|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 2 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 2 |
| 3 | Down-regulation of transcription factor peroxisome proliferator-activated receptor in programmed hepatic lipid dysregulation and inflammation in intrauterine growth-restricted offspring显示文摘 | Magee TR Han G Cherian B | 2008 | Am J Obstet Gynecol2008，199，3： | 1 |
| 4 | Resveratrol concentration in muscadine berry,juice,pomace,purees,seeds,and wines显示文摘 | ECTOR B J MAGEE J B HEGWOOD C P | 1996 | American Journal of Enology and Viticulture1996，47，1： | 1 |
| 5 | Responses of pigs fedwheat naturally infected with Fusarium gram inearum and containing the mycotoxins 4 - de- ~xynivalenol and zearalenone显示文摘 | William S K C Blaney B J Magee M H | 1988 | Australian Jounal of Agricultural Research1988，39，6： | 1 |
| 6 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 1 |
| 7 | The Christie Hospital breast conservation trial: an update at 8 years from inception 显示文摘 | Ribeiro GG Magee B Swindell R | 1993 | Clin Oncol (R Coll Radiol)1993，5，5： | 1 |
| 8 | Responses of pigs fed wheat naturally infected with Fusarium graminearum and containing the mycotoxins 4-deoxynivalenol and zearalenone显示文摘 | Williams K C Blaney B J Magee M H | 1988 | Aus J of Agr Res1988，39，6： | 1 |
| 9 | An optical method for estimating papaya maturity 显示文摘 | Birth G S Dull G G Magee J B | 1984 | J Am Sot Hortic Sci1984，109，： | 1 |
| 10 | Prognostic factors for breast recurrence after conservative breast surgery and radiotherapy : results from a randomised trim 显示文摘 | Magee B Swindell R Harris M | 1996 | Radiother Oncol1996，39，3： | 1 |
| 11 | Transport of dissolved organic macromolecules and their effect on the transport of phenanthrene in porous media显示文摘 | Magee B R Lion L W Lemley A T 1991 | 1991 | Environ Sci Technol1991，15，： | 1 |
| 12 | The inhibition of malignant cell growth by ketone bodies显示文摘 | MAGEE B A POTEZNY N ROFE A M | 1979 | Aust J Exp Bioi Med Sci1979，57，： | 1 |
| 13 | The cadherin superfamily:diversity in form and function显示文摘 | Angst B Marcozzi C Magee A | | 0，，04： | 1 |
| 14 | A GIS-based reconstruction of late Quaternary paleohydrology:Lake Eyre,arid central Australia显示文摘 | Devogel S B Magee J W Maliley W F | 2004 | Palaeogeography Palaeoclimatology Palaeoecology2004，204，： | 1 |
| 15 | Responses of pigs fed wheat naturally infected with Fusarium graminearum and contain- ing the mycotoxins 4-deoxynivalenol and zearalenone显示文摘 | Williams K C Blaney B J Magee M H | 1988 | Austra- lian Journal of Agricultural Research1988，39，6： | 1 |
| 16 | Colorectal cancer immunother- apy显示文摘 | Xiang B Snook AE Magee MS | 2013 | Discov Med2013，15，84： | 1 |
| 17 | Current issues with standards in the measurement and documentation of human skeletal anatomy 显示文摘 | Magee J McClelland B Winder J | 2012 | Journal of Anatomy2012，221，3： | 1 |
| 18 | Responses of pigs fed wheat naturally infected with Fusarium graminearum and containing the mycotoxins 4-deoxynivalenol and zearalenone 显示文摘 | WILLIAMS K C BLANEY B J MAGEE M H | 1988 | Aust J Agric Res1988，39，6： | 1 |
| 19 | Resveratrol concentration in muscadine berry,juice,pomace,purees,seeds,and wines显示文摘 | ECTOR B J MAGEE J B HEGWOOD C P | 1996 | Am J Enol Vitic1996，47，1： | 1 |
| 20 | Axillary recurrence following conservative surgery and radiotherapy in early breast cancer显示文摘 | Livsey JE Magee B Stewart AL | 2000 | Clin Oncol (R Coil Radiol)2000，12，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员