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| 1 | Antibody engineering: facing new challenges in cancer therapy显示文摘Antibody-based therapeutics are beginning to realize the promise enclosed in their early denomination as “magic bullets”. Initial disappointment has turned into clinical and commercial success, and engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials. Recent structural and functional data have allowed the design of a new generation of therapeutic antibodies, with strategies ranging from complement-mediated and antibody-dependant cellular cytotoxicity enhancement to improved cytotoxic payloads using toxins, drugs,radionucleids and viral delivery. This review considers the structure of different types of recombinant antibodies, their mechanism of action and how their efficacy has been increased using a broad array of approaches. We will also focus on the additional benefits offered by the use of gene therapy methods for the in vivo production of therapeutic antibodies. | Laura S■NZ ■ngel M CUESTA Mana COMPTE Luis ■LVAREZ-VALLINA | 2005 | Acta Pharmacologica Sinica2005，26，6： | 5 |
| 2 | Clinical-radiological-pathological correlation of cavernous sinus hemangioma: Incremental value of diffusion-weighted imaging显示文摘AIM To elucidate the clinical, magnetic resonance imaging(MRI), pathological features of these lesions and asses the incremental value of diffusion-weighted imaging(DWI) in diagnosing them.METHODS Fifteen consecutive patients(11 females and 4 males; mean age 40.93 years; age range 13-63 years) with cavernous sinus hemangiomas(CSH) who underwent examination between November 2008 and May 2016 were included for the analysis. MRI, clinical and surgical findings of each patient was retrospectively reviewed. DWI were also analysed and mean-apparent diffusion coefficient(ADC) value was calculated. Eleven patients underwent surgical removal of the lesion and 2 patients had biopsy only. Diagnosis of CSH was confirmed histologically in 13 patients.RESULTS Eleven patients(73%) presented with headaches and 10(66%) had cranial nerve involvement. Extra cavernous sinus extension was noted in 14(94%). Surgery was performed in 13(87%) and post-operative radiation was given to 4(28%) patients. Thirteen patients remained asymptomatic on follow up. Three conspicuous imaging features were highly suggestive of the diagnosis: Lack of diffusion restriction(100%), homogeneous hyperintensity on T2 weighted image sequences(93.3%) and intense post-contrast enhancement(100%). The mean ADC was 1.82 × 10-3 ± 0.2186 cm2/s.CONCLUSION T1-weighted hypointensity with homogeneous hyperintensity on T2-weighted sequences, intense enhancement and absence of hemosiderin within the lesion on GRE sequence favour the diagnosis. Facilitated diffusion on DWI differentiates CSH from other solid cavernous sinus lesions and significantly improves the diagnostic accuracy, a critical factor for planning surgery. | Abhishek Mahajan Vedula Rajni Kanth Rao Gudipati Anantaram Ashwin M Polnaya Sandeep Desai Paresh Desai Rammohan Vadapalli Manas Panigrahi | 2017 | World Journal of Radiology2017，9，8： | 4 |
| 3 | 7-Substituted 2-phenyl-benzofurans as ERβ selective ligands显示文摘 | COLLINI M D KAUFMAN D H MANAS E S | 2004 | Bioorg Med Chem Lett2004，14，19： | 1 |
| 4 | A fuzzy genetic algorithm with varying population size to solve an inventory model with credit linked promotional demand in an imprecise planning horizon显示文摘 | Manas K M | | 0，，01： | 1 |
| 5 | Ischemic cholangiopathy after liver transplantation from controlled non-heart-beating donors-a single-center experience显示文摘 | KACZMAREK B MANAS M D JAQUES B C | 2007 | Transplant Proe2007，39，9： | 1 |
| 6 | Mesaconitine- induced relaxation in rat aorta : involvement of Ca2 + influx and nitric - oxide synthase in the endothelium 显示文摘 | MANA M SYUNJI H MASARU S | 2002 | European Journal of Pharmacology2002，436，： | 1 |
| 7 | Recovery of Sac- charomyces cerevisiae sublethally injured cells after Pulsed Electric Fields 显示文摘 | Somolinos M Manas P Condon S | 2008 | International Journal of Food Microbi- ology2008，125，3： | 1 |
| 8 | The relationship between membrane damage, release of protein and loss of viability in Escherichia coli exposed to high hydrostatic pressure显示文摘 | KLOTZ B MANAS P MACKEY B M | 2010 | International Journal of Food Microbiology2010，137，23： | 1 |
| 9 | Trust key management scheme for wireless body area networks显示文摘 | MANA M FEHAM M BENSABER B A | 2011 | International Journal of Network Security2011，12，2： | 1 |
| 10 | An approach to the influence of nutrients and other food constituents on resistant starch formation显示文摘 | Escarpa A González M C Manas E J | 1997 | Journal of Agricultural Food Chemistry1997，60，4： | 1 |
| 11 | Optimal treatment for hepatocellular carcinoma in the cirrhotic liver显示文摘 | White S A Manas D M Farid S G | 2009 | Ann R Coil Surg Engl2009，91，7： | 1 |
| 12 | Molecular basis of proteinuria 显示文摘 | Akhtar M AI Mana H | 2004 | Adv Anat Pathol2004，11，6： | 1 |
| 13 | Sarcoidosis in pstients with chronic hepstftis C infection:snslysis of 68 csses显示文摘 | Ramos-Casala M Mana J Nardi N et el | 2005 | Medcine(Baltimore)2005，84，2： | 1 |
| 14 | Specific cutaneous lesions in patients with systemic sarcoidosis : relationship to severity and chronicity of dis- ease显示文摘 | Marcoval J Mana J Rubio M | 2011 | Clin Exp Dermatol2011，36，3： | 1 |
| 15 | Granulomatous cutaneous sarcoidosis: diagnosis, relationship to systemic disease, prognosis and treatment 显示文摘 | Mana J Marcoval J Rubio M | 2013 | Sarcoidosis Vasc Diffuse Lung Dis2013，30，4： | 1 |
| 16 | Dicopper( II ) Schiff base aminobenzoates with discrete molecular and 1D-chain polymeric structures 显示文摘 | Arindam M Manas K S Munirathinam N | 2004 | Polyhedron2004，23，： | 1 |
| 17 | Effect of emulsion temperature on physical properties of palm oil -based margarine 显示文摘 | MISKANDAR M S CHE MANA Y B YUSOFFB M S A | 2002 | J Am Oil Chem Soc2002，79，12： | 1 |
| 18 | Resistant starch formation:standardization of a high-pressure-autoclace process显示文摘 | Escarpa A González M C Manas E J | 1996 | Journal of Agricultural Food Chemistry1996，44，： | 1 |
| 19 | The role of membrane fluidity in pressure resistance of Escherichia coli 8164显示文摘 | CASADEI M A MANAS P NIVEN G | 2002 | Applied and Environmental Microbiology2002，68，12： | 1 |
| 20 | QoS-guaranteed bandwidth shifting and redistribution in mobile cloud environment显示文摘 | SUDIP M SNIGDLA D MANAS K | 2014 | IEEE Transacions on Cloud Computing2014，2，2： | 1 |
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