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| 1 | Controlled drug delivery vehicles for cancer treatment andtheir performance显示文摘Although conventional chemotherapy has been successful to some extent,the main drawbacks of chemotherapy are its poor bioavailability,high-dose requirements,adverse side effects,low therapeutic indices,development of multiple drug resistance,and non-specific targeting.The main aim in the development of drug delivery vehicles is to successfully address these delivery-related problems and carry drugs to the desired sites of therapeutic action while reducing adverse side effects.In this review,we will discuss the different types of materials used as delivery vehicles for chemotherapeutic agents and their structural characteristics that improve the therapeutic efficacy of their drugs and will describe recent scientific advances in the area of chemotherapy,emphasizing challenges in cancer treatments. | Sudipta Senapati Arun Kumar Mahanta Sunil Kumar Pralay Maiti | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 9 |
| 2 | Gene expression profile of esophageal cancer in North East India by cDNA microarray analysis显示文摘AIM: To identify alterations in genes and molecular functional pathways in esophageal cancer in a high incidence region of India where there is a widespread use of tobacco and betel quid with fermented areca nuts. METHODS: Total RNA was isolated from tumor and matched normal tissue of 16 patients with esophageal squamous cell carcinoma. Pooled tumor tissue RNA was labeled with Cy3-dUTP and pooled normal tissue RNA was labeled with Cy5-dUTP by direct labeling method. The labeled probes were hybridized with human 10K cDNA chip and expression profiles were analyzed by Genespring GX V 7.3 (Silicon Genetics). RESULTS: Nine hundred twenty three genes were differentially expressed. Of these, 611 genes were upregulated and 312 genes were downregulated. Using stringent criteria (P ≤ 0.05 and ≥ 1.5 fold change), 127 differentially expressed genes (87 upregulated and 40 downregulated) were identified in tumor tissue. On the basis of Gene Ontology, four different molecular functional pathways (MAPK pathway, G-protein coupled receptor family, ion transport activity, and serine or threonine kinase activity) were most significantly upregulated and six different molecular functional pathways (structural constituent of ribosome, endopeptidase inhibitor activity, structural constituent of cytoskeleton, antioxidant activity, acyl group transferase activity, eukaryotic translation elongation factor activity) were most significantly downregulated. CONCLUSION: Several genes that showed alterations in our study have also been reported from a high incidence area of esophageal cancer in China. This indicates that molecular profiles of esophageal cancer in these two different geographic locations are highly consistent. | Indranil Chattopadhyay Sujala Kapur Joydeep Purkayastha Rupkumar Phukan Amal Kataki Jagadish Mahanta Sunita Saxena | 2007 | World Journal of Gastroenterology2007，13，9： | 3 |
| 3 | Adaptive integral higher order sliding mode controller for uncertain systems显示文摘This paper proposes an adaptive integral higher order sliding mode (HOSM) controller for uncertain systems. Instead of a regular control input, the derivative of the control input is used in the proposed control law. The discontinuous sign function in the controller is made to act on the time derivative of the control input. The actual control signal obtained by integrating the derivative control signal is smooth and chattering free. The adaptive tuning law used in the proposed controller eliminates the need of prior knowledge about the upper bound of the system uncertainties. Stability and robustness of the proposed controller are proved by using the classical Lyapunov criterion. Simulation results demonstrate the advantages of the proposed control scheme. | Sanjoy MONDAL Chitralekha MAHANTA | 2013 | 控制理论与应用(英文版)2013，11，1： | 3 |
| 4 | Pharmacodynamics of aminoglycosides and tetracycline derivatives against Japanese encephalitis virus显示文摘Objective:To explore the antiviral activity of antibiotic compounds,mainly aminoglycosides and tetracyclines against Japanese encephalitis virus(JEV) induced infection in vitro.Methods:Antiviral activity were evaluated against JEV using cytopathic effect inhibition assay,virus yield reduction assay,caspase 3 level,extracellular viral detection by antigen capture ELISA and viral RNA levels.Roults:JEV induced cytopathic effect along with reduction of viral progeny plaque formation indicated antiviral potential of the compounds suggesting that antibiotics had broad spectrum activity.Doxycycline and kanamycin administration in dose dependent manner declined viral RNA replication.Conclusions:The present study shows kanamycin and doxycyclinc can affect virion structure and alter replication causing inhibition of JEV induced pathogenesis in vitro. | Rashmee Topno Siraj Ahmed Khan Pritom Chowdhury Jagadish Mahanta | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，3： | 3 |
