative sea level due to land subsidence(i.e., 0.20 m) and that obtained from intermonthly variability(i.e., 0.33 m), the PRD sea level will rise 1.94 m by the year 2100 under the RCP8.5scenario with the upper uncertainty level(i.e., 1.41 m). Accordingly, the potential submerged area is 8.57×103 km2 for the PRD, about 1.3 times its present area. | XIA Jiangjiang YAN Zhongwei ZHOU Wen FONG Soi Kun LEONG Ka Cheng TANG Iu Man CHANG S W LEONG W K JIN Shaofei | 2015 | Acta Oceanologica Sinica2015，34，9： | 3 |
| 8 | Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver显示文摘Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of obesity.Although cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains obscure.Using high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor immunosurveillance.Transcriptome analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD patients.Notably,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC development.Moreover,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell depletion.Mechanistically,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and NAFLD-HCC.This study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic. | Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan Ka Fai To John Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng | 2022 | Cellular & Molecular Immunology2022，19，7： | 3 |
| 9 | HBsAg Seroclearance in Chronic Hepatitis B in Asian Patients: Replicative Level and Risk of Hepatocellular Carcinoma显示文摘 | Man–Fung Yuen Danny Ka–Ho Wong James Fung Philip Ip David But Ivan Hung Kevin Lau John Chi–Hang Yuen Ching–Lung Lai | 2008 | Gastroenterology2008，，4： | 2 |
| 10 | Weather Information Acquisition and Health Significance during Extreme Cold Weather in a Subtropical City:A Crosssectional Survey in Hong Kong显示文摘Health and disaster risk reduction are important and necessary components in building a smart city,especially when climate change may increase the frequency of extreme temperatures and the health risks of urban dwellers.However,limited knowledge is available about the best way to disseminate weather warnings and health protection information.This study explores the weather information acquisition patterns of the Hong Kong public and examines the sociodemographic predictors of these patterns to establish the potential public health implications of smart city development.A population-based,stratified crosssectional,random digit dialing telephone survey was conducted among the Cantonese-speaking population aged over 15 years in Hong Kong in early 2016.Analyses were conducted based on 1017 valid samples,with a response rate of 63.6%.Cold Weather Warnings were well disseminated in Hong Kong,with 95.7% of the respondents reporting awareness of the public warnings.Television and smartphone apps were the two most important channels for weather information acquisition.Age and education level are the main social-demographic variables associated with the current utilization and future preference of smartphone technology.Among those who were not using a preferredchannel to acquire weather information,61.3% considered switching to a smartphone app.Moreover,the patterns of individual health protection measures and self-reported health impacts were significantly different between smartphone app users and non-users.Weather information dissemination should be tailored to the sociodemographic characteristics of the users. | Emily Ying Yang Chan Zhe Huang Carman Ka Man Mark Chunlan Guo | 2017 | International Journal of Disaster Risk Science2017，8，2： | 2 |
| 11 | Cathelicidins in inflammation and tissue repair: Potential therapeutic applications for gastrointestinal disorders显示文摘Cathelicidins,主人防卫肽的一个家庭,高度在感染,发炎并且创伤愈合期间被表示。这些肽不仅举办用途广泛的抗菌剂活动,而且由在 diseased 纸巾改变 cytokine 反应和煽动性的房间的 chemoattraction 调制发炎。在这个连接,老鼠 cathelicidin 被表明了通过提高粘液生产并且减少支持 inflammatory cytokines 的生产在冒号阻止发炎。另外, cathelicidins 支持创伤在受伤纸巾通过 re-epithelialization 和 angiogenesis 的刺激愈合。在胃的溃疡的一个动物模型,老鼠 cathelicidin 支持溃疡由在 vitro 并且在 vivo 导致胃的上皮的房间的增长愈合。在结论, cathelicidins 在在胃肠的 mucosa 和另外的机关操作发炎和组织修理的复杂集成的天生的免疫系统代表受动器分子的一个重要的组。 | William Ka Kei WU Clover Ching Man WONG Zhi Jie LI Lin ZHANG Shun Xiang REN Chi Hin CHO | 2010 | Acta Pharmacologica Sinica2010，31，9： | 2 |
