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| 1 | Clinical and pathological characterization of epstein-barr virus-associated gastric carcinomas in portugal显示文摘AIM To determine the prevalence of epstein-barr virus(eb V)-associated gastric carcinomas in the North Region of Portugal and to study its clinicopathological characteristics. METHODS We have performed a retrospective study including a total of 179 consecutive patients with gastric cancer(GC) submitted to gastrectomy during 2011 at the Portuguese Oncology Institute of Porto. Clinical and pathological data was collected from individual clinical records and inserted on a database with unique codification. Tumour tissues were collected from the institutional tumour bank. eb V was detected by in situ hybridization for the detection of eb V-encoded small RNAs(ebe Rs) and eb V latent proteins(LMP1 and LMP2 A) were detected by immunohistochemistry.RESULTS The analysis showed that eb V-associated gastric carcinomas(eb Va GC) represents 8.4%(15/179) of all GC cases, with a significant differential distribution among histological types(P < 0.001): 100%(3/3) of medullary carcinomas, 100%(1/1) of adenosquamous carcinoma, 8.7%(8/92) of tubular adenocarcinomas, 8.0%(2/25) of mixed carcinomas and 2%(1/51) in poorly cohesive carcinomas. The analysis revealed a higher predominance of eb Va GC in the upper third and middle(cardia, fundus and body) of the stomach(P = 0.041), a significant lower number of regional lymph nodes invasion(P = 0.025) and a tendency for better prognosis(P = 0.222). eb V latent protein expression revealed that all eb Va GC cases were LMP1-negative, nevertheless 6 cases(40%) expressed LPM2 A, which reveals that these cases show a distinct eb V-Latency profile(latency II-like).CONCLUSION eb Va GC represents 8.4% of all GC in the North Region of Portugal. The eb V-infected patients have specific clinic-pathological features that should be further explored to develop new strategies of management and treatment. | Joana Ribeiro Andreia Oliveira Mariana Malta Claudia Oliveira Fernanda Silva Ana Galaghar Luís Pedro Afonso Maria Cassiano Neves Rui Medeiros Pedro Pimentel-Nunes Hugo Sousa | 2017 | World Journal of Gastroenterology2017，23，40： | 9 |
| 2 | The importance of glutathione and phytochelatins on the selenite and arsenate detoxification in Arabidopsis thaliana显示文摘We investigated the role of glutathione(GSH) and phytochelatins(PCs) on the detoxification of selenite using Arabidopsis thaliana. The wild-type(WT) of Arabidopsis thaliana and its mutants(glutathione deficient Cad 2–1 and phytochelatins deficient Cad 1–3) were separately exposed to varying concentrations of selenite and arsenate and jointly to both toxicants to determine their sensitivities. The results of the study revealed that, the mutants were about 20-fold more sensitive to arsenate than the WT, an indication that the GSH and PCs affect arsenate detoxification. On the contrary, the WT and both mutants showed a similar level of sensitivity to selenite, an indication that the GSH and PCs do not significantly affect selenite detoxification. However, the WT is about 8 times more sensitive to selenite than to arsenate, and the mutants were more resistant to selenite than arsenate by a factor of 2. This could not be explained by the accumulation of both elements in roots and shoots in exposure experiments. The co-exposure of the WT indicates a synergistic effect with regards to toxicity since selenite did not induce PCs but arsenic and selenium compete in their PC binding as revealed by speciation analysis of the root extracts using HPLC–ICP–MS/ESI–MS. In the absence of PCs an antagonistic effect has been detected which might suggest indirectly that the formation of Se glutathione complex prevent the formation of detrimental selenopeptides. This study, therefore, revealed that PC and GSH have only a subordinate role in the detoxification of selenite. | Fatai Adigun Aborode Andrea Raab Matthias Voigt Leticia Malta Costa Eva M.Krupp Joerg Feldmann | 2016 | Journal of Environmental Sciences2016，28，11： | 6 |
| 3 | Differences in viral kinetics between genotypes 1 and 3 of hepatitis C virus and between cirrhotic and non-cirrhotic patients during antiviral therapy显示文摘AIM: To evaluate the impact of hepatitis C virus (HCV) infection with genotype 1 or 3 and the presence or absence of liver cirrhosis (LC) in the early viral kinetics response to treatment. METHODS: Naive patients (n = 46) treated with interferon-α (IFN-α) and ribavirin and followed up with frequent early HCV-RNA determinations were analysed. Patients were infected with genotype 1 (n = 28, 7 with LC) or 3 (n = 18, 5 with LC). RESULTS: The fi rst phase decline was larger in geno- type 3 patients than in genotype 1 patients (1.72 vs 0.95 log IU/mL, P < 0.001). The second phase slope decline was also larger in genotype 3 patients than in genotype 1 patients (0.87 vs 0.15 log/wk, P < 0.001). Differences were found in both cirrhotic and non-cirrhotic patients. Genotype 1 cirrhotic patients had a slower 2nd phase slope than non-cirrhotic patients (0.06 vs 0.18 log/wk, P < 0.02). None of