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| 1 | Effects of six compounds with different chemical structures on melanogenesis显示文摘Several chemical compounds can restore pigmentation in vitiligo through mechanisms that vary according to disease etiology.In the present study,we investigated the melanogenic activity of six structurally distinct compounds,namely,scopoletin,kaempferol,chrysin,vitamin D_3,piperine,and 6-benzylaminopurine.We determined their effectiveness,toxicity,and mechanism of action for stimulating pigmentation in B16F10 melanoma cells and in a zebrafish model.The melanogenic activity of 6-benzylaminopurine,the compound identified as the most potent,was further verified by measuring green fluorescent protein concentration in tyrp1 a:eGFP(tyrosinase-related protein 1)zebrafish and mitfa:eGFP(microphthalmia associated transcription factor)zebrafish and antioxidative activity.All the tested compounds were found to enhance melanogenesis responses both in vivo and in vitro at their respective optimal concentration by increasing melanin content and expression of TYR and MITF.6-Benzyamino-purine showed the strongest re-pigmentation action at a concentration of 20μmol·L^(-1 )in vivo and 100μmol·L^(-1) in vitro,and up-regulated the strong fluorescence expression of green fluorescent protein in tyrp1 a:e GFP and mitfa:e GFP zebrafish in vitro.However,its relative anti-oxidative activity was found to be very low.Overall,our results indicated that 6-benzylaminopurine stimulated pigmentation through a direct mechanism,by increasing melanin content via positive regulation of tyrosinase activity in vitro,as well as up-regulating the expression of the green fluorescent protein in transgenic zebrafish in vivo. | Rakotomalala Manda Heriniaina DONG Jing Praveen Kumar Kalavagunta WU Hua-Li YAN Dong-Sheng SHANG Jing | 2018 | Chinese Journal of Natural Medicines2018，16，10： | 2 |
| 2 | Synthesis and screening of some novel substituted indoles contained 1,3,4-oxadiazole and 1,2,4-triazole moiety显示文摘<正>A series of novel 3-[5-(1H-indol-3-yl-methyl)-2-oxo-[1,3,4]oxadiazol-3-yl]propionitrile(5),3-[4- amino-3-(1H-indol-3-yl-methyl)-5-oxo-4,5-dihydro-[1,2.4]triazol-1-yljpropionitrile(6),3-[5-(1H- indol-3-yl-methyl)-2-thioxo-[1,3,4]oxadiazol-3-yl]propionitrile(7) and 3-[4-amino-3-(1H-indol-3-yl-methyl) -5-thioxo-4,5-dihydro-[1,2,4]triazol-l -yljpropionitrile(8) were synthesized in good yields from the intermediate(1H-indol-3-yl)-acetic acid N’-(2-cyanoethyl)hydrazide(4).The chemical structures of the newly synthesized compounds were elucidated by their IR,~1H NMR and MS.Further,all the compounds were screened for their antimicrobial activity against Gram-positive,Gram-negative bacteria and also tested their ability toward anti-inflammatory activity. | Hemalatha Gadegoni Sarangapani Manda | 2013 | Chinese Chemical Letters2013，24，2： | 2 |
| 3 | Integrative Genomic Profiling of Human Prostate Cancer显示文摘 | Barry S. Taylor Nikolaus Schultz Haley Hieronymus Anuradha Gopalan Yonghong Xiao Brett S. Carver Vivek K. Arora Poorvi Kaushik Ethan Cerami Boris Reva Yevgeniy Antipin Nicholas Mitsiades Thomas Landers Igor Dolgalev John E. Major Manda Wilson Nicholas D. | 2010 | Cancer Cell2010，，： | 2 |
| 4 | Molecular evolution of Na^(+) channels in teleost fishes显示文摘Voltage-dependent sodium channels are critical for electrical excitability.Invertebrates possess a single sodium channel gene;two rounds of genome duplication early in vertebrates increased the number to four.Since the teleost-tetrapod split,independent gene duplications in each lineage have further increased the number of sodium channel genes to 10 in tetrapods and 8 in teleosts.Here we review how the occurrence of multiple sodium channel paralogs has influenced the evolutionary history of three groups of fishes:pufferfish,gymnotiform and mor-myriform electric fish.Pufferfish(tetraodontidae)produce a neurotoxin,tetrodotoxin,that binds to and blocks the pore of sodium channels.Pufferfish evolved resistance to their own toxins by amino acid substitutions in the pore of their sodium channels.These substitutions had to occur in parallel across multiple paralogs for organismal re-sistance to evolve.Gymnotiform and mormyriform fishes independently evolved electric organs to generate elec-tricity for communication and object localization.Two sodium channel genes are