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| 1 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 2 | Preparation of stable micropatterns of gold on cell-adhesion-resistant hydrogels assisted by a hetero-bifunctional macromonomer linker显示文摘Surface patterning is very useful in biomaterial studies, yet it is not easy to prepare a micropattern with cell-adhesion contrast that is stable in a wet environment. Recently, a platform technique of transfer photolithography was invented to fabricate stable metal microarrays on the surface of a cell-adhesion resistant and mechanically biomimetic poly(ethylene glycol) hydrogel; the linker is the key chemical in such a transfer strategy. This article reports the design and synthesis of a hetero-bifunctional macromonomer linker with a thiol group at one end and an acryloyl group at the other end. The bifunctional linker was characterized by GPC and 1H NMR, and the average number of thiol groups in the bifunctional linker was detected by Ellman's reagent. The regent stability under wet conditions was also confirmed by the model reactants. The resultant micropatterned surfaces are meaningful for future studies of cell behaviors on mechanically biomimetic matrixes. | SUN JianGuo GRAETER Stefan V TANG Jian HUANG JingHuan LIU Peng LAI YuXiao YU Lin MAJER Günter SPATZ Joachim P DING JianDong | 2014 | Science China Chemistry2014，57，4： | 2 |
| 3 | Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor显示文摘 | Majer P Jackson P F Delahanty G | 2003 | J Med Chem2003，46，10： | 1 |
| 4 | Hydrogen in the mechanically prepared nanostructured graphite显示文摘 | Orimo S Majer G Fukunaka T | 1999 | Appl Phys Lett1999，75，： | 1 |
| 5 | 查看详情显示文摘 | Khaykovich B Zeldov E Majer D Li T W Kes P H Konczykowski M | | 0，，： | 1 |
| 6 | Complete extirpation of benign breast lesions with an ultrasound-guided vacuum biopsy system显示文摘 | Krainick-Strobel U Huber B Majer I | | 0，，03： | 1 |
| 7 | Mosaic tissue distribution of the tandem duplication of LAMP2 exons 4 and 5 demonstrates the limits of Danon disease cellular and molecular diagnostics 显示文摘 | Majer F Pelak O Kalina T | 2014 | J Inherit Metab Dis2014，37，1： | 1 |
| 8 | Solubilities of oxygen and carbon dioxide in butyl methyl imidazolium tetrafluoroborate as a function of temperature and at pressures close to atmospheric pressure显示文摘 | Husson-Borg P Majer V Comes M F C | 2003 | J Chem Eng Data2003，48，3： | 1 |
| 9 | Determination of an optimal pitfall trap size for sampling spiders in a western Australian Jarrah forest 显示文摘 | Brennan K E C Majer J D Reygaert N | 1999 | Journal of Insect Conservation1999，3，： | 1 |
| 10 | Use of flow calorimetry for determining enthalpies of absorption and the solubility of CO2 in aqueous monoethanolamine solutions 显示文摘 | Mathonat C Majer V Mather A E Orolier J P E | 1998 | Industrial and Engineering Chemistry Research1998，37，： | 1 |
| 11 | Activation of central nervous system inflammatory pathways by interferon- alpha: relationship of monoamines an depression显示文摘 | Raison CL Borisov AS Majer M | 2009 | Biol Psychiatry2009，65，4： | 1 |
| 12 | The role of ants in degraded soils within dry andra state forest显示文摘 | Majer J D Walker T C Berlandier F | 1987 | Mulga Res Ctre J1987，9，： | 1 |
| 13 | Effects of heavy metal contamination of soils on micronucleus induction in Tradescantia and on microbial enzyme activities:A compareative investingation显示文摘 | Bernhard J Majer Dagmar Tscherko Albrecht Paschke | 2002 | Mutation Research2002，515，： | 1 |
| 14 | The occurrence,distribution and sources of PAHs in the sediments of the Georges River Estuary,Australia 显示文摘 | BROWN G MAJER W | 1992 | Org Geochem1992，18，5： | 1 |
| 15 | Diagnosis of fistula and sinus tracts in patients with Crohn disease:value of MR imaging显示文摘 | Koelbel G Schmiedl U Majer MC | | 0，，05： | 1 |
| 16 | Ursodeoxycholic acid amides as novel glucocorticoid receptor modulators显示文摘 | Sharma R Prichard D Majer F | | 0，，01： | 1 |
| 17 | The use of AFLP fingerprinting for the detection of genetic variation in fungi显示文摘 | MITHEN R LEWIS B G | 1996 | Mycol Res1996，100，9： | 1 |
| 18 | Diversity patterns of eucalypt canopy arthropods in eastern and western Australia显示文摘 | Majer J D Recher H F Ganesh S | 2000 | Ecological Entomology2000，25，： | 1 |
| 19 | Diversity patterns of eucalypt canopy arthropods in eastern and western Australia显示文摘 | MAJER J D RECHER H F GANESH S | 2000 | Ecol Entomol2000，25，： | 1 |
| 20 | Maternal urine for prenatal diagnosis--an analysis of cell-free fetal DNA in maternal urine and plasma in the third trimester显示文摘 | Majer S Bauer M Magnet E | 2007 | Prenat Diagn2007，27，： | 1 |
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