| 12 | Role of endothelin-1in lung disease显示文摘 | Fagan KA Mc Murtry IF Rod man DM | 2001 | Respir Res2001，2，2： | 1 |
| 13 | Eyelid movements before and after botu linum therapy in patients with lid spasm显示文摘 | Evinger C Sibony PA | 1990 | Ann Neurol1990，28，5： | 1 |
| 14 | Long non-coding RNA expression profiles predict clinical phenotypes in glioma显示文摘 | Xiaoqin Zhang Stella Sun Jenny Kan Suen Pu Anderson Chun On Tsang Derek Lee Venus On Ying Man Wai Man Lui Stanley Thian Sze Wong Gilberto Ka Kit Leung | 2012 | Neurobiology of Disease2012，，1： | 1 |
| 15 | A Voltage-Mode PWM Buck Regulator with End-Point Prediction显示文摘 | Man Siu Philip K T Mok Ka Nang Leung | 2006 | IEEE Transaction on Circuits and Systems-Ⅱ:Express Briefs2006，53，4： | 1 |
| 16 | A Long Financial March:Pension Reform in China显示文摘 | Daniel Beland Ka Man Yu | | 0，，02： | 1 |
| 17 | Candida glabrata sep- sis secondary to oral colonization, in bone marrow transplantation 显示文摘 | Redding SW Man' KA Kirkpatrick WR | 2004 | Med Mycol2004，42，2： | 1 |
| 18 | Identification of novel mutations in the ryanodine-receptor gene ( RyR1 ) in malignant hyperthermia : genotype-phenotype correlation 显示文摘 | Manning BM Quane KA Ording H | 1998 | Am J Hum Genet1998，62，： | 1 |
| 19 | Sources and seasonal variation of PAHs in the sediments of drinking water reservoirs in HongKong and the Dongjiang River(China)显示文摘 | Liang Yan Fung Pui Ka Tse Man Fung | 2008 | Environ Monit Assess2008，146，： | 1 |
| 20 | Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies in the targeted therapy era显示文摘Hepatitis due to hepatitis B virus(HBV)reactivation can be serious and potentially fatal,but is preventable.HBV reactivation is most commonly reported in patients receiving chemotherapy,especially rituximab-containing therapy for hematological malignancies and those receiving stem cell transplantation.Patients with inactive and even resolved HBV infection still have persistence of HBV genomes in the liver.The expression of these silent genomes is controlled by the immune system.Suppression or ablation of immune cells,most importantly B cells,may lead to reactivation of seemingly resolved HBV infection.Thus,all patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBsAg)and antibody to hepatitis B core antigen.Patients found to be positive for HBsAg should be given prophylactic antiviral therapy.For patients with resolved HBV infection,there are two approaches.The first is pre-emptive therapy guided by serial HBV DNA monitoring,and treatment with antiviral therapy as soon as HBV DNA becomes detectable.The second approach is prophy-lactic antiviral therapy,particularly for patients receiving high-risk therapy,especially anti-CD20 monoclonal antibody or hematopoietic stem cell transplantation.Entecavir and tenofovir are the preferred antiviral choices.Many new effective therapies for hematological malignancies have been introduced in the past decade,for example,chimeric antigen receptor(CAR)-T cell therapy,novel monoclonal antibodies,bispecific antibody drug conjugates,and small molecule inhibitors,which may be associated with HBV reactivation.Although there is limited evidence to guide the optimal preventive measures,we recommend antivi-ral prophylaxis in HBsAg-positive patients receiving novel treatments,including Bruton’s tyrosine kinase inhibitors,B-cell lymphoma 2 inhibitors,and CAR-T cell therapy.Further studies are needed to determine the risk of HBV reactivation with these agents and the best prophylactic strategy. | Joyce Wing Yan Mak Alvin Wing Hin Law Kimmy Wan Tung Law Rita Ho Carmen Ka Man Cheung Man Fai Law | 2023 | World Journal of Gastroenterology2023，29，33： | 1 |
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