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| 1 | Gastrointestinal stromal tumors:Thirty years experience of an Institution显示文摘AIM:To report our experience of gastrointestinal stromal tumors (GISTs) during the last 29 years. METHODS:Thirty two cases of GIST referred to our Institution from the 1st January 1981 to the 10th June 2010 were reviewed. Metastases,recurrence and survival data were collected in relation to age,history,clinical presentation,location,size,resection margins and cellular features. RESULTS:Mean age was 63.7 years (range,40-90) and incidence was slightly higher in males (56%). R0 resection was performed in 90.7% of cases,R1 in 6.2% (2 cases) and R2 in 3.1% (one case). Using Fletcher's classification 8/32 (25%) had high risk,9/32 (28%) intermediate and 15/32 (47%) low risk tumors. Follow-up varied from 1 mo to 29 years,with a median of 8 years; overall survival was 75% (24/32),disease-free survival was 72% and tumor-related mortality was 9.3%. Three patients with high risk GIST were treated with imatinib mesylate:one developed a recurrence after 36 mo,and 2 are free from disease at 41 mo. CONCLUSION:Surgical treatment remains the gold standard therapy for resectable GISTs. Pathological and biological features of the neoplasm represent the most important factors predicting the prognosis. | Simone Arolfo Paolo Mello Teggia Mario Nano | 2011 | World Journal of Gastroenterology2011，17，14： | 14 |
| 2 | Stimulus-responsive polymeric nanoparticles for biomedical applications显示文摘Polymeric nanoparticles with unique properties are regarded as the most promising materials for biomedical applications including drug delivery and in vitro/in vivo imaging.Among them,stimulus-responsive polymeric nanoparticles,usually termed as 'intelligent' nanoparticles,could undergo structure,shape,and property changes after being exposed to external signals including pH,temperature,magnetic field,and light,which could be used to modulate the macroscopical behavior of the nanoparticles.This paper reviews the recent progress in stimulus-responsive nanoparticles used for drug delivery and in vitro/in vivo imaging,with an emphasis on double/multiple stimulus-responsive systems and their biomedical applications. | LI YongYong1,2,DONG HaiQing1,2,WANG Kang1,SHI DongLu 2,ZHANG XianZheng1 & ZHUO RenXi1 1Key Laboratory of Biomedical Polymers,Ministry of Education Department of Chemistry,Wuhan University,Wuhan 430072,China 2Institute for Advanced Materials and Nano Biomedicine(iNANO),Tongji University,Shanghai 200092,China | 2010 | Science China Chemistry2010，53，3： | 11 |
| 3 | Large area mold fabrication for the nanoimprint lithography using electron beam lithography显示文摘The mold fabrication is a critical issue for the development of nanoimprint lithography as an effective low-cost and mass production process.This paper describes the fabrication process developed to fabricate the large area nanoimprint molds on the silicon wafers.The optimization of e-beam exposure dose and pattern design is presented.The overlayer process is developed to improve the field stitching accuracy of e-beam exposure,and around 10 nm field stitching accuracy is obtained.By means of the optimization of the e-beam exposure dose,pattern design and overlayer process,large area nanoimprint molds having dense line structures with around 10 nm field stitching accuracy have been fabricated.The fabricated mold was used to imprint commercial imprinting resist. | CHU JinKui1,2,MENG FanTao1,2,HAN ZhiTao1,2 & GUO Qing1,2 1 Key Laboratory for Micro/Nano Technology and System of Liaoning Province,Dalian University of Technology,Dalian 116024,China 2 Key Laboratory for Precision and Non-traditional Machining Technology of Ministry of Education,Dalian University of Technology,Dalian 116024,China | 2010 | Science China(Technological Sciences)2010，53，1： | 6 |
| 4 | Time amplifying techniques towards atomic time resolution显示文摘High speed imaging technology has opened applications in many fields,such as collision,detonating, high voltage discharge,disintegration and transfer of phonon and exciton in solid,photosynthesis primitive reaction,and electron dynamics inside atom shell.In principle,all of the transient processes need to be explained theoretically and,at the same time,the time amplifying technique is required for observations of these processes.The present review concerns the atomic time amplifying mechanism of optical information and the extremely-high speed imaging methods,which are expressed in terms of the short time amplifying techniques.It is well-known that for extremely-high speed imaging with the converter tube,the temporal resolution is in the order of sub-picosecond of the streak