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| 1 | Noninvasive model including right ventricular speckle tracking for the evaluation of pulmonary hypertension显示文摘AIM To find parameters from transthorathic echocardiography(TTE) including speckle-tracking(ST) analysis of the right ventricle(RV) to identify precapillary pulmonary hypertension(PH).METHODS Forty-four patients with suspected PH undergoing right heart catheterization(RHC) were consecutively included(mean age 63.1 ± 14 years, 61% male gender). All patients underwent standardized TTE including ST analysis of the RV. Based on the subsequent TTE-derived measurements, the presence of PH was assessed: Left ventricular ejection fraction(LVEF) was calculated by Simpsons rule from 4Ch. Systolic pulmonary artery pressure(s PAP) was assessed with continuous wave Doppler of systolic tricuspid regurgitant velocity and regarded raised with values ≥ 30 mmH g as a surrogate parameter for RA pressure. A concomitantly elevated PCWP was considered a means to discriminate between the precapillary and postcapillary form of PH. PCWP was considered elevated when the E/e' ratio was > 12 as a surrogate for LV diastolic pressure. E/e' ratio was measured by gauging systolic and diastolic velocities of the lateral and septal mitral valve annulus using TDI mode. The results were then averaged with conventional measurement of mitral valve inflow. Furthermore, functional testing with six minutes walking distance(6MWD), ECG-RV stress signs, NT pro-BNP and other laboratory values were assessed.RESULTS PH was confirmed in 34 patients(precapillary PH, n = 15, postcapillary PH, n = 19). TTE showed significant differences in E/e' ratio(precapillary PH: 12.3 ± 4.4, postcapillary PH: 17.3 ± 10.3, no PH: 12.1 ± 4.5, P = 0.02), LV volumes(ESV: 25.0 ± 15.0 mL, 49.9 ± 29.5 m L, 32.2 ± 13.6 m L, P = 0.027; EDV: 73.6 ± 24.0 mL, 110.6 ± 31.8 mL, 87.8 ± 33.0 mL, P = 0.021) and systolic pulmonary arterial pressure(sP AP: 61.2 ± 22.3 mm Hg, 53.6 ± 20.1 mm Hg, 31.2 ± 24.6 mm Hg, P = 0.001). STRV analysis showed significant differences for apical RV longitudinal strain(RVAS: -7.5% ± 5.6%, -13.3% ± 4.3%, -14.3% ± 6.3%, P = 0.03). NT pro-BNP was higher in patients with postcapillary PH(4677.0 ± 7764.1 pg/m L, precapillary PH: 1980.3 ± 3432.1 pg/mL, no PH: 367.5 ± 420.4 pg/mL, P = 0.03). Patients with precapillary PH presented significantly more often with ECG RV-stress signs(P = 0.001). Receiver operating characteristics curve analyses displayed the most significant area under the curve(AUC) for RVAS(cut-off < -6.5%, AUC 0.91, P < 0.001), sPAP(cut-off > 33 mmH g, AUC 0.86, P < 0.001) and ECG RV stress signs(AUC 0.83, P < 0.001). The combination of these parameters had a sensitivity of 82.8% and a specificity of 17.2% to detect precapillary PH. CONCLUSION The combination of non-invasive measurements allows feasible assessment of PH and seems beneficial for the differentiation between the pre- and postcapillary form of this disease. | Yossra Mahran Robert Schueler Marcel Weber Carmen Pizarro Georg Nickenig Dirk Skowasch Christoph Hammerstingl | 2016 | World Journal of Cardiology2016，8，8： | 4 |
| 2 | Recent Insights into Signaling Responses to Cope Drought Stress in Rice显示文摘Drought is one of the hot topics needing urgent attention in the current era of climate change.It massively disturbs the rice growth and productivity and is becoming a serious threat.The drought avoidance strategies in rice include stomatal closure,cellular adaptation and changes in root development.Moreover,the endogenous plant hormones(abscisic acid and jasmonic acid)and reactive oxygen species have paramount importance in drought tolerance in rice.The drought tolerance induces modification in biochemical,molecular and physiological properties of plants.At the molecular level,expression of several transcription-factors is modulated which further determine the activation of drought responsive gene families.Mitogen activated protein kinases and Ca signaling pathways initiate an array of signaling cascade for mediating the gene expression in