genotype 1 cirrhotic patients had a 1st phase decline larger than 1 log (non-cirrhotic patients: 55%, P < 0.02). A similar trend toward a slower 2nd phase slope was observed in genotype 3 cirrhotic pa- tients but the 1st phase slope decline was not different. Sustained viral response was higher in genotype 3 pa- tients than in genotype 1 patients (72% vs 14%, P < 0.001) and in genotype 1 non-cirrhotic patients than in genotype 1 cirrhotic patients (19% vs 0%). A secondphase decline slower than 0.3 log/wk was predictive of non-response in all groups. CONCLUSION: Genotype 3 has faster early viral decline than genotype 1. Cirrhosis correlates with a slower 2nd phase decline and possibly with a lower 1st phase slope decline in genotype 1 patients. | José Eymard Medeiros-Filho Isabel Maria Vicente Guedes de Carvalho Mello Joo Renato Rebello Pinho Avidan U Neumann Fernanda de Mello Malta Luiz Caetano da Silva Flair José Carrilho | 2006 | World Journal of Gastroenterology2006，12，45： | 3 |
| 4 | Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy——lysosomal pathway显示文摘Nonalcoholic fatty liver disease(NAFLD) is characterized by hepatic steatosis and insulin resistance and there are currently no approved drugs for its treatment.Hyperactivation of mTOR complex1(mTORCl) and subsequent impairment of the transcription factor EB(TFEB)-mediated autophagy-lysosomal pathway(ALP) are implicated in the development of NAFLD.Accordingly,agents that augment hepatic TFEB transcriptional activity may have therapeutic potential against NAFLD.The objective of this study was to investigate the effects of nuciferine,a major active component from lotus leaf,on NAFLD and its underlying mechanism of action.Here we show that nuciferine activated ALP and alleviated steatosis,insulin resistance in the livers of NAFLD mice and palmitic acid-challenged hepatocytes in a TFEB-dependent manner.Mechanistic investigation revealed that nuciferine interacts with the Ragulator subunit hepatitis B X-interacting protein and impairs the interaction of the Ragulator complex with Rag GTPases,thereby suppressing lysosomal localization and activity of mTORC1,which activates TFEB-mediated ALP and further ameliorates hepatic steatosis and insulin resistance.Our present results indicate that nuciferine may be a potential agent for treating NAFLD and that regulation of the mTORCl-TFEB-ALP axis could represent a novel pharmacological strategy to combat NAFLD. | Xiliang Du Chiara Di Malta Zhiyuan Fang Taiyu Shen Xiaodi Niu Meng Chen Bo Jin Hao Yu Lin Lei Wenwen Gao Yuxiang Song Zhe Wang Chuang Xu Zhijun Cao Guowen Liu Xinwei Li | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 2 |
| 5 | Regeneration through sprout formation in Chlorocardium rodiei (Lauraceae) in Guyana显示文摘 | RIJKS M H MALTA E J ZAGT R J | 1998 | Journal of Tropical Ecology1998，14，4： | 1 |
| 6 | Toxic activities of Brazilian centipede venoms显示文摘 | Malta MB Lira MS Soares SL | 2008 | Toxicon2008，52，2： | 1 |
| 7 | Femtosecond lasers in ophthalmology显示文摘 | Soong HK Malta JB | | 0，，02： | 1 |
| 8 | Analyses of radionuclides in soil, water, and agriculture products near the Urgeiri?a uranium mine in Portugal显示文摘 | Fernando P. Carvalho Jo?o M. Oliveira Margarida Malta | 2009 | Journal of Radioanalytical and Nuclear Chemistry2009，，3： | 1 |
| 9 | TFEB links autophagy to lysosomal biogenesis 显示文摘 | Settembre C Di Malta C Polito VA | 2011 | Science2011，332，6036： | 1 |
| 10 | The effect of testosterone propionate supplement on testicular toxicity with thiamphenicol in male Sprague-Dawley rats 显示文摘 | Malta K Kuwahara M Kosaka T | 2004 | J Toxicol Sci2004，29，3： | 1 |
| 11 | Femtosecond lasers in ophthalmology 显示文摘 | Soong HK Malta JB | 2009 | Am J Ophthalmol2009，147，2： | 1 |
| 12 | Characteristics and origins of haze in the continental united-states 显示文摘 | Malta W C | 1992 | Earth-Science Reviews1992，33，1： | 1 |
| 13 | Intraoperative without conjunctival and Tenen's capsule touch in primary trabeculectomy显示文摘 | Susanna R Jr Costa VP Malta RF | 2001 | Ophthalmology2001，108，6： | 1 |
| 14 | Automated DEM extraction using RADARSAT ScanSAR stereo data显示文摘 | MalTa M | 1998 | IEEE1998，5，1： | 1 |
| 15 | Fracture of the acetabulum:accuracy of reduction and clinical results in patients managed operativelywithin three weeks after th-e injury显示文摘 | MALTA JM | 1996 | J Bone Jsurg(AM)1996，78，： | 1 |
| 16 | Decision process in a water use conflict in Brazil显示文摘 | GETIRANA A C V MALTA V F de AZEYEDO J P S | 2008 | Water Resources Management2008，22，1： | 1 |
| 17 | Hyperbolic Birkhoff centers显示文摘 | Malta I P | 1980 | Trans Amer Math Soc1980，262，： | 1 |
| 18 | Characterization of the de- fense-attack transition of a soccer team显示文摘 | Pedro Malta Bruno Travassos | | Motricidade0，20，1： | 1 |
| 19 | Examining the relationship between atmospheric aerosols and light extinction at Mount Rainier and North Cascades National Parks显示文摘 | Malta William C | 1994 | Atmos Environ1994，28，2： | 1 |
| 20 | Production of micro- and mesoporous activated carbon from paper mill sludge 显示文摘 | Nasrin R K Malta C Giselle S | 2000 | Carbon2000，38，14： | 1 |
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