| 5 | 萎凋与红茶香气特性的关系显示文摘本文分析了正常萎凋和重萎凋叶制成的传统红茶和CTC红茶之挥发性芳香成分(VFC)、咖啡碱,粗纤维、灰分和水溶性固形物总量(TSS).随着萎凋程度加重,发现VFC、TSS和咖啡碱增加,但粗纤维无此趋势.红茶加工中的萎凋过程似乎控制着类萜烯化合物的变化,能改善冲泡茶叶的香气品质. | Pradip kr Mahanta Sabitri Baruah 黄孝原 | 1990 | 广东茶业1990，，2： | 3 |
| 6 | On a Class of Generalized Lacunary Difference Sequence Spaces Defined by Orlicz Functions显示文摘In this article we introduce the generalized lacunary difference sequence spaces [Nθ, M, Δ^m]0, [Nθ, M, Δ^m]1 and [Nθ, M, Δ^m]∞ using m^th- difference. We study their properties like completeness, solidness, symmetricity. Also we obtain some inclusion relations involving the spaces [Nθ, M, Δ^m]0,[Nθ, M, Δ^m]1 and [Nθ, M, Δ^m]∞ and the Cesàro summable and strongly Cesàro summable sequences. | Binod Chandra Tripathy Sabita Mahanta | 2004 | Acta Mathematicae Applicatae Sinica2004，20，2： | 3 |
| 7 | Dietary habits and stomach cancer in Mizoram, India显示文摘 | Rup Kumar Phukan Konwar Narain Eric Zomawia Nakul Chandra Hazarika Jagadish Mahanta | 2006 | Journal of Gastroenterology2006，，5： | 2 |
| 8 | A Position Synchronization Controller for Co-ordinated Links(COOL)Dual Robot Arm Based on Integral Sliding Mode:Design and Experimental Validation显示文摘In this study,a simple position synchronization control algorithm based on an integral sliding mode is developed for dualarm robotic manipulator systems.A first-order sliding surface is designed using cross-coupling error in order to ensure position synchronization of dual-arm manipulators.The design objective of the proposed controller is to ensure stability as well as to synchronize the movement of both arms while maintaining the trajectory as desired.The integral sliding mode eliminates the reaching phase and guarantees robustness throughout the whole operating period.Additionally,a low pass filter is used to smoothen the discontinuous element and minimize unwanted chattering.Lyapunov stability theory is utilized to prove the asymptotic stability of the controlled system.Simulation studies are performed to validate the proposed controller′s effectiveness.Also,to investigate the possibility of realizing the proposed dynamic control method in practical applications,experiments are conducted on a 14DoF coordinated links(COOL)dual-arm robotic manipulator system.Experimental evidence indicates adequate efficiency in trajectory tracking and guarantees robustness in the presence of parametric uncertainty and external disturbance. | Sumi Phukan Chitralekha Mahanta | 2021 | International Journal of Automation and computing2021，18，1： | 2 |
| 9 | Biomass gasification for decentralized power generation: the Indian perspective 显示文摘 | Buragohain B Mahanta P Moholkar V S | 2010 | Renewable and Sustainable Energy Reviews2010，14，1： | 1 |
| 10 | Conducting polyaniline-nano TiO2 composites for smart corrosion resistant coatings显示文摘 | RADHAKR1SHNAN S S1JU C R MAHANTA D | 2009 | Electro chimica Acta2009，54，12： | 1 |
| 11 | Thin layer drying of tomato slices显示文摘 | Manashi Das Purkayastha Amit Nath Bidyut Chandra Deka Charu Lata Mahanta | 2013 | Journal of Food Science and Technology2013，，4： | 1 |
| 12 | Theory of sheath in a multicomponent plasma显示文摘 | Mahanta M K Goswami K S | 1999 | PhysicsofPlasmas1999，6，12： | 1 |
| 13 | Empirical modeling of chemoviscosity of hydroxy terminated polybutadiene based solid composite propellant slurry显示文摘 | Mahanta Abhay K Goyal Monika Pathak Devendra D | 2010 | Malaysian Polymer Journal2010，5，1： | 1 |
| 14 | Blind adaptive recognition of different QPSK modulation signals for software defined radio application显示文摘 | Naik M V Bhattacharjee R Mahanta A | 2006 | IEEE COMSWARE2006，5，01： | 1 |
| 15 | Production of protease and lipase by solvent tolerant Pseudomonas aeruginosa PseA in solid state fermentation using Jatropha curcas seed cake as substrate显示文摘 | Mahanta N Gupta A Khare S K | 2008 | Bioresour Technol2008，99，6： | 1 |
| 16 | Fibroscan can avoid liver biopsy in Indian patients with chronic hepatitis B 显示文摘 | Goyal R Mallick SR Mahanta M | 2013 | J Gastmenterol Hepatol2013，28，11： | 1 |
| 17 | Stuctural evolution ingraphitization of nanofibers and mats from electospun polyim-ide-mesophase pitch blends显示文摘 | Yan H Mahanta N Wang B | 2014 | Carbon2014，71，： | 1 |
| 18 | Effect of hydrothermal treatment varying in time and pressure on the properties of parboiled rices with different amylose content显示文摘 | Dutta H C L Mahanta | 2012 | Food Research International2012，49，2： | 1 |
| 19 | Conducting polyaniline-nano-TiO2 composites for smart corrosion resistant coatings 显示文摘 | RADHAKRISHNAN S SIJU C R MAHANTA D | 2009 | Electrochimica Acta2009，54，4： | 1 |
| 20 | In situ preparation of silver nanoparticles on biocompatible methacrylated poly(vinyl alcohol)and cellulose based polymeric nanofibers显示文摘 | MAHANTA N VALIYAVEETTIL S | 2012 | RSC Adv2012，2，11： | 1 |
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