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| 1 | Syringomyelia associated with cervical spondylosis: A rare condition显示文摘Spinal spondylosis is an extremely common condition that has only rarely been described as a cause of syringomyelia. We describe a case of syringomyelia associated with cervical spondylosis admitted at our division and treated by our institute. It is the case of a 66-yearold woman. At our observation she was affected by moderate-severe spastic tetraparesis. T2-weighted magnetic resonance imaging(MRI) showed an hyperintense signal within spinal cord from C3 to T1 with a more sharply defined process in the inferior cervical spinal cord. At the same level bulging discs, facets and ligamenta flava hypertrophy determined a compression towards subarachnoid space and spinal cord. Spinal cord compression was more evident in hyperextension rather than flexion. A 4-level laminectomy and subsequent posterior stabilization with intra-articular screws was executed. At 3-mo follow up there was a regression of tetraparesis but motor deficits of the lower limbs residuated. At the same follow up postoperative MRI was executed. It suggested enlargement of the syrinx. Perhaps hyperintensity within spinal cord appeared 'bounded' from C3 to C7 with clearer margins. At the level of surgical decompression, subarachnoid space and spinal cord enlargement were also evident. A review of the literature was executed using Pub Med database. The objective of the research was to find an etiopathological theory able to relate syringomyelia with cervical spondylosis. Only 6 articles have been found. At the origin of syringomyelia the mechanisms of compression and instability are proposed. Perhaps other studies assert the importance of subarachnoid space regard cerebrospinal fluid(CSF) dynamic. We postulate that cervical spine instability may be the cause of multiple microtrauma towards spinal cord and consequently may damage spinal cord parenchyma generating myelomalacia and consequently syrinx. Otherwise the hemorrhage within spinal cord central canal can cause an obstruction of CSF outflow, finally generating the syrinx. On the other hand in cervical spondylosis the stenotic elements can affect subarachnoid space. These elements rubbing towards spinal cord during movements of the neck can generate arachnoiditis, subarachnoid hemorrhages and arachnoid adhesions. Analyzing the literature these 'complications' of cervical spondylosis are described at the origin of syringomyelia. So surgical decompression, enlarging medullary canal prevents rubbings and contacts between the bone-ligament structures of the spine towards spinal cord and subarachnoid space therefore syringomyelia. Perhaps stabilization is also necessary to prevent instability of the cervical spine at the base of central cord syndrome or syringomyelia. Finally although patients affected by central cord syndrome are usually managed conservatively we advocate, also for them, surgical treatment in cases affected by advanced state of the symptoms and MRI. | Alessandro Landi Lorenzo Nigro Nicola Marotta Cristina Mancarella Pasquale Donnarumma Roberto Delfini | 2013 | World Journal of Clinical Cases2013，1，3： | 7 |
| 2 | Trans-sacral screw fixation in the treatment of high dyplastic developmental spondylolisthesis显示文摘We describe the case of a 67-year-old woman with L5-S1 ontogenetic spondylolisthesis treated with pedicle fixation associated with interbody arthrodesis performed with S1-L5 trans-sacral screwing according to the technique of Bartolozzi. The procedure was followed by a wide decompressive laminectomy. The patient had a progressive improvement of the symptoms which gradually disappeared in 12 mo. The radiograph at 6 and 12 mo showed complete fusion system. The choice of treatment in L5-S1 ontogenetic spondylolithesis is related to a correct clinical and diagnostic planning(X-ray, computer tomography magnetic resonance imaging, Measurement). In particular, the severity index and the square of unstable zone, and the standard measurements already described in the literature, are important to understand and to plane the correct surgical strategy, that require, in most of the times, fusion and interbody artrodesis. | Alessandro Landi Nicola Marotta Cristina Mancarella Roberto Tarantino Roberto Delfini | 2013 | World Journal of Clinical Cases2013，1，3： | 4 |
| 3 | 360° fusion for realignment of high grade cervical kyphosis by one step surgery: Case report显示文摘Surgical treatment for cervical kyphotic deformity is still controversial. Circumferential approach has been well described in the literature but long terms outcomes are not well reported. Important to decide the correct treatment option is the preoperative radiological exams to value the type of deformity(flexible or fixed). We report the case of a 67-year-old woman affected by a severe cervical kyphotic deformity who underwent combined anterior/posterior surgical approach, getting a good reduction of the deformity and an optimal stability in a long term follow up. | Alessandro Landi Nicola Marotta Cristina Mancarella Demo Eugenio Dugoni Roberto Tarantino Roberto Delfini | 2014 | World Journal of Clinical Cases2014，2，7： | 4 |
| 4 | Distributed multi-generation: A comprehensive view显示文摘 | Gianfranco Chicco Pierluigi Mancarella | 2007 | Renewable and Sustainable Energy Reviews2007，，3： | 3 |
