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| 1 | Impacts of grassland fence on the behavior and habitat area of the critically endangered Przewalski's gazelle around the Qinghai Lake显示文摘The trend of fencing grassland as livestock paddocks is spreading on the Eurasian steppe,however,its impacts on grassland wildlife are little known.In order to explore such impacts,we carried out a field study on how grassland fencing impacts Przewalski's gazelle(Procapra przewalskii),a species listed as EN(Endangered) by SSC/IUCN,on the Qinghai-Tibet Plateau.The results revealed that(1) in the fenced areas,daily movement distance of Przewalski's gazelle was 5081±1187 m(Hudong-Ketu) and 4110±912 m(Yuanzhe),which was much shorter than the 7223±546 m recorded in an unfenced area(Kuaierma);(2) the feeding bout duration of Przewalski's gazelle was much shorter in the fenced habitat;(3) the frequency of walking along both high or low fence lines reached about 81%;while the frequency of jumping across the low fence line was only about 1.2% and frequency of crawling through the bottom of the high fence lines was about 17.8%;(4) the size of post-fencing habitat decreased to about 20% and 6% of the sizes of pre-fencing habitat in Hudong-Ketu and Yuanzhe areas respectively,but no clear change in the size of habitat area was found in the unfenced Kuaierma area;and(5) the fence lines impaired the possibility of gazelles to escape from predators and occasionally trapped the Przewalski's gazelle which failed to jump over the fence lines.Death occurrence of Przewalski's gazelle in the intensively fenced area,including gazelles strangled by fence lines and predated by wolves,reached 5% of the population size in Yuanzhe and up to 15%-20% in Hudong-Ketu.This study highlights the negative impacts of grassland fencing on Przewalski's gazelle and proposes measures for integrating conservation of this gazelle with livestock management practice. | YOU ZhangQiang JIANG ZhiGang LI ChunWang MALLON David | 2013 | Chinese Science Bulletin2013，58，17： | 11 |
| 2 | 女性治疗环境对女性精神病患者有益显示文摘 | Mallon S 吕振琪 李斌和 郭晓杰 | 2001 | 国外医学(护理学分册)2001，20，12： | 10 |
| 3 | Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy显示文摘AIM To study the innate immune function in ulcerative colitis(UC) patients who fail to respond to anti-tumor necrosis factor(TNF) therapy.METHODS Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell(PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor(TLR) expression and cytokine production post TLR stimulation was assessed in UC 'responders'(n = 12) and 'non-responders'(n = 12) and compared to healthy controls(n = 12). Erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) levels were measured in blood to assess disease severity/activity and inflammation. Pro-inflammatory(TNF, IL-1β, IL-6), immuno-regulatory(IL-10), Th1(IL-12, IFNγ) and Th2(IL-9, IL-13, IL-17A) cytokine expression was measured with enzyme-linked immunosorbent assay while TLR cellular composition and intracellular signalling was assessed with FACS.RESULTS Prior to anti-TNF therapy, responders and nonresponders had similar level of disease severity and activity. PBMC's ability to respond to TLR stimulation was not affected by TNF therapy, patient's severity of the disease and inflammation or their medication use. At baseline, non-responders had elevated innate but not adaptive immune responses compared to responders(P < 0.05). Following TLR stimulation, nonresponders had consistently reduced innate cytokine responses to all TLRs compared to healthy controls(P < 0.01) and diminished TNF(P < 0.001) and IL-1β(P < 0.01) production compared to responders. This innate immune dysfunction was associated with reduced number of circulating plasmacytoid dendritic cells(p DCs)(P < 0.01) but increased number of CD4+ regulatory T cells(Tregs)(P = 0.03) as well as intracellular accumulation of IRAK4 in non-responders following TLR-2,-4 and-7 activation(P < 0.001). CONCLUSION Reduced innate immunity in non-responders may explain reduced efficacy to anti-TNF therapy. These serological markers may prove useful in predicting the outcome of costly anti-TNF therapy. | Angela C Baird Dominic Mallon Graham Radford-Smith Julien Boyer Thierry Piche Susan L Prescott Ian C Lawrance Meri K Tulic | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 4 | 草原围栏对普氏原羚行为和栖息地面积的影响显示文摘在欧亚草原区,建设草原围栏将草原围成家畜放牧场的趋势越来越明显,然而草原围栏对野生动物的影响却鲜为人知.