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| 1 | Proteomic Analysis Shows Constitutive Secretion of MIF and p53-associated Activity of COX-2-/-Lung Fibroblasts显示文摘The differential expression of two closelyassociated cyclooxygenase isozymes, COX-1 and COX-2, exhibited functions beyond eicosanoid metabolism. We hypothesized that COX-1 or COX-2 knockout lung ?broblasts may display altered protein pro?les which may allow us to further differentiate the functional roles of these isozymes at the molecular level. Proteomic analysis shows constitutive production of macrophage migration inhibitory factor(MIF) in lung ?broblasts derived from COX-2^(-/-)but not wild-type(WT) or COX-1à/àmice. MIF was spontaneously released in high levels into the extracellular milieu of COX2^(-/-) ?broblasts seemingly from the preformed intracellular stores, with no change in the basal gene expression of MIF. The secretion and regulation of MIF in COX-2^(-/-)was ‘‘prostaglandin-independent.' GO analysis showed thatconcurrent with upregulation of MIF, there is a signi?cant surge in expression of genes related to?broblast growth, FK506 binding proteins, and isomerase activity in COX-2^(-/-)cells. Furthermore,COX-2^(-/-)?broblasts also exhibit a signi?cant increase in transcriptional activity of various regulators, antagonists, and co-modulators of p53, as well as in the expression of oncogenes and related transcripts. Integrative Oncogenomics Cancer Browser(Intro Gen) analysis shows downregulation of COX-2 and ampli?cation of MIF and/or p53 activity during development of glioblastomas,ependymoma, and colon adenomas. These data indicate the functional role of the MIF-COXp53 axis in in?ammation and cancer at the genomic and proteomic levels in COX-2-ablated cells.This systematic analysis not only shows the proin?ammatory state but also unveils a molecular signature of a pro-oncogenic state of COX-1 in COX-2 ablated cells. | Mandar Dave Abul B.M.M.K.Islam Roderick V.Jensen Agueda Rostagno Jorge Ghiso Ashok R.Amin | 2017 | Genomics, Proteomics & Bioinformatics2017，15，6： | 2 |
| 2 | Investigation of Paraffin Deposition During Multi-phase Flow in Pipelines and Wellbores-Part 1: Ex-periments显示文摘 | Mandar S Apte Hong-Quan Zhang Michael Volk etal | 2002 | Journal of Energy Resources Technol-ogy2002，124，3： | 1 |
| 3 | Myeoplasmas in semen of chronic prostatitis patients 显示文摘 | MANDAR R RAUKAS E TURK S | 2005 | Scand J Urol Nephrol2005，39，6： | 1 |
| 4 | Spectroscopic study of nanocrystalline TiO2 thin films grown by atomic layer deposition 显示文摘 | SUISALU A AARIK J MaNDAR | 1998 | The Solid Films1998，336，： | 1 |
| 5 | Investigation of paraffin deposition during multiphase flow in pipelines and wellbores-Part2: Modeling显示文摘 | Matzain A Mandar A | 2001 | Journal of Energy Resources Technology2001，123，： | 1 |
| 6 | Cellular effects of CPT-11 on colon carcinoma cells: dependence on P53 and h MLH1 status显示文摘 | ROBERTA M MANDAR R MARIE-LUISE HANSKI | 2004 | Int J Cancer2004，101，： | 1 |
| 7 | Mycoplasmas in semen of chronic prostatitis patients显示文摘 | Mandar R Raukas E Ttirk S | 2005 | Scand J Urol Nephrol2005，39，6： | 1 |
| 8 | Ultrasound-promoted synthesis of 1-amidoalkyl-2-naphthols via a three-component condensation of 2-naphthol, ureas/amides, and aldehydes, catalyzed by sulfamic acid under ambient conditions显示文摘 | Sachin B. Patil Pankajkumar R. Singh Mandar P. Surpur Shriniwas D. Samant | 2006 | Ultrasonics - Sonochemistry2006，，5： | 1 |
| 9 | Lung func- tion changes and complications after lobectomy for lung cancer in septuagenarians显示文摘 | Subotic D Mandaric D Radosavljevic G | 2009 | Ann Thorac Med2009，4，2： | 1 |
| 10 | Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches显示文摘 | Robert Machold Shigemi Hayashi Michael Rutlin Mandar D Muzumdar Susana Nery Joshua G Corbin Amel Gritli-Linde Tammy Dellovade Jeffery A Porter Lee L Rubin Henryk Dudek Andrew P McMahon Gord Fishell | 2003 | Neuron2003，，1： | 1 |
| 11 | Underwateracoustic communica- tions and networking : recent advances and {uture eb, a),|enges显示文摘 | Mandar C Shiraz S Stojanovic M | 2008 | Ma- rine Technology Society Journal2008，42，1： | 1 |
| 12 | Oral lactobacilli in chronic periodontitis and periodontal health:species composition and antimicrobial activity显示文摘 | KOLL KLAIS P MANDAR R LEIBUR E | 2011 | Oral Microbial Immunol2011，20，6： | 1 |
| 13 | Texture development in nanocrystalline hafnium dioxide thin films grown by atomic layer deposition 显示文摘 | Aarik J Aidla A Mandar H etal | 2000 | Journal of Crystal Growth2000，220，： | 1 |
| 14 | Acid catalyzed stereoselective rearangement and dimerization of avenes:synthesis of dependensin显示文摘 | Mandar D David S B Naresh K | 2007 | Tetrahedmn2007，63，： | 1 |
| 15 | Transmission of mother's micro-flora to the newborn at birth显示文摘 | Mandar R Mikelsaar M | | 0，，01： | 1 |
| 16 | Neurotrophic factor expres-sion in expandable cell populations from brain samples in living patients with Parkinson's disease 显示文摘 | Hu X Louiza B Mandar J | 2013 | Res Com2013，2，： | 1 |
| 17 | Childhood osteosarcoma relapse-treatment results and prognostic factors显示文摘 | Bekic Z Mandaric D Ilic V | 2009 | Eur Cancer J Suppl2009，7，2： | 1 |
| 18 | MycoplasmAs in semen ofchronic prostatitia paiens显示文摘 | Mandar g EAukas E Turk S eLal | 2005 | Scand J Urol Nephrol2005，39，6： | 1 |
| 19 | Spectroscopic study of nanocrystalline TiO, thin films grown by atomic layer deposition 显示文摘 | SUISALU A AARIK J MANDAR H SILDOS I | 1998 | Thin Solid Films1998，336，12： | 1 |
| 20 | Features Associated With,and the Impact of,Hemolytic Anemia in Patients With Systemic Lupus Erythematosus:LX,Results From a Multiethnic Cohort显示文摘 | Sergio Durán M D Mandar Apte M D Msph | 2008 | Arthritis Rheum2008，59，9： | 1 |
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