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| 1 | Severe irinotecan-induced toxicity in a patient with UGT1A1*28 and UGT1A1*6 polymorphisms显示文摘Many studies have demonstrated the impact of UGT1A1 on toxicity of irinotecan. In particular, patients bear-ing UGT1A1*28 (TA 7/7) have a higher risk of severe neutropenia and diarrhea. Based on this, prescribers of irinotecan are advised that patients with UGT1A1*28 (TA 7/7) should start with a reduced dose of irinotecan, although a particular dose is not specified. Research in Asian countries has shown a lower incidence of UG-T1A1*28 (TA 7/7), while UGT1A1*6 (A/A) is more often found and is associated with severe irinotecan-related neutropenia. We report here a case of a metastatic colorectal cancer patient who is heterozygous for the UGT1A1*28 polymorphism (TA 6/7) as well as the UG-T1A1*6 polymorphism (G/A). The patient was treated with FOLFIRI for 9 cycles and underwent two irinote-can dose reductions according to pharmacokinetic data regarding exposure to the active metabolite, SN-38. Simultaneous heterozygous UGT1A1*28 and UGT1A1*6 polymorphisms may produce higher exposure to SN-38 and a higher risk of adverse effects related to irinote-can. Additional studies will be necessary to determine the optimal starting dose of irinotecan for patients with both UGT1A1*28 and UGT1A1*6 polymorphisms. | Jian-Ming Xu Yan Wang Fei-Jiao Ge Li Lin Ze-Yuan Liu Manish R Sharma | 2013 | World Journal of Gastroenterology2013，19，24： | 14 |
| 2 | Current status of imaging in nonalcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is the most common diffuse liver disease, with a worldwide prevalence of 20% to 46%. NAFLD can be subdivided into simple steatosis and nonalcoholic steatohepatitis. Most cases of simple steatosis are non-progressive, whereas nonalcoholic steatohepatitis may result in chronic liver injury and progressive fibrosis in a significant minority. Effective risk stratification and management of NAFLD requires evaluation of hepatic parenchymal fat, fibrosis, and inflammation. Liver biopsy remains the current gold standard; however, non-invasive imaging methods are rapidly evolving and may replace biopsy in some circumstances. These methods include well-established techniques, such as conventional ultrasonography, computed tomography, and magnetic resonance imaging and newer imaging technologies, such as ultrasound elastography, quantitative ultrasound techniques, magnetic resonance elastography, and magnetic resonancebased fat quantitation techniques. The aim of this article is to review the current status of imaging methods for NAFLD risk stratification and management, including their diagnostic accuracy, limitations, and practical applicability. | Qian Li Manish Dhyani Joseph R Grajo Claude Sirlin Anthony E Samir | 2018 | World Journal of Hepatology2018，10，8： | 6 |
| 3 | Plasma glucose and tumour necro- sis factor-ctin adult patientswith severe falciparum malaria 显示文摘 | Manish R Tfipathy R Das B | 2003 | Trop Med Int Health2003，8，： | 1 |
| 4 | Surface chemical modification of silica aerogels using various alkyl/alkoxyl chlorosilanes显示文摘 | VENKATESWARA R A MANISH M | 2003 | Appl Surf Sci2003，206，： | 1 |
| 5 | Hydrophobic properties of TMOS/TMES-based silica aerogels显示文摘 | VENKATESWARA R A MANISH M | 2002 | Mater Res Bull2002，37，： | 1 |
| 6 | In vivo video rate optical coherence tomography显示文摘 | ANDREW M R MANISH D K SIAVASH Y et a l | 1998 | Optics Express1998，3，6： | 1 |
| 7 | Seismic damage detection in building frame via finite element model updating显示文摘 | Shiradhonkar S R Manish Shrikhande | 2011 | Computers and Structures2011，89，： | 1 |
| 8 | Solid particle erosion behaviour of metallic materials at room and elevated temperatures显示文摘 | Sundararajan G Manish R | 1997 | Tribology International1997，30，5： | 1 |
| 9 | Erosive wear of hardfaced Fe-Cr-C alloys at elevated temperature显示文摘 | KATSICHA C BADISCHA E MANISH R | 2009 | Wear2009，267，： | 1 |
| 10 | Review on Biodentine-A Bioactive Dentin Substitute 显示文摘 | Priyalakshmi S Manish R | 2014 | Journal of Dental and Medical Sciences2014，13，1： | 1 |
| 11 | Minimally invasive versus open transforaminal lumbar interbody fusion for degenerative spondylolisthesis grades 1-2:patient-reported clinical outcomes and cost-utility analysis显示文摘 | Wale A R Manish S | 2014 | The Ochsner Journal2014，14，1： | 1 |
| 12 | Intraventricular gan- glioglioma with bleed: a rare case report显示文摘 | Bhat D I Mahadevan A Manish R | 2010 | Neurol India2010，58，3： | 1 |
| 13 | A randomized con- trolled clinical trial to compare the safety and efficacy of edaravone in acute ischemic stroke 显示文摘 | Sharma Pawan Sinha Manish Shukla R | 2011 | Annals of Indian Academy of Neurology2011，14，2： | 1 |
| 14 | Migration ofradionuclides from a high-level radioactive waste repository in deep geological formations显示文摘 | Manish Chopra Nair R N Faby Sunny | 2014 | Environ Earth Sci2014，，： | 1 |
| 15 | Comparison of bio-hydrogen production processes显示文摘 | Manish S Banerjee R | 2008 | International Journal of Hydrogen Energy2008，33，1： | 1 |
| 16 | Conse- quence of pH variation on the dielectric properties of Cr- doped lithium ferrite nanoparticles synthesized by the sol- gel method显示文摘 | Manish Srivastava Mishra R K Jay Singh | 2015 | Journal of Alloys and Compounds2015，645，： | 1 |
| 17 | Japanese encephalitis virus: from genome to infectome显示文摘 | Salini Krishnan Unni Daniel R??ek Chintan Chhatbar Ritu Mishra Manish K. Johri Sunit K. Singh | 2011 | Microbes and Infection2011，，4： | 1 |
| 18 | Integration of scheduling with computer aided process planning显示文摘 | Manish K Sunil R | 2003 | Journal of Materials Processing Technology2003，138，： | 1 |
| 19 | Critical Insight into Direct Reduction of Iron Ores 显示文摘 | AMIT C MANISH R | 2009 | Steel Times International2009，33，8： | 1 |
| 20 | Comparison of biohydrogen production processes 显示文摘 | MANISH S BANERJEE R | 2008 | International Journal of Hydrogen Energy2008，33，1： | 1 |
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