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| 1 | Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells显示文摘Liver fibrosis is a consequence of chronic liver disease,causing morbidity and mortality.Interleukin-33(IL-33)is a critical mediator of inflammation,which may be involved in the development of liver fibrosis.Here,we investigated the role of IL-33 in human patients and experimental bile-duct ligation(BDL)-induced fibrosis in mice.We report increased hepatic IL-33 expression in the murine BDL model of fibrosis and in surgical samples obtained from patients with liver fibrosis.Liver injury,inflammatory cell infiltration and fibrosis were reduced in the absence of the IL-33/ST2 receptor,and the activation of hepatic stellate cells(HSCs)was decreased in ST2-deficient mice.Recombinant IL-33 activated HSCs isolated from C57BL/6 mice,leading to the expression of IL-6,TGF-β,α-SMA and collagen,which was abrogated in the absence of ST2 or by pharmacological inhibition of MAPK signaling.Finally,administration of recombinant IL-33 significantly increased hepatic inflammation in sham-operated BL6 mice but did not enhance BDL-induced hepatic inflammation and fibrosis.In conclusion,BDL-induced liver inflammation and fibrosis are dependent on ST2 signaling in HSCs,and therefore,the IL-33/ST2 pathway may be a potential therapeutic target in human patients with chronic hepatitis and liver fibrosis. | Zhongming Tan Qianghui Liu Runqiu Jiang Long Lv Siamak S Shoto Isabelle Maillet Valerie Quesniaux Junwei Tang Wenjie Zhang Beicheng Sun Bernhard Ryffel | 2018 | Cellular & Molecular Immunology2018，15，4： | 24 |
| 2 | Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease显示文摘 | Gentric Géraldine Maillet Vanessa Paradis Valérie Couton Dominique L’Hermitte Antoine Panasyuk Ganna Fromenty Bernard Celton-Morizur Séverine Desdouets Chantal | 2015 | Journal of Clinical Investigation2015，，： | 2 |
| 3 | Cardiovascular andhormonal response during a 4-week head-down tilt with and without exercise and LBNP countermeasures 显示文摘 | Maillet A Fagette S Allevard AM | 1996 | J Gravit Physiol1996，3，1： | 1 |
| 4 | Comparative study of Thoracoscopy versus thoracotomy in esophageal atresia显示文摘 | Allal H Perez-Bertolez S Maillet O | 2009 | Cir Pediatr2009，22，4： | 1 |
| 5 | Thermal dispersion for water or air flow through a bed of glass beads显示文摘 | TESTU A DIDIERJEAN S MAILLET D | 2007 | International Journal of Heat and Mass Tran- sfer2007，50，78： | 1 |
| 6 | Herpes simplex virus type 1 latently infected neurons differentially express latency-associated and ICP0 transcripts显示文摘 | Maillet S Naas T Crepin S | | 0，，18： | 1 |
| 7 | Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells 显示文摘 | Fischer K Scotet E Niemeyer M Koebernick H Zerrahn J Maillet S Hurwitz R Kursar M Bonneville M Kaufmann SH Schaible UE | 2004 | Proc Natl Acad Sci USA2004，101，29： | 1 |
| 8 | Cardiovascular and hormonal response during a 4-week head-down tilt with and without exercise and LBNP countermeasures显示文摘 | A Fagette S Allevard AM | 1996 | J Gravity Physiol1996，3，10： | 1 |
| 9 | Fungal lipochitooligosaccharide symbiotic signals in arbuscular mycorrhiza显示文摘 | Maillet F Poinsot V André O Puech-Pagès V Haouy A Gueunier M Cromer L Giraudet D Formey D Niebel A Martinez E A Driguez H Bécard G Dénarié J | 2011 | Nature2011，469，7328： | 1 |
| 10 | Herpes simplex virus type 1 latently infected neurons differentially express latency-associated and ICP0 transcripts 显示文摘 | Maillet S Naas T Crepin S | 2006 | J Virol2006，80，18： | 1 |
| 11 | Optimal experi- mental estimation of thermal dispersion coefficients in porous media 显示文摘 | Metzger T Didierjean S Maillet D | 2004 | International Journal of Heat and Mass Transfer2004，47，14： | 1 |
| 12 | Crosstalk between Rapl and Rac results secretion of sAPP alpha 显示文摘 | MAILLET M ROBERT S J CACQUEVEL M | 2003 | Nat Cell Bio2003，5，7： | 1 |
| 13 | Serous oligocystic and ill- demarcated adenoma of the pancreas : a variant of serous cystic ad- enoma显示文摘 | Egawa N Maillet B Schroder S | 1994 | Virchows Arch1994，424，1： | 1 |
| 14 | Inguinal hernia in premature boys:Should we systematically explore the contralateral side 显示文摘 | Maillet OP Gamier S Kalfa N | 2014 | J Pediatr Surg2014，49，9： | 1 |
| 15 | Herpes simplex virus type 1 latently infected neurons differentially express latency-associated and ICPO transcripts显示文摘 | Maillet S Naas T Crepin S | 2006 | J Virol2006，80，18： | 1 |
| 16 | First reported occurrence of MSX in Canada显示文摘 | Stephenson M F McGladdery S E Maillet M V | 2003 | Shellfish Res2003，22，： | 1 |
| 17 | Aerodynami-cal,immunological and pharmacological properties of the antican-cer antibody cetuximab following nebulization显示文摘 | Maillet A Congy-Jolivet N Le Guellec S | 2008 | Pharmaceutical Research2008，25，6： | 1 |
| 18 | Comparative study of thoracos- copy versus thoracotomy in esophageal atresia显示文摘 | Allal H P6rez-Bert61ez S Maillet O | 2009 | Cir Pediatr2009，22，4： | 1 |
| 19 | Unexpected citrate toxicity and severe hypocalcemia during apheresis显示文摘 | Uhl L Maillet S King S | 1997 | Transfusion1997，37，10： | 1 |
| 20 | Ureteral necrosis after kidney transplantation: risk factors and impact on graft and patient survival显示文摘 | Karam G Maillet F Parant S | 2004 | Transplantation2004，78，5： | 1 |
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