| 5 | First description of cervical intradural thymoma metastasis显示文摘Thymoma and thymic carcinoma are rare epithelial tumors, which originate from the thymus gland. According to the World Health Organization there are 'organotypic'(types A, AB, B1, B2, and B3) and 'non-organotypic'(thymic carcinomas) thymomas. Type B3 thymomas are aggressive tumors, which can metastasize. Due to the rarity of these lesions, only 7 cases of extradural metastasis are described in the literature. We report the first and unique case of a man with cervical intradural B3 thymoma metastasis. A 46-year-old man underwent thymoma surgical removal. The year after the procedure he was treated for a parietal pleura metastasis. In 2006 he underwent cervical-dorsal extradural metastasis removal and C5-Th1 stabilization. Seven years after he came to our observation complaining left cervicobrachialgia and a reduction of strength of the left arm. He underwent a cervical spine magnetic resonance imaging, which showed a new lesion at the C5-C7 level. The patient underwent a surgery for the intradural B3 thymoma metastasis. Neurological symptoms improved although the removal was subtotal. He went through postoperative radiation therapy with further mass reduction. Spinal metastases are extremely rare. To date, only 7 cases of spinal extradural metastasis have been described in the literature. This is the first case of spinal intradural metastasis. Early individuation of these tumors and surgical treatment improve neurological outcome in patients with spinal cord compression. A multimodal treatment including neoadjuvant chemotherapy, surgery and postoperative radiation therapy seems to improve survival in patients with metastatic thymoma. | Nicola Marotta Cristina Mancarella Davide Colistra Alessandro Landi Demo Eugenio Dugoni Roberto Delfini | 2015 | World Journal of Clinical Cases2015，3，11： | 3 |
| 6 | A Multidisciplinary Method for Evaluating Ship Stability显示文摘 | Francesca Calabrese Luisa Mancarella Alessandro Antonio Zizzari Angelo Corallo | 2012 | Journal of Shipping and Ocean Engineering2012，2，6： | 3 |
| 7 | Promotion of regeneration of corticospinal tract axons in rats with reeombinant vascular endothelial growth factor alone and combined with adenovirus coding for this factor 显示文摘 | Facchiano F Fernandez E Mancarella S | 2002 | J Neurosorg2002，97，1： | 1 |
| 8 | Malpractice in Radiology: What Should You Worry About?显示文摘 | Alessandro Cannavale Mariangela Santoni Paola Mancarella Roberto Passariello Paolo Arbarello Ali Guermazi | 2013 | Radiology Research and Practice2013，，： | 1 |
| 9 | Assessment of the greenhouse gas emissions from cogeneration and trigeneration systems. Part II: Analysis techniques and application cases显示文摘 | Pierluigi Mancarella Gianfranco Chicco | 2007 | Energy2007，，3： | 1 |
| 10 | OMOS-compatible fabrication of thermopiles with high sensitivity in the 3-5 μm atmospheric window显示文摘 | Roncaglia A Mancarella F Cardinali G C | 2007 | Sensors and Actuators B2007，125，1： | 1 |
| 11 | Promotion of regeneration of corticospinal tract axons in rats with recombinant vascular endothelial growth factor alone and combined with adenovims coding for this factor显示文摘 | Facchiano F Fernandez E Mancarella S | 2002 | J Neurosurg2002，97，1： | 1 |
| 12 | Isotactic Polypropylene/Ethylene-co-Propylene Blends: Effects of the Copolymer Microstructure and Content on Rheology, Morphology and Properties of Injection Moulded Samples 显示文摘 | D Orazio L Mancarella C Martuscelli E | 1999 | Polymer1999，40，10： | 1 |
| 13 | Rescue andworsening of congenital heart block-associated electrocardiographicabnormalities in two transgenic mice显示文摘 | Karnabi E Qu Y Mancarella S | 2011 | J CardiovascElectrophysiol2011，22，8： | 1 |
| 14 | Production system with negation as failure 显示文摘 | Phan Minh Dung Mancarella P | 2002 | Knowledge and Data Engineering2002，14，2： | 1 |
| 15 | Crystalline kinetics of poly(vinylidene fluoride)显示文摘 | MANCARELLA C MARTUSCELLI E | 1977 | Polymer1977，18，12： | 1 |
| 16 | Insulin secretion defects of human type 2 diabetic islets are corrected in vitro by a new reactive oxygen species scavenger显示文摘 | Lupi R Del Guerra S Mancarella R | 2007 | Diabetes Metab2007，335，： | 1 |
| 17 | Promotion of regeneration of corticospinal tract axons in rats with recombinant vascular endothelial growth factor alone and combined with adenovirus coding for this factor显示文摘 | Facchiano F Fernandez E Mancarella S | 2002 | Neurosurg2002，97，1： | 1 |
| 18 | Promotion of regeneration of corticospinal tract axons in rats with recombinant vascular endothelial growth factor alone and combined with adenovirus coding for this factor显示文摘 | Facchiano F Fernandez E Mancarella S | 2002 | J Neurosurg2002，97，： | 1 |
| 19 | Promotion of regeneration of corticospinal tract axons in rats with recmnbinant vascular endothelial growth factor alone and combined with adenovirus coding for this factor 显示文摘 | Facchiano F Fernandez E Mancarella S | 2002 | J Neurosurg2002，97，： | 1 |
| 20 | Impaired Ca^2+ homeostasis is associated with atrial fibrillation in the odD L-type Ca^2+ channel KO mouse显示文摘 | Mancarella S Yue Y Karnabi E | 2008 | Am J Physiol Heart Circ Physiol2008，295，5： | 1 |
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