imaging,and the imaging frequency is 6×10 8 ―5×10 9 fps(frame per second)of the frame imaging.On the other hand,for the tubeless extremely-high speed imaging,the imaging frequency is 10 7 ―10 14 fps,and its mechanism of forming high speed and framing could involve a lot of factors of the light under investigation,for instance,light speed,light parallelism,the parameters of light wave such as amplitude,phase,polari- zation and wavelength,and even quantum properties of photon.In the cascaded system of electro- magnetic wave and particle wave,it is possible to simultaneously realize extremely-high resolution in time and space,which is higher than a kite resolution.Then it would be possible to break the limit of the Heisenberg uncertainty relation of the optical frequency band. | LI JingZhen Institute of Photonic Engineering,College of Electron Science&Technology,Shenzhen University,and Shenzhen Key Laboratory of Micro·Nano Photonic Information,Shenzhen 518060,China | 2009 | Science China(Technological Sciences)2009，52，12： | 5 |
| 5 | Combined laparoscopic spleen-preserving distal pancreatectomy and islet autotransplantation for benign pancreatic neoplasm显示文摘AIM:To evaluate the safety and feasibility of laparoscopic spleen-preserving distal pancreatectomy(LSPDP)with autologous islet transplantation(AIT)for benign tumors of the pancreatic body-neck.METHODS:Three non-diabetic,female patients(age37,44 and 35 years,respectively)were declared candidates for surgery,between May and September 2011,because of pancreatic body/neck cystic lesions.The planned operation was an LSPDP associated with AIT from the normal pancreas distal to the neoplasm.Islets isolation was performed on the residual pancreatic parenchyma after frozen section examination of the margin.Purified autologous islets were infused into the portal vein by a percutaneous transhepatic approach the day after surgery.RESULTS:The procedure was performed successfully in all the three cases,and the spleen was preserved along with its vessels.Mean operation time was 283±52 min and average blood loss was 133±57 mL.Residual pancreas weights were 33,22 and 30 g,and105.200,40.390 and 94.790 islet equivalents were isolated,respectively.Surgical complications occurred in one patient(grade A pancreatic fistula).Postoperative stays were 6,6 and 7 d,respectively.Histopathological evaluation revealed mucinous cystic neoplasm in cases1 and 3,and serous cystic neoplasm in patient 2.No postoperative insulin administration was required.One patient developed a transient partial portal thrombosis2 mo after islet infusion.Patients are insulin independent at a mean follow up of 8±2 mo.CONCLUSION:Combination of LSPDP and AIT is feasible and could be effective to minimize the surgical impact for benign neoplasm of pancreatic body-neck. | Gianpaolo Balzano Michele Carvello Lorenzo Piemonti Rita Nano Riccardo Ariotti Alessia Mercalli Raffaella Melzi Paola Maffi Marco Braga Carlo Staudacher | 2014 | World Journal of Gastroenterology2014，20，14： | 4 |
| 6 | Reduction of internal stress in SU-8 photoresist layer by ultrasonic treatment显示文摘At present, high internal stress in SU-8 photoresist layer has become one of the most primary problems and restricted structure stability and higher aspect ratio of SU-8 photoresist. However, the existing studies all focused on optimizing the process pa-rameters or mask design, and could not be popularized. The purpose of this paper is to reduce the internal stress in cured SU-8 photoresist layer by ultrasonic stress relief technology. The ultrasonic stress relief mechanism in SU-8 photoresist layer was presented. Based on improved Stoney’s formula, the profile mothod calculation model for SU-8 internal stress was proposed. The effect of ultrasonic stress relief on SU-8 layers was studied by experiments. Some important factors, such as amplitude of vibration, power input and relief time, were discussed. The values of internal stress before and after the ultrasonic stress relief process were compared. The research results show that the internal stress in cured SU-8 layer can be reduced effectively if the proper experimental parameters are chosen, and ultrasonic stress relief technology in nonmetal field has some practical value. | DU LiQun1,2*, WANG QiJia2 & ZHANG XiaoLei2 1 Key Laboratory for Micro/Nano Technology and System of Liaoning Province, Dalian University of Technology, Dalian 116024, China 2 Key Laboratory for Precision & Non-traditional Machining Technology of Ministry of Education, Dalian University of Technology, Dalian 116024, China | 2010 | Science China(Technological Sciences)2010，53，11： | 2 |