expressed in muscle in most fishes.In both groups of weakly electric fishes,one gene lost its expression in muscle and became compartmen-talized in the evolutionary novel electric organ,which is a muscle derivative.This gene then evolved at elevated rates,whereas the gene that is still expressed in muscle does not show elevated rates of evolution.In the electric organ-expressing gene,amino acid substitutions occur in parts of the channel involved in determining how long the channel will be open or closed.The enhanced rate of sequence evolution of this gene likely underlies the spe-cies-level variations in the electric signal. | Harold H.ZAKON Manda C.JOST Derrick J.ZWICKL Ying LU David M.HILLIS | 2009 | Integrative Zoology2009，4，1： | 2 |
| 5 | TH2Cytokine-enhanced and TGF-beta-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by IFNgamma and corticosteroids显示文摘 | Wen F Q Liu X Manda W | 2003 | J Allergy Clin Immunol2003，111，6： | 1 |
| 6 | In vitro antimicrobial activity of gatifloxacin against 873 clinical isolates from respiration tract, urinary tract and surgical infections during 1997-1998 in Japan显示文摘 | Tsurumaki Y Manda H Takei M | 2002 | Antimicrob Chemother2002，45，5： | 1 |
| 7 | Differential expression of the lamb3 and LAMC2 genes between small cell and non - small cell lung carcinomas显示文摘 | Manda R Kohno T Niki T | 2000 | Biochem Biophys Res Commun2000，，2： | 1 |
| 8 | Th2 cytokine-enhanced and endothelial growth factor airway smooth muscle cells is attenuated by IFN-gamma and corticosteroids显示文摘 | Wen FQ Liu X Manda W et TGF-beta-enhanced vascular production by cultured human al | 2003 | J Allergy Clin Immunol2003，111，6： | 1 |
| 9 | Significance of catecholamines and cortisol levels in blood during transportation stress in goats 显示文摘 | Nwe T M Hori E Manda M | 1996 | Small Ruminant Research1996，20，： | 1 |
| 10 | Evaluation of polycyclic aromatic hydrocarbons (PAHs) content in foods sold in adobo market,Abidjan,C6te d'Ivoire显示文摘 | MANDA P DANO D S EHILE E S | 2012 | Toxicology and Environmental Health Sciences2012，4，6： | 1 |
| 11 | The HIV proteins (gpl20 and tat)and methamphetamine in oxidative stress- induced damage in the brain:the potential role of the thiol antioxidant N-acetyleysteine amide 显示文摘 | Banerjee A Zhang X Manda KR | 2010 | Free Radic Biol Meal2010，13，10： | 1 |
| 12 | Th2 Cytokine-enhanced and TGF-beta-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by INF-gamma and corticosteroids显示文摘 | LIU X MANDA W | 2003 | J Allergy Clin Immunol2003，111，： | 1 |
| 13 | Prevalence of renal artery stenosis requiring revascularization in patients initially referred for coronary angiography显示文摘 | Khosla S Kunjummen B Manda R | 2003 | Catheter Cardiovasc Interv2003，58，： | 1 |
| 14 | Identification of gene (spon2 and c20 orf2) differentially expressed between cancerous and non cancerous lung by mRNA differential display显示文摘 | Manda R Kohno T Matsuno Y | 1999 | Genomics1999，61，1： | 1 |
| 15 | Comparison of real time two- dimensional with live/real time three- dimensional transesopha- geal echocardiography in the evaluation of mitral valve prolapse and chordae rupture 显示文摘 | Manda J Kesanolla SK Hsuing MC | 2008 | Echocardiography2008，25，10： | 1 |
| 16 | HIV proteins (gp120 and Tat) and methamphetamine in oxidative stress-induced damage in the brain: potential role of the thiol antioxidant N -acetylcysteine amide显示文摘 | Banerjee A Zhang X Manda KR | 2010 | Free Radic Bioi Med2010，48，： | 1 |
| 17 | Finite element simulations of a focal knee reurfacing implant applied to localized carti- lage defects in a sheep model 显示文摘 | Manda K Ryd L Eriksson A | 2011 | J Biomech2011，44，5： | 1 |
| 18 | Inactivation of the PTEN/MMAC1/TEP1 gene in human lung cancer显示文摘 | Kohno T Takahashi M Manda R | 1998 | Genes Chromosomes Cancer1998，22，： | 1 |
| 19 | Th2 cytokine enhanced and TGF bata-enhanced vascular endothelial growth factor produc tion by cultured human airway smooth muscle cells is attenuated by IFN-gamma and corticosteroid 显示文摘 | Wen FQ Liu X Manda W | 2003 | J Allergy Clin Immonol2003，111，： | 1 |
| 20 | Comparison of real time two-dimensional with live/real time three-dimensional transesophageal echocardiography in tile evaluation of mitral valve prolapse and chordae rupture 显示文摘 | Manda J Kesanolla SK Hsuing MC | 2008 | Echocardiography2008，25，10： | 1 |
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