仅分布在青藏高原东部青海湖流域草原上的普氏原羚被国际自然保护联盟物种生存委员会列为濒危级物种.为了探索草原围栏对其行为和栖息地面积的影响,笔者开展了相关研究.结果表明:(1)在建有围栏的区域内,普氏原羚昼间活动距离平均值为5081±1187m(湖东-克图分布区)和4110±912m(元者分布区),远远低于无围栏分布区中普氏原羚的昼间活动距离7223±546m(快尔玛分布区);(2)在建有围栏区域内的普氏原羚采食周期比无围栏生境中的短;(3)普氏原羚沿围栏行走的频次比例达81%;跳越围栏的行为频次比例为1.2%,从围栏底部钻过围栏的频次为17.8%;(4)建立围栏后,湖东-克图和元者分布区内普氏原羚的活动范围分别缩小为建立围栏前的20%和6%;(5)围栏降低了普氏原羚逃离天敌的能力.在元者和湖东-克图,直接被围栏挂住死亡的比例为5%,或因围栏限制了逃避天敌的能力而导致普氏原羚被狼捕食的比例为15%~20%.由此可见,草原围栏不利于普氏原羚生存,建议加强草原生物多样性保护,对家畜牧场进行综合管理. | 游章强 蒋志刚 李春旺 MALLON David | 2013 | 科学通报2013，58，16： | 9 |
| 5 | Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells显示文摘 | A. M. Madec R. Mallone G. Afonso E. Abou Mrad A. Mesnier A. Eljaafari C. Thivolet | 2009 | Diabetologia2009，，7： | 3 |
| 6 | Retarding action of gypsum plaster retarders of various chemical composition in relation to the pH value of the plaster 显示文摘 | Mallon Th | 1988 | Zement-Kalk-Gips1988，41，6： | 2 |
| 7 | Community-acquired Klebsiella pneumoniae liver abscess: an emerging infection in Ireland and Europe显示文摘 | R. Moore D. O’Shea T. Geoghegan P. W. G. Mallon G. Sheehan | 2013 | Infection2013，，3： | 2 |
| 8 | HLA-CW * 0602 is a susceptibility factor in type I psoriasis, and evidence Ala-73 is increased in male type I psoriatics显示文摘 | Mallon E Bunce M | 1997 | Invest Dermatol1997，109，2： | 1 |
| 9 | GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes显示文摘 | Reijonen H Mallone R Heninger AK | 2004 | Diabetes2004，53，8： | 1 |
| 10 | Toward xeno-free culture of human embryonic stem cells显示文摘 | Mallon B S Park K Y Chen K G | 2006 | Int J Biochem Cell Biol2006，38，8： | 1 |
| 11 | Tracking the hydrophobicity recovery of PDMS compounds using the adhesive force determined by AFM force distance measurements显示文摘 | Meincken M Berhane T A Mallon P E | 2005 | Polymer2005，46，1： | 1 |
| 12 | Large strain and toughness enhancement of poly (dime- thyl siloxane) composite films filled with eleetrospun polyacrylonitrile-graft-poly (dimethyl siloxane ) fibres and multi-walled carbon nanotubes 显示文摘 | BAYLEY G M HEDENQVIST M MALLON P E | 2011 | Polymer2011，52，18： | 1 |
| 13 | Development and validation of a simple tape-based measurement tool for recording cervical rotation in patients with ankylosing spondylitis: comparison with a goniometer-based approach 显示文摘 | Maksymowych WP Mallon C Richardson R | 2006 | J Rheumatol2006，33，1： | 1 |
| 14 | The quality of life in acne:a comparison with general medical conditions using generic questionnaires显示文摘 | Mallon E Newton JN Klassen A | 1999 | Br J Dermatol1999，140，4： | 1 |
| 15 | Tracking the hydrophobicity recovery of PDMS compounds using the adhesive force determined by AFM force distance measurements显示文摘 | Meincken M Berhane T A Mallon P E | 2005 | Polymer2005，46，1： | 1 |
| 16 | Selective subunit antago-nists suggest an inhibitory relationship between NR2Band NR2A-subunit containing N-methyl-D:-aspartate receptors in hipp-ocampal slices显示文摘 | Mallon A P Auberson Y P Stone T W | 2005 | Exp Brain Res2005，162，： | 1 |
| 17 | Semantics,Cross-Cultural Style显示文摘 | Edouard Machery R on Mallon Shaun Nichols Stephen Stich | | 0，，： | 1 |
| 18 | Retarding Action of Gypsum Plaster Retarders of Various Chemical Composition in Relation to the pH Value of the Plaster显示文摘 | Mallon TH | 1988 | Zement-Kalk-Gips1988，，6： | 1 |
| 19 | Analysis of dental hard tissue by computerized microdensitometry 显示文摘 | Mallon DE Mellberg JR | 1985 | J Dent Res1985，64，2： | 1 |
| 20 | Regeneration of transgenic plants by Agrobacterium-mediated transformation of somatic embryos of juvenile and mature Quercus robur 显示文摘 | Vidal N Mallon R Valladares S | 2010 | Plant Cell Reports2010，29，12： | 1 |
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