rice.Approaches,conventional breeding methods combined with modern emerging techniques such as genetic engineering,to improve rice drought tolerance were discussed.This review provided recent insights into major regulatory factors against drought stress,signaling mechanisms and molecular engineering strategies(including conventional transgenic and recent genome editing approaches)to induce drought tolerance in rice. | Muhammad Mahran ASLAM Muhammad Abdul Rehman RASHID Mohammad Aquil SIDDIQUI Muhammad Tahir KHAN Fozia FARHAT Shafquat YASMEEN Imtiaz Ahmad KHAN Shameem RAJA Fatima RASOOL Mahboob Ali SIAL ZHAO Yan | 2022 | Rice science2022，29，2： | 2 |
| 3 | Novelsugar esters proniosomes for transdermal delivery of vinpo-cetine:Preclinical and clinical studies显示文摘 | EI-LAITHY H M SHOUKRY O MAHRAN L G | 2011 | EuropeanJournal of Pharmaceutics and Biopharmaceutics2011，77，1： | 1 |
| 4 | Transumbilical laparoscopic chole- cystectomy: towards a scarless abdominal surgery 显示文摘 | Abdel Azeez T Mahran KM | 2011 | Hepatogas- troenterology2011，58，106： | 1 |
| 5 | Protective effect of Nigella sativa oil against tramadol-induced tolerance and dependence in mice: Role of nitric oxide and oxidative stress显示文摘 | Ahmed O. Abdel-Zaher Mahran S. Abdel-Rahman Fahmy M. ELwasei | 2011 | Neurotoxicology2011，，6： | 1 |
| 6 | Qualitycontrol of reactive oxygen species measurement byluminol-dependent chemiluminescence assay 显示文摘 | Kobayashi H Gil-Guzman E Mahran AM | 2001 | JAndrol2001，22，： | 1 |
| 7 | Expression of the apoptosis inhibitor Bcl-2 in sputum eosinophils from children with acute asthma显示文摘 | E1-Gamal Y Heshmat N Mahran M | 2004 | Clin Exp Allergy2004，34，11： | 1 |
| 8 | Minimally invasive no hardware subtalar arthrodesis with autogenous posterior iliac bone graft显示文摘 | Eid MA E1-Soud MA Mahran MA | 2010 | Strategies Trauma Limb Reconstr2010，5，1： | 1 |
| 9 | Vascular lesions of the in- ternal auditory canal显示文摘 | Mahran A Samii M Penkert G | 1991 | Skull Base Surg1991，1，2： | 1 |
| 10 | Surgery of the petroclival meningiomas: report of 24 cases显示文摘 | Samrni M Ammirati M Mahran A | 1989 | Neurosurgery1989，24，1： | 1 |
| 11 | Prophylactic effect of aqueous propolis extract against acute experimental hepatotoxicity in vivo 显示文摘 | EI-Khatib AS Agha AM Mahran LG | 2002 | Z Naturforsch2002，57，： | 1 |
| 12 | Further experience with the urethral kock pouch显示文摘 | Ghorneim MA Shaaban AA Mahran MR | 1992 | J Urol1992，147，： | 1 |
| 13 | The impact of acne vulgaris on the quality of life and psychologic status in patients from upper Egypt显示文摘 | Abdel HK Mahran AM Hofny ER | 2009 | Int J Dermatol2009，48，3： | 1 |
| 14 | Further experience with the urethral Kock pouch显示文摘 | Ghoneim MA Shaaban AA Mahran MR | | 0，，02： | 1 |
| 15 | Synthesis and biological evaluation of certain α,β-unsaturated ketones and their corresponding fused pyridines as antiviral and cytotoxic agents显示文摘 | El-Subbagh I H Abu-Zaid S M Mahran M A | 2000 | Journal of Medicinal Chemistry2000，43，15： | 1 |
| 16 | Synthesis of Some New Benzothiazole Derivatives as Potential Antinicrobial and Antiparasitic Agents显示文摘 | Mahran M A El-nassry S M Allam S R | | 0，，08： | 1 |
| 17 | Bioremediation the toxic effect of mercury on liver histopathology, some hemato- logical parameters and enzymatic activity in Nile tilapia, Oreo- chromis niloticus显示文摘 | Kaoud HA Mahran KMA Rezk A | 2012 | Researcher2012，4，1： | 1 |
| 18 | Synthesis and biological evaluation of certain ct, fl-unsaturated ketones and their corresponding fused pyridines as antiviral and cytotoxic agents 显示文摘 | EI-SUBBAGH H I ABU-ZAID S M MAHRAN M A | 2000 | J Med Chem2000，43，15： | 1 |
| 19 | Co-ordinated control of synchronous generator excitation and static var compensator显示文摘 | MAHRAN A R HOGG B W ELSAYED M L | 1992 | IEEE Transactions on Energy Conversion1992，7，4： | 1 |
| 20 | Comparison of effects of ProTa- per, HeroShaper, and Gates Glidden Burs on cervical dentin thickness and root canal volume by using multislice computed tomography 显示文摘 | Mahran AH AboEI-Fotouh MM | 2008 | J Endod2008，34，10： | 1 |
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