| 7 | 利用微卫星DNA标记分析巴布亚新几内亚三个地方鸡群体的遗传多样性及亲缘关系显示文摘为了解巴布亚新几内亚地方鸡群体的遗传多样性和亲缘关系,本研究利用20个微卫星DNA遗传标记,对3个群体、96个个体的基因型进行了测定,估算了群体内的杂合度和近交系数(FIS)以及群体间的遗传分化系数(FST)等多样性参数;根据Nei氏标准遗传距离,构建群体水平的NJ树和个体水平上的无根UPGMA树。结果表明,3个群体内的平均期望(基因)杂合度介于0.665 9至0.680 6,平均FIS介于0.020至0.286,总群体水平上的遗传变异仅占5.5%;3个群体相互之间的遗传分化均达到显著水平,在个体水平的无根UPGMA树上,来源同一群体的个体会优先聚为一类。这说明巴布亚新几内亚的3个地方鸡群体的遗传多样性比较丰富,群体间的遗传分化显著,应该分别加以保护和利用。 | 曾盛诚 Gariba Danbaro William Nano Sammy Doka Tau Gerega Olivier Hanotte 韩建林 | 2010 | 畜牧兽医学报2010，41，7： | 2 |
| 8 | Modeling and simulation of a novel vertical actuator based on electrowetting on dielectric显示文摘A novel vertical actuator based on electrowettingon dielectric (EWOD) was designed, analyzed and simulated.Modeling results indicated that the vertical driving force ofthe actuator obeyed a second order polynomial of appliedvoltage, which was verified by Covent_ware 2006. As a result,the vertical driving force of the EWOD actuator with a1.1 nL droplet and a 1.75 μm thick polymer was about 0.5 |xNunder an applied voltage 100V which was comparable to thatof the electrostatic actuators. Moreover, the noise from planeforces we analyzed and simulated was very low. Therefore,we made a conclusion that the EWOD actuator can be usedin MEMS transducer. | Ping An Jing Chen Yilong Hao National Key Laboratory of Micro/Nano Fabrication Technology,Institute of Microelectronics, Peking University,100871 Beijing, China | 2009 | Acta Mechanica Sinica2009，25，5： | 2 |
| 9 | Impact of thickness of GaN buffer layer on properties of AlN/GaN distributed Bragg reflectors grown by metalorganic chemical vapor deposition显示文摘We studied the impact of the thickness of GaN buffer layer on the properties of distributed Bragg reflector (DBR) grown by metalorganic chemical vapor deposition (MOCVD). The samples were characterized by using metallographic microscope, transmission electron microscope (TEM), atomic force microscopy (AFM), X-ray diffractometer (XRD) and spectrophotometer. The results show that the thickness of the GaN buffer layer can significantly affect the properties of the DBR structure and there is an optimal thickness of the GaN buffer layer. This work would be helpful for the growth of high quality DBR structures. | WU ChaoMin1, SHANG JingZhi1, ZHANG BaoPing1,2, ZHANG JiangYong1,3, YU JinZhong1,3 & WANG QiMing1,31 Department of Physics and Semiconductor Photonics Research Center, Xiamen University, Xiamen 361005, China 2 Pen-Tung Sah Micro/Nano Technology Research Center, Xiamen University, Xiamen 361005, China 3 State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China | 2010 | Science China(Technological Sciences)2010，53，2： | 2 |
| 10 | Phase -transfer catalytic determination of phenols as methylated derivatives by gas chromatography with flame ionization and massselective detection显示文摘 | Fiamegos Yiannis C Nanos Christos G Pilidis George A | 2003 | Journal of Chromatography A2003，1183，12： | 1 |
| 11 | Human pancreatic islets produce and secrete MCP-1/CCL2:relevance in human islet transplantation显示文摘 | PIEMONTI L LEONE BE NANO R | 2002 | Diabetes2002，51，1： | 1 |
| 12 | Islet isolation for allotransplantation: variables associated with successful islet yield and graft function显示文摘 | R. Nano B. Clissi R. Melzi G. Calori P. Maffi B. Antonioli S. Marzorati L. Aldrighetti M. Freschi T. Grochowiecki C. Socci A. Secchi V. Carlo E. Bonifacio F. Bertuzzi | 2005 | Diabetologia2005，，5： | 1 |
| 13 | p38 MAPK turns hepatocyte growth factor to a death signal that commits ovarian cancer cells to chemotherapy-induced apoptosis显示文摘 | Coltella N Rasola A Nano E | 2006 | Int J Cancer2006，4，： | 1 |
| 14 | An asymmetric approach to coumarin anticoagulants via heteroDiels-Alder cycloaddition显示文摘 | CRAVOTTO G NANO G M PALMISANO G | 2001 | Tetrahedron:Asymmetry2001，12，5： | 1 |
| 15 | Human leukocyte antigen and antigen processing machinery component defects in astrocytic tumors显示文摘 | FACOETTI A Nano R Zelini P | 2005 | Clin Cancer Res2005，11，23： | 1 |
| 16 | Prenylalted Coumarins and Sesquiterpenoids from Ferula Communis 显示文摘 | Valle MG Appendino G Nano GM | 1987 | Phytochem1987，26，1： | 1 |
| 17 | Energy flow for integrated apple production in Greece显示文摘 | STRAPATSA A V NANOS G D TSATSARELIS C A | 2006 | Agrculture Ecosystems and Environment2006，116，： | 1 |
| 18 | Lactic acid production by electrodialysis显示文摘 | BONIARDI N ROTA R NANO G | 1997 | J Appl Electrochem1997，27，： | 1 |
| 19 | Balancing Effi- ciency of Health Services and Equity of Access in Remote Are- as in Greece显示文摘 | Kontodimopoulos N Nanos P Niakas D | 2006 | Health Policy2006，76，1： | 1 |
| 20 | Regarding 'Cutting balloon angioplasty of renal bromuscular dysplasia:a word of caution'显示文摘 | Lupatelli T Nano G Inglese I | 2005 | J Vasc Surg2005，42，： | 1 |
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