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| 1 | Combined laparoscopic spleen-preserving distal pancreatectomy and islet autotransplantation for benign pancreatic neoplasm显示文摘AIM:To evaluate the safety and feasibility of laparoscopic spleen-preserving distal pancreatectomy(LSPDP)with autologous islet transplantation(AIT)for benign tumors of the pancreatic body-neck.METHODS:Three non-diabetic,female patients(age37,44 and 35 years,respectively)were declared candidates for surgery,between May and September 2011,because of pancreatic body/neck cystic lesions.The planned operation was an LSPDP associated with AIT from the normal pancreas distal to the neoplasm.Islets isolation was performed on the residual pancreatic parenchyma after frozen section examination of the margin.Purified autologous islets were infused into the portal vein by a percutaneous transhepatic approach the day after surgery.RESULTS:The procedure was performed successfully in all the three cases,and the spleen was preserved along with its vessels.Mean operation time was 283±52 min and average blood loss was 133±57 mL.Residual pancreas weights were 33,22 and 30 g,and105.200,40.390 and 94.790 islet equivalents were isolated,respectively.Surgical complications occurred in one patient(grade A pancreatic fistula).Postoperative stays were 6,6 and 7 d,respectively.Histopathological evaluation revealed mucinous cystic neoplasm in cases1 and 3,and serous cystic neoplasm in patient 2.No postoperative insulin administration was required.One patient developed a transient partial portal thrombosis2 mo after islet infusion.Patients are insulin independent at a mean follow up of 8±2 mo.CONCLUSION:Combination of LSPDP and AIT is feasible and could be effective to minimize the surgical impact for benign neoplasm of pancreatic body-neck. | Gianpaolo Balzano Michele Carvello Lorenzo Piemonti Rita Nano Riccardo Ariotti Alessia Mercalli Raffaella Melzi Paola Maffi Marco Braga Carlo Staudacher | 2014 | World Journal of Gastroenterology2014，20，14： | 4 |
| 2 | Islet isolation for allotransplantation: variables associated with successful islet yield and graft function显示文摘 | R. Nano B. Clissi R. Melzi G. Calori P. Maffi B. Antonioli S. Marzorati L. Aldrighetti M. Freschi T. Grochowiecki C. Socci A. Secchi V. Carlo E. Bonifacio F. Bertuzzi | 2005 | Diabetologia2005，，5： | 1 |
| 3 | Renoprotective effect of contemporary blocking of angiotensin Ⅱ and endothelin-1 in rats with membranous nephropathy显示文摘 | Benigni A Corna D Maffi R | 1998 | Kidney Int1998，54，2： | 1 |
| 4 | Piranha: a CORBA tool for high availability显示文摘 | MAFFIES S | 1997 | IEEE Computer1997，30，4： | 1 |
| 5 | Secondary failure to oral hypoglycaemic agents in non-obese patients with noninsulin-dependent diabetes is related to reduced insulin release显示文摘 | Pontiroli AE Calderara A Maffi P | 1989 | Diabets Metab1989，15，： | 1 |
| 6 | Recent Work on Naturalized Epistemology显示文摘 | Maffie J | 1990 | American Philosophical Quarterly1990，27，4： | 1 |
| 7 | Recent Work on Naturalized Epistemology显示文摘 | James Maffie | 1990 | American Philosophical Quarterly1990，，4： | 1 |
| 8 | Transplant estimated function:a simple index to evaluate beta-cell secretion after islet transplantation显示文摘 | Caumo A Maffi P Nano R Bertuzzi F Luzi L Secchi A | | 0，，： | 1 |
| 9 | Early Increase of Retinal Arterial and Venous Blood Flow Velocities at Color Doppler Imaging in Brittle Type 1 Diabetes after Islet Transplant Alone显示文摘 | Massimo Venturini Paolo Fiorina Paola Maffi Claudio Losio Andrea Vergani Antonio Secchi Alessandro Del Maschio | 2006 | Transplantation2006，，9： | 1 |
| 10 | Early increase of retinal arterial and venous blood flow velocities at color Doppler imaging in brittle type 1 diabetes after islet transplant alone显示文摘 | Venturini M Fiorina P Maffi P | 2006 | Transplantation2006，81，9： | 1 |
| 11 | Early increase of retinal arterial and venous blood flow velocities at color Doppler imaging in brittle type 1 diabetes after islet transplant alone显示文摘 | Venturini M Fiorina P Maffi P | | 0，，： | 1 |
| 12 | Autoantibody response to islet transplantation in type 1 diabetes显示文摘 | Bosi E Braghi S Maffi P Scirpoli M Bertuzzi F Pozza G | | 0，，： | 1 |
| 13 | Both alloantibodies and autoantibodies are a significant barrier to preservation of islet cell function after transplantation 显示文摘 | Piemonti L Everly M J Maffi P | 2011 | Transpl Int2011，24，2： | 1 |
| 14 | DPP6 Locali- zation in brain supports function as a Kv4 channel associ- ated protein显示文摘 | CLARK B D KWON E MAFFIE J | 2008 | Front Mol Neurosci2008，1，： | 1 |
| 15 | Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells显示文摘 | Monti P Scirpoli M Maffi P | 2008 | J Clin Invest2008，118，5： | 1 |
| 16 | Rapamycin monotherapy in patients with type 1 diabetes modifies CD4^+CD25^+FOXP3^+ regulatory T-cells 显示文摘 | Monti P Scirpoli M Maffi P | 2008 | Diabetes2008，57，9： | 1 |
| 17 | Insulin-like growth factor-I mediates neuroprotection in proteasome inhibition-in- duced cytotoxieity in SH-SY5Y cells显示文摘 | Cheng B Maffi SK Martinez AA | 2011 | Mol Cell Neurosci2011，47，： | 1 |
| 18 | Islet transplantation improves vascular diabetic complications in patients with diabetes who underwent kidney transplantation:a comparison between kidney-pancreas and kidney-alone transplantation显示文摘 | Fiorina P Folli F Maffi P | 2003 | Transplantation2003，75，8： | 1 |
| 19 | Progressive glomerular injury in the MWF rat is predicted by inborn nephron deficit显示文摘 | Fassi A Sangalli F Maffi R | 1998 | J Am Soc Nephrol1998，9，： | 1 |
| 20 | Technique,complications,and therapeutic efficacy of percutaneous transplantation of human pancreatic islet cells in type 1 diabetes:the role of US显示文摘 | Venturini M Angeli E Maffi P Fiorina P Bertuzzi F Salvioni M | | 0，，： | 1 |
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