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| 1 | Inflammation-related gene expression profiles of salivary extracellular vesicles in patients with head trauma显示文摘At present,there is no reliable biomarker for the diagnosis of traumatic brain injury(TBI).Studies have shown that extracellular vesicles released by damaged cells into biological fluids can be used as potential biomarkers for diagnosis of TBI and evaluation of TBI severity.We hypothesize that the genetic profile of salivary extracellular vesicles in patients with head trauma differs from that in uninjured subjects.Findings from this hypothesis would help investigate the severity of TBI.This study included 19 subjects,consisting of seven healthy controls who denied history of head trauma,six patients diagnosed with concussion injury from an outpatient concussion clinic,and six patients with TBI who received treatment in the emergency department within 24 hours after injury.Real-time PCR analysis of salivary extracellular vesicles in participants was performed using TaqMan Human Inflammation array.Gene expression analysis revealed nine upregulated genes in emergency department patients(LOX5,ANXA3,CASP1,IL2RG,ITGAM,ITGB2,LTA4H,MAPK14,and TNFRSF1A)and 13 upregulated genes in concussion clinic patients compared with healthy participants(ADRB1,ADRB2,BDKRB1,HRH1,HRH2,LTB4R2,LTB4R,PTAFR,CYSLTR1,CES1,KLK1,MC2R,and PTGER3).Each patient group had a unique profile.Comparison between groups showed that 15 inflammation-related genes had significant expression change.Our results indicate that inflammation biomarkers can be used for diagnosis of TBI and evaluation of disease severity.This study was approved by the Institutional Review Board on December 18,2015(approval No.0078-12)and on June 9,2016(approval No.4093-16). | Yan Cheng Mandy Pereira Neha P.Raukar John L.Reagan Mathew Quesenberry Laura Goldberg Theodor Borgovan W Curt LaFrance Jr Mark Dooner Maria Deregibus Giovanni Camussi Bharat Ramratnam Peter Quesenberry | 2020 | Neural Regeneration Research2020，15，4： | 2 |
| 2 | Encapsulation of Curcumin in Cationic Micelles Suppresses Alkaline Hydrol- ysis 显示文摘 | MANDY H M L HANNAH C TAK W K | 2008 | Langmuir2008，24，： | 1 |
| 3 | The role of faults in hydrocarbon migration and trapping in Nigerian growth fault structures显示文摘 | WEBER K J MANDI G PILAAR W F | 1978 | Tenth Annual Offshore Technology Conference Proceeding Houston Texas1978，62，4： | 1 |
| 4 | Diagnostic value of post-heparin lipase testing in detecting common genetic variants in the LPL and LIPC genes显示文摘 | Mandy V H Geesje M D T Ewout W S | 2009 | European J Human Genetics2009，17，11： | 1 |
| 5 | Social communication competence and functional adaptation in a general population of children: preliminary evidence for sex-by-verbal IQ differential risk显示文摘 | Skuse DH Mandy W Steer C | 2009 | J Am Acad Child Adolesc Psychiatry2009，48，2： | 1 |
| 6 | Organotypic cultures of chick dorsal root ganglia in a semi-solid medium: A model for neurotoxicity testing 显示文摘 | Mandys V Tureek R Gispen W H | 1994 | Toxicology in Vitro1994，8，1： | 1 |
| 7 | High-FluxSolar-Driven Thermochemical Dissociation of CO2 andH2O Using Nonstoichiometric Ceria 显示文摘 | Chueh W C Christoph F Mandy A | 2010 | Science2010，330，： | 1 |
| 8 | Assessing landslide potential using GIS,soil wetness modeling and topographic attributes,Payette River,Idaho显示文摘 | Mandy Lineback Gritzner Andrew Marcus W Richard Aspinall | | 0，，1： | 1 |
| 9 | Evaluation of handgrip strength as a nutritional marker and prognostic indicator in peritoneal dialysis patients显示文摘 | Angela Yee - Moon W Mandy Man - Mei S Zoe So - Ying H | 2005 | Am J Clinical Nutrition2005，81，： | 1 |
| 10 | Assessing landslide potential using GIS, soil wetness modeling and topographic attributes, Payette River, Idaho 显示文摘 | MANDY L G ANDREW M W RICHARD A | 2001 | Geomorphology2001，37，2： | 1 |
| 11 | 5-Fluorouracil-related enhancement of adenoviral infection is Coxsackievirus-adenovirus receptor independent and associated with morphological changes in lipid membranes显示文摘瞄准:评估在 adenoviral 感染上位于 5 氟尿嘧啶(5-FU ) 的效果下面的机制。方法:表示人的结肠癌房间线的低、高的 Coxsackievirus 侵入人体气管粘膜的病菌受体(汽车) 与 5-FU 和二删除 E1 的 adenoviral 构造被对待,一转 GFP (Ad/CMV-GFP ) 另外的 bax (Ad/CEA-bax ) 。感染的房间的数字被 GFP 表示监视。为了在受体评估 5-FU 的效果,释放系统, Ad/GFP 在 lipo 被包含一些并且与 5-FU 对待。Ad/GFP 版本与上层清液与 293 个房间的 PCR 和感染被估计。建筑群被使调查词法的 Ad5-GFP-liposome 的电子显微镜学在 5-FU 以后 lipo 改变一些。结果:所有房间线的感染率与新兴的 5-FU 集中从 50% ~ 98% 增加了。提高的病毒的举起独立于 CAR 表示。另外, 5-FU 对待一些释放了的 lipo 2-2.5 时间更多的侵入人体气管粘膜的病菌。而且, 5-FU-treated lipo 一些显得不规则并且象多孔一样。结论:不管汽车, Adenoviral 举起面对 5-FU 被提高并且在做两个的联合的膜与词法变化被联系在基因治疗的一种有希望的选择。 | Chiara Cabrele Mandy Vogel Pompiliu Piso Markus Rentsch Josef Schroder Karl W Jauch Hans J Schlitt Alexander Beham | 2006 | World Journal of Gastroenterology2006，12，32： | 0 |
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